Activator
Activator
00/©JCCA 2012
Objective: The purpose of this study was to conduct a                    But : La présente étude a pour objet d’effectuer un
systematic review of the literature investigating clinical               recensement systématique des écrits portant sur les
outcomes involving the use of the Activator Adjusting                    résultats cliniques suivant l’utilisation de l’instrument
Instrument (AAI) or Activator Methods Chiropractic                       d’ajustement activateur (Activator Adjusting Instrument
Technique (AMCT).                                                        ou AAI) ou de la technique chiropratique des méthodes
   Methods: A literature synthesis was performed on the                  de l’activateur (Activator Methods Chiropractic
available research and electronic databases, along with                  Technique ou AMCT).
hand-searching of journals and reference tracking for                       Méthodologie : Une synthèse des écrits a été effectuée
any studies that investigated the AAI in terms of clinical               à partir des bases de données de recherches et celles sur
effectiveness. Studies that met the inclusion criteria                   support informatique disponibles, ainsi qu’en cherchant
were evaluated using an instrument that assessed their                   manuellement dans des revues et en effectuant un suivi
methodological quality.                                                  des références trouvées dans les études portant sur
   Results: Eight articles met the inclusion criteria.                   l’efficacité clinique de l’AAI. Les études qui répondent
Overall, the AAI provided comparable clinically                          au critère d’inclusion ont été évaluées au moyen d’un
meaningful benefits to patients when compared to high-                   instrument calculant leur qualité méthodologique.
velocity, low-amplitude (HVLA) manual manipulation or                       Résultats : Huit articles ont répondu au critère
trigger point therapy for patients with acute and chronic                d’inclusion. En général, les bienfaits cliniquement
spinal pain, temporomandibular joint (TMJ) dysfunction                   significatifs de l’AAI sont comparables à ceux de la
and trigger points of the trapezius muscles.                             manipulation à haute vitesse et faible amplitude ou de
   Conclusion: This systematic review of 8 clinical trials               la thérapie par zone gâchette pour les patients souffrant
involving the use of the AAI found reported benefits                     de douleur aiguë ou chronique à la colonne vertébrale,
to patients with a spinal pain and trigger points,                       de dysfonction de l’articulation temporomandibulaire
although the clinical trials reviewed suffered from many                 (ATM) et de zone gâchettes du trapèze.
methodological limitations, including small sample size,                    Conclusion : Selon la présente revue systématique de
                                                                         huit essais cliniques portant sur l’utilisation de l’AAI,
                                                                         on rapporte des bienfaits pour les patients souffrant de
                                                                         douleur à la colonne vertébrale et de zones gâchettes,
                                                                         quoique les essais cliniques étudiés étaient soumis à de
                                                                         nombreuses limites sur le plan méthodologique, comme
                                                                         un échantillon de petite taille, des périodes de suivi
* Professor, Chair of Department of Chiropractic Therapeutics, CMCC, 6100 Leslie St. Toronto, Ontario, M2H 3J1.
  E-mail: bgleberzon@cmcc.ca
© JCCA 2012
relatively brief follow-up period and lack of control or            relativement brèves, et d’un manque de groupes témoins
sham treatment groups.                                              ou placebo.
(JCCA 2012; 56(1):49–57)                                            (JCCA 2012; 56(1):49–57)
ing AMCT published in 200413 found only one additional           case series; studies using some type of outcome measure
clinical trial published between 2001 and 2004. More-            for determining the effect of chiropractic care [i.e. Vis-
over a DVD14 listing all published studies on the AAI or         ual Analogue Scale (VAS), Numerical Pain Rating Scale
AMCT [distributed by Activator Methods Inc to attendees          (NPRS), Neck Disability Index (NDI), Oswestry Dis-
of the 2011 Association of Chiropractic Colleges and Re-         ability Index (ODI), McGill Pain Questionnaire, range
search Agenda Conference (ACC-RAC)] had only one in-             of motion, algometer/goniometer devices]; published in
complete additional clinical trial, indicating a continued       peer-reviewed journal and; only studies involving human
under-representation of studies of this nature. Even so,         subjects.
notwithstanding the relative paucity of clinical investiga-         Subject age, sex, demographic, and pain type and
tions, advocates of the AAI and AMCT continue to extol           duration were not consistent among studies and were
its clinical value and usefulness.13,14                          therefore not utilized as inclusion criteria in this review.
   The purpose of this study was to conduct a systematic         Manuscripts from conference proceedings or abstracts of
review of the literature investigating clinical outcomes in-     studies were not included in this review since the criteria
volving the use of the AAI or AMCT. A brief narrative            for inclusion in a conference proceeding is often much
review of each article that met the inclusion criteria is also   less stringent than the criteria used for inclusion in peer-
provided.                                                        reviewed indexed journals. Using these inclusion criteria,
                                                                 eight articles qualified for review.
Methods
This study was approved by the Ethics Review Board of            Instrument Used to Review Eligible Articles
the Canadian Memorial Chiropractic College.                      The articles selected for review were evaluated using an
   The following electronic databases were searched              instrument developed by Sackett (see Table 1).15
from their earliest date of publication to April 2010: ICL,         Four authors (TH, ALB, MP, LB) independently re-
MANTIS, and AMED. CINHAHL and MEDLINE were                       viewed the studies meeting the inclusion criteria. The
searched through EBSCO publishing. The following                 data from all included articles were recorded onto a data
key terms were used: “Activator Adjusting,” “Activator           extraction sheet by the authors as part of the review. The
Technique,” “Neck pain,” Low back pain,” “Mechan-                authors checked and edited all entries for accuracy and
ical manipulation,” “Mechanically assisted device” and           consistency. Recorded data included study authors and
“Instrument assisted manipulation.”) The initial search          quality score, details of the study design, sample, inter-
strategy was then further refined by using the following         ventions, outcome measures, and main results/conclu-
MeSH terms: chiropractic*, therapy*, joint dysfunc-              sions of the study. These four authors met on April 5th,
tion* and cervical vertebrae*. References were also used         2010 to compare their graded scores. Any discrepancies
from citations found in papers that were included after          of scores between the authors were settled via discussion
reviewing the inclusion and exclusion criteria for each.         until consensus was reached.
Citations from specific articles (reference tracking) were
then researched independently through selected databases         Results
followed by hand searching throughout the periodicals.           The initial search strategy yielded 283 hits when using
                                                                 the search terms “Instrument and Manipulation.” Many
Inclusion/exclusion criteria                                     articles found that discussed instrumentation other than
Several inclusion/exclusion criteria were used to select         an AAI or discussed unrelated topics such as historical
studies eligible for this review. Inclusion criteria were as     development of the Activator, diagnostic testing used by
follows: studies must involve more than one subject; treat-      AMCT practitioners or other non-clinical issues. Once
ments must have been administered by a qualified chiro-          refined to “Mechanically Assisted Manipulation” 51
practor; papers were written in English; were published          articles were found. Of these 51 articles, only eight met
between January 1980 and March 2010; prospective or              our inclusion criteria.16–23 After methodological quality
retrospective studies including RCTs, controlled clin-           assessment of each article using the grading instrument,
ical/quasi-experimental trials, cohort, case control and         papers were allocated scores out of a possible 50 points
(Table 2). Articles are listed in descending order of their      adjusting demonstrates a better safety profile compared
score using the Sackett criteria; in the event two or more       to manual manipulation with respect to serious adverse
articles had the same score, they were arranged alphabet-        events (i.e stroke) in patients with identified or unidenti-
ically (Table 3).                                                fied vascular risk factors, since manual manipulation has
                                                                 not been conclusively linked to the incidence of stroke at
Discussion                                                       all.34
When assessed in terms of clinical effectiveness, AAI and           From the perspective of the practitioner, instrumented
manual manipulation were both found to result in equally         adjusting can be used in cases of doctor injuries (disabil-
statistically significant patient outcomes, although the dif-    ities of the hand, wrist, elbow or shoulder, for example)
ferences between the use of these two treatment interven-        and it can used to compensate for anthropomorphic dif-
tions was not statistically significant. Studies investigating   ferences between a small doctor and a large patient.2,30
the use of AAI only reported that it conveyed clinically         Lastly, AAI conveys benefits to the research community
meaningful benefits to patients.                                 since it can be used as a “sham” procedure by setting it
                                                                 to “0” since even set to “0” the AAI will still produce an
Instrumented-Adjusting in Chiropractic                           audible sound.2
Instrumented adjusting has grown in popularity since the            Currently, instrumented-adjusting is permitted for use
time Solon Langworthy first developed a table mount-             by chiropractors in all Canadian, American, British and
ed percussive device in the early 19th century.24 Along          Australian jurisdictions,5 although that has not always been
with the AAI other chiropractic technique systems have           the case. As recently as 2004, Saskatchewan prohibited its
developed adjusting instruments. There are a number of           members from instrumented adjusting. The reasonable-
instrumented Upper Cervical techniques that involve cer-         ness of this standard of practice was raised in an article by
vical adjusting devices that are handheld, floor-mounted         one the authors of this review (BG) in an article published
or table-mounted.25 Other notable examples include the           in 2002;30 this spawned a heated exchange of letters to
Integrator associated with Torque Release Technique26            the editor.35–37 Contemporaneously, the Chiropractic As-
and a floor mounted device used by CBP practitioners.27          sociation of Saskatchewan (CAS) struck a Committee to
An internet search for “instrumented-adjusting devices           evaluate the literature on the efficacy, safety, usage and
in chiropractor” found a device called an “Impulse Ad-           educational requirements for chiropractic practice rela-
justing Instrument” developed by NeuroMechanical In-             tive to AAI [or mechanical adjusting devices (MAD) as it
novations,28 and a device called the “Pro-Adjustor”29 has        was termed in that report38,39]. Overall, the majority of the
recently been demonstrated at chiropractic trade shows           Committee members (4–2) concluded that, while all of
over the past few years (for example, the 2011 World             the studies it reviewed were flawed to varying degrees and
Federation of Chiropractic conference in Rio de Janeiro,         the literature was generally weak, the evidence supported
Brazil and the 2010 Canadian Chiropractic Conference in          the statement that AAI procedures were as effective as
Toronto, Ontario, Canada).                                       manual HVLA procedures in producing clinical benefits
   Instrumented adjusting is thought to convey multiple          and biological change.38 The Committee reached consen-
benefits to both patients and practitioners.2,30–33 From the     sus (5–1) that AAI procedures are widely used for spine
perspective of the patient, benefits conveyed by instru-         related and extremity conditions, is safe and has no more
mented-adjusting include: the management of patients             risk than do manual HVLA procedures (majority opinion
with osteoporotic bone fragility;2,31–33 for children; for       4–2).39 Lastly, the Committee reached consensus (5–1)
patients who are fearful of manipulative procedures that         that there was no evidence with respect to educational re-
result in joint cavitation (i.e “cracking”); for extremity       quirement to form any conclusions.39
adjusting; to (theoretically) achieve greater joint specifi-
city2,30 and; it can be used for patients who wish not be        General Weaknesses of Studies Reviewed
physically touched (perhaps they have been physically or         Irrespective of the wide utilization rates among chiro-
sexually abused, for example).30 To date, no experimental        practors, and despite the plethora of practical benefits to
or clinical evidence exists that the use of instrumented-        patients and practitioners championed by its proponents,
Table 2
                 ARTICLE
                                 Gemmell Yurkiw/ DeVocht Osterbauer Wood et                    Gemmell Schneider Shearar
                                 et al. 2009 Mior. 1996 et al. 2003 et al. 1993 al. 2001       et al. 1995 et al. 2010 et al. 2001
     CRITERIA
Assignment of Patients
                                      7           7            5           6            7           7           7           7
         (/9)
     Baseline Values of
          Groups                      4           4            4           4            4           0           8           4
             (/8)
     Relevance of
  Outcomes & Clinical
                                      7           7            7           7            7           3           3           7
     Significance
          (/7)
          Prognostic
        Stratification
      (Comorbidity and                6           3            6           3            6           6           6           6
         Risk factors)
               (/6)
     Blinding Strategies
                                      3           3            0           0            0           3           0           0
             (/5)
      Contamination/
      Co-Intervention                 3           3            3           2            4           3           2           0
             (/4)
Compliance of Subjects
 to Study Procedures                  4           4            3           4            0           3           0           0
          (/4)
     Drop-out Rates of
         Subjects                     3           2            2           3            0           2           0           0
            (/3)
      Follow-Up Levels
                                      2           1            0           2            2           0           0           2
            (/2)
     Date of Publication
                                      2           1            2           1            2           1           2           2
              (/2)
            Total
                                     41           35          32          32           32          28          28          28
             (/50)
                                                                                 Table 3
                                                                   Patients/                                Main Outcome           Follow-Up
 Reference           Objective              Trial Design     /50   Conditions              Interventions    Measures               Period       Main Results/Conclusions
 Gemmell et al.      1 To examine           Randomized             52 volunteer            1 Ischemic       1 PGIC                 10 minutes   – Both interventions showed
 2009                  the effects          Clinical Trial         subjects w/ tender,       compression    2 NRS                                 improvement in all outcome
                       of ischemic                                 active trigger points   2 Activator      3 PPA (Algometer)                     measures, but no statistical
                                                             41
                       compression                                 of trapezius muscle                                                            significance b/w groups
                       vs. Activator on
                       trigger points
 Yurkiw & Mior       1 Comparison of        Randomized             14 established          1 Diversified    1 C-ROM                Immediate    – No statistical significance
 1996                  Diversified SMT      Comparative            patients w/               SMT              Goniomentric                        b/w interventions
                       & Activator on       Clinical Trial         subacute unilateral     2 Activator        (inclinometer)                    – Both interventions showed
                                                             35
                       ROM & Pain                                  neck pain                                  device                              improvement in all outcome
                                                                                                            2 VAS                                 measures, but no statistical
                                                                                                                                                  significance b/w groups
 DeVocht et al.      1 To evaluate the      Prospective            8 patients w/           1 Activator      1 VAS                  None         – Signs & symptoms of
 2003                  effectiveness        Case Series            chronic articular                        2 Maximum active                      patient TMD improved
                       of Activator                          32    TMD                                        mouth opening                       w/ course of Activator
                       treatment on                                                                           in pain free range                  treatment
                       TMD                                                                                    (ROM)
 Osterbauer et al.   1 To evaluate          Descriptive            10 patients w/          1 Activator      1 VAS                  1 year       – Activator proved beneficial
 1993                  diagnostic and       Case Series            chronic sacroiliac                       2 ODI                                 in treatment of chronic SIJS
                       biomechanical                               joint syndrome                           3 Lumbosacral
                       assessment of                                                                          provocation tests
                                                             32
                       SIJS                                                                                 4 Gait analysis
                     2 To assess                                                                            5 Postural Sway
                       treatment value of
                       Activator on SIJS
 Wood et al. 2001    1 Comparison of        Randomized             30 patients w/          1 Diversified    1 NDI                  1 month      – No statistical significance
                       Diversified SMT      Clinical Trial         subacute neck pain        SMT            2 NPRS                                b/w interventions
                       & Activator on                                                      2 Activator      3 McGill Pain                       – Both interventions showed
                                                             32
                       cervical spine                                                                         Questionnaire                       beneficial effects in
                       dysfunction                                                                          3 ROM w/                              reducing pain & disability
                                                                                                              Goniometer                          while increasing ROM
Gemmell et al.       To examine the         Randomized             30 established          1 Activator      1 VAS                  Immediate    – Both interventions showed
1995                 immediate effects of   Control Trial          patients w/ acute       2 Meric                                                improvement in all outcome
                     Activator vs. Meric                     28    LBP                                                                            measures, but no statistical
                     technique on acute                                                                                                           significance b/w groups
                     LBP
Schneider et al.     1 Examine              Non-                   92 established          1 Activator      1 NPRS                 None         – Study found neither
2010                   treatment effect     Randomized             patients from 3         2 Diversified    2 ODI                                 intervention superior to
                       on NPRS and          Cohort                 chiropractic clinics      Side Posture                                         the other, while providing
                       ODI when                                    w/ 3 month history                                                             profession with valuable
                                                             28
                       comparing                                   of low back pain                                                               information on the influence
                       Activator and                                                                                                              of treatment expectation
                       manual SMT
                       (Low back)
Shearar et al.       1 Comparison of        Prospective            60 subjects w/ a        1 Diversified    1 NRS-101              None         – No statistical significance
2001                   Diversified SMT      Randomized             previous history          SMT            2 Revised ODI                         b/w interventions
                       & Activator of       Clinical Trial         of SIJS                 2 Activator      3 Orthopedic rating                 – Both interventions showed
                                                             28
                       SIJS                                                                                   scales                              improvement in all outcome
                                                                                                            4 Algometer                           measures, but no statistical
                                                                                                                                                  significance b/w groups
this study found only 8 clinical trials that sought to de-                                  of them included a control (no-treatment) group or a sham
termine the clinical effectiveness of the AAI, the form                                     treatment group or included patients without any clinical
of instrumented-adjusting with the most publication in                                      symptoms at all.
the peer-reviewed journals. None of the clinical trials re-                                    In general, examiners in the studies reviewed in this
viewed here were randomized clinical trials; that is, none                                  article were seasoned practitioners well acquainted with
AAI use or with AMCT as well as the other treatment                       summary of the practice of chiropractic within the United
modality option employed (i.e. spinal manipulation, trig-                 States. Greeley, Colorado, USA. National Board of
ger point therapy). All the studies used small study popu-                Chiropractic Examiners; 2005.
                                                                      2   Cooperstein R, Gleberzon BJ. Activator Methods
lations, ranging from 8 to 92 subjects. Moreover, not all                 Chiropractic Technique. In: Technique Systems in
studies were adequately controlled with respect to both                   Chiropractic. Cooperstein R, Gleberzon BJ (editors).
subject and examiner blinding, with 5 of the studies be-                  Churchill-Livingston. 2004; 65–75.
ing assigned a “0” out of 5. An additional limitation was             3   National Board of Chiropractic Examiners. Job Analysis
that all but one study failed to either strategize or adjust              of Chiropractic: a project report, survey analysis and
                                                                          summary of the practice of chiropractic within Canada.
for relevant baseline characteristics. Due to the lack of                 Greeley, Colorado, USA. National Board of Chiropractic
long-term follow-up care and the use of a single treatment                Examiners; 1993.
intervention, contamination and co-intervention grading               4   Kopansky-Giles D, Papadopoulos C. Canadian
had to be assumed in 4 of the 8 studies which may have                    Chiropractic Resource Databank (CCRD). A profile
further influenced the overall quality of these studies. A                of Canadian chiropractors. J Can Chiro Assoc. 1997;
further limitation was that 7 of the 8 studies utilized a                 41(3):155–191.
                                                                      5   Watkins T, Saranchuk R. Analysis of the relationship
previously established patient base as study subjects, thus               between educational programming at the Canadian
introducing the possible confounding factors of treatment                 Memorial Chiropractic College and the professional
expectancy and type II errors.                                            practice of its graduates. J Can Chiro Assoc. 2000;
                                                                          44(4):230–244.
Conclusion                                                            6   Read DT, Wilson FJH, Gemmell HA. Activator as a
                                                                          therapeutic instrument: Survey of usage and opinions
This systematic review of 8 clinical trials involving the use             amongst members of the British Chiropractic Association.
of the AAI found reported benefits to patients with spinal                Clin Chiropr. 2006; 9(2):70–75
pain and trigger points, although these results were not sta-         7   National Board of Chiropractic Examiners. Job Analysis
tistically significantly different when compared to the use               of Chiropractic: a project report, survey analysis and
of HVLA manual manipulation or trigger point therapy.                     summary of the practice of chiropractic within the United
   Given the wide use and clinical utility of the AAI, it is              States. Greeley, Colorado, USA. National Board of
                                                                          Chiropractic Examiners; 1994.
unfortunate that most of the clinical trials investigating its        8   Cooperstein R, Perle SM, Gatterman MI et al. Chiropractic
effectiveness were only pilot studies involving between                   technique procedures for specific low back conditions:
8 and 92 patients and typically involving only one or                     Characterizing the literature. J Manipulative Physiol Ther.
two treating doctors with a limited post-study follow-up.                 2001; 24(6):407–411.
That said, there does exist case studies, case series, clin-          9   Gatterman MI, Cooperstein R, Lantz C et al. Rating
                                                                          specific chiropractic techniques procedures for common
ical trials and now this systematic review that suggests                  low back conditions. J Manipulative Physiol Ther. 2001;
patients do experience positive and clinically meaningful                 24(7):449–456.
benefits when treated for spinal pain and trigger points            10    Gleberzon BJ. Chiropractic Name Techniques: A review of
using an AAI. Clinically meaningful improvements were                     the literature. JCCA. 2001; 45(2):86–99
documented in patients with acute and chronic low back              11    Oakley PA, Harrison DD, Harrison DE, Haas JW.
or SIJ pain, acute and subacute neck pain, TMJ disorders                  Evidence-based protocol for structural rehabilitation of
                                                                          the spine and posture: review of clinical biomechanics of
and trigger points in the trapezius muscle.                               posture (CBP) publications. JCCA. 2005; 9(4):270–296.
   Further studies ought to include a larger patient base           12    Cooperstein R, Perle SM, Gleberzon BJ, Peterson DH.
using a placebo or sham group and a no-treatment group,                   Flawed trials, flawed analysis: Why CBP should avoid
better randomization and blinding protocols and longer-                   rating itself (Editorial). JCCA. 2006; 50(2):97–102.
term post-intervention follow-up in order to more defin-            13    Activator Methods Research DVD. Undated. Available
                                                                          upon request.
itively assess the benefits of AAI treatment.                       14    Activator Methods (r). www.activator.com. Accessed May
                                                                          11, 2011.
References                                                          15    Sackett DC, Williams MC, Rosenbery JA. Evidence Based
 1 National Board of Chiropractic Examiners. Job Analysis                 Medicine: What is it and what it isn’t. BMJ. 1996; 312:71–
   of Chiropractic: a project report, survey analysis and                 72.