PROTEOL™ APL EF
Cleansing Solution
      Inspired by Nature
                          Inspired by nature
                          & outstanding for its gentle approach
PROTEOL™ APL EF
is an anionic surfactant          Mildness touch of Beauty
obtained by acylation of
amino acids characteristic        Stability & foaming power by excellence
of apple juice
                                                                                                 T=0                                After 30 minutes            Protocol
                                  PROTEOL™ APL EF                                                                                                               • Foam expansion
                                  develops a dense foam,                                                                                                        • Inward-flow turbine
                                                                                                                                                                  3000 rpm for 2 min
                                  due to the formation of                                                                                                       • Solution at 1% a.m.
PROTEOL™ APL EF                   fine and compact bubbles.                                                                                                       in hard water
adds extra mildness                                                                                                                                             • 40°C
                                                                                                                                    X100
to all foaming formulas!
                                       More foam
Solubility
                                       than classical surfactant                                                       Excellent foam booster
- from pH 5.5 alone in water
- improved in combination
                                                                                F
                                                                              LE
                                                                            AP
  with other surfactants
                                                                                                                                                                               F
                                                                                                                                                                             LE
                                                                          L™
                                                                                                                                                                          AP
                                                                        EO
                                                                                                                                                                          te
                                                                                                                                                                SL tama
                                                                      OT
                                                                                                                                                                       L™
                                                         600                             Foam volume in hard water + dirt
                                                                    PR
                                                                                                                                                                     EO
                                                                                                                                                                PR +
                                                                                                                                                                    lu
                                                                                                                                                                  ES
                                                                                                                                                                  OT
                                                                   523
                                                                                                                                                                 lG
                                                         500                                                                        500
                                                                                                                                                                  y
                                                                                                                                                              uro
                                                                                                                                                                      408
                                                                                                                                                 ES
Doesn’t contain neither
                                                                                                                                                        Na S +
                                                                                    ES
                                                         400                                                                        400
                                                                                                                                                           La
                                                                                                                                               SL
                                                                                                                                                           E
                                                                               SL
EDTA nor preservative                                                                                                                                   SL
                                                                                                                Foam volume in mL
                                     Foam volume in mL
                                                         300                   262                                                  300        262       242
                                                                                                ma yl
and no sulfate
                                                                                                   te
                                                                                             uta uro
                                                         200                                                                        200
                                                                                           Gla La
                                                         100                                                                        100
                                                                                           N
                                                                                            10
                                                           0                                                                          0
Dry extract 29-34%                                             Protocol                                                                   Protocol
                                                               • Ross-Miles Tes (ISO 696-1975)                                            • Ross-Miles Tes (ISO 696-1975)
                                                               • 1% a.m.                                                                  • NaLES (9/10) / cosurfactant (1/10)
                                                               • pH 7                                                                     • 1% a.m.
                                                                                                                                          • pH 7
INCI name
Sodium Cocoyl Apple
Amino Acids
                                  Respectful of the environment
                                   • Biodegradability: 95% (28 days) 77% (10 day-window)
                                   • Aquatic toxicity on Daphnia: EC50 (48h): 45mg/L
                                   • Aquatic toxicity on algae: EC50 (72h): 76mg/L
                                   • Aquatic toxicity on fish: LC50 (96h) > 100mg/L
                                   • Suitable for EU Ecolabel formulations
                                   • NO EDTA
                               a.m. : active matter
  A well protected skin
  Barrier effect
  PROTEOL™ APL EF reduces the negative impact of SLES on the skin
  barrier function (TEWL) & dryness. It helps maintening the skin integrity.
  Protocol
  • Application of an occlusive patch for 48h on16 volunteers
  • Tested concentrations: SLES at 7% a.m.
    SLES + PROTEOL™ APL EF (7%/3% a.m.)                                    Mucosa tolerance
  • TEWL measurement at 2h and 24h after removing the patch
  • Measured TEWL between a 48h treated area with occlusive                PROTEOL™ APL EF demonstrates good vaginal tolerance
    patch and a non treated area
                                                                           Non irritant at 10% of PROTEOL™ APL EF for rinse-off
                                                                           applications
                                   2h                     24h
                                                                      %
                                                 %
                                                                    F3
                                               F3
                                                                  LE
                                             LE
                                                                                                   Tested on vaginal reconstructed human
         TEWL (g/m2/h)
                                                                AP
                                           AP
                                                                                                   epithelium "SkinEthic model"
                                                             L™
                                        L™
                                                          EO +
                                      EO +
                                                                                                   (Application on epithelial tissue cultures for
                                                           7%
                                                     PR S 7%
                                PR 7%
                                      7%
                                                                                                   10 min, 1h, 3h and 24h, cytotoxicity assessed
                                                        OT
                                                 ES
                                   OT
                                                                           HVE, in vitro
                                   ES
                             ES
                                                                                                   by MTT measurement)
                                                        E
                                                SL
                                                     SL
                                SL
                           SL
                                                                           reconstructed vaginal
           0
                                                                           epithelium
         -5
        -10
        -15
                                                        -15
        -20
                                               -19.1                                         PROTEOL™ APL EF
        -25
                                   -21.4
                                                                                            boosts and expands
        -30
                                                                                                the foam to
        -35
                           -31.8                                                             the skin’s delight!
                                                         Inspiration Formulations
                                                         Ideal for a pleasurable sensation for all skins!
                                                              Dense, abundant, gentle foam
                                                                           +
                                                                  Excellent tolerance
                                                                                in
                                                                              sk
                                                                              l
                                                                            ge
                                                                           ve
                                                                           as
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                                                                  on
                                                                  as
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                                                                 se
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                                                              ov
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                                                    in
                                                     e
                                                   er
                                                  in
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                                                  in
                                                  at
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                                                 ra
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                                               am
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 ip
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                         H
                                                                                 PROTEOL™ APL EF
                            Sulfate free                                         optimizes foaming formulations
                         composition with
                        optimized ratio for                                           More dense foam
                        a cleanser with 5%                                                                                                             Higher amount of foam
                          of active matter
                                                                                                               Fragrance free
                   4.5% PROTEOL APL EF             ™                                                                & transparent formulas
                     2% ORAMIX™ CG110
                     7% ORAMIX™ GB 10
                                                                                                                              Equilibrium Daily Intimate Wash
                                                                                                                              pH 5.5 - AS40054A
                    Optimized Foaming Power                                                                                   Transparent Gel
                    Make it cleanser!                                                                                          A Aqua/water                                Up to 100%
                    EU07384A                                                                                                     Xanthan Gum                                    0.20%
                                                                                                                               B Chelating Agent                                0.10%
                     A ORAMIX™ CG 110                       2.00%                                                                Glycerin                                       2.00%
                       Parfum/Fragrance                     0.15%                                                                AMONYL™ 380BA                                 10.00%
                     B PROTEOL™ APL EF                      4.50%                                                                PROTEOL™ APL EF                                5.00%
                       ORAMIX™ GB 10                        7.00%                                                                ORAMIX™ L 30                                   5.00%
                       Benzyl Alcohol & Benzoic Acid &      1.00%                                                                FLUIDIPURE™ 8G                                 3.00%
                       Dehydroacetic Acid &Tocopherol                                                                            Preservative                                   0.60%
                     C Aqua/Water                      Up to 100%                                                                GELALG™                                        3.00%
                       AQUAXYL™                             1.50%                                                                Parfum/Fragrance                               0.15%
                       BLUE SEAKALE HC                      1.00%                                                                Citric Acid (25%)                           Up to pH
Nota :
The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product.
Except as set forth above, SEPPIC* makes no warranties, whether express, implied of statutory, as to the product which is the subject of this document. Without
limiting the generality, of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose.
Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth
herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. Its is intended for use by persons having technical skill and
their own discretion and risk. Since conditions of use are outside SEPPIC*’s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in
connection with any use of this information. Nothing herein Is to be taken as a license to operate under or a recommendation to infrige any patents.
Air Liquide Healthcare is a world leader is medical gases, home healthcare, hygiene products and healthcare specialty ingredients. It aims to provide customers in the continuum of care from hospital to home
with medical products, specialty ingredients and services that contribute to protecting vulnerable lives.
*SEPPIC being:
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