Personal Health Smart Report: K V Sharma
Personal Health Smart Report: K V Sharma
SMART REPORT
A comprehensive analysis of your health using
Blood, Physicals, and Health Questionnaire data
Prepared for
K V Sharma
Basic Info Patient ID
Female /49 Yrs KOL593655
Table of contents
Your smart report includes the following sections.
04 Wellness Recommendations 12
05 References 13
06 Lab Report
Disclaimer
• This is an electronically generated report and is not a • Analysis uses the attached blood test report and Well
substitute for medical advice. Being Index Questionnaire data, if present, and urine
of any allergies or intolerances. • Tata 1mg is not liable for any direct, indirect, special,
• If you are pregnant or lactating, some of the consequential, or other damages. This report cannot be
recommendations and analyzed information in the used for any medico-legal purposes. Partial reproduction
Smart Report may not directly apply to you. Please of the test results is not permitted. Also, TATA 1mg Labs is
consult a doctor regarding your test results and not responsible for any misinterpretation or misuse of the
recommendations. information.
Patient ID Date of Collection
KOL593655 28/04/25
For
Doctor Summary For K V Sharma
Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Note This is an electronically generated summary of the attached report. It is advised to read this summary in conjunction with the
attached report and to correlate it clinically. For the trends section, the out of range values are highlighted with respect to the
bio reference range of respective reports.
Test Name Result, 28/04/25 Bio. Ref. Interval Trends (For last three tests)
Inflammatory markers
We don't have any of your
Erythrocyte Sedimentation previous lab results for
19 mm/hr 0.5 - 12
Rate
these tests in our records
C-Reactive Protein
7.70 mg/L 0 - 3.3
(Quantitative)
Iron Studies
Diabetes Profile
Page 3/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Doctor Summary For K V Sharma
Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Note This is an electronically generated summary of the attached report. It is advised to read this summary in conjunction with the
attached report and to correlate it clinically. For the trends section, the out of range values are highlighted with respect to the
bio reference range of respective reports.
Test Name Result, 28/04/25 Bio. Ref. Interval Trends (For last three tests)
Glycosylated Hemoglobin
10.8 % 4 - 5.6
(HbA1c)
Lipid Profile
Alanine Transaminase
13 U/L 10 - 49
(SGPT)
Page 4/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Doctor Summary For K V Sharma
Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Note This is an electronically generated summary of the attached report. It is advised to read this summary in conjunction with the
attached report and to correlate it clinically. For the trends section, the out of range values are highlighted with respect to the
bio reference range of respective reports.
Test Name Result, 28/04/25 Bio. Ref. Interval Trends (For last three tests)
Vitamin Profile
Arthritis Screening
Rheumatoid Factor -
< 3.5 IU/mL 0 - 14
Quantitative
Page 5/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Wellbeing Index K V Sharma
Important Findings from your Wellbeing Index Female /49 Yrs
Physicals
Heart Age BP
Data not available Data not available
Disease Risks
Lifestyle Data
Page 6/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Important Parameters K V Sharma
From your Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
MPV PDW
12.5 fl 32.1 fl
Inflammatory markers
Helps to understand presence of an inflammation in the body. Inflammation is bodies defence
against infection or injury.
Page 7/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Important Parameters K V Sharma
From your Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Iron Studies
Iron is a vital mineral. It helps our blood cells to transport oxygen. Iron studies are used to assess level
of iron in blood and blood's ability to attach itself to iron.
Diabetes Profile
Measures the level of glucose in the body and helps identify the body's ability to process glucose. It
can be used for screnning as well as monitoring the treatment of diabetes.
Range: 0.55 - 1.02 Range: 2.7 - 6.1 Range: 136 - 145 Range: 3.5 - 5.1
Page 8/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Important Parameters K V Sharma
From your Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Lipid Profile
Measures the amount of Cholesterol and Triglycerides in your blood. This gives an insight into the
health of heart and blood vessels.
Range: <= 199.9 Range: 0 - 149.9 Range: >= 39.9 Range: <= 99.9
Page 9/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Important Parameters K V Sharma
From your Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Vitamin Profile
Vitamins are the essential nutrients for human life. This profile offers tests to check level of different
types of vitamin B, vitamin D, vitamin E and vitamin K.
Page 10/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Important Parameters K V Sharma
From your Comprehensive Gold Full Body Checkup with Smart Report Female /49 Yrs
Arthritis Screening
Measures the amount of rheumatoid factor (RF) and Anti-CCP Antibody in the blood, which helps
diagnose or monitor rheumatoid arthritis (RA) and differentiates it from other types of arthritis.
Range: 0 - 14
Page 11/13
Patient ID Date of Collection
KOL593655 28/04/25
For
Recommendations K V Sharma
Female /49 Yrs
Care for better health and wellbeing
Lifestyle
Healthy Do's
Do's Sleep
Regular Bedtime And Rise Avoid A Large Meal Close hygiene
Time To Bedtime
Maintain consistent bedtime and Eat a healthy dinner early and avoid
wake time to regulate sleep late-night snacks to promote better
patterns and prevent sleep sleep.
irregularities.
Exercise Do's
Page 12/13
Patient ID Date of Collection
KOL593655 28/04/25
For
References K V Sharma
Female /49 Yrs
From trusted sources
12 Smoking cessation
Age-friendly Primary Health Care Centres Toolkit. World Health Organization
13 Sleep Hygiene
Irish LA, et al. The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep Med Rev. 2015;22:23-36.
Page 13/13
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Comment:
Microalbumin/Albumin-to-Creatinine Ratio (UACR) Categories
UACR
ACR Category Terms
(mg/g creatinine)
A1 <30 Normal
A2 30 - 299 Microalbuminuria
A3 >=300 Clinical Albuminuria
Note: ACR categories: A1 - normal to mildly increased; A2 - moderately increased; A3 - severely increased.
(Source- American Diabetes Association (ADA):Standards of Care in Diabetes-2024)
As per ADA, due to high biological variability (>20%) between measurements of urinary albumin excretion; two out of
three specimens collected within a 3-to 6-month period should be abnormal before considering albuminuria (after
excluding non-renal causes).
Certain factors may raise UACR even without kidney damage - physiological like exercise within 24 hours, menstruation,
pregnancy, benign postural proteinuria or pathological like infection (UTI), hematuria, fever, marked hyperglycemia,
congestive heart failure, marked hypertension & poor metabolic control. A high albumin-to-creatinine ratio can be due to
low urinary creatinine seen in females, low muscle mass, low protein intake or acute kidney injury.
A random spot urine sample can be used, but due to high variability, it is recommended that abnormal UACR (>= 30
mg/g) should be confirmed with subsequent first morning midstream sample or 24 hr urine collection.
Due to inherent day to day variability in albumin excretion, UACR is a better indicator than urine albumin alone.
Microalbuminuria is defined as the small but abnormal increase in the excretion of urinary albumin (30-300 mg/g
creatinine), but it is recommended to use the term albuminuria for ACR >= 30 mg/g creatinine.
Persistent albuminuria present for a minimum of 3 months is one of the diagnostic markers of kidney damage and used for
classification of chronic kidney disease (CKD).
Clinical Utility: Useful in early screening of diabetic nephropathy, as a risk marker for stroke & heart disease and also for
classification and progression of CKD.
Page 1 of 18
PO No :PO1981085980-181
CLINICAL PATHOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Comment:
•Note: Pre-test condition to be observed while submitting the sample-first void, mid stream urine, collected in a clean, dry, sterile
container is recommended for routine urine analysis, avoid contamination with any discharge from vaginal, urethra, perineum,
Avoid prolonged transit time & undue exposure to sunlight.
•During interpretation, points to be considered are Negative nitrite test does not exclude the urinary tract infections. Trace
proteinuria can be seen with many physiological conditions like prolonged recumbency, exercise, high protein diet. False positive
reactions for bile pigments, proteins, glucose and nitrites can be caused by peroxidase like activity by disinfectants, therapeutic
dyes, ascorbic acid and certain drugs.• Urine microscopy is done in centrifuged urine specimens
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PO No :PO1981085980-181
HAEMATOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
As per the recommendation of International council for Standardization in Hematology, the differential leucocyte counts are
additionally being reported as absolute numbers of each cell in per unit volume of blood.
DHSS : Double Hydrodynamic Sequential System Flowcytometry
Calculated parameters are either derived from Impedence measure, RBC pulse measurement, RBC/platelet histograms or
formula derived.
Page 3 of 18
PO No :PO1981085980-181
HAEMATOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
ESR provides an index of progress of the disease and is widely used as an indicator of inflammation, infection, trauma, or
malignant diseases. Changes are more significant than a single abnormal test
It is specifically indicated to monitor the course or response to the treatment of diseases like rheumatoid arthritis,
tuberculosis bacterial endocarditis ,acute rheumatic fever ,Hodgkins disease,temporal arthritis , and systemic lupus
erythematosis; and to diagnose and monitor giant cell arteritis and polymyalgia rheumatica.
An elevated ESR may also be associated with many other conditions, including autoimmune disease, anemia,
infection,malignancy,pregnancy, multiple myeloma, menstruation, and hypothyroidism.
Although a normal ESR cannot be taken to exclude the presence of organic disease, its rate is dependent on various
physiologic and pathologic factors.
The most important component influencing ESR is the composition of plasma. High level of C-Reactive Protein, fibrinogen,
haptoglobin, alpha-1antitrypsin, ceruloplasmin and immunoglobulins causes the elevation of Erythrocyte Sedimentation
Rate.
Drugs that may cause increase ESR levels include: dextran, methyldopa, oral contraceptives, penicillamine, procainamide,
theophylline, and Vitamin A. Drugs that may cause decrease levels include: aspirin, cortisone, and quinine
Page 4 of 18
PO No :PO1981085980-181
HAEMATOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Interpretation: HbA1c%
≤5.6 Normal
5.7-6.4 At Risk For Diabetes
≥6.5 Diabetes
Comments:
A 3 to 6 monthly monitoring is recommended in diabetics. People with diabetes should get the test done more often if their blood
sugar stays too high or if their healthcare provider makes any change in the treatment plan. HbA1c concentration represent the
integrated values for blood glucose over the preceding 8-12 weeks and is not affected by daily glucose fluctuation, exercise &
recent food intake.
Please note, Glycemic goal should be individualized based on duration of diabetes, age/life expectancy, comorbid conditions,
known CVD or advanced microvascular complications, hypoglycemia unawareness, and individual patient considerations.
Factors that interfere with HbA1c Measurement: Hemoglobin variants, elevated fetal hemoglobin (HbF) and chemically modified
derivatives of hemoglobin (e.g. carbamylated Hb in patients with renal failure) can affect the accuracy of HbA1c measurements.
Factors that affect interpretation of HbA1c Measurement: Any condition that shortens erythrocyte survival or decrease mean
erythrocyte age (e. g., recovery from acute blood loss, hemolytic anemia, HbSS, HbCC, and HbSC) will falsely lower HbA1c test
results regardless of the assay method used. Iron deficiency anemia is associated with higher HbA1c.
Note: Presence of Hemoglobin variants and/or conditions that affect red cell turnover must be considered, particularly when the
HbA1c result does not correlate with the patient's blood glucose levels.
Page 5 of 18
PO No :PO1981085980-181
HAEMATOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Page 6 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
FBG higher than PPBG may be seen in both diabetics and healthy population.Low PPBG is seen
after inadequate intake or intake of non-carbohydrate meal before test, anti-diabetic medication
and strenuous activity.Also seen with Reactive hypoglycemia & Insulin resistance.
Comment:
Impaired glucose tolerance (IGT) fasting, means a person has an increased risk of developing type 2 diabetes but does not
have it yet. A level of 126 mg/dL or above, confirmed by repeating the test on another day, means a person has diabetes.
IGT (2 hrs Post meal ), means a person has an increased risk of developing type 2 diabetes but does not have it yet. A 2-hour
glucose level of 200 mg/dL or above, confirmed by repeating the test on another day, means a person has diabetes
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PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Lipid Profile
Cholesterol - Total 271 mg/dL Low (desirable): < 200 Enzymatic (CHO-POD)
mg/dL
Moderate (borderline)
200–239 mg/dL
High: >/= 240 mg/dL
Triglycerides 651 mg/dL Normal: < 150, Enzymatic, GPO
Borderline: 150 - 199,
High:200 - 499, Very
High >=500
Result rechecked with recommended dilution, please correlate clinically.
Page 8 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
High:190 - 219,
Very High: >= 220
Since Triglycerides are more than 400 mg/dl, LDL-C tested by Direct LDL method.
Repeat Lipid Profile after 10-12 hrs fasting if clinically indicated.
Note: High triglycerides levels may be seen in obesity, physical inactivity, smoking, excess alcohol intake, high carbohydrate diet,
foods rich in saturated and trans fats, type 2 diabetes, chronic renal failure, hypothyroidism, liver disorders, certain drugs (e.g.
corticosteroids,estrogens,retinoids, beta-blockers, birth control pills, diuretics) and genetic disorders (e.g. familial
hypertriglyceridemia, familial dysbetalipoproteinemia etc.)
Comment:
•Lipid profile measurements in the same patient can show physiological & analytical variations. It is recommended that 3 serial
samples 1 week apart may be tested.
•Indians are at a high risk of developing atherosclerotic cardiovascular disease (ASCVD); at a much earlier age and more severe
with high mortality. Dyslipidemia (abnormal lipid profile) is the major risk factor and found in almost 80% Indians.
•Total cholesterol is the total amount of cholesterol in blood comprising of HDL, LDL-C, and VLDL.
•LDL Cholesterol (LDL-C) or “bad”cholesterol contributes most significantly to atherosclerosis leading to heart disease or
stroke and is the primary target for reducing risk for cardiovascular disease.
•High-density lipoprotein (HDL) or “good” cholesterol can lower risk of heart disease and stroke.
•Triglyceride (TG) level also plays a major role in CVD. Indians are more prone to Atherogenic dyslipidemia, a condition
associated with high TG, low HDL-C and high LDL-C; this is associated with diabetes, metabolic syndrome and insulin resistance.
Hence high triglyceride levels also need to be treated.
•Non-HDL-Cholesterol (Non-HDLC) measures all plaque forming lipoproteins (e.g. remnants, LDL-C, VLDL, Lp(a), Apo-B).
Monitoring of Non-HDLC is important in patients with high TG (e.g. diabetics, obese persons) and those already on statin
therapy.
•Lipid Association of India (LAI-2020) recommends:-
Screening of all Indians above the age of 20 years for CVD risk factors, esp. lipid profile.
Identification of Risk factors: Age (male ≥45 years, female ≥55 years); Family h/o heart disease at younger age (<55 yrs
in males, <65 yrs in female), Smoking/tobacco use, High blood pressure, Low HDL (males <40 mg/dl and females
<50mg/dl).
Fasting lipid profile is not mandatory for screening. Both fasting and non-fasting lipid profiles are equally important for
managing Indian patients.
Non-HDLC should be calculated in every subject. LAI recommends LDL-C as the primary target and Non-HDLC as the co-
primary target for initiating drug therapy.
Lifestyle modifications are of first and foremost importance for management and prevention of dyslipidemia. Among low
risk groups, treatment is started only after 3 months of lifestyle changes.
Testing for Apolipoprotein B, hsCRP, Lp(a ) should be considered for patients in moderate risk group.
Newer treatment goals based on Risk Groups and values of LDL-C and Non-HDLC
Page 9 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
<50 <80
Extreme Risk Gp Cat. A ≥50 ≥80
(Optional ≤30) (Optional ≤60)
Extreme Risk Gp Cat. B >30 >60 ≤30 ≤60
Very High Risk ≥50 ≥80 <50 <80
High Risk ≥70 ≥100 <70 <100
Moderate Risk ≥100 ≥130 <100 <130
Low risk ≥130* ≥160* <100 <130
*After an adequate non-pharmacological intervention for at least 3 months
•As per NCEP Expert Panel (2011) guidelines, universal screening for dyslipidemia is recommended for children between 9
- 11 yrs (repeat at 17-21 yrs). Screening is not recommended before the age of 2yrs. Above the age of 2 yrs, selective screening
is done in children with family history of premature CVD or risk factors like obesity, diabetes, and hypertension.
Note: Reference Interval as per National Cholesterol Education Program (NCEP) Report.
Page 10 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Raised ALT and AST indicate hepatocellular damage (e.g. viral or drugs etc). ALT is more liver-specific while AST is also
found in heart, skeletal muscle, and kidney. Mild elevation (less than twice normal) often resolves on its own. Fatty liver
disease (especially with metabolic syndrome) is a common cause in asymptomatic cases. Certain drugs (paracetamol,
statins), herbal supplements, energy drinks, and antibiotics may also affect liver function.
SGOT/SGPT Ratio: Typically <1 in healthy individuals (vary between 0.7-1.4; higher in women than men). High SGPT (ratio
<1) seen in acute or chronic hepatitis, autoimmune disorders, medications, toxins while ratio >1 indicates alcoholic
hepatitis, cirrhosis, metastasis or non-hepatic issues (hemolytic diseases, CVS disorders).
Elevated Alkaline Phosphatase and GGT: Suggest cholestatic diseases (e.g. bile duct obstruction, primary biliary
cirrhosis etc.) and can also be due to bone disease, pregnancy, chronic renal failure, malignancy, and congestive heart
failure.
High Bilirubin: Indicates jaundice due to increased RBC breakdown, liver damage (e.g., infections, toxins), or cholestasis
(e.g., gallstones, tumors).
High Protein Levels: Seen in dehydration (e.g., severe vomiting, diarrhea) or increased production (e.g., inflammation,
hematopoietic neoplasms). Low protein and albumin: Result from impaired synthesis (liver disease), decreased intake,
tissue damage, malabsorption, or increased renal excretion.
Page 11 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
BUN is directly related to protein intake and nitrogen metabolism and inversely related to the rate of excretion of urea.Blood
urea nitrogen (BUN) levels reflect the balance between the production and excretion of urea. Increased levels are seen in renal
failure (acute or chronic), urinary tract obstruction, dehydration, shock, burns, CHF, GI bleeding, nephrotoxic drugs. Decreased
levels are seen in hepatic failure, nephrotic syndrome, cachexia (low-protein and high-carbohydrate diets).
Urea is a non-proteinous nitrogen compound formed in the liver from ammonia as an end product of protein metabolism. Urea
diffuses freely into extracellular and intracellular fluid and is ultimately excreted by the kidneys. Increased levels are found in
acute renal failure, chronic glomerulonephritis, congestive heart failure, decreased renal perfusion, diabetes, excessive protein
ingestion, gastrointestinal (GI) bleeding, hyperalimentation, hypovolemia, ketoacidosis, muscle wasting from starvation,
neoplasms, pyelonephritis, shock, urinary tract obstruction, nephrotoxic drugs. Decreased levels are seen in inadequate dietary
protein, low-protein/high-carbohydrate diet, malabsorption syndromes, pregnancy, severe liver disease, certain drugs.
Creatinine is catabolic product of creatinine phosphate, which is excreted by filtration through the glomerulus and by tubular
secretion. Creatinine clearance is an acceptable clinical measure of glomerular filtration rate (GFR). Increased levels are seen in
acute/chronic renal failure, urinary tract obstruction, hypothyroidism, nephrotoxic drugs, shock, dehydration, congestive heart
failure, diabetes. Decreased levels are found in muscular dystrophy.
BUN/Creatinine ratio (normally 12:1–20:1) is decreased in acute tubular necrosis, advanced liver disease, low protein intake,
and following hemodialysis. BUN/Creatinine ratio is increased in dehydration, GI bleeding, and increased catabolism.
Uric acid levels show diurnal variation. The level is usually higher in the morning and lower in the evening. Increased levels are
seen in starvation, strenuous exercise, malnutrition, or lead poisoning, gout, renal disorders, increased breakdown of body cells
in some cancers (including leukemia, lymphoma, and multiple myeloma) or cancer treatments, hemolytic anemia, sickle cell
anemia, or heart failure, pre-eclampsia, liver disease (cirrhosis), obesity, psoriasis, hypothyroidism, low blood levels of
parathyroid hormone (PTH), certain drugs, foods that are very high in purines - such as organ meats, red meats, some seafood
and beer. Decreased levels are seen in liver disease, Wilson's disease, Syndrome of inappropriate antidiuretic hormone (SIADH),
certain drugs.
Calcium
Calcium 9.4 mg/dL 8.7-10.4 Arsenazo III
Page 12 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Increased in: Hyperparathyroidism primary and secondary, Acute and chronic renal failure, Following renal transplantation,
Osteomalacia with malabsorption, Acute osteoprosis, Malignant tumours (specially of breast, lung and kidney), Drugs: Vit. D and
A intoxication, Diuretics, estrogen, androgen, tamoxifen, lithium
Decreased in: Hypoparathyroidism, Surgical and Idiopathic, Pseudohypoparathyroidism, Chronic renal disease with uremia and
phophate retention, Malabsorption of Calcium and Vit.D, obstructive jaundice, Bone Disease ( Osteomalacia and rickets), Drugs:
Cancer chemotherapy drugs, calcitonin, loop-actives diuretics, Hypomagnesemia,Hypoalbuminemia
Comment:
Iron is an essential trace mineral element which forms an important component of hemoglobin, metallocompounds and Vitamin
A. Deficiency of iron is seen in iron deficiency and anaemia of chronic disorders.
Increased iron concentration are seen in hemolytic anaemias, hemochromatosis and acute liver disease. Serum Iron alone is
unreliable due to considerable physiologic diurnal variation in the results with highest values in the morning and lowest values in
the evening as well as variation in response to iron therapy .
Total Iron Binding capacity (TIBC) is a direct measure of the protein Transferrin which transports iron from the gut to storage
sites in the bone marrow. Increased levels of TIBC suggest that total iron body stores are low, increased concentration may be
the sign of Iron deficiency anaemia, polycythemia vera ,and may occur during the third trimester of pregnancy. Decreased levels
may be seen in hemolytic anaemia, hemochromatosis, chronic liver disease, hypoproteinemia ,malnutrition.
Unsaturated Iron Binding Capacity (UIBC) is increased in low iron state and decreased in high iron concentration such as
hemochromatosis. In case of anaemia of chronic disease the patient may be anaemic but has adequate iron reserve and a low
uIBC.
Transferrin Saturation occurs in Idiopathic hemochromatosis and Transfusional hemosiderosis where no unsaturated iron
binding capacity is available for iron mobilization. Similar condition is seen in congenital deficiency of Transferrin.
Comment:
•C-Reactive Protein [CRP] is an acute phase reactant ,hepatic secretion of which is stimulated in response to inflammatory
Page 13 of 18
PO No :PO1981085980-181
BIOCHEMISTRY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
cytokines.
•CRP is a very sensitive but nonspecific marker of inflammation and infection.
•The CRP test is useful in patient with Inflammatory bowel disease, arthritis, Autoimmune diseases, Pelvic inflammatory disease
(PID), tissue injury or necrosis and infections.
•CRP levels can be elevated in the later stages of pregnancy as well as with use of birth control pills or hormone replacement
therapy i.e. estrogen. Higher levels of CRP have also been observed in the obese.
•As compared to ESR, CRP shows an earlier rise in inflammatory disorders which begins in 4-6 hrs, he intensity of the rise being
higher than ESR and the recovery being earlier than ESR. Unlike ESR, CRP levels are not influenced by hematologic conditions
like Anemia, Polycythemia.
Comment:
The detection of Rheumatoid factor (RF) is one of the criteria of the American Rheumatism Association (ARA) for the
diagnosis of Rheumatoid Arthritis (RA).
RF are heterogeneous group of auto antibodies directed against Fc- region of IgG molecules.
They are useful in diagnosis of Rheumatoid Arthritis, but can also be found in other inflammatory diseases and in various
non-rheumatic diseases.
These occur in all the immunoglobulin classes, although the usual analytical methods are limited to the detection of
Rheumatoid Factors of the IgM type.Healthy individuals >65 years of age may also show positive RF results.
Page 14 of 18
PO No :PO1981085980-181
IMMUNOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Comment:
Below mentioned are the guidelines for pregnancy related reference ranges for TSH, total T3 & Total T4.
Pregnancy
TSH (μIU/mL) (as per
American Thyroid Total T3 (ng/mL) Total T4(μg/dL)
Association )
1st trimester 0.1-2.5 0.81-1.90 7.33-14.8
2nd trimester 0.2-3.0 1.00-2.60 7.93-16.1
3rd trimester 0.3-3.0 1.00-2.60 6.95-15.7
TSH levels are subject to circadian variation, reaching peak levels between 2 - 4.a.m. and at a minimum between 6-10 pm
.
The variation is of the order of 50%, hence time of the day has influence on the measured serum TSH concentrations.
TSH is secreted in a dual fashion: Intermittent pulses constitute 60-70% of total amount, background continuous secretion
is 30-40%.These pulses occur regularly every 1-3 hrs.
Total T3 & T4 concentrations are altered by physiological or pathological changes in thyroxine binding globulin (TBG)
capacity .
The determination of free T3 & free T4 has the advantage of being independent of changes in the concentrations and
binding properties of the binding proteins.
Changes in thyroid status are typically associated with concordant changes in T3, T4 and TSH levels.
Unexpectedly abnormal or discordant thyroid test values may be seen with some rare, but clinically significant conditions
such as central hypothyroidism, TSH-secreting pituitary tumors, thyroid hormone resistance, or the presence of
heterophilic antibodies (HAMA) or thyroid hormone autoantibodies.
For diagnostic purposes, results should be used in conjunction with other data.
TSH T3 T4 Interpretation
Page 15 of 18
PO No :PO1981085980-181
IMMUNOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
High Normal Normal Subclinical Hypothyroidism
Low Normal Normal Subclinical Hyperthyroidism
High High High Secondary Hyperthyroidism
Low High/Normal High/Normal Hyperthyroidism
Non thyroidal illness / Secondary
Low Low Low Hypothyroidism
Vitamin D (25-OH)
Vitamin D (25-OH) 5.5 ng/ml Deficiency:< 20, CLIA
Insufficiency:20-29,
Sufficiency:30 - 100,
Toxicity possible:> 100
Comment:
Vitamin D is a fat-soluble steroid prohormone involved in the intestinal absorption of calcium and the regulation of calcium
homeostasis.
Two forms of vitamin D are biologically relevant - vitamin D3 (Cholecalciferol) and vitamin D2 (Ergocalciferol).
Both vitamins D3 and D2 can be absorbed from food but only an estimated 10-20perc. of vitamin D is supplied through
nutritional intake.
Vitamin D is converted to the active hormone 1,25-(OH)2-vitamin D (Calcitriol) through two hydroxylation reactions. The
first hydroxylation converts vitamin D into 25-OH vitamin D and occurs in the liver. The second hydroxylation converts 25-
OH vitamin D into the biologically active 1,25-(OH)2-vitamin D and occurs in the kidneys as well as in many other cells of
the body.
Most cells express the vitamin D receptor and about 3perc. of the human genome is directly or indirectly regulated by the
vitamin D endocrine system.
The major storage form of vitamin D is 25-OH vitamin D and is present in the blood at up to 1,000 fold higher
concentration compared to the active 1,25-(OH)2-vitamin D. 25-OH vitamin D has a half-life of 2-3 weeks vs. 4 hours for
1,25-(OH)2-vitamin D. Therefore, 25-OH vitamin D is the analyte of choice for determination of the vitamin D status.
Risk factors for vitamin D deficiency include low sun exposure, inadequate intake, decreased absorption, abnormal
metabolism, vitamin D resistance and and liver or kidney diseases.
Vitamin D deficiency is a cause of secondary hyperparathyroidism and diseases resulting in impaired bone metabolism (like
rickets, osteomalacia).
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PO No :PO1981085980-181
IMMUNOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Recently, many chronic diseases such as cancer, high blood pressure, osteoporosis and several autoimmune diseases
have been linked to vitamin D deficiency.
The assay measures both D2 (Ergocalciferol) and D3 (Cholecalciferol) metabolites of vitamin D
Vitamin B12
Vitamin B12 222.0 pg/ml 211-911 CLIA
Comment:
Vitamin B12 along with folate is essential for DNA synthesis and myelin formation.
Decreased levels a r e s e e n i n a n a e m i a , t e r m p r e g n a n c y , v e g e t a r i a n d i e t , i n t r i n s i c f a c t o r d e f i c i e n c y , p a r t i a l
gastrectomy/ileal damage, celiac disease, oral contraceptive use, parasitic infestation, pancreatic deficiency, treated
epilepsy, smoking, hemodialysis and advanced age.
Increased levels are seen in renal failure, hepatocelluar disorders, myeloproliferative disorders and at times with excess
supplementation of vitamins pills.
Comment:
Folate plays an important role in the synthesis of purine & pyrimidines in the body and is important for the maturation of
erythrocytes. It is widely available from plants and to a lesser extent organ meats, but more than half the folate content of food
is lost during cooking. Folate deficiency is commonly prevalent in alcoholic liver disease, pregnancy, and the elderly. It may result
from poor intestinal absorption, nutrition deficiency, excessive demand as in pregnancy or in malignancy, and in response to
certain drugs like Methotrexate & anticonvulsants. It is now routine practice to recommend dietary folate supplements from
conception to the 12th week of pregnancy; such supplementation has been proven to reduce the incidence of neural tube
defects.
Decreased Levels: Megaloblastic anemia, Infantile hyperthyroidism, Alcoholism, Malnutrition, Scurvy, Liver disease, B12
deficiency, dietary amino acid excess, adult Celiac disease, Tropical Sprue, Crohn’s disease, Hemolytic anemias, Carcinomas,
Page 17 of 18
PO No :PO1981085980-181
IMMUNOLOGY
COMPREHENSIVE GOLD FULL BODY CHECKUP WITH SMART REPORT
Test Name Result Unit Bio. Ref. Interval Method
Myelofibrosis, vitamin B6 deficiency, pregnancy, Whipple’s disease, extensive intestinal resection, and severe exfoliative
dermatitis.
Note:
Certain drugs like Pyrimethamine, methotrexate, and trimethoprim are all folate antagonists i.e. they stop the action of the folic
acid; phenytoin can decrease the intestinal absorption of folates, and ethanol both decreases absorption and increases
excretion of folic acid.
To differentiate vitamin B12 & folate deficiency, measurement of Methylmalonic acid in urine & serum Homocysteine level is
suggested.
Disclaimer: Results relate only to the sample received. Test results marked "BOLD" indicate abnormal results i.e. higher or lower than normal. All
lab test results are subject to clinical interpretation by a qualified medical professional. This report cannot be used for any medico-legal purposes.
Partial reproduction of the test results is not permitted. Also, TATA 1mg Labs is not responsible for any misinterpretation or misuse of the
information. The test reports alone may not be conclusive of the disease/condition, hence clinical correlation is necessary. Reports should be
vetted by a qualified doctor only.
Page 18 of 18
Ensuring accuracy IN every single report
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