Last updated: January 07, 2025 View the latest guidelines online

Scope of the Journal

Organic Letters invites original reports of fundamental research in all branches of the theory and
practice of organic, physical organic, organometallic, medicinal, and bioorganic chemistry. Organic
Letters provides rapid disclosure of the key elements of significant studies that are of interest to a
large portion of the organic community. In selecting manuscripts for publication, the Editors place
emphasis on the originality, quality and wide interest of the work. Authors should provide enough
background information to place the new disclosure in context and to justify the rapid publication
format. Back-to-back Letters will be considered. Full details should be reserved for an Article,
which should appear in due course.

Scope Details

● Organic Letters is a communications journal focusing on rapid but brief reports of cutting-edge
results, hence to keep article length within our four-page maximum the number of compounds
required does not need to be exhaustive. While the number of compounds reported is not
limited, for methods discoveries we generally recommend 10–20 diverse substrates including
some that are unreactive or give low yields as sufficient, provided they are diverse and
represent the true scope of each reported reaction.
● One-step organic transformations must be highly innovative and include one detailed
complete method at the 1 mmol scale; exceptions may be discussed with the editor for certain
materials chemistry and electrochemistry work.
● Designed structures: if the design, synthesis and spectral data of a new compound are not
exceptionally novel, then data such as biological, binding, or materials properties must be
included.
● Novel organic electronic materials need to illustrate either a novel synthetic method or
interesting device properties.
● Supramolecular assemblies: a novel method should be demonstrated and/or the materials
should have either interesting properties or a significant application.
● Analytical detection of a selected species (we are highly selective in this category): Letters
must contain a novel synthetic protocol and/or demonstrate notable improvement on the limits
of detection of the species.The synthesis of a novel compound or a significantly improved
route to a known compound will only be considered if appropriate improved device or use data
is provided.The synthesis of a known compound via known methods together with new
sensing data will not be considered, unless the new binding or sensing data provides a
significant advance on previously reported selectivity and/or sensitivity for a target species
and/or a novel mode of binding for a particular species under consideration.Manuscripts
focusing on mechanistic studies (experimental or theoretical) should show methodological
advances or provide novel insight into the course of chemical reactions, rather than only
confirming previously established mechanisms.

If you are a new Organic Letters author, or if you have not submitted a manuscript during the past
year, please read and familiarize yourself with these complete Author Guidelines to ensure you
are up to date with all of the journal's manuscript preparation and submission requirements.
Editors, Authors, and Reviewers should read the ACS Ethical Guidelines.

Emphasis on Chemical Safety

In 2021, in support of ACS’s core value of “Professionalism, Safety, and Ethics,” ACS Publications
added a Safety Considerations requirement to the Author Guidelines of every ACS journal
(Appendix 1):
Authors must emphasize any unexpected, new, and/or significant hazards or risks associated with
the reported work. This information should be in the Experimental Section of a full article and
included in the main text of a letter. Statement examples can be found in the Safety Statement
Style Sheet and additional information on communicating safety information from the ACS Guide
to Scholarly Communication is freely available here.
Organic Letters is participating in a pilot program to further encourage use of Safety Statements in
manuscripts, including details on how to mitigate hazards and risks. Reviewers and Editors will be
more carefully checking manuscripts to determine whether an existing Safety Statement is
accurate and complete, and if there is no Safety Statement in a manuscript whether there are any
hazards or risks that require a Safety Statement be added. If a Safety Statement is needed,
authors will be asked to include one in their manuscript at revision and before acceptance.

Manuscript Types
Organic Letters publishes only communications-length manuscripts. Authors are required to use
the document template to help facilitate placement of figures and to determine whether your
submission meets the journal’s length requirements.

A manuscript may not exceed 2,200 words at submission. This word count includes the title,
abstract, main text, and titles/footnotes of typically five graphics (one of which is the TOC graphic).
Tables and graphics count toward the word-count limit at the rate of 20 words per vertical
centimeter for one-column items and 50 words per vertical centimeter for wider items up to two
columns. Large graphics or additional graphics will require a reduced amount of text. Authors are
reminded that any graphics that are reduced in size to help adhere to the length limits need to be
fully legible when the page is printed at 100% scale.

The goal for these length requirements is for manuscripts to fit within four pages, end matter
(Supporting Information, Author Information, Notes, Acknowledgments) and references excluded
— end matter and references are not included in the word count, and are the only part of the
manuscript that will be allowed to extend beyond the end of the fourth page. Authors of submitted
manuscripts that exceed the length requirements will be asked to adjust their manuscript by
removing material, which can be placed in the Supporting Information. Note that authors should
take care to not allow the length of their manuscript to exceed these requirements when making
revisions.

ACS Researcher Resources

While this document will provide basic information on how to prepare and submit the manuscript
as well as other critical information about publishing, we also encourage authors to visit ACS
Researcher Resources for additional information on everything that is needed to prepare (and
review) manuscripts for ACS journals and partner journals, such as
 ● Mastering the Art of Scientific Publication, which shares editor tips about a variety of topics
including making your paper scientifically effective, preparing excellent graphics, and writing
cover letters.
● Resources on how to prepare and submit a manuscript to the ACS Publications manuscript
submission and peer review system, including details on selecting the applicable Journal
Publishing Agreement.
● Sharing your research with the public through the ACS Publications open access program.
● ACS Reviewer Lab, a free online course covering best practices for peer review and related
ethical considerations.
● ACS Author Lab, a free online course that empowers authors to prepare and submit strong
manuscripts, avoiding errors that could lead to delays in the publication process.
● ACS Inclusivity Style Guide, a guide that helps researchers communicate in ways that
recognize and respect diversity in all its forms.

Manuscript Preparation
Submit with Fast Format

All ACS journals and partner journals have simplified their formatting requirements in favor of a
streamlined and standardized format for an initial manuscript submission. Read more about the
requirements and the benefits these serves authors and reviewers here.

Manuscripts submitted for initial consideration must adhere to these standards:

● Submissions must be complete with clearly identified standard sections used to report original
research, free of annotations or highlights, and include all numbered and labeled components.
● Figures, charts, tables, schemes, and equations should be embedded in the text at the point
of relevance. Separate graphics can be supplied later at revision, if necessary.
● When required by a journal's structure or length limitations, manuscript templates should be
used.
● References can be provided in any style, but they must be complete, including titles. For
information about the required components of different reference types, please refer to
the ACS Style Quick Guide.
● Supporting Information must be submitted as a separate file(s).

Document Templates and Format

The templates facilitate the peer review process by allowing authors to place artwork and tables
close to the point where they are discussed within the text. Learn more about document templates
here.

General information on the preparation of manuscripts may also be found in the ACS Guide to
Scholarly Communication.

Acceptable Software, File Designations, and TeX/LaTeX

See the list of Acceptable Software and appropriate File Designations to be sure your file types
are compatible with the submission system. Information for manuscripts generated from
TeX/LaTeX is also available.

Cover Letter

A cover letter must accompany every manuscript submission. During the submission process, you
may type it or paste it into the submission system, or you may attach it as a file.

The cover letter should address the criteria of significance and the need for rapid disclosure and, if
the author wishes, list the name of a suggested Associate Editor for consideration. Information
regarding previous submission to Organic Letters should be included. If back-to-back publication
with another paper is desired, this should be stated, along with the desired order of publication in
the cover letters of both manuscripts.

Manuscript Text Components

Letters contain a Title, Abstract, main text without section headings, a Data Availability Statement,
and references/end matter.

The title should be descriptive of the topic of the article and as short as possible (not exceeding 20
words), using easily searchable keywords and avoiding/minimizing hyphenation. To that end,
avoid using abbreviations and acronyms unless they are more commonly used than spelled out
words. Also avoid complex compound names as much as possible in the title by using generic
names, and spell out elements rather than using symbols unless part of a compound formula.
Neither the title nor any other text should indicate that the article is part of a numbered series on a
broader research topic, or a numbered contribution from a particular institution or research group.

The Abstract of 75 words or less of text should briefly state the purpose of the research, the
principal results, and the major conclusions. A well-written Abstract along with its graphic figure
can attract the attention of potential readers and increase the likelihood that the published article
will be read and cited by other researchers. Summaries of numerical results should be
quantitative, for example, “in yields of 65 to 90%” rather than “in good to excellent yields”).

A graphic must be included with each manuscript for display in Abstract and in the Table of
Contents (TOC). The graphic should capture the reader’s attention and, in conjunction with the
Title and Abstract text, should give the reader a quick impression of the essence of the article. In
preparing the graphic, creativity is welcome, but avoid images of people living or from the past and
avoid caricatures or parodies that could be socially/culturally insensitive or considered racist or
discriminatory, especially when taken out of context. Ensure that cartoon depictions of machinery,
nature, and processes do not indicate actions or settings that are improbable. The graphic must fit
in an area no larger than 8.25 cm by 4.45 cm (3.25 inches by 1.75 inches); the Abstract and
graphic together should not exceed the space required for 200 words. See Appendix 2 for full
details on graphics requirements.

The introduction of the main text should include sufficient background information to provide
appropriate context as to the novelty and importance of the new work and clearly state the
purpose and objectives of the research. An extensive review of prior work is not appropriate, and
documentation of the relevant background literature should be selective rather than exhaustive,
particularly if reviews can be cited.

A Data Availability Statement is required for all peer-reviewed articles and is not required for the
following non-peer-reviewed articles: Addition/Correction, Editorial, Expression of Concern, or
Retraction. The ACS Research Data Policy provides additional information on Data Availability
Statements, Data Citation, and Data Repositories.

Claims of priority, originality, convenience, effectiveness, or value should be avoided or used with
great restraint in the title and throughout the main text. For example, the words “concise,”
“convenient,” “efficient,” “elegant,” “expedient,” “facile,” “first,” “new,” “novel,” “practical,” “simple,”
“unique,” “unprecedented,” and “versatile” should not be used. The use of “free” should also be
avoided, that is “metal-free,” “catalyst-free,” “light-free,” and so on, as these terms can be
misleading. In addition, editors may ask authors to moderate or remove what they judge to be
excessive use of subjective evaluative language elsewhere in the manuscript.

Abbreviations, Symbols, Units, Compound Names. Authors should use abbreviations and
acronyms in the text to conserve space. A list of standard abbreviations is provided in the ACS
Guide to Scholarly Publishing. Nonstandard abbreviations and acronyms must be defined the first
time they are used in the abstract, text, and supporting information. The use of abbreviations
should be consistent throughout the manuscript text and graphics. For example, either CH3 or Me
may be used for “methyl,” but not both. Full systematic names of compounds (see Part 4 and Part
5 of the ACS Guide to Scholarly Communication for guidance) should be included in the
Experimental Section on first mention and for brevity assigned a molecule number for reference
throughout the article. In other sections of the manuscript, authors should use their judgement on
common usage of compound names or use a generic name or molecule numbers in lieu of full
systematic names. As a courtesy to the research community, a list of abbreviations used in your
manuscript if extensive can be included under Associated Content at the end of the manuscript
and at the end of the Supporting Information before the References section.

References
Authors should be judicious in citing the literature; unnecessarily long lists of references should be
avoided. If a number of publications are relevant to a statement in the text, not more than two or
three of the most seminal or recent should be cited; if appropriate, the author may add “and
references cited therein” following a reference. Authors must also cite any previously published
work wherein portions of the submitted work have been disclosed. It is seldom necessary or
appropriate for an author to cite more than 5 of their own publications. No reference should repeat
a reference that appears elsewhere in the manuscript’s list of references. Authors are encouraged
to include additional references cited in Supporting Information files in the main article reference
list. Long endnotes should be avoided; peripheral discussion should be placed in the supporting
information. Endnotes should not contain graphics, experimental procedures, or compound
characterization data.

Supporting Information

This information is provided to the reviewers during the peer-review process (for Review Only) and
is available to readers of the published work (for Publication). Supporting Information must be
submitted at the same time as the manuscript. See the list of Acceptable Software by File
Designation and confirm that your Supporting Information is viewable.

If the manuscript is accompanied by any supporting information files for publication, these files will
be made available free of charge to readers. A brief, nonsentence description of the actual
contents of each file, including the file type extension, is required. This description should be
labeled Supporting Information and should appear before the Acknowledgement and Reference
sections. Examples of sufficient and insufficient descriptions are as follows:

Examples of sufficient descriptions: “Supporting Information: 1H NMR spectra for all compounds
(PDF)” or “Additional experimental details, materials, and methods, including photographs of
experimental setup (DOC)”.

Examples of insufficient descriptions: “Supporting Information: Figures S1-S3” or “Additional

figures as mentioned in the text”.

When including supporting information for review only, include copies of references that are
unpublished or in-press. These files are available only to editors and reviewers.

Research Data Policy

All ACS journals strongly encourage authors to make the research data underlying their articles
publicly available at the time of publication.
Research data is defined as materials and information used in the experiments that enable the
validation of the conclusions drawn in the article, including primary data produced by the authors
for the study being reported, secondary data reused or analyzed by the authors for the study, and
any other materials necessary to reproduce or replicate the results.
The ACS Research Data Policy provides additional information on Data Availability Statements,
Data Citation, and Data Repositories.

Data Requirements

Supporting Information

Supporting Information (SI) is required and is reviewed for completeness and accuracy by a Data
Analyst. Submissions without adequate SI will be inactivated and the authors will be asked to
provide the requested information. You are encouraged to share primary research data via a data
repository.

Introductory Section

An introductory section should include general procedures, standard techniques, and instruments
employed in the synthesis and characterization of the compounds described in this section.
● General reaction conditions
● Instruments used (NMR, microwave reactors, etc.)
● Suppliers for commercial compounds
● Citations to references for noncommercial known compounds

Experimental Details Section

● New procedures should be fully described in detail to ensure reproducibility.

● When a new or improved synthetic method is described, at least one detailed complete
method must be provided at the 1 mmol scale.
● The yields reported in key experimental examples, and yields used for comparison with
existing methods, should represent amounts of isolated and purified products.
● Chromatographically or spectroscopically determined yields are not acceptable
● Reactant quantities and product yields should be reported in weight and molar units;
percentage yields should only be reported for materials of demonstrated purity
 ● Experimental details and spectra in the SI are in the sequence that corresponds to the
manuscript

In addition to emphasizing safety hazards or risks associated with the reported work and how to
mitigate them, the Editors encourage authors to mention the use of toxic and/or environmentally
persistent reagents and solvents and provide a rationale on choice of these reagents and solvents.
This acknowledgement is especially important in cases of “dual use” potential when the reported
work could be directly misapplied by others to pose a threat to public health and safety. Organic
Letters further encourages authors to consider the Principles of Green Chemistry in carrying out
their research and consider reporting metrics such as atom economy, mass efficiency, E-factor, or
others. For more information, please consult Research Tools provided by the ACS Green
Chemistry Institute.

For each procedure, include the following details:

● Title containing the compound number and structure that corresponds to the manuscript
● For synthetic procedures, include: Reactant quantitiesDetailed purification techniquesProduct
quantitesIsolated yieldsPhysical state/description of the compounds (i.e., color, solid,
etc.)Characterization data Report 1H chemical shift to two digits after the decimal pointReport
13
C chemical shifts to one digit after the decimal point

Chromatography

● When flash chromatography is used for product purification, the support should be identified
and the solvent should be identified for each compound.
● HPLC analyses should be performed in two different solvent systems. The stationary phase,
solvents (HPLC), detector type, and percentage of total chromatogram integration should be
reported; alternatively, a copy of the chromatogram may be included as a figure in the
Supporting Information.

Crystal Data

All Crystallographic Information Files (CIFs), structure factor tables, and CheckCIF reports must
be submitted to the Cambridge Crystallographic Data Centre (CCDC) prior to manuscript
submission. See Requirements for Depositing X-Ray Crystallographic Data [PDF] for complete
details on submission of CIFs and a list of file types accommodated by CCDC.
● Before being submitted to CCDC, CIFs should be checked using the free checkCIF data-
validation utility on the CIF Validation site.
● Any reported syntax errors should be corrected. Authors are required to correct/defend/or
respond to any A-level alerts. Comments may be inserted into the CIF file using a Validation
Response Form or uploaded as a separate document as Supporting Information for Review
Only.
● checkCIF output files (combined into one PDF file) should be uploaded at submission as
Supporting Information for Review Only.
● Any subsequent revisions to the CIFs or structure factor tables should be deposited directly
with the CCDC before resubmitting the manuscript.

Microwave Experiments
For reactions that require heating, identify the temperature and heat source (oil bath, heating
mantle, etc.) or the model and manufacturer number if a device is used, e.g. a microwave or
sonicator. Reports of syntheses conducted in microwave reactors must indicate whether sealed or
open reaction vessels were used, how the reaction temperature was monitored (external surface
sensor or internal probe type), and the temperature reached or maintained in each experiment.
Authors must comply with the requirement that at least one detailed complete method must be
provided at the 1 mmol scale. Organic Letters does not publish reports of studies conducted with
domestic (kitchen) microwave ovens in which yields or selectivities observed using microwave
irradiation are compared with results obtained using conventional heating.

Compound Characterization

When manuscripts report the synthesis of compounds, submission of a Compound

Characterization Checklist is recommended. The Checklist will be provided to Editors and
reviewers to help them assess the thoroughness of the characterization of synthesized
compounds. Compound characterization data provided should be sufficient to ensure that
compounds being added to the chemical literature have been correctly identified and can be
synthesized in known yield and purity by the reported preparation, isolation, and purification
methods.

Note that authors are responsible for retaining their original data or having available original data
from collaborators or from contractors who perform analyses on their behalf. Authors may be
asked to provide copies of spectra or analytical reports if an editor or reviewer raises a question
about reported results. Upon publication, authors are encouraged to link the manuscript to their
data housed in a repository or other location, and to make their primary data freely available to
others upon request.

New compounds: Evidence adequate to establish both identity and degree of purity
(homogeneity) should be provided (see below).

Known compounds: Purity documentation must be provided for known compounds whose
preparation by a new or improved method is reported (see below). Listings of IR absorptions and
NMR resonances for known compounds should be presented only if they do not duplicate
previously published data.

In addition, for noncommercial, known compounds used as starting materials, the method of
preparation and the literature data used to confirm the materials’ identity must be cited.

Authors are further encouraged to include additional data or revised data that was not reported in
original references cited, and in doing so indicate which part of the data set is new information.
Identity – Compound Requirements
For all new compounds, a listing of 1H and 13C resonances, either HRMS or elemental analysis
data and important IR absorptions should be included in the experimental details section.
HPLC/LCMS can be substituted for biochemistry papers where the focus is not on compound
synthesis. Hydrogen multiplicity (C, CH, CH2, CH3) information obtained from routine DEPT
spectra should be included. If detailed peak assignments are made, the type of NOESY or COSY
methods used to establish atom connectivities and spatial relationships should be identified in the
Supporting Information.

If a required type of data is not obtainable, the reason for the absence of the data should be noted
in the experimental section of the Supporting Information. For example:
● Compound is too insoluble to record a 13C NMR spectrum
● Compound is too unstable to obtain a good elemental analysis

The following data should be included:

● Spectral data: Copies of 1H and 13C NMR spectra and/or relevant heteronuclei if appropriate
should be provided for key transformations and final products.
● HRMS/elemental analysis: To support the molecular formula assignment, either the HRMS
data accurate within 5 ppm, or combustion elemental analysis data accurate within 0.4%,
must be reported for new compounds.
NOTE: in certain cases, a crystal structure may be an acceptable substitute for HRMS/elemental
analysis (see Crystal Data for information on submitting CIF files to CCDC).
● Melting point: A melting point range should be reported for all crystalline compounds.Melting
points of noncrystalline amorphous compounds should not be reported.
● Specific Rotation. Specific optical rotations should be reported for isolated natural products
and enantioenriched compounds when sufficient sample is available. Specific rotations based
on the equation [] = (100·)/(l·c) should be reported as unitless numbers as in the following
example: []D20 -25 (c 1.9, CHCl3), where the concentration c is in g/l00 mL and the path length
l is in decimeters. The units of the specific rotation, (deg·mL)/(g·dm), are implicit and are not
included with the reported value. See also the section on Computational Data.

Experimental Electronic Circular Dichroism and Vibrational Circular Dichroism Spectra.

When reported, experimental conditions of ECD and VCD spectra such as concentration, solvent,
and optical path length should be indicated. Spectral intensities should be reported in units of
molar absorptivity (, M-1 cm-1). The method of baseline correction (subtraction of solvent or
racemate spectrum) must be noted. The spectra should always be presented together with the
corresponding unpolarized absorption spectra (UV/vis and IR) shown at the same scale. See also
the section on Computational Data.
Oxygen Balance. Oxygen balance parameter gives potential of a compound or an explosive
towards oxidation. Please report the oxygen balance in the following format including the complete
formula used for calculation:
● Oxygen balance (OB, %) for CaHbNcOd: OB=1600×(d-2a-b/2)/Mw, Mw= molecular weight
(based on carbon dioxide).

Purity – Compound Requirements

The types of evidence appropriate for demonstrating a compound’s purity will necessarily depend
on the method of preparation, the compound’s air and thermal stability, the complexity of the
structure, the nature of reasonably likely impurities, and the amount of sample available. For
example, combustion analysis would not be a good choice for the product of an isomerization or
rearrangement reaction; a “clean” NMR spectrum would need to be supplemented with other
evidence when a reasonably likely impurity is NMR silent (e.g., an inorganic salt).

For all known compounds synthesized by a new or improved method, include one or more
of the following characterization data:
● A well-resolved high field 1H NMR spectrum showing at most only trace peaks not attributable
to the assigned structure.
● A standard 1D proton-decoupled 13C NMR spectrum.
 ● Combustion elemental analytical values for carbon and hydrogen (and nitrogen, if present)
agreeing with calculated values within 0.4%.
● Quantitative gas chromatographic analytical data for distilled or vacuum-transferred samples
or quantitative HPLC analytical data for materials isolated by column chromatography or
separation from a solid support.
● Electrophoretic analytical data obtained under conditions that permit observing impurities
present at the 5% level.

Note: A typical example to report 1H and 13C NMR data to conform to ACS Guide format is (high
to low): 1H NMR (C6D6, 400 MHz): 6.00 (t, 1H, J = 4.0 Hz), 5.62 (t, 1H, J = 4.0 Hz), 1.95 (d, 1H, J
= 4.0 Hz), 1.73 (s, 15H), 1.62 (s, 3H), 1.58 (s, 15H), 0.98 (s, 1H), 0.72 (d, 1H, J = 4.0 Hz), -0.53 (s,
1H). 13C{1H} NMR (C6D6, 125 MHz): 88.7, 88.0, 81.0, 80.8, 60.6, 54.2, 51.5, 38.3, 17.4, 10.6,
10.2.

Note: HRMS data may be used to support a molecular formula assignment but cannot be used as
a criterion of purity.

Guidelines for Specific Compound Classes

Combinatorial libraries containing more than 20 compounds: complete characterization data

must be provided for at least 20 diverse members.

Natural products whose structures are being proposed or revised: sufficient data should be
provided to definitively establish molecular composition. Suggested analyses include: melting point
of crystalline compounds, HRMS, IR spectra, 1H and 13C NMR spectra, 2D 1H COSY, 2D 1H/13C
HMQC, and 1D DEPT spectra as well as long-range 1H COSY spectra and NOESY and/or NOE
spectra (where NOE data is being used to assign a structure). An X-ray crystal structure can also
be employed to establish the structure assignment. Specific optical rotations as []D values should
be reported for isolated natural products and enantiopurecompounds.

Configurational Isomer Mixtures: For reporting the compositions, enantiomeror diastereomer

ratios are preferred over enantiomeric or diastereomeric excess values.

Non-racemic chiral substances: Data to permit correlation ofabsolute configuration should be

provided, preferably including []D values.

Biomacromolecules: The structures of biomacromolecules may be established by providing

evidence about sequence and mass. Sequences may be inferred from the experimental order of
amino acid, saccharide, or nucleotide coupling; from known sequences of templates in enzyme-
mediated syntheses; or by standard sequencing techniques. Typically, a sequence will be
accompanied by MS data that establish the molecular weight.

Spectra Standards. Spectra files should not be manipulated in any manner that could result in
misinterpretation or misrepresentation of the original spectra. Nothing within an image such as
spectral baselines or solvent/impurities should be enhanced, obscured, moved, removed, or
introduced.
● Label each spectra with an image of the structure and a compound number
● Spectra should be legible and images are not faint or blurry
● Spectra should be at least a half page in size, preferably a full page Include magnified
 region(s) when necessary to show detail
● Display the NMR baseline and include the minimum chemical shift range: -1-9 ppm for 1H
spectra-10-190 ppm for 13C spectraExtended range for functional groups that resonate from
9-14 ppm
● Integrate all peaks in the 1H NMR arising from the compound
● Chemical shift values should be included for all peaks arising from the compound in the 1H
and 13C spectra
● The largest peak in the 1H NMR spectrum should normally be full scale and arise from the
compound, not the solvent or impurities
● Field strength, solvent peak and nucleus being measured should be noted on each spectrum

Primary NMR Data Files

Submission of primary NMR data files (FID files, acquisition data, processing parameters) is highly
recommended. All original primary NMR data supporting a submission should be retained and
provided if requested. Primary NMR data should be submitted to a data repository, please see the
ACS Research Data Policy for additional information on choosing a data repository.

When submitting FID files:

● One folder should be created for each compound
● Folder should be named clearly, using the compound number
● Include the FID files, acquisition data and processing parameters for each experiment
● Name each spectrum according to the type of nucleus measured: 1H,13C, DEPT, COSY, etc.
● NMR files should be compressed into zip file(s)
● Name the zipped file, "FID for Publication"

In a text document, include the name of the manufacturer of the spectrometer used to collect the
data, the acquisition software and processing programs used to analyze the data, and the field
strength used to measure each nucleus (i.e., 300 MHz 1H or 50 MHz 13C). Include a structure file
that shows the structure and compound identifier for each provided dataset. MolFile is the
recommended format and is strongly preferred.

Electrochemistry Data. For reporting Voltammetry and Amperometry measurements, and for
reporting Bulk Electrolysis procedures, please see the ACS Electrochemistry Guidelines.

Biological Data. For reporting information on specimens, techniques, and data, please see the
ACS Biological Data Guidelines.

Computational Data. When computational results are included in a manuscript, complete details
of computational methods and results, reported in sufficient detail to allow other researchers to
repeat the computations, should be included either within the article or as Supporting Information.
Graphics of computationally derived models that are not vital to the discussion should be placed in
the Supporting Information. The level of theory, basis set, and relevant input parameters should be
identified along with the specific program used. The data should include Z-matrices or Cartesian
coordinates, grid size (for DFT calculations), and computed total energies of target or optimized
structures. Where applicable, the number of imaginary frequencies should be reported to identify
stable structures and transition states.
Description of specific programs and versions. If the author’s own or a modified version of a
commercially available program is used, it is required that the program/code/modification be made
available to the scientific community (QCPE, publication in a computational journal, commercially,
etc.). Policies in this regard are identical with those of several other ACS journals, as summarized
in J. Chem. Inf. Model. 2006, 46, 937. A clear exposition of any nonstandard equations and
algorithms used and, where feasible, tests of the codes in various limiting cases should also be
provided.

Details of the computations. The computed molecular model should be described clearly, possibly
with a ChemDraw figure. If the model is based on an experimentally known complex/reaction, any
modifications (such as truncations) should be clearly described and justified. Final optimized
coordinates and keywords are to be provided. For DFT computations, the choice of functional
must be justified, or the validation of the functional provided. The choice of basis sets must be
explicitly discussed, including any deviation from standard basis sets. Convergence criteria,
integration parameters, active space definition in multireference calculations, and, for open-shell
systems, the way in which spin states are handled should be mentioned explicitly. The exact
definition of any applied numerical or symmetry constraint should be indicated.

Details of the computational results. When relevant to the results of the study, data such as
absolute energies, gross orbital populations, atomic spin densities, etc., should be supplied.
Where feasible, critical checkpoint/restart files should be saved and made available upon request.

Cartesian Coordinates. Cartesian coordinates of all molecules, intermediates, transition states,

etc. that are part of the manuscript must be uploaded in a single file that is formatted for
convenient viewing with widely available molecular modeling packages. The .xyz and .mol formats
are accepted at this time. The .xyz format is the most basic and easily prepared from
computational output.

The first line of the .xyz format file denotes the number of atoms in the molecule.

The second line of the file is a comments line, and should begin with a descriptive name of the
molecule/structure consistent with the designation in the manuscript, and any other pertinent
information selected by the author, such as total energy.

Next follow lines for each element in the molecule. Each line contains the element symbol followed
by the x, y, and z coordinates in angstroms (Å) separated by spaces in free-field format (i.e.
precise formatting not required). More information on the .xyz file format is available at
http://openbabel.sourceforge.net/wiki/XYZ.

Multiple structures are placed directly end-to-end in the file.

The file name should have the extension “.xyz”. A simple example with three molecules is shown
below.

It is strongly recommended that authors view the structures in the file with a modeling program
before uploading the file. The program Mercury (version 3.3 or later) is recommended for viewing
and manipulating the multiple structures. The Cambridge Crystallographic Data Centre (CCDC)
offers Mercury at no cost. Include the phrase “a text file of all computed molecule Cartesian
coordinates in a format for convenient visualization” in the Supporting Information statement.
For additional guidance, see the ACS Simulations, Machine Learning, Computational Data
guidelines.

When computational prediction of spectral properties is used to establish identity of new

compounds, the following guidelines will apply:
● General: The level of theory, basis set, and relevant input parameters used for optimization
and the prediction of spectral properties should be indicated in all cases. It must be
noted/justified when geometry optimization and property calculations are carried out at
different levels of theory.
● Conformational search. A thorough conformational search should be performed for all
molecules, except those with no rotatable bonds. The methods and results of the
conformational search should be reported in detail.
● Optimized conformers. The optimized geometries of all the conformers actually used to
calculate a property should be reported, along with their energies and number of imaginary
frequencies (if conformers are more than five, only significantly populated conformers, that is
those with a calculated Boltzmann weight larger than 5%, can be reported).
1
● H and/or 13C NMR chemical shifts. The scaling parameters used to calculate chemical shifts
must be indicated. Calculated isotropic shielding values (before scaling to chemical shifts) for
H and/or C atoms of all considered conformers should be reported. If possible, comparison
with experimental chemical shifts should be accompanied by R2, RMSD, or DP4+ values.
Statistical methods can be used as well.
● Electronic Circular Dichroism. Parameters used to simulate the UV/Vis and ECD curves such
as Gaussian band width and UV shift must be indicated. A qualitative comparison of the
experimental and computed ECD spectra is generally sufficient. A comparison of the
experimental and computed UV/Vis spectra should also be presented. Transition energies (or
frequencies) and rotational strengths should be reported in tabular form for the significantly
populated conformers. A figure with computed ECD curves of individual conformers is
suggested, but not required. Any figure comparing the experimental and computed spectra
should include both the UV and ECD spectra in the same figure; both sets of spectra should
be shown in the same wavelength range.
● Vibrational Circular Dichroism. Parameters used to simulate the spectra such as the
Lorentzian band width and the frequency scaling factor must be indicated. The presentation of
the comparison of experimental and computed spectra should include both the IR and VCD
spectra in the same figure; both sets of spectra should be shown in the same wavenumber
range (e.g., 1800-900 cm-1). A qualitative comparison between experimental and computed
spectra is sufficient as long as convincing band correlations between major features in the
experimental and computed spectra are indicated. Quantitative comparison can be made
using similarity analysis algorithms which provide a degree of congruence between measured
and calculated VCD spectra for the assigned enantiomer versus its opposite enantiomer. If
VCD is used to distinguish diastereomers, a particular emphasis of the spectra comparison
must be given to those signals that are used to differentiate the stereoisomers.
● Optical rotation. When computed optical rotation values are used to assign or to complement
the assignment of an absolute configuration, it must be ensured that the experimental value is
not solvent dependent (at least two experimental values in a polar and a non-polar solvent
must be provided). Ideally, the optical rotation is also measured and computed at different
wavelength.

Language and Editing Services

A well-written paper helps share your results most clearly. ACS Publications’ English Editing
Service is designed to help scientists communicate their research effectively. Our subject-matter
expert editors will edit your manuscript for grammar, spelling, and other language errors so your
ideas are presented at their best.

Preparing Graphics

The quality of illustrations in ACS journals and partner journals depends on the quality of the
original files provided by the authors. Figures are not modified or enhanced by journal production
staff. All graphics must be prepared and submitted in digital format.

Graphics should be inserted into the main body whenever possible. Please see Appendix 2 for
additional information.

Any graphic (figure chart, scheme, or equation) that has appeared in an earlier publication should
include a credit line citing the original source. Authors are responsible for obtaining written
permission to re-use this material.

Figure and Illustration Services

The impact of your research is not limited to what you can express with words. Tables and figures
such as graphs, photographs, illustrations, diagrams, and other visuals can play a significant role
in effectively communicating your findings. Our Artwork Editing and Graphical Abstract services
generate publication-ready figures and Table of Contents (TOC) graphics that conform to your
chosen journal’s specifications. For figures, this includes changes to file type, resolution, color
space, font, scale, line weights, and layout (to improve readability and professional appearance).
For TOC graphics, our illustrators can work with a rough sketch or concept or help extract the key
findings of your manuscript directly for use as a visual summary of your paper.

Preparing for Submission

Manuscripts, graphics, supporting information, and required forms, as well as manuscript
revisions, must all be submitted in digital format through ACS Publishing Center, which requires an
ACS ID to log in. Registering for an ACS ID is fast, free, and does not require an ACS
membership. Please refer to Appendix 1 for additional information on preparing your submission

Prior Publication Policy

Organic Letters is committed to the rapid publication of exciting new original work that has not
previously been published and/or is not under consideration for publication elsewhere. Any
relevant content that has been made publicly available, either in print or electronic format, may
jeopardize the originality of a submission and preclude consideration for publication in Organic
Letters. The exception to these restrictions is the final version of a thesis filed as a publicly stated
requirement for an undergraduate, masters, or Ph.D. degree posted on the official Web site of the
degree-granting institution. When submitting a manuscript, the authors should inform the editor of
any prior dissemination of the submission content, including conference presentations, posters,
and reports in institutional repositories.

Authors are allowed to deposit an initial version of their manuscript in a preprint repository such as
ChemRxiv, arXiv, bioRxiv, or the applicable repository for their discipline prior to submission.
Authors must note any use of a preprint repository in the cover letter, include a link to the preprint,
and as appropriate state how the manuscript has been adjusted/updated between preprint
deposition and journal submission. The preprint should be cited as a reference in the manuscript.
Authors are discouraged from posting a revised version of the preprint, or for depositing the initial
version of manuscript as a preprint, after the manuscript has been submitted and a decision is
pending.

Editorial Policies

Previous Submission. If substantially the same manuscript has been previously submitted to
this journal, the cover letter must mention the earlier submission with manuscript number and
handling editor name and provide a rationale for reconsideration. If the manuscript was reviewed,
the cover letter should include a detailed explanation of any revisions, whether or not they were
made in response to reviewer and editor comments; an annotated copy of the prior manuscript
showing these revisions is welcome.

Information for Reviewers. Organic Letters operates under a single-anonymized peer review
process. The quality of the articles published in the peer-reviewed chemical literature depends
heavily on the thoroughness and rigor of the manuscript evaluations provided by reviewers. In
addition, the editors of Organic Letters rely on each reviewer’s conscientiously prepared
comments for helping maintain the high scientific standards of the journal. Please read the general
information about ACS Peer Review and ACS Publication Policies.

To help facilitate timeliness in the peer-review process, reviewers are expected to promptly
respond to invitations to conduct a review and to promptly return their review before the deadline.
The editors ask all reviewers to access the manuscripts they are reviewing and submit their
reviews on the ACS Publishing Center website; manuscript files will not be e-mailed or made
available to reviewers by other means.

During their evaluation, reviewers are requested to adhere to the precepts in the “Ethical
Obligations of Reviewers of Manuscripts” section of the ACS Ethical Guidelines for Publication of
Chemical Research. These include treating the manuscript as a privileged document and
disclosing any potential conflict of interest to the editor. The editors will not disclose the names of
any reviewer to the author of a manuscript. Reviewers should keep the reviewing process
confidential by not contacting authors about the content of manuscripts, or disclosing to authors
their role as reviewer, without prior approval of the editor.

Reviewers should become familiar with this complete Author Guidelines document; tools for
viewing Supporting Information are provided here. Comments about the content of the manuscript
should be entered in the “Comments to the Author” section of the review form. These comments
are seen by the editor as well as by the author. Review comments should be objective,
impersonal, and constructive. The “Comments to the Editorial Office” section of the form should be
used only for ethical concerns and other remarks intended for the editor only.

For the invited reviewer, you might on occasion ask a postdoctoral researcher or graduate student
in your group to review the manuscript along with you. This approach is acceptable so long as the
reviewer enters a note in the “Comments to the Editorial Office” section of the form when the
review is returned. We encourage junior group members to first complete the ACS Reviewer Lab.

Reviewing manuscripts is recognized as a professional obligation of scientists who themselves

publish in the literature. Editors are aware of the demands placed on reviewers and have
individual reviewer records available to help avoid assigning multiple reviews simultaneously or for
making review requests too often.

Reviewer Credit. Reviewers of manuscripts submitted to ACS journals may claim credit for their
hard work and contributions through an ACS collaboration with ORCID. Reviewers will receive one
credit on their ORCID account for all review activity associated with each manuscript. To claim
credit, simply ensure that your ORCID iD is associated with your ACS Publishing Center account.
If you do not have an ORCID iD, you can create one using the ORCID link on your ACS Publishing
Center profile page. For more information, click here.

Note for Authors about Reviews. As an ethical obligation, authors are expected to clearly and
succinctly address all reviewer comments and concerns during manuscript revision and note how
the manuscript has been revised, with an eye toward improving their manuscript. Authors are
encouraged to include “for review only” a tracked changes manuscript for revisions and for
resubmissions.

Appeals. Appealing an editorial rejection decision is always an option available to authors, one
that the Editorial Team takes seriously. But such appeals must be based on rational arguments
focused specifically on why a decision should be overturned. Appeals may be successful if they
address objective issues (such as interpretation of data, for example) with calm and clear
arguments rather than emotional pleas, and address all of the critiques rather than focusing
selectively on positive parts of the reviews and ignoring negative comments. Appeals are less
likely to be successful if the rejection of the manuscript was based on the Editor’s view that the
work does not accommodate the broad readership of the journal (scope). During an appeal, the
Editors may obtain additional opinions from other Editors or members of the Editorial Advisory
Board before coming to a decision. Authors should not resubmit a rejected manuscript without
approval from the journal editorial office.

Providing Potential Reviewer Names

To help the editors identify reviewers with appropriate expertise, please suggest three reviewers,
avoiding those who coauthored recent publications with any of the authors or who have a close
academic or private relationship. ACS requests that you consider the gender and geographic
diversity of your suggested reviewers in addition to their topical expertise. Authors are encouraged
to give reasons for their suggestions. You may also ask editors to exclude certain reviewers and
you may suggest a handling editor. Authors are encouraged to avoid suggesting reviewers from
the authors’ institutions. Do not suggest reviewers who may have a real or perceived conflict of
interest. Whenever possible, suggest academic email addresses rather than personal email
addresses.

Manuscript Transfer

If your submission is declined for publication by this journal, the editors might deem your work to
be better suited for another ACS Publications journal or partner journal and suggest that the
authors consider transferring the submission. Manuscript Transfer simplifies and shortens the
process of submitting to another ACS journal or partner journal, as all the coauthors, suggested
reviewers, manuscript files, and responses to submission questions are copied to the new draft
submission. Authors are free to accept or decline the transfer offer.

Note that each journal is editorially independent. Transferring a manuscript is not a guarantee that
the manuscript will be accepted, as the final publication decision will belong to the editor of the
next journal.
PRODUCTION AND PUBLICATION
Proofs via ACS Direct Correct

Correction of the galley proofs is the responsibility of the Corresponding Author. The
Corresponding Author of an accepted manuscript will receive e-mail notification and complete
instructions when page proofs are available for review via ACS Direct Correct. Extensive or
important changes on page proofs, including changes to the title or list of authors, are subject to
review by the editor.

It is the responsibility of the Corresponding Author to ensure that all authors listed on the
manuscript agree with the changes made on the proofs. Galley proofs should be returned within
48 hours in order to ensure timely publication of the manuscript.

Publication Date and Patent Dates

Accepted manuscripts will be published on the ACS Publications Web site as soon as page proofs
are corrected and all author concerns are resolved. The first date on which the document is
published on the Web is considered the publication date.

Publication of manuscripts on the Web may occur weeks in advance of the cover date of the issue
of publication. Authors should take this into account when planning their patent and intellectual
property activities related to a document and should ensure that all patent information is available
at the time of first publication, whether ASAP or issue publication.

All articles published ahead of print receive a unique Digital Object Identifier (DOI) number, which
is used to cite the manuscript before and after the paper appears in an issue. Additionally, any
supplemental information submitted along with the manuscript will automatically be assigned a
DOI and hosted on Figshare to promote open data discoverability and use of your research
outputs.

ASAP Publication

Manuscripts will be published on the “ASAP Articles” page on the web as soon as page proofs are
corrected and all author concerns are resolved. ASAP publication usually occurs within a few
working days of receipt of page proof corrections, which can be several weeks in advance of the
cover date of the issue.

Post-Publication Policies

The American Chemical Society follows guidance from the Committee on Publication Ethics
(COPE) when considering any ethical concerns regarding a published article, Retractions, and
Expressions of Concern.

Additions and Corrections

Additions and Corrections may be requested by the author(s) or initiated by the Editor to address
important issues or correct errors and omissions of consequence that arise after publication of an
article. All Additions and Corrections are subject to approval by the Editor, and should bring new
and directly relevant information and corrections that fix scientific facts. Minor corrections and
additions will not be published. Readers who detect errors of consequence in the work of others
should contact the corresponding author of that work.

Additions and Corrections must be submitted as new manuscripts via the ACS Publishing Center
by the Corresponding Author for publication in the “Addition/Correction” section of the Journal. The
corresponding author should obtain approval from all coauthors prior to submitting or provide
evidence that such approval has been solicited. The manuscript should include the original article
title and author list, citation including DOI, and details of the correction.

Retractions

Articles may be retracted for scientific or ethical reasons and may be requested by the article
author(s) or by the journal Editor(s), but are ultimately published at the discretion of the Editor.
Articles that contain seriously flawed or erroneous data such that their findings and conclusions
cannot be relied upon may be retracted in order to correct the scientific record. When an article is
retracted, a notice of Retraction will be published containing information about the reason for the
Retraction. The originally published article will remain online except in extraordinary circumstances
(e.g. where deemed legally necessary, or if the availability of the published content poses public
health risks).

Expressions of Concern

Expressions of Concern may be issued at the discretion of the Editor if:

● there is inconclusive evidence of research or publication misconduct by the authors;
● there is evidence that the findings are unreliable but the authors’ institution will not investigate
the case;
● an investigation into alleged misconduct related to the publication either has not been, or
would not be, fair and impartial or conclusive;
● an investigation is underway but a judgment will not be available for a considerable time.

Upon completion of any related investigation, and when a final determination is made about the
outcome of the article, the Expression of Concern may be replaced with a Retraction notice or
Correction.

Sharing Your Published Article

At ACS Publications, we know it is important for you to be able to share your peer reviewed,
published work with colleagues in the global community of scientists. As sharing on sites known as
scholarly collaboration networks (SCNs) is becoming increasingly prevalent in today’s scholarly
research ecosystem, we would like to remind you of the many ways in which you, a valued ACS
author, can share your published work.

Publishing open access makes it easy to share your work with friends, colleagues, and family
members. In addition, ACS Publications makes it easy to share your newly published research
with ACS Articles on Request (see below). Don’t forget to promote your research and related data
on social media, at conferences, and through scholarly communication networks. Increase the
impact of your research using the following resources: Altmetrics, Figshare, ACS Certified Deposit
E-Prints

When your article is published in an ACS journal or partner journal, corresponding authors are
provided with a link that offers up to 50 free digital prints of the final published work. This link is
valid for the first 12 months following online publication, and can be shared via email or an
author’s website. After one year, the access restrictions to your article will be lifted, and you can
share the Articles on Request URL on social media and other channels. To access all your Articles
on Request links, log in to your ACS Researcher Resources account and visit the “My Published
Manuscripts” page.

Reprints

Article, journal, and commercial reprints are available to order.

Appendix 1: PREPARING FOR SUBMISSION

We’ve developed ACS’ publishing and editorial policies in consultation with the research
communities that we serve, including authors and librarians. Browse our policies below to learn
more.

Ethical Guidelines

ACS editors have provided Ethical Guidelines for persons engaged in the publication of chemical
research—specifically, for editors, authors, and reviewers. Each journal also has a specific policy
on prior publication.

OFAC Compliance

As a U.S.-based non-profit organization, the American Chemical Society (ACS) is required to

comply with U.S. sanctions laws and regulations administered by the U.S. Treasury Department’s
Office of Foreign Assets Control (OFAC). While these laws and regulations permit U.S.-based
publishers like ACS to engage in publishing-related activities with authors located in sanctioned
regions in many cases, ACS may be prohibited under U.S. law from engaging in publishing-related
activities in some cases, including, but not limited to, instances where an author or the institution
with which an author is affiliated is located in a particular sanctioned region or has been
designated by OFAC as a Specially Designated National (SDN) pursuant to certain U.S. sanctions
programs. ACS reserves the right to refrain from engaging in any publishing-related activities that
ACS determines in its sole discretion may be in violation of U.S. law.

Safety Considerations

Authors must emphasize any unexpected, new, and/or significant hazards or risks associated with
the reported work. This information should be in the Experimental Section of a full article and
included in the main text of a communication or letter. Statement examples can be found in the
Safety Statement Style Sheet and additional information on communicating safety information
from the ACS Guide to Scholarly Communication is freely available here.

Conflict of Interest Disclosure

A statement describing any financial conflicts of interest or lack thereof is published in each ACS
journal and partner journal article.

During the submission process, the Corresponding Author must provide a statement on behalf of
all authors of the manuscript, describing all potential sources of bias, including affiliations, funding
sources, and financial or management relationships, that may constitute conflicts of interest. If the
manuscript is accepted, the statement will be published in the final article.

If the manuscript is accepted and no conflict of interest has been declared, the following statement
will be published in the final article: “The authors declare no competing financial interest.”

Plagiarism

In publishing only original research, ACS is committed to deterring plagiarism, including self-
plagiarism. ACS Publications uses CrossCheck's iThenticate software to screen submitted
manuscripts for similarity to published material. Note that your manuscript may be screened during
the submission process.

Further information about plagiarism can be found in Part B of the Ethical Guidelines to Publication
of Chemical Research. See also the press release regarding ACS' participation in the CrossCheck
initiative.

Authorship, Author List, and Coauthor Notification

Authors are required to obtain the consent of all their coauthors prior to submitting a manuscript.
The submitting author accepts the responsibility of notifying all coauthors that the manuscript is
being submitted.

During manuscript submission, the submitting author must provide contact information (full name,
email address, institutional affiliation, and mailing address) for all of the coauthors. Because all of
the author names are automatically imported into the electronic Journal Publishing Agreement, the
names must be entered into the submission system. (Note that coauthors are not required to
register in the ACS Publishing Center.) Author affiliation should reflect where the work was
completed, even if the author has since left that institution. Authors may include a note with a
current address if their institution has changed since the work was completed.

To expedite the processing of your manuscript, please format your author and affiliation
information according the guidelines in this document.

Criteria for authorship can be found in Part B of the Ethical Guidelines to Publication of Chemical
Research. Artificial intelligence (AI) tools do not qualify for authorship. The use of AI tools for text
or image generation should be disclosed in the manuscript within the Acknowledgment section
with a description of when and how the tools were used. For more substantial use cases or
descriptions of AI tool use, authors should provide full details within the Methods or other
appropriate section of the manuscript.

If any change in authorship is necessary after a manuscript has been submitted, confirmation is
required that all of the authors (including those being added or removed) have been notified and
have agreed to the change. To provide this confirmation, authors are asked to complete and sign
an authorship change form and provide the completed form to the appropriate editorial office.

Authors with a single name: If you, or any of your coauthors, have only one name, please follow
these steps for proper submission to the ACS Publishing Center:
1. First (Given) Name Field: Enter an asterisk (*) into the "First (Given) Name" field.
2. Last (Family) Name Field: Enter your single name into the "Last (Family) Name" field.
If your paper is accepted, the asterisk (*) will be removed from the published version of the paper.

Patent Activities and Intellectual Property

Authors are responsible for ensuring that all patent activities and intellectual property issues are
satisfactorily resolved prior to first publication (ASAP or in issue). Acceptance and publication will
not be delayed for pending or unresolved issues of this nature.

Open Researcher and Contributor ID (ORCID)

Authors submitting manuscript revisions are required to provide their own personal, validated
ORCID iD before completing the submission, if an ORCID iD is not already associated with their
ACS Publishing Center user profiles. This ID may be provided during original manuscript
submission or when submitting the manuscript revision. All authors are strongly encouraged to
register for an ORCID iD, a unique researcher identifier. The ORCID iD will be displayed in the
published article for any author on a manuscript who has a validated ORCID iD associated with
ACS when the manuscript is accepted.

ORCID iDs should not be typed into the manuscript. ACS publishes only those ORCID iDs that
have been properly verified and linked before the manuscript is accepted. After your ORCID iD
is linked, it will be displayed automatically in all subsequently accepted manuscripts for any/all
ACS journals. We do not publish ORCID iDs provided during proof review or via other
communications after a manuscript is accepted for publication.

With an ORCID iD, you can create a profile of your research activities to distinguish yourself from
other researchers with similar names, and make it easier for your colleagues to find your
publications. If you do not yet have an ORCID iD, or you wish to associate your existing ORCID iD
with your ACS Publishing Center account, you may do so by clicking on “Profile” from your ACS
Publishing Center dashboard and following the ORCID-related links. Learn more at www.orcid.org.

Copyright and Permissions

To obtain forms and guidelines for completing the Journal Publishing Agreement or obtaining
permissions from copyright owners, and to explore a Copyright Learning Module for chemists,
click here.

Funder Reporting Requirement

Authors are required to report funding sources and grant/award numbers. Enter ALL sources of
funding for ALL authors in BOTH the Funder Registry Tool in the submission system and in your
manuscript to meet this requirement.
Open Access Compliance

ACS offers options by which authors can fulfill the requirements for open access and deposition
into repositories for funded research. Visit our ACS Open Science site to see how to fulfill
requirements for specific funders and to find out if you are eligible to publish under a Read +
Publish agreement between ACS and your institution. You can also find out more about Open
Access Compliance and ACS Open Science initiatives.

Diversity and Inclusion Statement

During manuscript submission, ACS journal authors have the option to submit a statement sharing
information related to diversity and inclusion that is relevant for their paper. If supplying a diversity
and inclusion statement, the corresponding author must provide this on behalf of all authors of the
manuscript during the submission process. These statements include but are not limited to
analysis of citation diversity and acknowledgment of indigenous land on which research was
conducted. Statements expressing political beliefs are not permitted and may be removed by the
journal office. All statements are subject to final review by the Editor.
● Citation Diversity Statement:The citation diversity statement should appear in the
Acknowledgements section of the manuscript. ACS recommends including the following: (1)
the importance of citation diversity, (2) the proportion of citations by gender and race/ethnicity
for the first and last authors, (3) the method used to determine those proportions and its
limitations, and (4) steps taken to by the authors to improve citation diversity in the article. We
recognize that one limitation of the current methods is that it cannot account for intersex, non-
binary, and transgender people, or Indigenous and mixed-race authors. (Adapted from
BMES/Springer Guidelines)
● Land acknowledgment:The land acknowledgment statement should appear in the
Acknowledgements section of the manuscript. The statement should link to the institutions’
formal land acknowledgments on which the research took place, if possible. Further guidance
for creating these statements can be found here: https://nativegov.org/news/a-guide-to-
indigenous-land-acknowledgment/.

Appendix 2: Preparing Graphics

Resolution

Digital graphics pasted into manuscripts should have the following minimum resolutions:
● Black and white line art, 1200 dpi
● Grayscale art, 600 dpi
● Color art, 300 dpi

Size

Graphics must fit a one- or two-column format. Single-column graphics can be sized up to 240
points wide (3.33 in.) and double-column graphics must be sized between 300 and 504 points
(4.167 in. and 7 in.). The maximum depth for all graphics is 660 points (9.167 in.) including the
caption (allow 12 pts. For each line of caption text). Lettering should be no smaller than 4.5 points
in the final published format. The text should be legible when the graphic is viewed full-size.
Helvetica or Arial fonts work well for lettering. Lines should be no thinner than 0.5 point.

Color

Color may be used to enhance the clarity of complex structures, figures, spectra, and schemes,
etc., and color reproduction of graphics is provided at no additional cost to the author. Graphics
intended to appear in black and white or grayscale should not be submitted in color.

Type of Graphics

Table of Contents (TOC)/Abstract Graphic

Consult the Guidelines for Table of Contents/Abstract Graphics for specifications.

Our team of subject-matter experts and graphical designers can also help generate a compelling
TOC graphic to convey your key findings. Learn more about our Graphical Abstract service.

Figures

A caption giving the figure number and a brief description must be included below each figure. The
caption should be understandable without reference to the text. It is preferable to place any key to
symbols used in the artwork itself, not in the caption. Ensure that any symbols and abbreviations
used in the text agree with those in the artwork.

Charts

Charts (groups of structures that do not show reactions) may have a brief caption describing
their contents.

Tables

Each table must have a brief (one phrase or sentence) title that describes the contents. The title
should be understandable without reference to the text. Details should be put in footnotes, not in
the title. Tables should be used when the data cannot be presented clearly in the narrative, when
many numbers must be presented, or when more meaningful inter-relationships can be conveyed
by the tabular format. Tables should supplement, not duplicate, information presented in the text
and figures. Tables should be simple and concise.

Schemes

Each scheme (sequences of reactions) may have a brief caption describing its contents.

Chemical Structures

Chemical structures should be produced with the use of a drawing program such as ChemDraw.

Cover Art

The Editor-in-Chief’s office will contact authors to invite submission of front cover artwork, however
volunteer front cover suggestions will be considered. The journal is looking for aesthetically
pleasing covers that exhibit simplicity, clarity, and eye-catching graphics. Some covers may
include supporting text if the artwork is not self-explanatory. Authors should use the “About the
Cover” description to describe the cover concept and how it relates to the article, and also as a
place to acknowledge those who created or contributed toward the cover artwork. If your art is
selected for front cover, ACS will send you information about how to request one complimentary
18” by 24” printed poster featuring your work.

Organic Letters also offers authors a great way to promote their work through Supplementary
Covers. Submit your cover idea, artwork, and caption when submitting your manuscript revision in
the ACS Publishing Center. If your article is accepted for publication, your suggestion may be
selected for use on one of the journal’s supplementary covers.

Web Enhanced Objects (WEO)

The Web editions of ACS journals allow readers to view multimedia attachments such as
animations and movies that complement understanding of the research being reported.

WEOs should be uploaded in the submission system with ‘Web Enhanced Object’ selected as the
file designation. Consult the list of compatible WEO formats.