Pulmocare ®
Salbutamol Sulphate BP
Presentation The most frequent adverse reactions to Salbutamol are
Pulmocare® 4 mg tablet: Each tablet contains nervousness, tremor, headache, tachycardia, and
Salbutamol Sulphate BP equivalent to 4 mg palpitation. Less frequent adverse reactions are muscle
Salbutamol. cramps, insomnia, nausea, weakness, dizziness,
drowsiness, flushing, restlessness, irritability, chest
Description discomfort and difficulty in micturation. Hypersensitivity
Pulmocare® is a synthetic sympathomimetic amine, reactions including paradoxical broncospasm are rare.
commercially available as its sulphate salt. It is beta-2
adrenoceptor agonist which stimulates beta-adrenergic Drug Interaction
receptors. It is believed that beta-adrenergic agonists The concomitant use of Pulmocare® tablets and other
stimulate the production of cyclic adenosine oral sympathomimetic agents are not recommended
monophosphate (cAMP) which appears to mediate since such combined use may lead to deleterious
numerous cellular responses. cardiovascular effects. Salbutamol should be
Pulmocare® appears to act on uterine and vascular administered with extreme caution to patients being
smooth muscles (beta-2 receptors) than on treated with monoamine oxidase inhibitors or tricyclic
beta-adrenergic receptors of the heart (beta-1 antidepressants because the action of Salbutamol on
receptors). The main effect following oral the vascular system may be potentiated. Beta-receptor
administration of Salbutamol is bronchodilation blocking agents and Salbutamol inhibit the effect of
resulting from relaxation of smooth muscles of the each other.
bronchial tree.
Results of animal studies indicate that Salbutamol does Use In Pregnancy And Lactation
not cross the blood brain- barrier, but the drug Administration of drugs during pregnancy should only
apparently crosses the placenta. Salbutamol is be considered if expected benefit to the mother is
extensively metabolized in the liver mainly to greater than any possible risk to the fetus. As
Salbutamol 4-o-sulphate which has little or no Salbutamol is probably secreted in breast milk, its use
beta-adrenergic blocking effect. Salbutamol and its in nursing mothers is not recommended unless the
metabolites are rapidly excreted in urine and feces. expected benefits out-weigh any potential risk.
Indication Over dosage
Pulmocare® is indicated for the relief of bronchospasm The symptoms with over dosage are angina, headache,
in patients with reversible obstructive airway diseases nausea, vomiting, tremor etc. The preference antidote
like Bronchial asthma, chronic bronchitis, Emphysema, for over dosage with Salbutamol is cardio-selective
etc. Because of the sustained release formulation beta-blocking agent but beta-blocking drugs should
be used with caution in patients with a history of
Dosage And Administration bronchospasm
Adults: The recommended usual oral dose is 2-4 mg
tablet 3-4 times daily or as prescribed by physicians. Commercial pack
Children (2-6 years of age): 1-2 mg three to four times Pulmocare® 4 mg tablet: Box containing 10 x 10 tablets
daily or as prescribed by the physician. in strip pack.
Not recommended under the age of 2 years. Storage
Elderly: Usually dose adjustment is not required in the Store in a cool and dry place below 30 ºC.
elderly. Protect from light.
Contraindication And Precaution Medicine: Keep out of reach of children
Salbutamol is contraindicated in patients with a history
of hypersensitivity to any of their components.
Salbutamol should be used with caution in patients
with hyperthyroidism, cardiovascular disease, occlusive
vascular disorders, hypertension and aneurysms.
Hypokalaemia associated with high doses of
Salbutamol may result in increased susceptibility to
digitalis-induced cardiac arrhythmia.
Side Effect
The adverse reactions to Salbutamol are similar in Manufactured by
nature to reactions to other sympathomimetic agents. Healthcare Pharmaceuticals Ltd.
Rajendrapur, Gazipur, Bangladesh HP
