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Biology Topic 3

CRISPR-Cas9 is a groundbreaking genome-editing technology that enables precise modifications to DNA using a guide RNA and Cas9 nuclease. It has significant applications in research, agriculture, and medicine, particularly for treating genetic disorders. However, ethical issues related to germline editing and off-target effects require careful consideration and regulation.

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11 views1 page

Biology Topic 3

CRISPR-Cas9 is a groundbreaking genome-editing technology that enables precise modifications to DNA using a guide RNA and Cas9 nuclease. It has significant applications in research, agriculture, and medicine, particularly for treating genetic disorders. However, ethical issues related to germline editing and off-target effects require careful consideration and regulation.

Uploaded by

Nick
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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3.

CRISPR and Genome Editing Technologies


CRISPR-Cas9 is a revolutionary genome-editing technology derived from a bacterial immune

system. It allows scientists to make precise, targeted changes to the DNA of living organisms. The

system includes a guide RNA that directs the Cas9 nuclease to a specific DNA sequence, where it

induces a double-strand break. The cell then repairs this break through non-homologous end joining

or homology-directed repair, which can be exploited to insert or delete genes. CRISPR has vast

applications in research, agriculture, and medicine. In humans, it holds promise for correcting

genetic disorders like sickle cell anemia and cystic fibrosis. However, ethical concerns arise over

germline editing and potential off-target effects, necessitating cautious development and regulation.

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