Grants Homework Help

1. Step
To get started, you must first create an account on site StudyHub.Vip.
The registration process is quick and simple, taking just a few moments.
During this process, you will need to provide a password and a valid
email address.

2. Step
In order to create a "Write My Paper For Me" request, simply complete the
10-minute order form. Provide the necessary instructions, preferred
sources, and deadline. If you want the writer to imitate your writing style,
attach a sample of your previous work.

3. Step
When seeking assignment writing help from StudyHub.Vip, our platform
utilizes a bidding system. Review bids from our writers for your request,
choose one of them based on qualifications, order history, and feedback,
then place a deposit to start the assignment writing.

4. Step
After receiving your paper, take a few moments to ensure it meets your
expectations. If you're pleased with the result, authorize payment for the
writer. Don't forget that we provide free revisions for our writing services.

5. Step
When you opt to write an assignment online with us, you can request
multiple revisions to ensure your satisfaction. We stand by our promise to
provide original, high-quality content - if plagiarized, we offer a full
refund. Choose us confidently, knowing that your needs will be fully met.

Grants Homework Help Grants Homework Help Grants Homework Help Grants Homework Help Grants
Homework Help Grants Homework Help Grants Homework Help Grants Homework Help Grants Homework
Help
 Assignment ( Hatters ) ( Transthyretin )
B30001 Assignment (Hatters) Transthyretin

Benjamin Andrikopoulos759192

Introduction to TTR:

Transthyretin (TTR) is a protein in the blood (serum) and cerebrospinal fluid of humans that
functions in the transport of the thyroid hormone thyroxine (T4) and retinol (also known as
Vitamin A1). [1] It is secreted by the liver into the blood and by the choroid plexus into the
cerebrospinal fluid. [2] Studies have shown that as less than 1% of TTR s T4 binding sites (T4BS)
in the blood are in use and occupied, new drug designs can be specialised and optimised to bind to
these sites, thus preventing TTR misfolding, dissociation, and aggregation. [4] Amyloid diseases are
associated with the misfolding and dissociation of the TTR tetramer and ... Show more content on
Helpwriting.net ...
Figure 1.Three dimensional cartoon style structure of transthyretin (TTR) showing two monomers
/one dimer of the dimer of dimers quaternary structure (monomers pink and orange) at the binding
interface. Stick style top view of AG10 (blue) highlighting two binding sites per tetramer and key
binding serine and lysine residues S117 and K15 of TTR (green). All monomers of TTR contain 1 α
helix and an 8 stranded β sheet with Greek key topology.

Interaction differences AG10 vs. tafamidis:

With AG10 binding to TTR, the dimethyl pyrazole like ring of AG10 sits deep within the T4BS
cavity, forming two H bonds to two Ser117 residues of subunits adjacent to each other. The CH3
pair of the pyrazole ring are positioned into halogen binding pocket 3 (HBP 3), which is
considered a hydrophobic area. [4] The terminal COOH group on the benzene ring allows for van
der Waals interactions with the side chain amino groups of the two Lys15 residues directly on
different monomers at the edge of the T4BS, with the F moiety in the para position fitting into HBP
1. These interactions close to the binding environment surrounding AG10 are protected in part from
the surrounding solvent, leading to high affinity binding of AG10 to TTR. [4]

Contrasting with tafamidis hydrogen bonding is absent at the base of the binding pocket like with
AG10, but the Cl substituents are instead located in HBP 3, where hydrophobically the subunits are
bridged. [4] This absence of additional
 The Characteristics Of Heroism In The Epic Of Beowulf
Heroism has been the main theme in many stories that were passed down orally throughout the
generations, centering around the good guy versus bad guy plot. As time passed, people began to
redefine their own version of heroism in various ways and sometimes depict the protagonist as a
person with just as good of a flaw as the antagonist. Beowulf, written from the early 11th century
into Anglo Saxon script, is one of the oldest variations of a heroas far as writings date. Based on real
people from modern day Scandinavia, Beowulf is a historical fiction telling of monsters from
various lands who oppress the Danes, until a warrior prince named Beowulf ventures from his own
land to defeat these monsters. When examining Beowulf s actions, it s clear to find that his
motives for defeating the monsters is not to save people per se, but to attain glory and battle fame
for himself. This is a normal reaction for a hero, but some may see it as only standing for the title of
a hero, not actually satisfying the essence of heroic deeds. There are many characteristics to a hero,
but narrowing it down to three will show the main points essential to a hero, shown and collected
from most depictions of them. Heroes may attribute to haughtiness in response to fame, fortune and
the opposite sex suddenly attracted to them, if the hero is coincidentally good looking. After fighting
a certain battle that they are known for clashing with, many heroes develop an internal battle within
themselves
 Essay On Baskin Robbins
INTRODUCTION: An established ice cream company, Baskin Robbins located at Aeon Bukit
Indah was chosen as a study in this report. Baskin Robbins was started back in 1945 where two
brothers in law, Burton Burt Baskin and Irvine Irv Robbins had been sharing in the same
intention in creating a special, improved and high quality ice cream store (Baskin Robbins, n.d.).
The two brothers in law started out their ice cream store business through separate business
ventures until 1953, where Burt and Irv decided to put their stores on sale and merged together as
Baskin Robbins and currently a part of Dunkin Brands Group (Baskin Robbins, n.d.). Baskin
Robbins was named as the world s largest chain of ice cream specialty store as more than 7
thousand stores located across 50 different countries worldwide (Baskin Robbins, n.d). It is also
known for its 31 flavours slogan where the idea is to give the opportunity for customers to
experience different flavour each day in a month. According to Irv Robbins (n.d), Not everyone
likes all our flavors, but each... Show more content on Helpwriting.net ...
Generally, Baskin Robbins is known for its high premium ice cream and indulgent flavours.
According to Baskin Robbins (n.d), Baskin Robbins has more than 1200 variety of unique ice
cream flavours to offer the customers to choose from every day in a month. As mention by Irv
Robbins (n.d), Not everyone likes all our flavors, but each flavor is someone s favorite .
Therefore, it is one of the ways Baskin Robbins had differentiate and position itself from other ice
cream brand for having variety of unique ice cream flavours. In addition, Baskin Robbins took their
premium ice cream to the next level by creating ice cream cakes, milkshakes and sundaes by using
the same ice cream flavours to offer their
 The Role Of Business In The Godfather
The Godfather by Francis Ford Coppola introduces the lifestyle of an Italian American mobster
family in New York. This film shows an authentic perspective of mobs in the 40 s and 50 s. We see
that family business is very important in this film. But Michael Corleone put it best, It s not
personal, it s strictly business. This relationship between the Corleone Familyand business is what
shows up multiple times throughout the movie. In the movie we see a difference between Vito and
his son Michael Corleone. Vito is the norm for what a superior leader should be. He is caring for his
family and also very strong when it comes to business. He is also a man of his word. On the flip
side if you cross him, he will take matters into his own hands.... Show more content on
Helpwriting.net ...
For example where he takes initiative and volunteers to kill both McCluskey and Sollozzo at the
restaurant. This shot is made in a threatening way. As Michael proposes the plan to Sonny, we see
the camera gently and slowly creeps towards Michael.He does not make any eye contact with the
people around him. To add on to this the way Michael sets himself up in the chair shows that he is
in charge and has power. As soon as the camera stops moving, Michael says I ll kill them both.
This type of panning of the camera brings us, the audience, into his eyes. This scene is one of the
many key scenes where see Michael s character truly made out. As the camera pans towards his
face, we see vigour of his
 When We Were First Introduced This Assignment, I Was Both
When we were first introduced this assignment, I was both excited and nervous. I was excited
because it gave me the opportunity to step of my comfort zone; in addition, I was excited to be
able to get out into the community and practice some of the social work skills that we have
learned in class. However, I was nervous because I knew it would be hard to hear the struggles of a
single parent experiencing homelessness. As someone who was raised by a single parent and almost
experienced homelessness, I know how easy it can be to fall into homelessness. Overall, I was
excited about doing this assignment because I truly did want to hear the stories that single parents
experiencing homelessness wanted to tell.
Experiences Related to ... Show more content on Helpwriting.net ...
The reality is that no one chooses to be homeless; therefore, it is important that we try to humanize
people that are facing homelessness because far too often they feel invisible. My thoughts have
stayed the same about homelessness; however, I certainly have started to acknowledge that
homelessness is a very real thing in our society. I also try my hardest to recognize that these
individuals are people; therefore, I now make it a point to at least make eye contact with them on the
street.
Social Justice
As I stated before, far too often our society ignores that homelessness is a struggle several people.
Additionally, our society often thinks people choose to be homeless. Terra talked about an incident
at a gas station, and how one of the employees at the gas station said all the people across the street
(Salvation Army) are drunks and addicts. She talked about how upset she gets when people have
these misconceptions about people that are struggling with homelessness. Hearing her talk about this
broke my heart because our society should not shame people for being homeless; instead, we should
be looking at solutions to end homelessness. It is a human right to have basic human needs, yet our
society continually provokes their unjust agenda.
Our society also tends to ignore domestic violence, which is something that my mother and Terra
both faced. Terra could not get any help with service providers because her children and her were not
in immediate danger; although,
 Death And Its Effects On The Reality Of Death
They were afraid of dying but there were even more afraid to show it. They found jokes to tell.
They used a hard vocabulary to contain the terrible softness. Greased they d say. Offed, lit up,
zapped while zipping. It wasn t cruelty, just stage presence. They were actors. When someone died,
it wasn t quite dying, because in a curious way, it seemed scripted, and because they had their lines
mostly memorized, irony mixed with tragedy, and because they called it by other names, as if to
encyst and destroy the reality of deathitself. pg. 19 To someone just picking up this book, this scene
would simply look like some poor soldiers developing a temporary and innocent coping mechanism
to deal with Death as they face him head on. But... Show more content on Helpwriting.net ...
One character is obviously the comic relief, another the beloved hero. The rest, valiant men
fighting for their country, their lives, their freedom. The scene ends and the curtain rises, all of
the pseudo soldiers take a bow and go home to their normal lives, far from the hands of death that
grasp at the men forgotten in Vietnam, the real soldiers. They, who saw the hardships of war as
more than just a script, beyond the glamorized versions that are seen by the American eyes. They
saw the death and the tragedy, slowly becoming worn down into less of a human and more of a
desensitized killing machine because that s what war does. It permanently scars the soldiers, tearing
away the feeling of loss and inappropriately replacing it with comedy, showing that war is
destructive, stealing away an ounce of humanity with each bullet. As seen in The Things They
Carried, written by Tim O Brien, the Vietnam War destroyed the minds of soldiers, causing them to
lose their human emotions in an unglamorous setting, devaluing death as they lose their ability to
appropriately handle situations. Center stage stands a man, young and valiant, seemingly fearless.
Well, until a bullet collides with his brain and he loses his identity as Ted Lavender and adapts his
new one as another tally of the total number of men killed in action. But he is not actually killed.
No, he is greased they d say.
 What Is An Ethical Issue For Or Against Direct-To-Consumer...
Assignment 4: Legal and Ethical Considerations in Marketing,
Product Safety, and Intellectual Property
1. Research three to five (3 5) ethical issues relating to marketing and advertising, intellectual
property, and regulation of product safety. Many people may not be able to fully process
information about the safety and risk about products. The organizations that attempt to make
products that are safe have a difficult time competing with those who provide unsafe products at
cheaper prices. Just how safe a product is can be difficult for any company to determine and is
compounded by the cost of making the products safe. Costs of manufacturing safe products extend to
the total price of the product and can the company economically. Pressures ... Show more content on
Helpwriting.net ...
Analyze the manner in which PharmaCARE used U.S. law to protect its own intellectual property
and if John has any claim to being the true inventor of AD23. John was not the sole creator of AD23
and, therefore, could not claim intellectual property rights. He was a part of a research team that
developed the new formulation of the drug as part of his job function and did not solely develop
AD23 on his own. Similarly, if an engineer creates things for a company, that business will own all
rights to all of it. AD23 was not a project that John was working on by himself and there were not
any agreements or contracts stating otherwise, thus, AD23 is the property of the organization.
PharmaCARE does not need to compensate for John s assistance with the development AD23.
However, they could compensate him by giving a percentage of the profit to him. His assistance
with the drug helped boost the drug s popularity and profit. John did receive a bonus and this could
be viewed as compensation for the work he did. There is no requirement under United States
intellectual property law that an employee should be compensated (Lobel, 2014). If the company is
looking for motivated staff, a compensation program could keep their pharmacists focused and
 The Narrative Of The Life Of Frederick Douglass Essay
Bishnu Mahat Term paper Frederick Douglass In the 1800 s, subjection was a significant issue in
the United States. The Narrative of the Life of Frederick Douglass reveals much about American
history in the midst of the period of servitude and outlines conflicts for the cancelation of subjection.
As a chronicled report, it goes on data about the slave family, work, the master slave relationship,
and the treatment and living states of slaves. As an abolitionist tract, it fights against recognizable
methods for pondering subjection s favorable circumstances and its moral quality, making strong
centers for discarding subjugation. Slave families were much of the time torn isolated by the expert
secluding them. Frederick Douglass was the essential slave to stand transparently and report his
fugitive status. He was the individual who participate in securing the invalidation of suppression and
fairness of African American over his exercises, rationalities, speakers, creator/chief, and
government official. Each and every through hi account, he portrays his own specific genuine
encounters, as they truly happened. Douglass contentions against the appalling establishment of
persecution are presented in the depicting these encounters. Douglass could see his mom just a few
times before she went on when he was a particularly fiery age. Whatever is left of his family was in
addition dead or far away, and he had no believability of unendingly watching them once more.
Douglass could
 Fleur Dialectical Journal
Throughout the evening, Fleur noticed the Malfoy boy watching Harry, and as soon as the
headmaster dismissed them, he made straight for her three charges. So, she followed. Potter, the
Prophet says you ve gone round the twist, the boy jeered outside the Great Hall s doors. Harry
ignored the comment and kept walking. Scarehead! I m talking to you . . . You owe us an
explanation for killing Cedric. A collective gasp escaped the gathering students as Harry stopped.
Fleur fought the urge to curse Malfoy herself for invoking the name of her friend to hurt someone
else. Ron tugged Harry s shoulder and whispered into his ear, then faced Malfoy. Say that again. A
nasty sneer crept across Malfoy s lips. Why? Is your family too poor to see a Healer for... Show more
content on Helpwriting.net ...
Albus s famed Phoenix stood proud in his cage, but he looked old. Fleur wondered if he d burst
into flame during the meeting. Zhat s one way to put it, she answered. I daresay it was an eye
opening introduction, but Minerva will be here any moment, so we ll wait on her before
critiquing your handling of the affair. However, I must confess, countering Severus in front of
half the school will ingratiate yourself to Gryffindor, not to mention your three charges. She
leaned back on the couch and relaxed. True. So, who was zhe other Gryffindor today? I don t
remember him from last year. Neville Longbottom, Minerva answered as she entered the room,
her eyes downcast. It s the first initiative we ve seen from him in five years. Albus pulled at his
beard. I dislike how he showed, but happy he did. I also remember a similar occurrence birthing a
great Auror twenty years ago; let s hope like father, like son. So, what did Ronald Weasley say for
himself? Minerva conjured a chair and sat. He accepted his detentions without argument and went
on his way after I informed him we will not tolerate any such future behavior, and he was lucky to
keep his Prefect
 The Fair Restriction of Civil Liberties Essay
With the advent of a new age of Terrorism sweeping the world since the 9/11 attacks on America,
much debate has followed as to whether the prevention of terrorist attacks should take prevalence
over basic civil liberties enjoyed by any civilian of a liberal democracy. If we take the definition of
civil liberties to be Fundamental individual rights, such as freedom of speech and religion, protected
by law against unwarranted governmental or other interference , it is very hard to envisage a society
in which both can exist.

The main argument for placing greater emphasis on the prevention of terrorism rather than on the
protection of civil liberties is of course the protection of many lives which the prevention of a major
attack would ... Show more content on Helpwriting.net ...
Nonetheless his expertise make his assessment of this valid, and we can see from this that in
America at least, the presidential clemency Bush granted legally and with wide acceptance infringed
upon the Bill of Rights in order to protect America from what Eastman claims to be an act of war ,
thus backing the proposed argument. However, it must be argued that although befitting, Eastman s
conclusions have been uploaded by an anonymous organizations press release primarily. It has then
been uploaded by yet another anonymous member of society to the easily editable website,
Wikipedia. The reliability of the information is therefore questionable at best, and the views of
Professor Eastman may either have been tampered with in the most questionable of scenarios, or at
the very least misquoted through the regurgitation of information.

Despite the trampling of civil liberties seeming plausible in even the most erroneous of
circumstances, there remains the argument of creating unnecessary collateral damage combined
with the progressive evolution of moderates into extremists as a result of misjudged assumptions
by high ranking government officials. Deepak Chopra; Doctor and infamous public speaker, gives
backing to these claims arguing that, if we do not appease and actually recruit the help of this
Muslim world, we re going to have a problem on our hands; the problem being terrorism. These
comments were as a direct result of the Mumbai terrorist attacks
 Aladdin a Disney Fairytale
A long, long time ago, in the year of 1992, a very famous Disney Fairytale hit the big screen.
Aladdin is about a young orphan on a fascinating journey to becoming a heroic man. The majority
of people are unaware of the qualifications of a real hero. Many people think the only way to
achieve heroism is by dying for something or someone you love. There are heroes everywhere you
look, Disney movies, fairytales, cartoons, books etc. A hero doesn t have to possess unusual
superpowers like, immortality, time traveling, invisibility, mind control or superhuman strength. In
fact, some super heroes possess nothing more than, love, generosity, kindness, cheer and trust.
Sometimes all you need to be a hero is abandonment at birth, a friend and a will to survive. This is
exactly why I chose the Disney character of Aladdin. This charming story, made famous by Disney
takes place in the Middle East. The trials and tribulations of Aladdininclude moments of love,
adventure, trickery, and deceit. Aladdin embarks in this journey unintentionally but proves to have
endured a comprehensive maturation of character while achieving valuable insight about who is
truly is and what he stands for by the time he completes his adventure. When following the journey
of a hero you will usually find something on the lines of an unusual birth, or something unique about
the hero s childhood. Aladdin was born to his father, Cassim and his mother, who is unnamed in the
film. Cassim left Aladdin and his mother
 Arthroplasty Essay
Background: Total knee arthroplasty is associated with moderate to severe postoperative pain and
effective analgesia is essential for postoperative recovery and rehabilitation. The challenge of
analgesic regimes is to obtain adequate pain relief and maximum muscle control to enable the patient
to mobilize and rehabilitate early without troublesome side effects. Local Infiltration Analgesia
(LIA) is widely thought to be effective and is frequently applied as part of a multimodal painstrategy
due to its simplicity and apparent safety in multiple types of surgery. However, the optimal dose,
technique and best composition in perioperative consummated pain medication are not known.

Objectives: The goal of this prospective randomized clinical trial ... Show more content on
Helpwriting.net ...
Results: The four groups were comparable for patient characteristics, preoperative NRS pain
scores and operating time. The mean LOS for the entire cohort was 2.3 nights (1 6), adequate
pain relief was achieved in all patients before discharge. GEE analysis revealed a significant
difference between group A and B (p = 0.021) with group B experiencing higher pain scores post
operatively than group A. No differences between group A and C (p=0.451) and group A and D
were found (p=0.059). Secondly there was a significant difference between group A and B using
rescue medication found with GEE (p = 0.003) with group B using more medication. No differences
regarding LOS, adverse effects, wound leakage, operating time and destination of discharge were
found between the four groups.

Conclusions: The results of this study show that local infiltration with 300mg (150ml) ropivacaine
might be more effective for pain management than 150mg (75ml) ropivacaine. Furthermore,
alteration in the dose of gabapentin appears not to have influence on the course of pain after TKA.
The percentage of adverse effects seems comparable for all
 Susan B Anthony Dares To Vote Analysis
The story Susan B Anthony Dares to Vote and the life of Bethany Hamilton share the common
theme, overcoming obstacles. Susan B Anthony in Susan B Anthony Dares to Vote has to overcome
the obstacle of not being able to vote. Bethany Hamilton gets her arm bitten off by a shark, coming
back to be a professional surfer. While the story and person share a common theme, the social
implication of each person is different. Susan B Anthony started the movement of getting women to
vote, which came true 100 years after her death. Bethany Hamilton proved that you can overcome
any obstacle thrown your way.

In the story, Susan B Anthony Dares to Vote, the common theme overcoming obstacles is shown in
many ways. For one, she was put on trial for registering ... Show more content on Helpwriting.net ...
Susan B Anthony changed the world for all women, while Bethany Hamilton changed a few
people s lives through her non profit organization. Throughout the story Susan B Anthony Dares to
Vote there are many pieces of evidence that support my claim. One piece of evidence from the
story Susan B Anthony Dares to Vote, In 1919, Congress passed the 18th Amendment to the
Constitution which was ratified in 1920 by the states. It said The right of a citizen of the United
States or any state on account of gender. This supports my claim because it shows that due to
Susan never giving up in her fight, she truly did overcome her obstacle and got Congress to pass
the law that women were allowed to vote. Before Susan gained rights for all women, she actually
died. My evidence from the text is, One hundred years after her birth, Susan B. Anthony s dream had
come true. This shows that even if you can t accomplish your goals within your lifetime, never
giving up while you still have the chance, can, in fact, make your goals come true. Bethany
Hamilton s accomplish in life, also changed a few other s lives. After she overcame the loss of
her arm, she started her own non profit organization called Friends of Bethany. Friends of Bethany
helps to mentor youth, amputees, and shark attack survivors. Friends of Bethany wrote on their
website, We began to send out encouragement packages to those who experienced shark attacks or
suffered limb loss. This piece of evidence supports my claim because it shows that they only send
out packages to the few people who do get attacked by sharks, while Susan changed life for all of
women in
 The Deterrence Of Death Penalty
The Deterrence of Death Penalty in Texas Almost a month ago, I accidently came across the
Stanford Prison Experiment documentary, which is available to view on Youtube. The document
based on real event in Stanford University. It is an experiment to study psychology of imprisonment
on prisoners and guards by dividing selected Stanford students into two groups. As the time passed,
the researchers have discovered some drastically changes in both groups within days. At the end, Dr.
Philip Zimbardo, one of the researchers concluded that, these students were physically and
psychologically suffered, and nobody have right or privilege to do that to other people. The
document have raised many questions in my head. Does the death penalty... Show more content on
Helpwriting.net ...
According to Texasattorneygeneral.gov, when a person is charged with capital murder, the trial is
placed in county jail, then the state must prove beyond a reasonable doubt that the defendant is
intentionally and knowingly caused the death of another person, and the act clearly present the
danger to other human lives. In Texas, the defendants could offer any argument or mitigating
evidence that they consider relevant. The conclusion of a trial was a series of questions, to be
answered by the jury. Depending on the answers given by the jury to these questions, the defendant
automatically receive a sentence of either life in a prison or death penalty. After the trial in district
court is completed, the defendant is designated to an appeal, which takes place in the Texas Court
of Criminal Appeals. At this point, the judges can reverse or order a new trial if there are some
errors during the trial in district court. The side that loses can request for a rehearing, or the
defendant can appeal to U.S. Supreme court for a writ of certiorari. If the writ of certiorari is
denied, or the defendant does not request the writ, then the conviction is final. The next additional
appeal is habeas corpus review. The defendant can argue issue that were not raised before in the
trial. In a rare case, the court may reverse the trial if there are serious errors. After this process is
finished, a state district judge can set an execution date