ANTI DEPRESSANTS

SSRI (SELECTIVE SEROTININ REUPTAKE INHIBITOR)

GENERIC NAME SERTRALINE. CITALOPRAM: ESCITALOPRAM: FLUOXETINE: PAROXETINE:

BRAND NAME Zoloft, Lustral. Celexa, Citol, Citalon Lexapro, Cipralex, Prozac, Fludac Paxil, Pexeva,
Esipram Parotin

USUALLY, PESCRIBED Major depressive Depression. Major depressive Major depressive Major depressive
FOR disorder, Premenstrual disorder (ages 12 disorder (ages 8 and disorder
Premenstrual dysphoric disorder and older). older) Obsessive-
dysphoric disorder (PMDD). Generalized anxiety Obsessive- compulsive disorder
(PMDD). Panic Panic disorder disorder. compulsive disorder (OCD)
disorder, Obsessive- Panic disorder (OCD) (ages 7 and Social anxiety
posttraumatic stress compulsive disorder Obsessive- older) disorder (social
disorder (PTSD). (OCD) compulsive disorder Premenstrual phobia)
Social anxiety (OCD) dysphoric disorder Vasomotor
disorder (social Posttraumatic stress (PMDD) symptoms
phobia), obsessive- disorder (PTSD) Bulimia nervosa Posttraumatic stress
compulsive disorder Social anxiety Bipolar depression [ disorder (PTSD)
(OCD) disorder (social Posttraumatic stress Panic disorder
phobia) disorder (PTSD)

Depression: 20–50 mg
DOSAGES 50–200 mg/day 20–40 mg/day 10–20 mg/day 20–80 mg for (25–62.5 mg CR)
depression and Vasomotor symptoms:
anxiety disorders, 7.5 mg at bedtime
Anxiety disorders and
60–80 mg for bulimia
OCD: 10–60 mg/day
(12.5–75 mg CR)
 Children: Children: Children: Children Children dizziness,
SIDE EFFECTS Constipation, Constipation, increased thirst, Appetite changes insomnia, tremor,
diarrhea, stomach diarrhea, yawning, abnormal increase in (increase or nervousness, nausea,
pain, upset stomach, sleep trouble, muscle movement or decrease), decreased appetite,
throwing up, or shakiness and signs agitation. Gastrointestinal constipation, dry
decreased appetite. of common cold. Nosebleeds and symptoms (e.g., mouth and sweating.
Adults: Nausea, Adults: Nausea, dry trouble urinating. nausea, upset Adults: nervousness,
diarrhea, dizziness, mouth, drowsiness, Adults: Nausea, dry stomach, and weakness, height
sexual dysfunction, sexual dysfunction, mouth, drowsiness, diarrhea), gain, higher risk of
dry mouth, increased increased sweating. sexual dysfunction, Restlessness and bleeding and nausea.
sweating. Pregnant women: increased sweating sleep changes.
Pregnant women: Premature birth, and weight changes and Adults: nervousness, Pregnant women:
Fetal growth Low birth weight, heavy menstrual anxiety, heartburn, might affect the
problems, Premature Older Adults: periods. dry mouth, yawning development of
birth, Low birth bleeding, loss of Pregnant women: and nausea. baby’s heart.
weight, Postpartum coordination, and QT Premature birth, and Pregnant women:
complications in the prolongation and Low birth weight, acute increase in Older Adults vison
parent. hyponatremia. Older Adults: plasma serotonin changes, weakness,
Older Adults: Nausea, dry mouth, levels. tiredness, infection,
Increased risk of trouble sleeping, Older Adults, risk of dry mouth and
falls, hyponatremia, constipation, falling, bleeding and infection.
potential drug tiredness, loss of coordination.
interactions drowsiness,
dizziness, and
increased sweating
 SNRI (SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITOR)

GENERIC NAME VENLAFAXINE DULOXETINE DESVENLAFAXINE MILNACIPRAN LEVOMILNACIPRAN:

BRAND NAME Effexor, Effexor XR. Cymbalta Pristiq, Desfax Savella Fetzima

USUALLY, PESCRIBED Depression Major depressive Major depressive Major depressive Major depressive
FOR Generalized anxiety disorder disorder disorder disorder
disorder. (GAD) Diabetic peripheral Vasomotor Neuropathic Neuropathic
Premenstrual neuropathic pain symptoms pain/chronic pain pain/chronic pain
dysphoric disorder (DPNP) Generalized anxiety Fibromyalgia Fibromyalgia
(PMDD). Fibromyalgia disorder (GAD)
Panic disorder Generalized anxiety Fibromyalgia
Posttraumatic stress disorder, acute and Panic disorder
disorder (PTSD). maintenance Premenstrual
Social anxiety Chronic dysphoric disorder
disorder (social musculoskeletal pain (PMDD)
phobia) Stress urinary
incontinence
40–60 mg/day in 1–2
DOSAGES Depression: 75–225 doses for depression Depression: 50 mg 30–200 mg/day in 2 40–120 mg once daily.
mg/day, once daily 60 mg once daily for once daily doses
(extended-release) or diabetic peripheral
divided into 2–3 neuropathic pain and
doses (immediate- fibromyalgia
release) 60 mg once daily for
GAD: 150–225 generalized anxiety
mg/day disorder
 Children: Children: Children Children Children Not
SIDE EFFECTS confusion, Fatigue, nausea, Not typically used in Not typically used in typically used in
hallucinations, fever, weight loss, children. children. children.
a fast or abnormal xerostomia, Adults: Nausea, Adults racing
heartbeat, muscle abdominal pain headache, dizziness, heartbeat, high or Adults racing
twitching or Adults: difficult insomnia, sweating. low blood pressure, heartbeat,
stiffness; seizures; sleeping, dry mouth Pregnant women nausea, vomiting, Hyperhidrosis,
shivering or shaking. vomiting and preterm birth, neo and flushing Erectile dysfunction,
Adults: Nausea, hot headaches. natal complications Pregnant women high or low blood
flushes, dizziness, Pregnant women and withdrawal not usually pressure, nausea,
sleepy, constipation difficult sleeping, symptoms. prescribed in vomiting, and
and dry mouth. blurred vision, Older Adults pregnancy. flushing
Pregnant women constipation, Increased risk of Older Adults
jitteriness, increased diarrhea, feeling falls, hyponatremia, Increased risk of Pregnant women
muscle tone, dizzy. serotonin syndrome. hypertension, not usually
irritability, changes in Older Adults urinary retention. prescribed in
sleep patterns, bleeding, dizziness, pregnancy.
tremors, trouble light-headedness, or
eating, and problems loss of coordination. Older Adults
with breathing. Increased risk of
Older Adults: hypertension,
Increased risk of urinary retention
falls, dizziness,
hyponatremia (low
blood sodium levels)
 TCA (TRICYCLIC ANTIDEPRESSANT)

GENERIC NAME AMITRIPTYLINE IMIPRAMINE: NORTRIPTYLINE DOXEPIN CLOMIPRAMINE

BRAND NAME Elavil, Tryptanol Tofranil Pamelor, Aventyl Sinequan Anafranil

USUALLY, PESCRIBED Depression Depression Major depressive Psychoneurotic Obsessive

FOR Endogenous Enuresis Anxiety disorder patient with compulsive disorder
depression Insomnia. Anxiety depression and/or Anxiety
Neuropathic Neuropathic Insomnia. anxiety Depression
pain/chronic pain pain/chronic pain Neuropathic Depression and/or Insomnia
Fibromyalgia Treatment-resistant pain/chronic pain anxiety associated Neuropathic
Headache depression Treatment-resistant with alcoholism pain/chronic pain
Low back pain/neck Cataplexy syndrome depression Psychotic depressive Severe and
pain disorders with Treatment-resistant
Anxiety associated anxiety depression
Insomnia. Depression and/or Cataplexy syndrome
anxiety associated
with organic disease
Manic-depressive
disorder

DOSAGES 50–150 mg/day 50–150 mg/day 75–150 mg/day once 75–150 mg/day for 100–200 mg/day
daily or in up to 4
depression
divided doses (for
depression) 3–6 mg at bedtime
50–150 mg/day (for for insomnia
chronic pain)
 Children Children: Children: Children Children agitation,
SIDE EFFECTS Not typically used in Not typically used in Nortriptyline is Feeling dizzy, sleepy, change in balance,
children. children generally not tired, or weak, dry confusion,
Adults: Dry mouth, Adults: Dry mouth, recommended for mouth and change in hallucinations, fever,
constipation, blurred weight gain, seizures, use in children due taste. a fast or abnormal
vision, drowsiness, sexual dysfunction, to the potential for Adults: nausea, heartbeat, flushing,
weight gain sweating serious side effects increase in pupil size, muscle twitching or
Pregnant women Pregnant women: and limited evidence mouth sores, stiffness, shivering or
withdrawal during not suitable during of its safety and vomiting Dry mouth, shaking, sweating a
the last trimester of pregnancy., efficacy in this age and tiredness. lot, upset stomach,
pregnancy. Older Adults: group. Pregnant women: or very bad
Older Adults Increased risk of Adults: Dry mouth, preterm delivery headache
increased risk of falls, urinary weight gain, seizures, (birth before week Adults: decreased
falls, cognitive retention, cognitive sexual dysfunction, 37) or low birth sexual ability,
impairment, impairment sweating and Severe weight (weighing less drowsiness,
sedation. dizziness or fainting than 5 pounds vomiting,
Pregnant women: Older Adults constipation and
not suitable during dizziness, nervousness.
pregnancy drowsiness, Pregnant women:
Older Adults: confusion, difficulty risk of your baby
dizziness, confusion, urinating. developing heart
and falls defects, spina bifida
or cleft lip
Older Adults
stomach upset,
nausea, vomiting,
changes in
appetite/weight,
flushing, sweating,
tiredness and blurred
vision
 MAOI (MONOAMINE OXIDASE INHIBITOR)

GENERIC NAME PHENELZINE TRANYLCYPROMINE ISOCARBOXAZID SELEGILINE Moclobemide

BRAND NAME Nardil Parnate Marplan Emsam, Eldepryl Aurorix Arima

USUALLY, PESCRIBED Depressed patients Major depressive Depression Major depressive Depression
FOR characterized as episode without Treatment-resistant disorder Social anxiety
“atypical,” melancholia depression Parkinson’s disease disorder
“nonendogenous,” Treatment-resistant Treatment-resistant or symptomatic
or “neurotic” depression panic disorder parkinsonism(oral)
Treatment-resistant Treatment-resistant Treatment-resistant Alzheimer disease
depression panic disorder social anxiety and other dementias
Treatment-resistant Treatment-resistant disorder Treatment-resistant
panic disorder social anxiety depression
Treatment-resistant disorder panic disorder
social anxiety Treatment-resistant
disorder anxiety disorder
Social anxiety
disorder

Depression 6 mg/24
DOSAGES 45–75 mg/day 30–50 mg/day in 40–60 mg/day hours–12 mg/24 hours
300–600 mg/day
divided doses
Parkinson’s
disease/Alzheimer
disease: 5–10 mg/day
 Children Children: Children: Children Children not
SIDE EFFECTS agitation, change in dizziness, constipation, dry not recommended recommended for
balance, confusion, drowsiness, mouth and nausea for children below 18 use in children and
hallucinations, fever, constipation, dry Adults extreme years. adolescents less than
a fast or abnormal mouth and feeling tiredness, Adults: dizziness, 18 years of age
heartbeat, flushing, shaky or excited forgetfulness, light headed, Adults: : Fast or
muscle twitching or Adults irritability, frequent, painful, or fainting, dry mouth, racing heartbeat,
stiffness. abnormal behavior difficult urination nausea and vomiting pounding or irregular
Adults: drowsiness, and suicidal thoughts Pregnant women: Pregnant women: heartbeat, neck
dizziness, weight Pregnant women: sudden and severe flu-like symptoms stiffness
gain and weakness increased risk of headache, rapid such as sweating, Pregnant women:
Pregnant women congenital heartbeat, stiffness chills, nausea, and not generally not
increased risk of abnormalities with in your neck, nausea, headaches, as well as recommended
congenital antidepressant use vomiting, cold sweat, anxiety, agitation, during pregnancy.
abnormalities with during pregnancy as vision problems, and trouble sleeping Older Adults severe
antidepressant use well as an increase in sensitivity to light, Older Adults high or throbbing headache
during pregnancy as pre-term delivery. swelling and rapid low blood pressure, which starts at the
well as an increase in Older Adults: dry weight gain orthostatic back of the head and
pre-term delivery. mouth, headaches, Older Adults: hypotension, radiates forward,
Older Adults cold diarrhea, urinary Dizziness, unusual drowsiness slow heartbeat.
sweats, dizziness, hesitancy, insomnia, drowsiness,
faintness, or light- agitation, anxiety, tiredness, weakness,
headedness when nausea, and sexual problems sleeping,
getting up from a dysfunction constipation, and dry
lying or sitting mouth may occur.
position. overactive
reflexes and
shakiness in the legs,
arms, hands, or feet.
.