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07.21 Containment Solutionslr

Extract Technology specializes in innovative containment solutions, including Downflow Booths and Isolators, designed to ensure operator safety and meet cGMP standards in pharmaceutical and biotech industries. Their products offer customizable features, energy efficiency, and proven containment levels, with operator exposure levels as low as 10ng/m3. The company emphasizes a comprehensive design and testing process to deliver effective containment solutions tailored to specific client needs.
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0% found this document useful (0 votes)
57 views8 pages

07.21 Containment Solutionslr

Extract Technology specializes in innovative containment solutions, including Downflow Booths and Isolators, designed to ensure operator safety and meet cGMP standards in pharmaceutical and biotech industries. Their products offer customizable features, energy efficiency, and proven containment levels, with operator exposure levels as low as 10ng/m3. The company emphasizes a comprehensive design and testing process to deliver effective containment solutions tailored to specific client needs.
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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DELIVERING

INNOVATION
extract-technology.com
TO PROTECT

CONTAINMENT
SOLUTIONS
DOWNFLOW BOOTHS

ISOLATOR
CONTAINMENT
ISOLATOR
OPERATOR
PROTECTION
TO <1μg/m³

DOWNFLOW BOOTH
OPERATOR PROTECTION
TO <100µg/m3
(ACHIEVABLE <1µg/m3)

PACK OFF PACK OFF


AND PROCESS
SAMPLING FACILITY DUST FREE
OFFLOAD TO
CUSTOM DESIGN TO SUIT cGMP STANDARD
THE CUSTOMER’S SPECIFIC
APPLICATION
FACILITIES
Containment Booths Facilities Containment Isolators Pack Off Systems

Achievable
Operator
Exposure
Levels (OEL) of

1μg/m3
(task duration), process dependant

Complete containment solutions based around an innovative range of Downflow


Containment Booths bring different features and benefits to your application. But all
have one thing in common: they provide a Guaranteed Working Environment.

When you need to provide a clean, contained


environment for the safe handling of powders in
dispensing, weighing, sampling, or subdivision
operations, our PharmAir booths are a highly
effective option.

As a provider of total containment


Safe Working solutions we can tailor Downflow
Containment Booths to your exact
Depths to requirements. However, you will find
a summary of some of our standard
2.2m optional features.

> Stainless steel or epoxy – coated mild


steel construction.
> High efficiency EC fan system
> Safe change filters
> Overhead lighting within supply
“Extract Technology have designed their new energy plenum
efficient Downflow Booth boasting energy savings of up > Mobile workbenches
to 70% compared to that of conventional systems.” > Hazardous area electrics
> Flush mounted computer integration
Extract Technology has prided itself on being at the forefront of Booth design > Front/side access doors
for the last 30 years, and as such has continued to invest in R&D to ensure > Glass walls and windows
the ever changing demands of the Pharmaceutical and Biotech industries are > Floor/coving interfaces
met. In order to achieve this impressive saving Extract Technology looked at > PLC controlled audible and visual
every aspect of the design from component selection to airflow design. Not alarm packages
only did this result in a more energy efficient system but it also presented an > Pallet stop rails
opportunity to look at cost reduction as a whole for the Booth. This culminated > Cooling coils and controls
in a design which was far more cost effective both in the short and long term
> Increased internal height
with key benefits such as:
> Photo sensitive lighting
> High level exhausts grilles
IMPROVED LIGHTING LEVELS
70% ENERGY SAVINGS
WITH EASY LIGHT ACCESS
> Incorporation of lifting and tipping
equipment
LOWER CAPITAL COST
MODULAR CONSTRUCTION AND > Materials and personnel airlocks
SHORTER LEAD TIMES DUE TO BATCH MULTIPLE CONFIGURATIONS systems
COMPONENT PRODUCTION AND TOGETHER WITH AN EXTENSIVE > Roller conveyors, rapid roller doors
MODULAR DESIGN LIST OF OPTIONS
and turntables
FLUSH LIGHT FITTINGS WITH TERMINAL LOWER NOISE LEVELS DUE TO
IMPROVED FAN AND CEILING
HEPA FILTERS.
PLENUM DESIGN

QUICKER INSTALLATION AND


COMMISSIONING TIMES
BOOTHS

Incorporating the Extract Technology patented


Flexible® or Rigid Screens into a Downflow Booth
provides a physical barrier between the active
product and the operator, thereby immediately
improving the attainable containment levels.

Independent tests have confirmed that levels


of <1μg/m3 can be achieved, depending
upon the application.

5D CONTAINMENT
SCREENS
Low noise
levels
DESIGN FEATURES
(<75 dBA)
Available in epoxy coated mild steel, Custom filtration designs with a minimum of
304/316L stainless steel or a combination of fine dust and then Hepa filters in either the
both technical stack or the ceiling plenum

Various heights and widths (up to 6m) are Single pass/once through airflow systems
available used in applications where solvent vapours
are present

DIMENSIONS

Overall depth (mm)


External Internal “L” model “LS” model “LX” model Chilled water Fused
Booth
width width (containment depth (containment depth (containment depth flow rate supply
size
(mm/in) (mm/in) 1200mm/44in) 1800mm/71in) 2300mm/90in) I/sec (gpm) (Amps)*

1.5m 1500/59” 1400/55” 2750/108” 3630/143” 4425/174” 0.13 (2) 25


2.0m 2100/83” 2000/79” 2750/108” 3630/143” 4425/174” 0.13 (2) 25
2.5m 2500/98” 2400/94” 2750/108” 3630/143” 4425/174” 0.13/0.26 (2/4) (LX) 25
3.0m 3000/118” 2900/114” 2750/108” 3630/143” 4425/174” 0.13/0.26 (2/4) (LS & LX) 25
3.5m 3600/142” 3500/138” 2750/108” 3630/143” 4425/174” 0.26 (4) 25
4.0m 4200/165” 4100/161” 2750/108” 3630/143” 4425/174” 0.26 (4) 25
4.5m 4600/181” 4500/177” 2750/108” 3630/143” 4425/174” 0.26 (4) 32
5.0m 5000/197” 4900/193” 2750/108” 3630/143” 4425/174” 0.26/0.39 (4/6) (LX) 32

Standard Internal Height on all Booths: 2300mm/90” – Standard Overall Height on all Booths: 2750mm/108” – Standard Technical Area Depth: 1050mm/41”
US dimensions are approximate. *480VAC 3 Phase Power
Containment Booths Facilities Containment Isolators Pack Off Systems

TURNKEY

package
solutions

Providing a suitable cGMP environment for operators to perform either sampling or dispensing tasks in a safe
and comfortable atmosphere, Extract Technology facilities are high class state of art pieces of equipment.
Complete with material and personnel airlocks and a downflow booth, the facility operates with a positive
pressure to aid in achieving a clean cGMP environment.

Though made to order, facilities are usually designed around our standard downflow CUSTOM
booth sizes which can be suitably selected to accommodate the client’s process.
Facilities can be designed to house any operations from small scale sampling to design to
large material handling processes - operational aids such as post hoists, conveyor suit process
lines, workbenches etc. can be integrated into the equipment.

Hazardous DESIGN FEATURES SECONDARY CONTAINMENT SOLUTIONS


Ratings A wide variety of secondary containment
Internal furnishings solutions can be used in conjunction with
available the Extract Technology Pack Off Heads to
Battery backup LED lighting in airlocks improve the overall containment level.

PLC control with touch screen HMI interface available These include Horizontal Laminar
Flow Booths, X-Flow Booths, Isolators
Signalling between facility and clients BMS available and Continuous Liner Discharges.

Rapid roller shutter doors for material entry and exit


CONTINUOUS LINER
Single Pass airflow for solvent/liquid handling available, DISCHARGE
complete with full air handling packlages
On disconnection of any make and break
connection “sealing head inflate/deflate” the
Cascading pressure regime issue of powder discharge from the upstream
process chute into the atmosphere becomes
a contamination issue not only for the operator
and surrounding environment but also for the
AVAILABLE OPTIONS product. By forming a continuous flexible barrier
between the process and the surrounding
envrionment this can be prevented.
> Mobile Work Benches
> Hazardous area electrics
> Flush mounted computer integration
> Pallet stop rails Integrated exhaust complete with
> Cooling coils and controls modulating exhaust valve. This valve
> Increased internal height provides a low rate of exhaust during
filling (displaces air removal only) and
> Incorporation of lifting and tipping equipment
a high rate of extraction when the
> Materials and personnel airlocks systems seal is deflating capturing airborne
> Roller conveyors, rapid roller doors and turntables material and assisting in operator
> Customisation available on request necking and tying the liner.
Containment Booths Facilities Containment Isolators Pack Off Systems

Extract
Technology also designs
OUTWARD INFLATING HEAD INWARD INFLATING HEAD
and manufactures innovative
Forms a clean and dust tight Ensuring a clean dust tight
seal within the open mouth
process connection devices as seal as the liner (normally
or inner surface of either a stand alone items to provide continuous) is compressed
continuous liner or single liner against the feed tube so
primary dust containment in fine there is no product contact
within customers containers
chemical industries. with the FDA approved
natural rubber seal
The Process Pack Off Heads are
DOWNWARD INFLATING HEAD
designed to offer a basic form of
The membrane inflates
downwards to form a seal
primary dust containment when
against the top of unlined off-loading and packing off
drums or inlet rim of IBCs product in the pharmaceutical
or chemical industry.

DESIGN ADVANTAGES

Guaranteed Containment Levels

Available in a wide range of materials -


HORIZONTAL LAMINAR FLOW
BOOTHS
solvent compatible

A “once through” even laminar FDA approved seals


airflow is pulled uniformly across
the work area to the rear
plenum, extracting any airborne cGMP design throughout - minimum
particulate away from the of ledges, easy clean surfaces
operator and into the fan/filter
unit or to the clients own dust Hazardous Area controls
colletion or scrubbing system. (UL and Atex approved)
All units are designed
specifically for the application, Optional :
and are supplied with a fan and N2 Purge
motor system, suitably zoned for CIP Cap
the application area. Support Frames
Weighing Systems
A fully welded stainless steel
construction, they can also
incorporate weighing and
control systems as required.
X-FLOW BOOTHS
A unique design of crossflow or “side to side”
airflow, removing any airborne particulate away from the
operators breathing zone. Air is introduced from one of the
side plenums at a constant velocity and is then exhausted
at the opposite side, passing through fine dust and Hepa
filters before being recirculated back into the booth.
SPECIAL FEATURES
The presence of the operators’ arms does not interfere with
the airflow, thus enhancing the containment levels
achievable to between 1-20μg/m3.
Containment Booths Facilities Containment Isolators Pack Off Systems

Extract Technology Rigid Containment Isolators have been designed for handling potent compounds
that can offer guaranteed levels of operator protection as low as 10ng/m3 (task duration).

These include designs for sampling, dispensing and sub-division, mixing, milling and vessel charging,
as well as containing integrated process devices such as filter dryer units, tablet press enclosures,
blenders, mills and pack off systems.

Whatever else you look for in a high containment solution, you will want it to be proven, tested and
guaranteed. Extract Technology’s Isolator solutions deliver all these things and more.

DESIGN PHILOSOPHY
Containment
Levels The Isolator is designed to not only provide a physical barrier
down to between the operator and the product but to also provide a
controlled environment, negatively pressurised with an
10ng/m3
atmospheric condition or a reduced oxygen
content using an inert gas.
To maximize both operator and equipment interfaces 3D
modelling and full scale mock–ups are used extensively to
Design facilitate the best understanding possible of the
model in pharmaceutical process and the operators involvement
whilst ensuring high levels of containment are achieved.
3D

DESIGN FEATURES
Available
Ergonomic design Inflatable seals
with Mock Up
and Extract Technology Pharmaport™ 17mm / 5/8’’ radiused corners
Glove Port
FAT Safe change “push-push” filters
Fully welded 316L stainless steel
fabrication PLC control system
ISOLATORS

4. Factory Acceptance Testing


Only when the equipment is fully
built and fully tested to the design
2. Design parameters is it exposed to a range
We generate of tests and standard operating
conceptual designs procedures (SOPs). These can
based upon proven include internal / external
solutions, before finally surface swabbing, dust in air
compiling product monitoring, and full scale
specifications, standard operational tests of performance,
operating procedures all being performed within our
(SOPs) and working controlled test environment.
schematics (P&IDs)

1. Mock up 3. Manufacturing
We can create full scale Manufactured in high
mock–ups which take quality stainless or other
into account ancillary alloy steels the Isolator
equipment and fabrications are formed,
manipulation devices. welded and polished to
The client review exacting standards and
follows, at which stage client requirements.
any necessary
modifications are made.

COMPREHENSIVE RANGE OF CONTAINMENT ISOLATORS

DISPENSING FILTERING AND PROCESS


AND SUB-DIVISION TRAY-DRYING OFFLOADING

AVAILABLE OPTIONS
As a provider of total containment solutions we can tailor
High Containment Isolators to your exact requirements.
However, you will find a summary of some of the main
options below:

> Multiple chambers


SAMPLING > Drum/product manipulation devices
> Integration of proprietary contained transfer
devices e.g. Rapid Transfer Ports, Split Butterfly Valves etc
> Controlled environment re: temperature, humidity
and oxygen content
> Fully integrated WIP/CIP clean systems including wash
lances, rotary spray balls and solvent atomizing devices
> Raise/lower systems
> Dispensing equipment including scales,displays,
printers and dispensing management systems.
THE CONTROL STRATEGY PYRAMID

Designed to satisfy both


EXTRACT TECHNOLOGY’S current and projected
industry standards it
CONTAINMENT provides pharmaceutical
and chemical companies
PYRAMID IS SET TO with a clear guide to
CREATE A assessing the level of
containment required to
STANDARD WITHIN safely handle differing
hazadrous materials
THE INDUSTRY

DEFINING THE CONTROL STRATEGY


EXTRACT TECHNOLOGY LTD
The selection grid at the heart of the Control Strategy UK OFFICE
Pyramid permits the exposure potential rating and operator
exposure band to intersect at the recommended Control +44 (0) 1484-432-727
Strategy selection. This is a simple cross reference to identify
the correct equipment to be used to control and handle a BRADLEY JUNCTION IND ESTATE,
specific process. LEEDS RD, HUDDERSFIELD,
HD2 1UR,
UNITED KINGDOM

FOR MORE INFORMATION ON CONTAINMENT SOLUTIONS EXTRACT TECHNOLOGY


PLEASE VISIT OUR WEBSITE OR CONTACT US DIRECTLY: AMERICAS OFFICE

EXTRACT TECHNOLOGY +1 608-562-7761

extract-technology.com 618 STATE STREET


info@extract-technology.com NEW LISBON, WI 53950

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