Hematology Past Paper Questions
1. During the hemostatic process, what is the term for platelets interacting with and
binding to other platelets?
2. What does not induce platelet aggregation?
3. In which condition may a significantly increased mean platelet volume (MPV) be
observed?
4. What should be the anticoagulant ratio to blood for coagulation procedures?
5. What is Von Willebrand’s factor?
6. What enzymatically degrades fibrin?
7. Which deficiency will affect the results of the protamine sulfate test?
8. What does the thrombin time test evaluate when thrombin is added to citrated
plasma?
9. What condition is characterized by a normal platelet count, prolonged bleeding
time, and deficient clot retraction?
10. What test results are characteristic of disseminated intravascular coagulation
(DIC)?
11. Which coagulation factors are referred to as “vitamin K-dependent”?
12. What is a component of platelet alpha granules?
13. Hageman factor disease is another name for which deficiency?
14. What are fibrin split products?
15. What are the cells that line the central cavity of all blood vessels and related
tissues called?
16. Which group of coagulation factors requires vitamin K for synthesis?
17. What is the normal lifespan of platelets in peripheral blood?
18. What functions as cofactors in hemostasis?
19. What are platelet dense bodies storage organelles for, which is released after
activation?
20. Which platelet receptor is needed for platelet adhesion?
21. What can be said about formation of thromboxane A₂ in the activated platelet?
22. What effect does thrombopoietin have on the megakaryocyte?
23. What is the function of microtubules in the resting platelet?
24. How may contents of the platelet granules be released from the platelet?
25. Which factor is basically a transglutaminase in its activity?
26. What is not involved in hemostasis?
27. For which factor is plasma concentration and half life often quoted as ‘not
applicable’?
28. What is true about the relationship between ADP and platelets?
29. Which factor is not absorbed from plasma by BaSO₄?
30. Which coagulation factor is the “odd man out” compared to the others?
31. Which factors’ activity is lost in stored plasma?
32. Which factor is not consumed during coagulation?
33. Which factor is the “odd man out” compared to the others?
34. Which factor is synthesized by the endothelium and has a half life of about 10
days in vivo?
35. Which factor is also referred to as stable factor?
36. What are the end products of breakdown of fibrin?
37. Which is not a non-thrombogenic hemostatic function of endothelial cells?
38. Which condition is the “odd man out” compared to the others?
39. What is High molecular weight Kininogen also referred to as?
40. Where do the two pathways meet and generate insoluble fibrin?
41. Which condition is not associated with macrothrombocytosis?
42. Which is not activated by snake venoms?
43. What is the inheritance pattern of von Willebrand disease?
44. Which is not a non-thrombogenic hemostatic component of endothelial cells?
45. Which clotting factor is deficient in a patient with hemophilia A?
46. What is the reference range for platelet count?
47. What is the reference range for bleeding time?
48. What is the reference range for APTT?
49. What is the reference range for Factor VIII assay?
50. Based on the patient’s results, how would you describe the platelet count?
51. Based on the patient’s results, how would you describe the bleeding time?
52. Based on the patient’s results, how would you describe the APTT?
53. Based on the patient’s results, how would you describe the PT?
54. Based on the patient’s results, how would you describe the Factor VIII assay?
55. Based on the patient’s results, how would you describe the Factor IX assay?
56. What is the most probable cause of the patient’s bleeding in the given case?
57. Which factors does Prothrombin time monitor?
58. What causes vasodilatation?
59. In disseminated intravascular coagulation (DIC), which factor cannot directly
activate factor X?
60. What might explain why a patient has a deficiency of a clotting factor?
61. What platelet count result would you expect in a patient with hemophilia A?
62. What laboratory test is helpful in diagnosis of lupus anticoagulant?
63. What findings would a patient with DIC most likely have?
64. What serves as cofactors in the coagulation system?
65. What is a component of the intrinsic pathway that activates the coagulation
system?
66. What is an inhibitor of the coagulation system?
67. What inhibits plasmin in the fibrinolytic system?
68. What is another example of a cofactor in the coagulation system?
