Large Intestine MCQ
Large Intestine MCQ
1. Which answers are true? In contrast to ulcerative colitis, Crohn's disease of the
colon:
A. Is not associated with increased risk of colon cancer.
B. Seldom presents with daily hematochezia.
C. Is usually segmental rather than continuous.
D. Has a lower incidence of perianal fistulas.
E. Never develops toxic megacolon.
Answer: BC
2. Which answers are true? Options to consider when operating for Crohn's disease
of the large intestine include:
A. Colectomy and ileorectostomy.
B. Colectomy, closure of the rectal stump, and ileostomy.
C. Colectomy and continent ileostomy (Kock pouch).
D. Proctocolectomy and ileostomy.
E. Proctocolectomy and ileal pouch–anal canal anastomosis.
Answer: ABD
3. Crohn's disease:
A. Is caused by Mycobacterium paratuberculosis.
B. Is more common in Asians than in Jews.
C. Tends to occur in families.
D. Is less frequent in temperate climates than in tropical ones.
E. Is improved by smoking.
Answer: C
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7. The most common indication for operation in Crohn's disease of the colon is:
A. Obstruction.
B. Chronic debility.
C. Bleeding.
D. Perforation.
E. Carcinoma.
Answer: B
8. Which of the following statements about surgical anatomy of the colon and
rectum is/are correct?
A. The cecum has the largest inner diameter of all segments of the colon (13 to 15
cm.).
B. The rectosigmoid junction is situated at approximately 15 to 18 cm. from the anus.
C. The rectum is entirely an intraperitoneal organ.
D. The ileocolic, right colic, and middle colic arteries are branches from the inferior
mesenteric artery.
E. The arterial arcade created by communicating vessels at 1 to 2 cm. from the
mesenteric is called the artery of Drummond. Answer: BE
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9. Which of the following statements about surgical procedures on the colon and
rectum is/are correct?
A. Successful healing of colonic anastomoses depends on the adequacy of the blood
supply.
B. In excising part of the colon containing cancer, the lymphatics should be avoided
by dividing the mesentery close to the wall of the colon.
C. Despite complete removal of the colon and rectum, transanal fecal flow can be
preserved by means of an ileal pouch–anal anastomosis.
D. When a colostomy is created it cannot be reversed.
E. Colostomy can be life saving in patients with colonic perforation or obstruction.
Answer: ACE
10. Which of the following statements about colon physiology is/are correct?
A. Colonic recycling of urea is accomplished by the splitting of urea by bacterial
ureases.
B. Fermentation by colonic bacteria may rescue malabsorbed carbohydrates.
C. The preferred fuel of the colonic epithelium is glucose.
D. Absorption by the colonic mucosa is a passive process.
E. Insoluble fibers create bulk in the stool.
Answer: ABE
11. Which of the following statements about colonic motility is/are true?
A. Mass contractions involve only the rectum.
B. “Antiperistaltic” contractions occur in the descending colon.
C. The rectum can accommodate stool by receptive relaxation.
D. Stool in the colon is propelled by tonic contractions.
E. Defecation involves both sensory and motor pathways.
Answer: ADE
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12. Which of the following statements about diagnostic studies for the colon and
rectum is/are true?
A. Acetylcholinesterase staining of rectal biopsies is unreliable for the diagnosis of
Hirschsprung's disease.
B. Cinedefecography is useful for detecting “hidden” prolapse or rectal
intussusception.
C. A negative osmotic gap in stool is indicative of secretory diarrhea.
D. A colonic transit time study involves serial abdominal x-rays after ingestion of
radiopaque markers.
E. Carcinoembryonic antigen (CEA) is useful for monitoring patients after resection for
colon cancer.
Answer: BCDE
13. Which of the following statements about anorectal functional testing is/are
true?
A. Anorectal manometry is often performed through open-tipped multilumen
catheters perfused with fluid.
B. Anorectal manometry can differentiate between segmental and global defects of
the anal sphincter in patients with incontinence.
C. Electromyography can demonstrate persistent contraction of the pubis rectalis
muscle during defecation, which is diagnostic of paradoxical pelvic floor contraction.
D. Measurement of sensory thresholds may reveal insensitivity in patients with chronic
constipation.
Answer: ABCD
14. Which of the following statements about the microbiology of the colon is/are
true?
A. The colon contains no more bacteria than the stomach.
B. The predominant bacteria in the colon are aerobic.
C. Nearly one third of the dry weight of feces is bacteria.
D. Common bacteria in the colon are Bacteroides, Bifidobacterium, and
Enterobacterium species.
E. The colonic microflora is relatively stable.
Answer: CDE
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15. Which of the following statements about bowel preparation for colon surgery
is/are true?
A. Bowel preparation is accomplished by a combination of mechanical cleansing and
nonabsorbable antibiotics.
B. Three days of clear liquids provides sufficient mechanical cleansing.
C. Commercial electrolyte-polyethylene glycol solutions provide mechanical cleansing
without inducing electrolyte imbalance.
D. Nonabsorbable antibiotics such as neomycin and erythromycin base are
administered the day before the operation in three doses.
E. Intravenous antibiotics are also administered the day before surgery.
Answer: ACD
16. Which of the following patients generally does not require surgical
intervention as a consequence of acute diverticulitis?
A. A 35-year-old man with no history of diverticulitis.
B. A 68-year-old man status 2 weeks post–renal transplantation.
C. A 55-year-old woman with hypertension and diabetes mellitus.
D. A 50-year-old man with pneumaturia.
E. A 46-year-old man with right-sided diverticulitis.
Answer: C
17. The test with the highest diagnostic yield for detecting a colovesical fistula is:
A. Barium enema.
B. Colonoscopy.
C. Computed tomography (CT).
D. Cystography.
E. Cystoscopy.
Answer: E
19. The most common indication for surgery secondary to acute diverticulitis is:
A. Abscess.
B. Colonic obstruction.
C. Colovesical fistula.
D. Free perforation.
E. Hemorrhage.
Answer:A
21. Which of the following statements about familial adenomatous polyposis (FAP)
is/are true?
A. Inherited in an autosomal-dominant manner, this genetic defect is of variable
penetrance, some patients having only a few polyps whereas others develop
thousands.
B. The phenotypic expression of the disease depends mostly on the genotype.
C. Appropriate surgical therapy includes total abdominal colectomy with ileorectal
anastomosis and ileoanal pull-through with rectal mucosectomy.
D. Panproctocolectomy with ileostomy is not appropriate therapy for this disease.
E. Pharmacologic management of this disease may be appropriate in some instances.
Answer: C
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22. Which of the following statements about the etiology of chronic ulcerative
colitis are true?
A. Ulcerative colitis is 50% less frequent in nonwhite than in white populations.
B. Psychosomatic factors play a major causative role in the development of ulcerative
colitis.
C. Cytokines are integrally involved in the pathogenesis of ulcerative colitis.
D. Ulcerative colitis has been identified with a greater frequency in family members
of patients with confirmed inflammatory bowel disease.
E. Ulcerative colitis is two to four times more common in Jewish than in non-Jewish
populations.
Answer: ACDE
23. Surgical alternatives for the treatment of ulcerative colitis include all of the
following except:
A. Colectomy with ileal pouch–anal anastomosis.
B. Left colectomy with colorectal anastomosis.
C. Proctocolectomy with Brooke ileostomy or continent ileostomy.
D. Subtotal colectomy with ileostomy and Hartmann closure of the rectum.
Answer: B
26. An 80-year-old man who has been bedridden for many years following a stroke
presents with acute onset of abdominal distention, obstipation, and colicky
abdominal pain. Abdominal x-rays reveal dilated loops of small bowel and a dilated
sigmoid colon resembling a bent inner tube. Examination reveals distention with
mild direct tenderness but no rigidity or rebound tenderness. Initial management
should consist of:
A. Barium enema examination.
B. Laparotomy with resection of descending colon and descending colostomy.
C. Multiple cleansing enemas to remove impacted feces.
D. Rigid sigmoidoscopy and decompression of the sigmoid colon.
Answer: D
27. Axial twisting of the right colon or cecal volvulus has been shown to be
associated with each of the following except:
A. A history of abdominal operation.
B. A mobile cecum.
C. An obstructing lesion in the transverse or left colon.
D. Inflammatory bowel disease.
Answer: D
28. Sigmoid volvulus has been associated with each of the following except:
A. Chronic constipation and laxative abuse.
B. Chronic rectal proplapse.
C. Chronic traumatic paralysis.
D. Medical management of Parkinson's disease.
Answer: B
29. Which of the following statements is not true about inhereted susceptibility to
colon cancer?
A. There is no known genetic susceptibility to colon cancer.
B. There are known genetic susceptibilities to colon cancer, but they are always
associated with multiple adenomatous polyps.
C. There are known genetic susceptibilities to colon cancer, but they are always
associated with specific ethnic or racial groups.
D. None of the above.
Answer: D
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32. Which of the following statement(s) is/are true about the maintenance of
continence?
A. It depends on both the internal and external sphincters as well as the puborectalis.
B. Resting pressure offers a high-pressure zone that increases resistance to the
passage of stools.
C. Maximal squeeze pressure can last no more than 1 minute.
Answer: ABC
34. Which of the following statements about hemorrhoids is/are not true?
A. Hemorrhoids are specialized “cushions” present in everyone that aid continence.
B. External hemorrhoids are covered by skin whereas internal hemorrhoids are
covered by mucosa.
C. Pain is often associated with uncomplicated hemorrhoids.
D. Hemorrhoidectomy is reserved for third- and fourth-degree hemorrhoids.
Answer: C
37. Which of the following statements regarding the vasculature of the colon and
rectum is/are correct?
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a. Acetylcholine
b. Substance P
c. Calcitonin gene-related peptide
d. Bradykinin
e. Somatostatin
Answer: b, c
39. How much of the daily insensible water loss is due to loss in stool?
a. 200 ml
b. 400 ml
c. 600 ml
d. 800 ml
e. 1000 ml
Answer: a
40. A 52-year-old woman is involved in an automobile accident and sustains an
open fracture of the fight femur, compression fractures of the 10th and 11th
thoracic vertebrae and right pulmonary contusion. On the fourth day after injury,
her abdomen is noted to be distended, tympanitic and diffusely tender. Abdominal
radiographs reveal gaseous distension of the ascending and transverse segments of
the colon. The cecum is 13 cm in greatest diameter. Appropriate management
includes which of the following as the next step?
a. Right hemicolectomy
b. Operative cecostomy
c. Colonoscopy
d. Contrast enema
e. Observation
Answer: c
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41. Which of the following features is/are consistent with a diagnosis of colonic
inertia?
42. Which of the following statements regarding the myenteric plexus of the colon
is/are correct?
a. The myenteric plexus is located between the longitudinal and circular layers of the
bowel wall
b. The myenteric plexus contains only sensory neurons
c. The density of neurons with the colonic plexuses decreases along the length of the
bowel
d. Neurons of the myenteric plexus control the motor function of the colon
Answer: a, c, d
a. Iridis
b. Uveitis
c. Retrobulbar neuritis
d. Ulcerative panophthalmitis
Answer: a, b, c
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44. Which of the following statements regarding the risk of cancer in the context
of ulcerative colitis is/are correct?
a. After 10 years of active disease, the risk of cancer approximates 20% to 30%
b. After 10 years of active disease, the risk of cancer approximates 2% to 3%
c. The risk of colon cancer in ulcerative colitis is identical to controls
d. After 20 years of disease activity, the risk of colon cancer approximates 80%
Answer: b
45. Which of the following features would be more consistent with Crohn’s disease
than with ulcerative colitis?
a. Transmural inflammation
b. Microscopic evidence of granulomas within mucosal biopsies
c. Microscopic evidence of submucosal thickening and fibrosis
d. Microscopic evidence of submucosal inflammation
Answer: a, b, c, d
a. Barium enema
b. Flexible sigmoidoscopy
c. Liver biopsy
d. Chest x-ray
Answer: b
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47. Which of the following statement(s) regarding ulcerative colitis is/are correct?
a. The most common age of onset for ulcerative colitis is in early adulthood
b. Approximately 25% of cases of ulcerative colitis occur after the age of 60
c. Males are affected approximately twice as frequently as females
d. Approximately 10% to 25% of patients with ulcerative colitis have first degree
relatives with the disease
Answer: a, d
48. Many patients with ulcerative colitis are operated upon electively with total
abdominal colectomy, rectal mucosectomy, formation of a small intestinal
reservoir, and ileoanal anastomosis. The most common postoperative complication
after this operation is which of the following?
a. Enterocutaneous fistula
b. Small bowel obstruction
c. Pulmonary embolism
d. Urinary retention
Answer: b
49. A 25-year-old woman with known ulcerative colitis presents to the emergency
room with a 24-hour history of abdominal pain, distention, and obstipation.
Physical examination reveals a temperature of 38.6° C, abdominal distention, and
diffuse abdominal tenderness. Abdominal x-rays show marked colonic dilatation,
most pronounced in the transverse colon. Laboratory examination reveals a white
blood count of 19,000/mm3. Over the first 24 hours of hospitalization, symptoms
are progressive in spite of intravenous fluid resuscitation, nasogastric suctioning,
and intravenous antibiotics. The most appropriate management for this patient
would include which of the following?
a. Decompressive colonoscopy
b. Proctocolectomy with formation of end ileostomy
c. Total abdominal colectomy with formation of Hartmann pouch and end ileostomy
d. Cecostomy
Answer: c
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51. One year following ileal pouch-anal anastomosis, the mean 24-hour stool
frequency is which of the following?
a. Two to three
b. Five to six
c. Eight to nine
d. Eleven to twelve
Answer: b
52. A 30-year-old male two years postoperative after total abdominal colectomy
with ileoanal anastomosis reports a sudden increase in stool frequency, nocturnal
leakage, and low-grade fevers. Physical examination is unremarkable. Flexible
endoscopic examination of the small intestinal pouch reveals a friable
erythematous mucosa. Biopsies of the mucosa are obtained. While awaiting biopsy
results, which of the following is the most appropriate empiric therapy?
a. Oral corticosteroids
b. Oral vancomycin
c. Oral metronidazole
d. Corticosteroid enema
Answer: c
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53. A 72-year-old man returns to the hospital 2 weeks following right hip
arthroplasty with complaints of 48 hours of mucoid diarrhea, fever, and crampy
abdominal pain. Physical examination reveals dehydration, diffuse abdominal
tenderness, and a temperature of 102°F. Outpatient medications have included
digoxin, propranolol, and cephalothin. If antibiotic-associated colitis is suspected,
which of the following is/are appropriate diagnostic tests?
54. For the patient in the preceding question, after obtaining diagnostic samples,
the most appropriate management would include which of the following?
a. Oral metronidazole
b. Intravenous metronidazole
c. Oral vancomycin
d. Intravenous vancomycin
e. Oral bacitracin
Answer: c
55. A 72-year-old woman undergoes anterior resection for a rectal cancer located
7 cm proximal to the anal verge. Pathologic examination of the resected specimen
reveals invasion of the tumor into the muscularis propria. Five of 8 lymph nodes
contain microscopic tumor. There is no evidence of disseminated disease.
Appropriate subsequent management includes which of the following?
56. Which of the following are tumor suppressor genes that have been associated
with the development of colorectal cancer?
57. Which of the following statement(s) is/are correct with regard to the use of
carcinoembryonic antigen (CEA) determinations in management of colorectal
cancer?
a. CEA determination has 95% specificity when used for screening for colon cancer
development in patients with ulcerative colitis
b. CEA levels are increased in 20% of patients with local recurrence after resectional
therapy
c. CEA measurements are increased in 90% of patients with disseminated disease
d. CEA levels are increased in 90% of patients with local recurrence after resectional
therapy
Answer: b, c
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59. Which of the following types of colonic polyps is associated with the highest
incidence of malignant degeneration?
a. Tubular adenoma
b. Tubulovillous adenoma
c. Villous adenoma
d. Hamartomatous polyp
Answer: c
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63. Which of the following statements with regard to resection of rectal cancers
is/are true?
64. A 58-year-old male undergoes resection of a Dukes C2 colon cancer via right
hemicolectomy. Three years postoperatively, rising CEA levels prompt evaluation
including abdominal computed tomography. Two lesions, each measuring 2 cm,
are noted in the right hepatic lobe. No other abnormalities are noted. A right
hepatic lobectomy is performed without complication. Which of the following most
closely approximates anticipated 5-year survival?
a. 85–90%
b. 65–70%
c. 45–50%
d. 25–30%
Answer: d
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a. Observation
b. Transanal excision
c. Low anterior resection
d. Abdominoperineal resection
Answer: b
67. For the patient in the preceding question, biopsy revealed an invasive
apocrine gland neoplasm. The deep margins included striated muscle infiltrated by
neoplastic cells. Appropriate management includes which of the following?
a. Primary radiation
b. Abdominoperineal resection with bilateral inguinal lymph node dissection
c. Abdominoperineal resection only
d. Carbon dioxide laser fulguration
Answer: c
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68. A 43-year-old woman presents with complaints of anal pain and spotting of
blood with defecation. Physical examination reveals a 2 3 cm area of ulceration
within the anal canal. The remainder of the physical examination is normal.
Incisional biopsy is positive for squamous cell carcinoma. Appropriate management
includes which of the following?
a. Abdominoperineal resection
b. Wide local excision, skin grafting, proximal diverting colostomy
c. Primary radiation therapy
d. Local excision and primary closure
Answer: c
70. An elderly man presents with complaints that he is passing gas with urination.
The past medical history is positive for one episode of diverticulitis, treated
medically, transurethral resection of the prostate for benign prostatic
hypertrophy, and diabetes. Which of the following diagnostic tests is most
appropriate initially?
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71. For the patient in the preceding question, a colovesical fistula originating from
the sigmoid colon is demonstrated. Colonoscopy reveals diverticula and excludes
carcinoma. During laparotomy, a thickened sigmoid colon is found to be adherent
to the dome of the bladder. A definite fistula is not observed. Appropriate
operative management includes which of the following?
72. A 65-year-old woman develops obstipation, lower abdominal pain, and fever.
Physical examination reveals a temperature of 38.5°C, left lower quadrant
tenderness, and an ill-defined lower abdominal mass. White blood count is 17,500
per mm3. Intravenous hydration, broad spectrum antibiotics, and analgesics are
ordered. After 48 hours, symptoms have not improved. Appropriate management
includes which of the following?
a. Barium enema
b. Computed tomography of the abdomen
c. Immediate laparotomy
d. Intravenous pyelogram
Answer: b
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73. Which of the following statement(s) relating to anal sphincteric function is/are
correct?
a. When the rectum is distended, the internal anal sphincter relaxes and the external
anal sphincter contracts
b. When the rectum is distended, the internal anal sphincter contracts and the
external anal sphincter relaxes
c. The external anal sphincter is responsible for resting anal pressure
d. The internal anal sphincter is responsible for resting anal pressure
Answer: a, d
a. Urinary retention
b. Rectal bleeding
c. Incontinence
d. Wound infection
Answer: a
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76. A 65-year-old man presents with complaints of mucous discharge and perianal
discomfort. Physical examination reveals a fistulous opening lateral to the anus.
Anoscopic examination permits passage of a probe through the fistula tract. The
fistula traverses the internal anal sphincter, the intersphincteric plane, and a
portion of the external anal sphincter. The fistula is categorized as which type?
a. Intersphincteric
b. Transsphincteric
c. Suprasphincteric
d. Extrasphincteric
Answer: b
77. For the patient in the preceding question, appropriate management includes
which of the following?
a. Division of the tissues over the probe with electrocautery, leaving the wound open
to heal by secondary intention
b. Division of the tissues over the probe with electrocautery, closing the wound using
a pedicled skin flap
c. Division of the internal anal sphincter using electrocautery, encircling the external
sphincter with a seton
d. Proximal diverting colostomy and antibiotics
Answer: c
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