Brewer 2004
Brewer 2004
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PSYCHOLOGY, HEALTH & MEDICINE
VOL. 9, NO. 2, MAY 2004
USA
Abstract This study examined the relationship between adherence to postoperative physical therapy
and outcome after surgical reconstruction of the anterior cruciate ligament (ACL) of the knee in a
sample of 72 men and 36 women. Indices of adherence were obtained during the first 6 weeks of
postsurgical rehabilitation. Outcome measures were administered before surgery and approximately 6
months after surgery. Results of a canonical correlation analysis indicated a statistically significant
association between the adherence variables and the outcome variables (r = 0.56, p 5 0.05). Greater
attendance at rehabilitation sessions and more favourable practitioner ratings of adherence during
rehabilitation sessions were associated with fewer self-reported knee symptoms and greater knee laxity.
The findings highlight the complex nature of the adherence – outcome relationship.
Introduction
Adherence to therapeutic regimens is considered a vital process in health care delivery.
Volumes of research have been devoted to documenting adherence rates, identifying factors
associated with adherence, and evaluating interventions designed to enhance adherence.
Implicit in the study of adherence is the assumption that people who adhere to medical
regimens experience better treatment outcomes than those who fail to adhere. This
assumption, however, may not always be warranted. Indeed, although positive associations
between treatment adherence and therapeutic outcome have been observed for many medical
regimens (Dunbar-Jacob & Schlenk, 1996), only 11 of 132 comparisons of adherent and
nonadherent individuals in a sample of 2125 adults with depression and/or one of four chronic
medical conditions showed statistically significant positive effects of adherence on health
outcome (Hays et al., 1994).
For medical treatments involving a substantial investment of time, effort, or money, the
presence or absence of a significant relationship between adherence and outcome may have
important implications for patient and practitioner behaviour. One such medical treatment
is rehabilitation following surgical reconstruction of the anterior cruciate ligament (ACL),
Address for correspondence: Britton W. Brewer, Center for Performance Enhancement and Applied Research,
Department of Psychology, Springfield College, Springfield, MA 01109, USA. Tel: + 1-413-748-3696. Fax: + 1-413-
748-3854. E-mail: bbrewer@spfldcol.edu
which is critical to the stability of the knee joint (Muller, 1983). It has been estimated that
approximately 80,000 Americans sustain acute tears of the ACL each year, often while
participating in physical activity, and that the health care costs associated with ACL tears are
nearly 1 billion dollars per annum (Griffin et al., 2000). ACL and other knee injuries during
adolescence and early adulthood are associated with a substantially elevated risk for
osteoarthritis in later adulthood (Gelber et al., 2000). Reconstructive surgery followed by a
course of physical therapy is generally recommended for young, active individuals who incur
ACL tears (Blair & Wills, 1991; DeCarlo et al., 1992; 1994; Marzo & Warren, 1991). In
response to clinical findings suggesting that adherence to the restrictions in activity
mandated in traditional conservative approaches to ACL rehabilitation was inversely related
to postoperative success, ‘accelerated’ postoperative physical therapy protocols have been
advocated for the past 15 years (Shelbourne et al., 1992; Shelbourne & Wilckens, 1990).
Accelerated rehabilitation programmes typically feature clinic- and home-based activities
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designed to promote rapid restoration of range of motion, quadriceps strength, and normal
gait and facilitate an early return to physical activity (Blair & Wills, 1991; DeCarlo et al.,
1994; Shelbourne et al., 1992; Shelbourne & Nitz, 1990). A consequence of the
implementation of accelerated protocols is an increased burden on patients to adhere to
the rigorous behavioural requirements of the prescribed rehabilitation regimen (Haynes et
al., 1979).
Although positive adherence – outcome associations have been documented for a variety
of orthopedic conditions treated with physical therapy, including low back pain (DiFabio et
al., 1995; Friedrich et al., 1996; Kolt & McEvoy, in press) and knee osteoarthritis (O’Reilly
et al., 1999; Rejeski et al., 1997), there is scant empirical evidence that better adherence to
rehabilitation is related to better outcomes following ACL reconstruction. Only three studies
have reported a positive adherence – outcome relationship for ACL rehabilitation. Derscheid
and Feiring (1987) documented a positive relationship between attendance at rehabilitation
sessions and clinical improvement following ACL reconstructive surgery. Treacy et al.
(1997) found that greater adherence to a clinic-based postoperative rehabilitation
programme was associated with better knee function, higher patient satisfaction, and a
faster return to physical activity. Similarly, Brewer, Van Raalte, Cornelius et al. (2000)
found that three adherence measures were significant predictors of functional ability (as
measured by the one-leg hop for distance test). Attendance at rehabilitation sessions and
practitioner ratings of adherence during rehabilitation sessions were positively correlated
with functional ability and home cryotherapy completion was negatively correlated with
functional ability.
Although certainly suggestive of a positive adherence – outcome relationship for
rehabilitation following ACL reconstruction, the investigations by Derscheid and Feiring,
Treacy et al., and Brewer et al. are limited in that none of the studies controlled for
preoperative levels of the outcome variables. It is possible that the participants whose knees
were more functional prior to surgery were more inclined or better able to adhere to the
rehabilitation protocol after surgery. Further, adherence to home-based rehabilitation activities
in the study by Brewer et al. was assessed exclusively through retrospective self-reports, which
are subject to both bias and inaccuracy. Consequently, the primary purpose of the present
study was to examine the relationship between rehabilitation adherence and rehabilitation
outcome following ACL reconstructive surgery while statistically controlling for preoperative
levels of the outcome variables and assessing adherence to home-based rehabilitation activities
concurrently with daily self-reports. Based on the findings of Derscheid and Feiring (1987),
Treacy et al. (1997), and Brewer et al. (2000), positive associations between adherence indices
and outcome measures were expected.
ADHERENCE AND OUTCOME IN KNEE REHABILITATION 165
Methods
Participants
Participants were 108 consecutive patients (72 men and 36 women) with knee injuries who
had ACL reconstructive surgery from one of the three orthopedic surgeons on the project, who
were slated to receive physical therapy after surgery at one of three designated clinic locations,
and who agreed to participate in the study. In recruiting the sample, only one patient who
satisfied eligibility criteria decided not to participate in the study. The mean age of participants
was 29.38 (SD = 9.93) years, with a range of 14 – 54 years. The racial/ethnic breakdown of
participants was: 90% White, not of Hispanic Origin; 6% Hispanic; 4% Black, not of Hispanic
Origin; and 1% Asian/Pacific Islander.
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Rehabilitation protocol
The accelerated rehabilitation protocol following ACL reconstruction developed by
Shelbourne and his colleagues (DeCarlo et al., 1992; Shelbourne et al., 1992; Shelbourne &
Nitz, 1990; Shelbourne & Wilckens, 1990) and subsequently updated (DeCarlo et al., 1994)
was prescribed by the orthopaedic surgeons and followed by the physical therapists affiliated
with the proposed study. This physical therapy protocol emphasizes early attainment of range
of motion (extension and flexion of the knee), quadriceps strength, and normal gait (DeCarlo
et al., 1994; Shelbourne et al., 1992; Shelbourne & Nitz, 1990). Under this protocol, patients
are instructed to complete daily home exercises. At the clinics affiliated with the study, home
exercise prescriptions were given to participants using Personalized Rehabilitation Programme
(PReP) videocassettes (EBI Medical Systems, Parsippany, NJ, USA) that were customized for
the accelerated physical therapy programme following ACL reconstruction. The videocassettes
provided detailed auditory and visual instructions on how to perform each rehabilitation
exercise as well as real-time information on number of repetitions and sets of each exercise to
perform, stretch hold times, range of motion, and rest times.
Measures
Demographic, injury-related, adherence, and rehabilitation outcome variables were measured
in this study.
Adherence measures
Adherence to the accelerated ACL rehabilitation protocol was assessed for both home- and
clinic-based activities. Adherence to the home exercise programme was measured through self-
report and objective methodologies. After their first physical therapy appointment following
ACL reconstruction, participants recorded on a daily basis for a six-week period the number of
times that they completed their home exercise regimen with and without the use of their PReP
166 B. W. BREWER ET AL.
videocassette. Mean numbers of daily exercise completions with and without the use of the
PreP videocassette over the six-week period were calculated for each participant. A mean total
number of daily exercise completions was also calculated for each participant. An overall home
exercise completion variable, HOMEX, was computed by dividing the total number of daily
exercise completions reported by the number of days for which self-reports were obtained.
Although the self-report method of assessing adherence helped to guard against memory
bias in the recall of home rehabilitation behaviour, it did not eliminate the possibility of social
desirability bias in participants’ responses. Therefore, an objective measure of home exercise
completion was used to corroborate self-reported home exercise completion. Specifically,
using technology developed by the video rental industry, participants’ PreP videocassettes
contained a hidden electronic counter that recorded each instance in which the videocassettes
were played. This unobtrusive, objective method for assessing adherence to the home exercise
programme is similar to approaches that have been employed effectively to assess adherence to
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home exercises using audio tapes (Hoelscher et al., 1984; 1986; Martin et al., 1981; Taylor et
al., 1983) and biofeedback equipment (Levitt et al., 1996). Participants brought their PReP
videocassette back to the clinic on an approximately weekly basis for the first six weeks after
their first physical therapy appointment so that the number of times that the videocassette had
been played could be recorded. The mean number of daily exercise completions registered by
the electronic counter was calculated for each participant.
Two measures of adherence to clinic-based aspects of the accelerated ACL rehabilitation
protocol were taken. First, patient attendance at rehabilitation sessions was monitored. For
each participant, a ratio of sessions attended to sessions scheduled was calculated. Second, at
each physical therapy appointment attended by participants, the practitioner (e.g., physical
therapist, athletic trainer) responsible for the rehabilitation of each participant on that day
completed the Sport Injury Rehabilitation Adherence Scale (SIRAS; Brewer et al., 2000). The
SIRAS is a three-item measure in which practitioners rate participants’ intensity of completion
of rehabilitation exercises, frequency of following practitioner instructions and advice, and
receptivity to changes in the physical therapy programme during that day’s appointment on 5-
point Likert-type scales. Scale anchors for the three items are ‘minimum effort’/‘maximum
effort,’ ‘never’/‘always,’ and ‘very unreceptive’/‘very receptive,’ respectively. Cronbach’s alpha
coefficients of 0.81 and 0.82 have been reported for the SIRAS and a test – retest reliability
coefficient of 0.77 has been obtained for the SIRAS over a one-week period. In support of the
criterion-related validity of the SIRAS, attendance at rehabilitation sessions has been positively
correlated with SIRAS scores in two samples (Brewer et al., 2000). High levels of interrater
agreement have been documented for the SIRAS (Brewer et al., 2002). A mean SIRAS score
across physical therapy appointments was computed for each participant.
Outcome measures
Consistent with previous investigations in which ACL rehabilitation outcome was evaluated
(e.g., DeCarlo et al., 1992; Shelbourne & Nitz, 1990; Shelbourne et al., 1990), multiple
measures of ACL rehabilitation outcome were taken. Specifically, laxity, functional ability, and
subjective symptoms were assessed.
Anterior – posterior laxity of the knee joint was assessed manually with a Lachman test
(Jonsson et al., 1982; Torg et al., 1976). Possible scores for the Lachman test are 0 (0 mm joint
play), 1 + (5 5 mm joint play), 2 + (5 – 10 mm joint play), and 3 + (4 10 mm joint play).
The one-leg hop for distance (Daniel et al., 1984) was used as a test of functional ability.
In this test, patients hopped for distance on one leg, taking off and landing with the same leg.
Hop distances were recorded in cm. Both the involved and uninvolved legs were tested three
ADHERENCE AND OUTCOME IN KNEE REHABILITATION 167
times in the one-leg hop. The greatest distance hopped on the involved leg was divided by the
greatest distance hopped on the uninvolved leg. Support for the test – retest reliability of the
hop index (intraclass correlation coefficient = 0.81) has been obtained (Kramer et al., 1992),
and the index has been used effectively to evaluate the rehabilitation of ACL injuries (Tegner et
al., 1986).
Subjective symptoms were assessed with the Knee Outcomes Survey – Sports Activities
Scale (KOS-SAS; Borsa et al., 1998). The KOS-SAS is a self-report questionnaire with 6 items
measuring the extent to which various knee symptoms (i.e., pain, grinding or grating, stiffness,
swelling, partial giving way or slipping, complete giving way or slipping) affect respondents’
sports activity level and four items measuring the extent to which respondents’ knee affects
their ability to perform various sport tasks (i.e., running straight ahead, jumping and landing
on the involved leg, stopping and starting quickly, cutting and pivoting on the involved leg).
Item responses are given on 6-point Likert type scales scored from 0 to 5 and are summed and
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multiplied by two to create a 100-point (maximum) scale. Scores on the KOS-SAS are highly
correlated (r s ranging from 0.67 to 0.87) with those on other major knee scoring systems
(Borsa et al., 1998). Cronbach’s alpha was 0.91 for the KOS-SAS in the current study.
Procedure
Patients meeting selection criteria were recruited from the office practices of the three
orthopaedic surgeons who are affiliated with this research. A research associate described the
purpose and procedures of the study to patients who expressed interest in participating in the
study. When the patients who agreed to participate in the study attended their preoperative
physical therapy appointment at one of the three participating physical therapy clinics
approximately one week before reconstructive surgery, they (and their parents or guardians
when appropriate) were asked to read and complete an informed consent form. At this time,
the research associate obtained from participants the addresses and telephone numbers of a
next of kin and a close friend (to facilitate tracking of participants over the course of the study)
and administered the questionnaire assessing demographic and injury-related variables to
participants. One of the rehabilitation practitioners affiliated with the project then conducted
an evaluation of participants in which all of the outcome variables except one-leg hop
performance (i.e., laxity and subjective symptoms) were assessed. It was not medically
advisable for participants to complete the one-leg hop test prior to surgery. Immediately
following reconstructive surgery, the orthopaedic surgeons recorded knee injuries sustained by
participants in addition to the ACL tear (e.g., meniscal damage).
At their first physical therapy appointment following reconstructive surgery, participants
received their PreP videocassette and instructions for the home exercise programme.
Participants were asked to bring their PreP videocassette back to the physical therapy clinic
on a weekly basis for the first six weeks after the initial postsurgical physical therapy
appointment to have the home exercise regimen updated to reflect progress in rehabilitation.
When videocassettes were returned, the rehabilitation practitioner updated the home exercise
regimen (by adding, subtracting, or modifying exercises as needed) and the research associate
covertly recorded the number displayed on an electronic device designed to read the value
registered by the electronic counter inside the videocassettes. Because informing participants
about the electronic counter in their PreP videocassette could have served as an intervention
(Taylor & May, 1996) and artificially inflated adherence to the home exercise regimen, it was
considered inappropriate to disclose the presence of the counter.
To facilitate self-reports of adherence to the home exercise programme, participants were
a given a six-week supply of data sheets and business reply envelopes addressed to the research
168 B. W. BREWER ET AL.
team. Given the importance of having participants record their home adherence behaviour on
a daily basis (Stone et al., 1991), participants were instructed to mail each day’s self-report data
sheet back to the researchers the following morning. As an incentive to enhance compliance
with this procedure, participants were given one dollar for each completed data sheet that was
received and an additional seven dollars for each week of complete responding.
Measurement of adherence to the clinic-based portion of the accelerated rehabilitation
protocol also commenced at the first physical therapy appointment following reconstructive
surgery. At each participant’s physical therapy appointment, a research assistant documented
participant attendance/nonattendance and obtained SIRAS ratings for participant adherence
behaviour during that appointment (from the practitioner most involved with the patient’s
rehabilitation on that day).
Rehabilitation outcome measures were administered by a rehabilitation practitioner
affiliated with the project approximately six months after reconstructive surgery. To minimize
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participant attrition, a participation incentive of $15.00 was offered for completion of each
assessment. Outcome assessments were coordinated through reminder letters, email messages,
and telephone calls to participants. When necessary, follow-up contacts were made with
participants through the relatives and friends identified by participants during preoperative
data collection. Participants were fully debriefed upon completion of their participation in the
study.
Statistical analyses
All statistical analyses were conducted with the SPSS for Windows (SPSS, Inc., Chicago, IL,
USA) statistical package.
and had a functional PReP videocassette in their possession were considered in the
correspondence and concordance analyses. Due to battery malfunction in the electronic
counter of several of the PReP videocassettes, only participants with at least one valid
videocassette play recorded were included in the correlation and t-test.
Main analysis
Canonical correlation analysis was used to evaluate the relationship between adherence to the
accelerated rehabilitation protocol (assessed by the set of three adherence measures) and
rehabilitation outcome following ACL reconstruction (assessed by the three outcome
measures). The influence of age, preoperative conditions, and the length of elapsed time
since surgery was controlled by using participants’ age, outcome scores from the preoperative
assessment, the number of days between surgery and the postoperative assessment as
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covariates. The effect of these covariates was partialled out of the matrix of correlations
between the adherence measures and outcome measures prior to conducting the canonical
correlation analysis. Canonical loadings were examined to determine which variables
contributed to each variate in the canonical correlation analysis.
Results
Preliminary data screening and analyses
Descriptive statistics for and intercorrelations among adherence and preoperative and
postoperative outcome variables are presented in Table 1. In the MANOVA comparing
participants with missing adherence or outcome data to those without missing adherence or
outcome data, the multivariate effect was not statistically significant, indicating the presurgical
equivalence of the two groups of participants on the continuous variables assessed prior to
surgery. The series of one-way MANCOVAs with the postoperative outcome measures as
dependent variables and the preoperative outcome measures as covariates revealed no
significant multivariate effects of participants’ gender, surgeon, graft type, and presence/
absence of meniscal damage on postoperative outcome. Consequently, the data were collapsed
across participants’ gender, surgeon, graft type, and presence/absence of meniscal damage in
subsequent analyses.
In the repeated-measures MANOVA performed on the outcome variables, the
multivariate within-subjects time effect was statistically significant, Wilks’ lambda = 0.34,
F(2, 58) = 52.19, p 5 0.001. Statistically significant improvements were observed for scores on
both the Lachman test, F(1, 59) = 24.99, p 5 0.001, and the KOS-SAS, F(1, 59) = 103.17,
p 5 0.001. Intercorrelations among the adherence variables were generally weak, although the
correlations between attendance and SIRAS scores (r = 0.25, p 5 0.01) and attendance and
HOMEX scores (r = 7 0.29, p 5 0.005) were statistically significant. The correlation between
the two outcome measures administered at the preoperative assessment (i.e., Lachman test
and KOS-SAS) was weak and not statistically significant. Among the outcome measures
administered at the postoperative assessment, the correlation between KOS-SAS and one-leg
hop scores (r = 0.46, p 5 0.001) was significant and the correlation between KOS-SAS and
Lachman test scores (r = 7 0.22, p = 0.08) approached significance.
The correlation between the total number of self-reported completions of the home
exercise routine using the PReP videocassette and the number of times the PReP videocassette
was played was statistically significant, r = 0.58, p 5 0.001. The total number of self-reported
completions of the home exercise routine using the PReP videocassette was significantly
170
B. W. BREWER ET AL.
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Table 1. Means, standard deviations, intercorrelations, and canonical loadings of adherence and preoperative and postoperative outcome measures
Canonical
Variable M SD 2 3 4 5 6 7 8 loading
1 HOMEX 2.89 1.43 7 0.29** 7 0.18 0.12 7 0.09 0.15 7 0.05 7 0.10 0.22
2 Attendance 0.91 0.14 0.25* 7 0.12 0.18 0.20 7 0.03 0.09 0.58
3 SIRAS 13.72 0.89 0.02 0.03 0.33** 0.08 7 0.07 0.86
4 Lachman test (pre) 1.96 0.68 7 0.06 0.26* 7 0.02 7 0.13
5 KOS-SAS (pre) 39.23 24.98 7 0.08 0.19 0.31*
6 Lachman test (post) 1.38 0.66 7 0.22 7 0.03 0.74
7 KOS-SAS (post) 76.80 19.48 0.46** 0.63
8 One-leg hop (post) 0.83 0.14 0.07
Note. n = 63 – 107. HOMEX = home exercise completion; SIRAS = Sport Injury Rehabilitation Adherence Scale; KOS-SAS = Knee Outcomes Survey—Sports Activities Scale.
*p 5 0.05.
**
p 5 0.005.
ADHERENCE AND OUTCOME IN KNEE REHABILITATION 171
greater than the number of times the PReP videocassette was played, t(63) = 7.92, p 5 0.001,
although the mean difference between the two values was only 0.41 (SD = 0.42) counts per
day.
Main analysis
In the canonical correlation analysis performed between the set of three adherence variables
and the three outcome measures (controlling for preoperative conditions and the length of
elapsed time since surgery), the omnibus multivariate test was statistically significant, Wilks’
lambda = 0.65, Chi2(9) = 21.11, p 5 0.05, with only the first canonical correlation contribut-
ing significantly to the relationship (r = 0.56), accounting for 31% of the relationship between
the two variates in the canonical correlation.
To interpret which variables contributed significantly to each of the variates of the
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canonical correlation, only loadings greater than 0.30 were considered (Pedhazur, 1982). For
the adherence variate, attendance and SIRAS scores had substantial positive loadings. For the
outcome variate, Lachman test and KOS-SAS scores had substantial positive loadings. These
findings indicate that greater attendance and higher SIRAS scores were associated with higher
levels of Lachman test and KOS-SAS scores. Thus, although better adherence to clinic-based
activities was related to a better outcome in terms of self-reported physical symptoms (KOS-
SAS), it was also related to greater knee laxity (i.e., higher scores on the Lachman test). The
loadings for HOMEX and the one-leg hop were not significant contributors to their respective
variates.
Discussion
The current study improved upon previous investigations of the adherence – outcome
relationship in ACL rehabilitation (Brewer et al., 2000; Derscheid & Feiring, 1987; Treacy
et al., 1997) in several key respects. Administering outcome measures both before and after
surgery enabled participants to serve as their own controls, allowed for the accounting of
approximately 10% of error variance in the outcome measures, and facilitated documentation
of participants’ improvements in knee laxity and self-reported physical symptoms over the
course of surgery and rehabilitation. Further, obtaining a concurrent daily record of
participants’ adherence to home-based rehabilitation activities is likely to have enhanced the
accuracy of their self-reports, the reliability of which was corroborated in an unbiased manner
through objective measurement. Although there was a tendency for participants to overreport
the number of times they did their home rehabilitation exercises while watching their PReP
videocassette each day, the magnitude of the overreporting was small and relatively constant
across levels of adherence (as indicated by the 0.58 correlation between self-report and
electronic counter values).
The results indicated that adherence to an accelerated rehabilitation protocol
following ACL reconstructive surgery accounted for a substantial portion of the variance
in rehabilitation outcome. Consistent with previous ACL research (Brewer et al., 2000;
Derscheid & Feiring, 1987; Treacy et al., 1997), adherence to clinic-based rehabilitation
activities was associated with knee rehabilitation outcomes. The hypothesized positive
adherence – outcome relationship was documented for one of the three outcome
variables—self-reported physical symptoms. Thus, the participants who reported experien-
cing fewer adverse knee symptoms 6 months after surgery were those who attended a
higher percentage of their scheduled rehabilitation sessions and were rated by their
rehabilitation practitioners as giving greater effort, following instructions better, and
172 B. W. BREWER ET AL.
Acknowledgements
This article was supported in part by grant number R29 AR44484 from the National Institute
of Arthritis and Musculoskeletal and Skin Diseases. Its contents are solely the responsibility of
the authors and do not represent the official views of the National Institute of Arthritis and
Musculoskeletal and Skin Diseases. We thank Howard Tennen for his helpful comments on
an earlier draft and Josh Avondoglio, Lisa Benjamin, Jeff Benoit, Kathy Bernardini, Jim Biron,
Ruth Brennan, Matt Buman, Judy Catalano, Tarra Cemborski, Kim Cochrane, Rosa Correa,
Bob Crawford, Candi Danielle, Amie Dillman, Joann Golden, Reubin Gonzalez, Bryan Gross,
Stephanie Habif, Whitney Hartmann, Jay Hatten, Carter Hunt, Jean Hutchinson, Angie
Jensen, Aaron Kopish, Dawn Kresge, Ellie Laino, Amy Lowery, Kevin McAllister, Thomas
Melvin, Alexa Mignano, Joe Monserrat, Liz Montemagni, Jonna Mullane, Rob Olenchak, Jens
Omli, Scott Quarforth, Alice Robitaille, Raylene Ross, Carrie Scherzer, Josie Scibelli, Wendy
Downloaded by [Uppsala universitetsbibliotek] at 11:14 06 October 2014
Sewack, Ben Shachar, Sumiyo Shiina, and Marie Trombley for their assistance in data
collection.
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