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The document provides a comprehensive overview of ionic liquids (ILs), including their history, structure, and various applications in pharmaceutical synthesis and drug delivery. It discusses the biological activity of ILs, their potential as antibacterial, antifungal, and anticancer agents, as well as their environmental impact. The document concludes with insights into the development of new active pharmaceutical ingredients based on ionic liquids.

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10 views2 pages

Index

The document provides a comprehensive overview of ionic liquids (ILs), including their history, structure, and various applications in pharmaceutical synthesis and drug delivery. It discusses the biological activity of ILs, their potential as antibacterial, antifungal, and anticancer agents, as well as their environmental impact. The document concludes with insights into the development of new active pharmaceutical ingredients based on ionic liquids.

Uploaded by

apnaoffice883
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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INDEX

S. No. Particulars Page No.

1. INTRODUCTION 1-7

1.1 Introduction 1

1.2 A Brief History of Ionic Liquids 5

1.3 Structure and Organization of Ionic Liquids 6

1.4 Generations of ionic liquids 6

2. ILS IN THE SYNTHESIS OF PHARMACEUTICAL COMPOUNDS 8-13

2.1 Overview 8

3. IONIC LIQUIDS (ILS) USED AS SOLVENTS 14-25

3.1 Pharmaceutical Drug Synthesis Using Ionic Liquids 14

3.2 Drug Delivery Using Ionic Liquids 16

3.2.1 Enhancement of Permeability of Cell Membrane 17

3.2.2 Support for Low Solubility Drug Dissolution 21

3.2.3 Designing New Active Pharmaceutical Ingredients-Ionic Liquids 22

3.3 Remedies for Pharmaceutical Drug Polymorphism-Related Problems 24

4. REVEALING BIOLOGICAL ACTIVITY OF IONIC LIQUIDS 26-39

4.1 Organism-Dependent Biological Activity of Ionic Liquids 26

4.2 Ionic Liquids as Antibacterial and Antifungal Agents 28

4.3 Ionic Liquids as Anticancer Agents 31

4.4 Biodegradation of Ionic Liquids 33

4.5 Toxicity and Environmental Effects 36

5. IONIC LIQUID-BASED NEW ACTIVE

PHARMACEUTICAL INGREDIENTS 40-43

5.1 Pharmaceutical Salts Ionic Liquid (API-ILs) Synthesis 40

5.2 Salts of Protic Pharmaceuticals 42


5.3 Assessing Enhanced Properties of API-IL 43

6. CONCLUSIONS 44

7. REFERENCES 45-47

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