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Oncology Usmle

The document provides high-yield clinical presentations of various lymphomas and leukemias, detailing specific markers, genetic translocations, and associated clinical features. It includes information on Hodgkin Lymphoma, Burkitt Lymphoma, Multiple Myeloma, and other hematological malignancies, highlighting key diagnostic criteria and symptoms. Additionally, it addresses conditions like Tumor Lysis Syndrome and Myelodysplastic Syndrome, emphasizing their clinical significance.

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Hamna Yasir
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© © All Rights Reserved
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81 views11 pages

Oncology Usmle

The document provides high-yield clinical presentations of various lymphomas and leukemias, detailing specific markers, genetic translocations, and associated clinical features. It includes information on Hodgkin Lymphoma, Burkitt Lymphoma, Multiple Myeloma, and other hematological malignancies, highlighting key diagnostic criteria and symptoms. Additionally, it addresses conditions like Tumor Lysis Syndrome and Myelodysplastic Syndrome, emphasizing their clinical significance.

Uploaded by

Hamna Yasir
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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STEP 1 REVIEW

ONCOLOGY
High-Yield Clinical Presentations
- CD15/30+
- Owl eye, bilobed Reed
Hodgkin Lymphoma
Sternberg cells

- Most common subtype of

Nodular Sclerosis
Hodgkin lymphoma
- More common in females
- Bands of fibrosis

- Child with giant jaw mass

Burkitt Lymphoma
- t(8;14)
- Small blue cells on
histology
- t(14;18)

Follicular Lymphoma
- BCL2 activation
- Lymphadenopathy comes
and goes

Mantle Cell Lymphoma


- t(11;14)
- Cyclin D1

- t(11;18)
- Hx of chronic inflammatory
condition like Sjogren, Marginal Cell Lymphoma
H. pylori gastritis,
hashimoto
- HIV/AIDs pt gets EBV
infection
Primary CNS Lymphoma
- Single ring enhancing
lesion in brain

- Pt from Tokyo, Africa,

Adult T-Cell Lymphoma


Carribean gets lytic bone
lesions
- T cells affected

- Skin patches and plaques


- Atypical CD4+ cells with Mycosis Fungoides
cerebriform nuclei
Sezary Syndrome (blood)
- Pautrier microabscesses
- Elder male with bone pain
- Hypercalcemia, low Hb
- High BUN and cr Multiple Myeloma
- PBS shows stacked RBCs

- Headaches
- Blurry vision Waldenstrom
- Finger pain in cold
- M spike Macroglobulinemia

- Overproduction of
paraproteins MGUS
- No CRAB findings
Myelodysplastic
- Hx of cancer radiation
- Cells have abnormal
maturation syndrome

- Child with painless


enlarged LN ALL
- TdT+

- Elder male with fatigue


- Low Hb, +Coombs test CLL
- Smudged out cells
- Male with enlarged spleen
- Low RBCs, WBCs and Hairy Cell
platelets
- TRAP + Leukemia

- t(15;17)
- Increases risk of DIC AML
- Tx with ATRA (vitamin A)

- t(9;22)

CML
- BCR-ABL
- Low LAP score
- Tx with tyrosine kinase
inhibitor
- Itchy after a shower
- High RBCs, low EPO Polycythemia Vera

- Bleeding and thrombosis


Essential
- High platelet count
Thrombocythemia

Myelofibrosis
- Bone marrow fibrosis
- RBCs look like teardrops
Leukemoid Reaction
- High LAP score
- Severe pneumonia pt

CML
- Low LAP score
- Being treated with imatinib
- Kid with bone lesions,
skin rash, recurrent ear
infections
- Tennis racket shaped Langerhans Cell
-
granules
S-100 and CD1a Histiocytosis
expressed

- Recent treatment for


newly diagnosed leukemia
- Labs show elevated
potassium, phosphorus Tumor Lysis Syndrome
and uric acid but a low
calcium
THANK YOU!
Questions?
medstudentsuccess.contact@gmail.com
More STEP Resources: medstudentsuccess.com

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