Bio Module4
Bio Module4
Echolocation (ultrasonography, sonars), Photosynthesis (photovoltaic cells, bionic leaf). Bird flying
(GPS and aircrafts), Lotus leaf effect (Super hydrophobic and self-cleaning surfaces), Plant burrs
(Velcro), Shark skin (Friction reducing swim suits), Kingfisher beak (Bullet train). Human Blood
substitutes - hemoglobin-based oxygen carriers (HBOCs) and Perflourocarbons (PFCs).
ECHOLOCATION:
In nature's sonar system, echolocation occurs when an animal emits a sound wave that bounces off
an object, returning an echo that provides information about the object's distance and size. Over a
thousand species echolocate, including most bats, all-toothed whales, and small mammals. Human
echolocation is the ability of humans to detect objects in their environment by sensing echoes from
those objects and by actively creating sounds: for example, by tapping their canes, lightly stomping
their feet, snapping their fingers, or making clicking noises with their mouths. People trained to
orient by echolocation can interpret the sound waves reflected by nearby objects, accurately
identifying their location and size.
Many blind individuals passively use natural environmental echoes to sense details about their
environment: however, others actively produce mouth clicks and can gauge information about their
environment using the echoes from those clicks. Both passive and active echolocation help blind
individuals sense their environments.
Those who can see their environments often do not readily perceive echoes from nearby objects,
due to an echo suppression phenomenon brought on by. the precedence effect. However, with
training, sighted individuals with normal hearing can learn to avoid obstacles using only sound,
showing that echolocation is a general human ability.
A comparison of biological echolocation and technological echolocation is given below:
Biological Echolocation
   •   Found in various animals such as bats, dolphins, and some species of whales.
   •   Relies on the emission of sound waves, usually in the form of clicks or vocalizations.
   •   Animals emit sound waves and listen for the echoes produced when the sound waves
       bounce off objects in their environment.
   •   By analyzing the echoes, animals can determine the location, distance, and even theshape
       of objects around them.
   •   This ability is mainly used for navigation, hunting, and communication in the animal
       kingdom.
   •   Biological echolocation is a natural adaptation that has evolved over millions of years.
                                   DEPARTMENT OF SCIENCE & HUMANITIES/21BE45/2022-23/IV          1
                              CANARA ENGINEERING COLLEGE
Technological Echolocation
   •   Replicates the concept of biological echolocation using technological devices.
   •   Utilizes sound waves, typically generated by artificial sources such as sonar or ultrasonic
       sensors.
   •   These devices emit sound waves and analyze the echoes that bounce back from objects.
   •   The information from the echoes is processed and interpreted by the technology togenerate
       useful data, such as distance, location, and object recognition.
   •   Technological echolocation has applications in various fields, including navigation,
       robotics, obstacle detection, and medical imaging.
   •   It is a human-engineered solution inspired by the natural abilities of animals.
Principle of Echolocation
Both biological and technological echolocation rely on the same basic principles and have the
same underlying purpose: to determine the location, distance, and shape of objects in the
environment using sound waves and their echoes.
The principle of echolocation is based on the emission of sound waves and the interpretation of the
echoes that bounce back from objects in the environment.
Comparing the Sound Emission and Reception in Biological Ecosystem and Technological
Ecosystem
In biological systems, sound emission and sensory reception organs are specialized adaptations that
allow animals to engage in echolocation. Technological systems, on the other hand, employ devices
designed to replicate and enhance these abilities.
Here's a concise comparison of sound emission and sensory reception organs/devices in biological
and technological systems:
ULTRASONOGRAPHY:
Ultrasound:
Ultrasound refers to sound above the human audible limit of 20 kHz. Ultrasound of frequencies upto
10 MHz and beyond is used in medical diagnosis, therapy, and surgery. In investigative
applications, an ultrasound source (transmitter) directs pulses into the body.
When the pulse encounters a boundary between organs or between two tissue regions of different
densities, reflections of sound occur. By scanning the body with Ultrasound and detecting echoes
generated by various organs, a sonogram of the internal structure(s) can be generated. The
method is called diagnostic imaging by echolocation.
                        (Sonography of Kidney)
Diagnostic ultrasound, also called sonography or diagnostic medical sonography, is an imaging
method that uses sound waves to produce images of structures within your body. The images can
provide valuable information for diagnosing and directing treatment for a variety of diseases and
conditions.
Ultrasonography is a medical imaging technique that uses high-frequency sound waves to produce
images of the internal organs and tissues of the body. It is also known as ultrasound imaging or
sonography.
The ultrasound machine emits high-frequency sound waves (usually in the range of 2 to 18 MHz)
that travel through the body and bounce back off of the internal organs and tissues. The returning
echoes are captured by the ultrasound machine and used to create images of the internal structures.
Ultrasonography is a non-invasive, safe, and painless imaging method that can be used to visualize
a wide range of structures within the body, including the organs of the abdomen, pelvis, and chest,
as well as the uterus, fetus, and other soft tissues. It is commonly used in prenatal careto monitor
the growth and development of the fetus and to diagnose any potential problems.
Advantages of Ultrasonography
Non-invasive: Ultrasonography does not involve any incisions or injections, making it a safe and
convenient imaging method.
No ionizing radiation: Ultrasonography does not use ionizing radiation, making it a safer option for
patients, especially pregnant women and children.
Real-time imaging: Ultrasonography provides real-time images that can be used to monitor the
movement and function of internal organs and tissues in real-time.
Portable: Ultrasonography machines are portable and can be used in a variety of settings, making it
a valuable tool for emergency and rural medicine.
Cost-effective: Ultrasonography is a cost-effective imaging method that does not require any special
preparation or recovery time.
Versatile: Ultrasonography can be used to image a wide range of structures within the body,
including the organs of the abdomen, pelvis, and chest, as well as the uterus, fetus, and other soft
tissues.
SONARS:
Sonar (Sound Navigation and Ranging or Sonic Navigation and Ranging) is a technique that uses
sound propagation (usually underwater, as in submarine navigation) to navigate, measure distances
(ranging), communicate with or detect objects on or under the surface of the water, such as other
vessels.
“sonar” can refer to one of two types of technology:
Passive sonar means listening for the sound made by vessels
Active sonar means emitting pulses of sounds and listening for echoes.
solid object will produce a strong, low-frequency echo, while a small, porous object will produce a
weaker, high-frequency echo.
Display of results: The results of the sonar measurement are typically displayed on a screen or other
output device, allowing the operator to visualize the target object and its location.
Advantages of Sonar Technology
Versatility: Sonar technology is versatile and can be used in a variety of applications, such as
underwater navigation, mapping, and imaging, as well as for military and scientific purposes.
Cost-effective: Compared to other underwater imaging technologies, sonar is relatively cost-
effective and affordable.
Non-invasive: Unlike other imaging technologies, such as diving and remote-operated vehicles,
sonar does not physically disturb the underwater environment, making it an ideal choice for
environmental monitoring and scientific research.
Real-time imaging: Sonar provides real-time imaging, allowing operators to quickly and easily
assess the underwater environment.
High resolution: Modern sonar systems have high-resolution capabilities, allowing for detailed
images of underwater objects and structure
PHOTOSYNTHESIS:
Most life on Earth depends on photosynthesis. The process is carried out by plants, algae, and some
types of bacteria, which capture energy from sunlight to produce oxygen (02) and chemical energy
stored in glucose (a sugar). Herbivores then Obtain this energy by eating plants, and carnivores
obtain it by eating herbivores.
The Process:
During photosynthesis, plants take in carbon dioxide (CO2) and water (H20) from the air and soil. Within
the plant cell, the water is oxidized, meaning it loses electrons, while the carbon dioxide is reduced,
meaning it gains electrons. This transforms the water into oxygen and the carbon dioxide into glucose.
The plant then releases the oxygen back into the air, and stores energy within the glucose molecule.
In plants, photosynthesis takes place in the chloroplasts of the cells located in the leaves.
The process starts with the absorption of light energy by pigments such as chlorophyll, which then
excites electrons. These excited electrons are used to power the transfer of carbon dioxideinto
organic molecules, such as sugars and starches, through a series of chemical reactions. The end
product of photosynthesis in plants is stored chemical energy in the form of organic compounds.
In some animals, such as algae, photosynthesis also takes place in chloroplasts. The process is
essentially the same as in plants, with the absorption of light energy and the conversion of
carbon dioxide into organic molecules.
Chlorophyll:
Inside the plant cell are small organelles called chloroplasts, which store the energy of sunlight.
Within the thylakoid membranes of the chloroplast is a light-absorbing pigment called chlorophyll, which
is responsible for giving the plant its green color. During photosynthesis, chlorophyll absorbs
energy from blue- and red-light waves and reflects green-light waves, making the want appear green.
PHOTOVOLTAIC CELLS:
WHAT IS PHOTOVOLTAIC?
The sun’s copious energy is captured by two engineering systems: photosynthetic plant cells
and photovoltaic cells (PV). Photosynthesis converts solar energy into chemical energy, delivering
different types of products such as building blocks, biofuels, and biomass; photovoltaics turn it into
electricity which can be stored and used to perform work.
The connection between photosynthesis and photovoltaics lies in the conversion of light energy into
usable forms of energy. In photosynthesis, light energy from the sun is converted into chemical
energy stored in organic molecules, such as sugars and starches. In photovoltaics, light energy is
converted into electrical energy.
Both photosynthesis and photovoltaics use the same basic principle of converting light energy into
usable forms of energy, but the end products are different. In photosynthesis, the end product is
stored chemical energy, while in photovoltaics, the end product is electrical energy. However, the
similarities between photosynthesis and photovoltaics go beyond just the conversion of light energy.
Both processes also involve the use of specialized components and materials, such as chlorophyll in
photosynthesis and silicon in photovoltaics, to absorb and convert light energy into usable forms of
energy.
The development of photovoltaics has been heavily influenced by the natural process of
photosynthesis, and many researchers have sought to mimic and improve upon the efficiency and
effectiveness of photosynthesis in order to develop more advanced and efficient photovoltaic
systems. The study of photosynthesis has thus played a significant role in the development
ofsustainable energy systems and continues to be an important area of research in the field of
renewable energy.
       (Photovoltaic cell )
A solar cell or, photovoltaic cell is an electronic device that converts the energy of light
directly into electricity by the photovoltaic effect, which is a physical and chemical
phenomenon. It is a form of photoelectric cell, defined as a device whose electrical
characteristics, such as current, voltage, or resistance, vary when exposed to light.
Individual solar cell devices are often the electrical building blocks of photovoltaic
modules, known colloquially as solar panels. The common single-junction silicon
solar cell can produce a maximum open -circuit voltage of approximately 0.5 volts to 0.6
volts.
Application:
   •   Remote Locations
   •   Stand-Alone Power
   •   Power in space
   •   Building -Related Needs
   •   Military Uses.
   •   Transportation
BIONIC LEAF:
The bionic Leaf is a biomimetic system that gathers solar energy via photovoltaic cells that can be
stored or used in several different functions. Bionic leaves can be composed of both synthetic (metals,
ceramics, polymers, etc.) and organic materials (bacteria), or solely made of synthetic materials. The
Bionic Leaf has the potential to be implemented in communities, such as urbanized areas to provide
clean air as well as providing needed clean energy.
Mechanics:
Natural Photosynthesis vs. The Bionic Leaf at its simplest form.
In natural photosynthesis, photosynthetic organisms produce energy-rich organic molecules
from water and carbon dioxide by using solar radiation. Therefore, the process of
photosynthesis removes carbon dioxide, a greenhouse gas, from the air. Artificial
photosynthesis, as performed by the Bionic Leaf, is approximately 10 times more efficient than
natural photosynthesis. Using a catalyst. the Bionic Leaf can remove excess carbon dioxide in
the air and convert that to use alcohol fuels. like isopropanol and iso butanol.
The efficiency of the Bionic Leaf’s artificial photosynthesis is the result of bypassing obstacles
in natural photosynthesis through its artificiality. In natural systems, numerous energy
conversion bottlenecks limit the overall efficiency of photosynthesis. As a result, most plants
do not exceed 1% efficiency and even microalgae grown in bioreactors do not exceed 3%.
Existing artificial photosynthetic solar-to-fuels cycles may exceed natural efficiencies but
cannot complete the cycle via carbon fixation. When the catalysts of the Bionic Leaf are coupled
with the bacterium Ralstonia eutropha, this results in a hybrid system capable of carbon dioxide
fixation. This system can store more than half of its,input energy as products of carbon dioxide
fixation. Overall, the hybrid design allows for artificial photosynthesis with efficiencies
rivaling that of natural photosynthesis.
Components of Bionic Leaf
A bionic leaf is a biohybrid system that mimics the natural process of photosynthesis to convert
sunlight into chemical energy. It typically consists of several key components that work
together to facilitate this conversion. Here are the main components of a bionic leaf:
Photosynthetic Organism: The bionic leaf utilizes a photosynthetic organism, such as a
cyanobacterium or a genetically modified plant, as the primary component. This organism
contains chlorophyll or other light-absorbing pigments that capture solar energy and initiate
the photosynthetic process.
Light Harvesting System: The bionic leaf includes a light harvesting system, which can be
artificial or natural, to efficiently capture sunlight. In some designs, light-absorbing dyes or
semiconductor materials are incorporated to enhance light absorption and conversion
efficiency.
Catalysts: The bionic leaf incorporates catalysts, such as enzymes (Examples: Hydrogenase,
Nitrogenase, etc.) or synthetic catalysts (Example: Rubisco (Ribulose-1,5- bisphosphate
carboxylase/oxygenase)), to facilitate the chemical reactions involved in photosynthesis. These
catalysts play a crucial role in splitting water molecules, generating electrons, and catalyzing
the conversion of carbon dioxide into fuels or other chemical compounds.
Electron Transfer Pathway: An electron transfer pathway is an essential component of the
bionic leaf system. It allows the generated electrons from water splitting to be efficiently
transported to the catalysts involved in carbon dioxide reduction or other chemical reactions.
This pathway ensures the flow of electrons necessary for fuel production or other desired
chemical transformations.
Carbon Dioxide Source: To sustain the photosynthetic process, a bionic leaf requires a source
of carbon dioxide. This can be obtained from various sources, including ambient air, industrial
emissions, or concentrated carbon dioxide solutions.
Energy Storage or Conversion System: The bionic leaf includes an energy storage or
conversion system to capture and store the chemical energy produced during photosynthesis.
This can involve the production of hydrogen gas, liquid fuels, or other energy-rich compounds
that can be stored and used as needed.
Control and Monitoring System: To optimize performance and ensure efficient operation, a
bionic leaf typically incorporates a control and monitoring system. This system monitors
various parameters such as light intensity, temperature, pH, and carbon dioxide levels, and
allows for adjustments and optimization of the overall process.
Applications:
Renewable Energy Production: One of the primary applications of bionic leaf technology is
in the production of renewable energy. Bionic leaf systems can harness solar energy and
convert it into chemical energy in the form of hydrogen gas or other carbon-based fuels. These
fuels can be used as clean energy sources for various applications, including transportation,
electricity generation, and heating.
Agriculture and Food Production: Bionic leaf technology can have applications in
agriculture and food production. By utilizing sunlight and carbon dioxide, bionic leaf systems
can generate oxygen and energy-rich compounds that can enhance plant growth and improve
crop yields. This technology can potentially contribute to sustainable agriculture practices and
help address global food security challenges.
Environmental Remediation: Bionic leaf technology has the potential to aid in environmental
remediation efforts. By utilizing the energy generated from sunlight, bionic leaf systems can
power processes that remove pollutants or contaminants from air, water, or soil, contributing
to the restoration and preservation of ecosystems.
BIRD FLYING:
Birds fly by flapping their wings and using their body weight and the movement of the air to
stay aloft. They navigate using a combination of visual cues, the Earth's magnetic field, and
celestial navigation. Aircraft, on the other hand, use engines to generate thrust and lift from the
wings to stay in the air. They navigate using a combination of instruments and systems,
including GPS (Global Positioning System), which uses satellite signals to determine the
aircraft's position and help it navigate. Although birds and aircraft both fly, their mechanisms
and methods of navigation are quite different.
Birds flying influenced the invention of aircraft in that early aviation pioneers, such as the
Wright brothers, observed and studied the flight of birds to develop their flying machines.
They noted how birds used their wings and body to achieve lift and control their flight, and
used this knowledge to design and improve aircraft.
The development of GPS technology was not directly influenced by birds, but rather by the
need for accurate and reliable navigation systems for various purposes, including aviation.
GPS uses a network of satellites to provide location and time information, which is used by
aircraft for navigation, communication, and safety purposes.
User segment: The user segment consists of the GPS receivers used by individuals and
organizations to obtain location and time information.
GPS technology has a wide range of applications, including navigation, mapping, surveying,
search and rescue, and military operations. The accuracy and reliability of GPS have improved
over time, and the technology continues to evolve with new developments in satellite and
receiver technology, as well as the integration of GPS with other technologies such as
augmented reality and artificial intelligence.
Positioning and Navigation: GPS helps aircraft accurately determine their position and follow
precise routes. Signals from satellites are received by GPS receivers onboard, allowing the
system to calculate the aircraft's position.
Flight Planning: GPS assists pilots and planners in creating optimal flight plans, considering
waypoints, altitudes, and current information on navigation aids, weather, and airspace
restrictions.
Approach and Landing: GPS-based navigation systems provide precise guidance during
approach and landing, even in low visibility. This enhances safety and reduces reliance on
ground-based navigation aids.
Air Traffic Management: GPS is integrated into air traffic management systems, improving
airspace efficiency, reducing congestion, optimizing routing, and enhancing aircraft tracking
and situational awareness for controllers.
Collision Avoidance: GPS contributes to collision avoidance systems like TCAS and ADS-B.
These systems use GPS data to track nearby aircraft, provide alerts, and ensure safe separation.
Flight Data Recording: GPS data is often recorded by flight data recording systems, aiding
post-flight analysis, accident investigation, and overall flight safety improvements.GPS
technology has revolutionized aircraft navigation and has become an integral part of modern
aviation. It provides accurate positioning, enhances safety, improves operational efficiency, and
contributes to the overall advancement of the aviation industry.
GPS AND BIRD FLIGHT:
Scientists have long known that birds navigate using the earth’s magnetic field. Now, a new
study has found subtle mechanics in the brain of pigeons that allow them to find their way.
A team at Baylor College of Medicine in the U.S. identified a group of 53 cells in a pigeon's
brain that record detailed information on the Earth's magnetic field, a kind of internal global
positioning system (GPS).
Experiment:
Prof. Dickman and his colleague Le-Qing-Wu set up an experiment in which pigeons were held
in a dark room and used a 3D coil system to cancel out the planet's natural geomagnetic
field and generate a tunable, artificial magnetic field inside the room. While they adjusted
the elevation angles and magnitude of their, artificial magnetic field, they simultaneously
recorded the activity of the 53 neurons in the pigeons' brains which had already been identified
as candidates for such sensors.
Comparing Birds and Aircrafts with GPS Technology for Navigation
AIRCRAFT:
MECHANISM:
Lift, Drag, and Thrust: The fundamentals of bird night are similar to those of aircraft, in
which the aerodynamic forces sustain night lilt, drag, and thrust. Lift force is produced by
the action of airflow on the wing, which is an airfoil. The airfoil is shaped such that the air
provides a net upward force on the wing, while the movement of air is directed downward.
The additional net lift may come from airflow around the bird's body in some species,
especially during intermittent flight while the wings are folded or semi-folded (cf. lilting body).
Aerodynamic drag is the force opposite to the direction of motion, and hence the source of
energy loss in flight. The drag force can be separated into two portions, lift-induced drag,
which is the inherent cost of the wing producing lift (this energy ends up primarily in the wingtip
vortices), and parasitic drag, including skin friction drag from the friction of air and body
surfaces and form drag from the bird's frontal area. The streamlining of the bird's body and
Wings reduces these forces. Unlike aircraft, which have engines to produce thrust, birds flap
their wings with a given flapping amplitude and frequency to generate thrust.
Lift, Drag, and Thrust:
   •   Thrust is a force that moves an aircraft in the direction of the motion. It is created with
       a propeller, jet engine, or rocket. Air is pulled in and then pushed out in an opposite
       direction. One example is a household fan.
   •   Drag is the force that acts opposite to the direction of motion. It tends to slow an object.
       Drag is caused by friction and differences in air pressure. An example is putting your
       hand out of a moving car window and feeling it pull back.
   •   Weight is the force caused by gravity.
   •   Lift is the force that holds an airplane in the air. The wings create most of the lift used
       by airplanes.
The way the four forces act on the airplane make the plane do different things. Each force has
an opposite force that works against it. Lift works opposite of weight. Thrust works opposite
of drag. When the forces are balanced, a plane flies in a level direction. The plane goes up if
the forces of lift and thrust are more than gravity and drag. If gravity and drag are bigger than
lift and thrust, the plane goes down. Just as drag holds something back as a response to wind
flow, lift pushes something up. The air pressure is higher on the bottom side of a wing, so it is
pushed upward.
Flapping-wing drones: Researchers have developed drones that use flapping wings to fly,
mimicking the way birds and insects fly. These drones can be used for various applications,
such as monitoring crops and wildlife, inspecting buildings and infrastructure, and search and
rescue operations.
a)                                             b)
      a) The globular flower heads of burdock             b) indicating the hook shape
The burrs have small hooks that can latch onto clothing, fur, or feathers, allowing them to
disperse their seeds over a wider area.
a) hook and loops normal view of Velcro b) microscopic view of hooks and loops of velcro
Velcro was invented by Swiss engineer George De Mestral in 1941, after he becamefascinated
by the way burrs clung to his clothes and his dog's fur during a walk. He examined the burrs
under a microscope and found that they had small hooks thatcould latch onto loops in
fabric. De Mestral spent years experimenting with different materials before finally developing
Velcro, which consists of two strips of nylon fabric, one with tiny hooks and the other with
small loops. When pressed together, the hooks latch onto the loops, creating a strong bond that
can be easily detached by pulling the two strips apart. Velcro has a wide range of applications,
including in clothing, shoes, bags, and medical devices. It has become a popular alternative to
traditional fasteners, such as buttons and zippers, due to its ease of use and versatility.
The name "Velcro" is actually a combination of the words "velvet" and "crochet," as the fabric
strips resemble velvet and are hooked together like crochet. Velcro has since become a popular
alternative to traditional fasteners, such as buttons and zippers, due to its ease of use and
versatility.
Relevance to humans:
Burrs are best known as sources of irritation, injury to livestock, damage to clothing, punctures
to tires and clogging equipment such as agricultural harvesting machinery. Furthermore,
because of their ability to compete with crops over moisture and nutrition. Bur plants can be
labels as weeds and therefore also be subject to removal. Methods of controlling the spread of
bur plants include the use of herbicides, slashing and cultivation among others.
Some have however been used for such purposes as fabric fulling, for which fuller’s teasel is a
traditional resource. The bur of burdock was the inspiration for the hook and loop fastener also
Known as Velcro.
Materials Used
The materials used to create friction-reducing swim suits inspired by shark skin include:
Polyurethane: A type of polymer that is commonly used in the production of swim suits,
asit is durable and can be molded into a variety of shapes.
Lycra/Spandex: Lycra and spandex are made from the same synthetic fiber, which is
technically called elastane. Elastane fibers are typically composed of a polymer called
polyurethane which is then blended with other fibers like nylon, polyester, or cotton) that is
known for its stretch and flexibility.
High-tech fabrics: A range of high-tech fabrics have been developed specifically for use in
swim suits. These fabrics are designed to be lightweight, water-repellent, and hydrodynamic,
and often incorporate materials such as silicone or Teflon to reduce drag.
Figure: Indicating the shape similarities of kingfisher beak and design of the front of the bullet
train
The kingfisher beak is an excellent example of nature's design for efficient diving and fishing.
Its unique shape and structure enable the kingfisher to minimize the impact of water resistance
and achieve a successful dive.
Technological Importance : The use of the kingfisher beak as a design inspiration for the front
of the bullet train is an example of how nature-inspired engineering can lead to innovative
solutions that improve the performance and efficiency of machines. Shinkansen bullet train of
Japan is the best example which used the biomimicry of kingfisher’s beak.
Aerodynamic Design: The front of the Shinkansen is meticulously shaped to reduce air
resistance and improve aerodynamic performance. The streamlined design minimizes drag as
the train travels at high speeds, allowing it to maintain stability and efficiency. The smooth,
tapered shape reduces the pressure difference between the front and rear of the train, reducing
noise and vibration.
Pressure Wave Reduction: When a high-speed train moves through a tunnel, it creates
pressure waves that can cause noise and discomfort for passengers. The nose of the Shinkansen
is designed to reduce these pressure waves by effectively managing airflow and minimizing
the compression and expansion of air as the train enters and exits tunnels. This reduces the
noise level and enhances passenger comfort.
sedimentation as the blood is cooled. Donated cord blood can be screened for infections
organisms and other contaminants. Research concerning its potential use for transfusion is
ongoing. Of particular concern for implementation are the establishment of safe, effective and
ethical procedures for cord blood collection as well as the development of criteria that help to
ensure safe transfusion and the preservation of cord blood quality.
Haemoglobin-based oxygen carriers (HBOCs) AND Perfluorocarbons(PFC):
Pharmaceutical companies attempted to develop HBOCs ( also called oxygen therapeutics) and
PFCs starting in the 1980 and at first ,seemed to have some success .However ,the results of
most human clinical trials have been disappointing. A study published in 2008 in the journal of
the American Medical Association summarized the results of 16 clinical trials on five different
blood substitutes administered to 3,500 patients.
Those receiving blood substitutes had a threefold increase in the risk of heart attacks compared
with the control group given human donor blood. However, a closer analysis of the results
showed that some of the negative statistics were misleading. The artificial blood products
reviewed in this study varied in their benefits and risks, and some blood substitutes had very
few serious side effects. The findings suggest that some blood substitutes may be safer and
more beneficial than scientists originally thought.
1) HBOCs:
Haemoglobin-based oxygen carriers (HBOCs) are “made of”’ natural haemoglobins that were
originally developed as blood substitutes but have been extended to a variety of hypoxic
clinical situations due to their ability to release oxygen. Compared with traditional preservation
protocols, the addition of HBOCs to traditional preservation protocols provides more oxygen
to organs to meet their energy metabolic needs prolongs preservation time, reduces ischemia-
reperfusion injury to grafts, improves graft quality , and even increases the number of
transplantable donors. The focus of the present study was to review the potential applications
of HBOCs in solid organ preservation and provide new approaches to understanding the
mechanism of promising strategies for organ preservation.
2)PFCs:
PFCs remain in the bloodstream for about 48 hours. Because of their oxygen-dissolving ability,
PFCs were the first group of artificial blood products studied by scientists. They are first-
generation blood substitutes. Unlike the red-coloured HBOCs, PFCs are usually white.
However, since they do not mix with blood they must be emulsified before they can be given to
patients. PFCs are such good oxygen carriers that researchers are now trying to find out if they
can reduce swollen brain tissue in traumatic brain injury. PFC particles may cause flu-like-
symptoms in some patients when they exhale these compounds.