Transport in Human Body
- It’s the process of transporting blood, and lymph,
   through different blood vessels, so the process of
   transport depends on:
 A- Circulatory system.
 B- Lymphatic system.
A- The circulatory system consists of:
 1- The heart.           2- Arteries.          3- Veins.
 4- Blood capillaries.   5- Blood.
    The heart:
Comparison between Arteries and Veins:
Comparison:            Arteries                    Veins
Picture:
Type of blood:   - Oxygenated blood,       - Deoxygenated blood,
                   except pulmonary          except pulmonary vein
                   artery which comes        which comes out the
                   out of the heart and      two lungs and goes to
                   goes to the two           the heart.
                   lungs.
Outer layer:      Connective tissue.         Connective tissue.
Middle layer:      Thick (Pulsate)        Less thick (don’t pulsate)
Inner layer:     - Epithelial cells        - Epithelial cells, and
                 with elastic fibers.        there’s valves to direct
                                             the blood without back
                                             flowing.
Location:        - Buried among the        - Near to the skin
                   body muscles.             surface.
Diameter:        - Relatively smaller      - Relatively wider than
                   than that of the          that of the artery.
                   vein.
    Blood capillaries:
  - It’s the connection of the tiny microscopic vessels,
    which branches from arteries and veins, and the
    microscopic vessel that branch from the arteries is
    called arteriole, and the one that is branched from the
    veins is called venule.
The blood :
  - It’s the fluid that is being transported through the
    circulatory system, and it consists of many contents,
    as the following :
   A- Plasma.    B- RBCs      C- WBCs      D- Platelets.
                     Properties of blood
Color:                           pH:                         Volume:
Red viscous fluid.   7.4 (Weak alkaline).   About 5-6 liters of blood.
  - A sample of blood from regular human body,
    contains plasma with a percentage of 55%, and the
    45% contains WBCs, RBCs, and blood platelets,
    Also plasma contains proteins (like: Albumin,
    Globulin, Fibrinogen, and Prothrombin) with a
    percentage of 7% of the whole volume of the plasma,
    and 91% of it is water, and 2% of it is hormones,
    antibodies, Enzymes, wastes (Urea), and the
    remaining 1% contains inorganic salts [like: Na⁺,
    Ca²⁺, Cl- , (HCO₃)¯ ], as the following diagram:
Comparison between RBCs, WBCs, and platelets:
Comparison            RBCs                    WBCs                     Platelets
Shape         Biconcave              Don’t have specific         Non-cellular small
              round shaped cells.    shape.                      sized particles.
Number/       Male:                  Average volume is       About 250,000 cells.
mm³           4.35 - 5.65 million.   7000 cells and increase
              Female:                in case of infection.
              3.92 – 5.13 million.
Age                 120 days.        Some types live for 13:        About 10 days.
                                           20 days.
Color                 Red.                 Colorless                       --
Presence of         Enucleated            Nucleated                        --
nucleus
Function         - Transport O₂         - Protect the body          - Play an
                   from the lungs          through:                   important role
                   to all body       1- Attack microbes.              in the blood
                   parts.            2- Get rid of dead cells.        clotting process
                 - Transport CO₂     3- Produce antibodies.           after injuries.
                   from all body
                   parts to the
                   lungs.
Site of            Bone marrow        Bone marrow/Spleen/            Bone marrow
formation                              Lymphatic system
    Hemoglobin:
  - Hemoglobin is a protein found in red blood cells that
    is responsible for carrying oxygen from the lungs to
    the rest of the body. It also helps to carry carbon
    dioxide from the body's tissues back to the lungs, as
    the following diagram:
Blood clot process:
  - Blood clotting is the process that helps stop bleeding
    when a blood vessel is injured, in which when a
    blood vessel is cut or damaged, platelets (tiny cell
    fragments) rush to the site, platelets stick together to
    form a temporary plug over the injury, special
    proteins in the blood called clotting factors work
    together to create a mesh-like network called fibrin.
    This fibrin network traps more platelets and blood
    cells, forming a solid clot, as in the following
    diagram:
Mechanism of heart beat (pumping blood):
  - The heartbeat is a rhythmic contraction and
    relaxation of the heart muscle, which pumps blood
    throughout the body. This rhythmic action is
    orchestrated by an electrical system within the heart
    itself, through the following procedures:
1- Electrical Impulse Generation:
- Sino-atrial (S.A node): This cluster of cells in the right
atrium is often called the "pacemaker" of the heart. It
spontaneously generates electrical impulses at a regular
rate.
2- Electrical Signal Propagation:
- The electrical impulse from the SA node spreads across
the atria, causing them to contract and push blood into the
ventricles.
- The impulse then reaches the atrio-ventricular (A.V
node), located in the wall between the atria and ventricles.
- The A.V node slightly delays the signal, allowing the
ventricles to fill completely before they contract.
- The impulse then travels down the bundle of His and
through the Purkinje fibers, which rapidly distribute the
signal to the ventricular muscle.
3- Cardiac Muscle Contraction:
  - The electrical signals cause the heart muscle to
    contract in a coordinated manner.
  - First, the atria contract, pushing blood into the
    ventricles.
  - Then, the ventricles contract forcefully, pumping
    blood out of the heart:
  - The right ventricle pumps blood to the lungs for
    oxygenation.
  - The left ventricle pumps blood to the rest of the body.
Types of blood circulations:
  - There three major types of blood circulations, which
    are:
1- Pulmonary circulation:
  - It’s the process of transporting blood from the heart
    (right ventricle) to the two lungs through the
    pulmonary artery, to oxygenate the blood, then the
    blood is transported to the heart again through the
    pulmonary veins, then poured in the left ventricle.
Path: Right ventricle -> Pulmonary artery -> Lungs ->
Pulmonary vein -> Left ventricle.
2- Systemic circulation:
  - It’s the process of transporting blood from the heart
    (left ventricle) to all body parts (cells) through the
    aorta, to enrich all body cells with oxygen gas and
    nutrients and carry out the wastes, then the blood is
    deoxygenated, then the blood is transported to the
    heart again through the all body vessels, then poured
    in the right ventricle, to restart the whole cycle.
Path: Left ventricle -> Aorta -> Body tissues -> Veins ->
Vena cava -> Right ventricle.
3- Hepatic portal circulation:
  - It’s the process of transporting blood from the small
    intestine to liver through the hepatic portal vein, and
    the blood is being filtered in the liver from nutrients,
    and stored in the liver in the form of glycogen, and
    then the remaining blood is transported to heart
    through two vessels, which are hepatic vein and then
    to inferior vena cava, and then poured in the right
    ventricle.
    Path: Small intestine -> Hepatic portal vein -> Liver ->
    Hepatic vein -> Inferior Vena cava -> Right ventricle.
B- Lymphatic system:
  - It‘s a vital part of your immune system, playing a
    crucial role in defending your body against infection
    and disease, it’s a network of vessels, nodes, and
    organs that circulate a fluid called lymph throughout
    the body, and works closely with the circulatory
    system, but it's a separate system with distinct
    functions.
  - The lymphatic system consists of :
1- Lymphatic routes:
  - Similar to blood vessels, these tubes carry lymph
    throughout the body.
2- Lymphatic nodes:
  - Small, bean-shaped structures located throughout the
    body (neck, armpits, and groin).
  - They filter lymph, trapping bacteria, viruses, and
    other harmful substances.
3- Lymph:
  - It’s a clear, colorless fluid that circulates through the
    lymphatic vessels. It contains:
  - White blood cells (lymphocytes) that fight infection.
- Proteins.   - Cellular debris.   – Fats.