Total No. of Questions : 3] SEAT No.
P-1409 [Total No. of Pages : 2
[6019]-8011
Final Year B. Pharmacy
BP 801T : BIOSTATISTICS AND RESEARCH
METHODOLOGY
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Neat labeled diagrams must be drawn wherever necessary.
3) Figures to the right indicate full marks.
Q1) Answer the following (Any Five) : [15]
a) Explain different types of errors in hypothesis testing.
b) Discuss in brief about Mean as a measure of central tendency.
c) What is the need for research design?
d) Enumerate the steps needed to condense raw data to grouped data.
e) What is 23 factorial design?
f) Weights of 10 tablets in mg in a sample data are 210, 212, 215, 220, 224,
215, 218, 220, 225 and 221. Find out the sample mean.
g) A first aid box contains 20 tablets of Paracetamol and 10 tablets of
Aspirin. What is the probability of picking a Aspirin tablet from the box?
Q2) Answer the following (Any Two) : [20]
a) Discuss about designing of clinical trials and phases of clinical trials.
b) What is hypothesis testing? Explain in detail the procedure for hypothesis
testing.
c) What is optimization? Explain principle and steps involved in experimental
design.
d) What is statistical data? Explain in detail about collection, organization
and presentation of data.
P.T.O.
Q3) Answer the following (Any Eight) : [40]
a) Define statistics. Write applications of statistics.
b) Enlist the steps for constructing a frequency distribution.
c) Write about Pie chart.
d) Explain in brief about ANOVA.
e) Write note on MINITAB.
f) Write short note on Central Composite Design.
g) Write a note on Plagiarism.
h) What is statistical data? Explain in brief about types of data.
i) Write a note on 'Student's test'.
j) Find the mean, median and mode for the following data for weight of 12
tablets in mg :
X : 500, 520, 530, 540, 540, 520, 500, 550, 530, 540, 550, 560.
▽▽▽▽
[6019]-8011 2
Total No. of Questions : 3] SEAT No. :
P-1464 [Total No. of Pages : 2
[6019]-8012
Final Year B. Pharmacy
SOCIAL AND PREVENTIVE PHARMACY
(2019 Pattern) (Semester - VIII) (BP802T)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) Neat diagrams must be drawn wherever necessary.
2) Figures to the right indicate full marks.
Q1) Answer any five (05 out of 07) : [15]
a) What is Marasmus?
b) Explain community services for health promotion.
c) Explain Prevention and control of deafness.
d) Write significance of Health education in schools.
e) Write the objectives of National Tuberculosis Programme
f) What is Cholera? Write the measures for prevention of it.
g) Explain the methods for diagnosis of Diabetes mellitus?
Q2) Answer any Two. (02 out of 04) : [20]
a) Elaborate on need of nutrition and balanced diet. Explain the causes,
and symptoms of malnutrition and its prevention.
b) Explain prevention and control of Cancer.
c) Explain Integrated disease surveillance programme (IDSP).
d) What is SARS write its symptoms, prevention and control.
P.T.O.
Q3) Answer any eight. (08 out of 10) [40]
a) What is influenza? Write its prevention and control.
b) Explain prevention, and control of hypertension.
c) What are the Socio cultural factors related to health and disease
d) What is chicken guinea? Explain its treatment and prevention
e) What are the objectives of the national family welfare program?
f) Explain measures for improvement in rural sanitation.
g) Write a note on drug addiction and drug substance abuse
h) Write a note on relation of nutrition and health.
i) Write objectives and implementation of the national tobacco control
program.
j) Define diabetes. Write its treatment and management
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[6019]-8012 2
Total No. of Questions : 3] SEAT No. :
P-891 [Total No. of Pages : 2
[6019]-8013
F.Y. B. Pharmacy
BP803ET : PHARMA MARKETING MANAGEMENT
THEORY
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates :
1) All questions are compulsory.
2) Neat labeled diagram must be drawn wherever necessary.
3) Figures to the right indicate full marks.
Q1) Answer all the questions (Objectives) (Any 5 out of 7) : [5 × 3 = 15]
a) Discuss the consumer buying behavior in marketing.
b) Demonstrate product life cycle.
c) Enumerate the factors to be considered for new product decisions.
d) What are the role & responsibilities of Professional sales representative?
e) Describe various ways of marketing a product.
f) Correlate the factors affecting product pricing strategy.
g) Write about designing pharmaceutical marketing channels.
Q2) Long Answers (Any 2 out of 4) : [2 × 10 = 20]
a) Explain with examples launching of new product.
b) Describe the ways and means of marketing segmentation &.targeting.
c) What are different methods and determinants of promotional mix.
d) Discuss in detail Primary and Secondary research state their importance.
P.T.O.
Q3) Short Answers (Any 8 out of 10) : [8 × 5 = 40]
a) Write about the role of market research.
b) Discuss about factors regulating patient choice of physician.
c) Write a note methods of determining budget for promotional
expenditure.
d) Discuss on OTC marketing strategies.
e) Write in detail about conflicts in channels.
f) Explain the objectives and importance of pricing.
g) Address the issues in price management in pharmaceutical industry.
h) Elaborate on importance of rural marketing.
i) Describe the role of DPCO.
j) Explain the need & importance of e-detailing.
[6019]-8013 2
Total No. of Questions : 3] SEAT No. :
P892 [Total No. of Pages : 2
[6019]-8014
Fourth Year B.Pharmacy
PHARMACEUTICAL REGULATORY SCIENCE
(2019 Pattern) (Semester-VIII) (BP804ET)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Figures to the right indicate full marks.
3) Draw well labeled diagram whenever necessary.
Q1) Answer the following (any 5 out of 7) [5×3=15]
a) What is clinical trial?
b) Explain the purple book.
c) What is CTD? (Common Technical Documents)
d) Explain about generic drug.
e) Explain the role of regulatory affairs professionals.
f) Explain federal register.
g) What are the stages of drug discovery.
Q2) Answer the following (Any 2 out of 4) [2×10=20]
a) Explain registration process for new drug approval in India.
b) What is NDA and ANDA? Give approval process and timeline involved
in investigational new drug IND.
c) Explain organization structure and application of regulatory authorites of
US.
d) Explain procedure for development of protocol.
[6019]-8014 1 P.T.O.
Q3) Answer the following (Any 8 out of 10) [8×5=40]
a) What is orange book? Give its application.
b) Write a note on DMF? (Drug Master File).
c) Summarize ASEAN (ACTD) research.
d) Give brief overview of guidelines for the export of drug issued by minis-
try of health and Family Welfare.
e) Explain preclinical studies and non-clinical activities in drug development.
f) Explain regulatory authority in Japan.
g) Explain clinical trial protocol.
h) Give brief account on electronic common technical document.
i) Explain procedure of GCP of investigators, sponsors, and monitors.
j) Explain import and export of pharmaceutical products in detail.
[6019]-8014 2
Total No. of Questions : 3] SEAT No. :
P-893 [Total No. of Pages : 2
[6019]-8015
Final Year B. Pharmacy
BP805ET : PHARMACOVIGILANCE
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Figures to the right indicate full marks.
Q1) Solve any FIVE : [5 × 3 = 15]
a) Write a note on cohort study.
b) Define serious adverse event, side effect and adverse event.
c) Enlist steps involved in vaccine pharmacovigilance.
d) What is the role of post approval phase?
e) Write about the importance of safety monitoring of medicines.
f) What is under reporting of ADRs?
g) What is periodic safety update reports?
Q2) Solve any TWO : [2 × 10 = 20]
a) Define pharmacovigilance. Discuss in detail reporting and management
of ADRs along with causality assessment scales.
b) Discuss in detail the drug information sources and give specialized
resources for ADR.
c) Discuss in detail about ICH and GCP guidelines in Pharmacovigilance.
d) What are different pharmacovigilance methods? Explain in detail
different types of pharmacovigilance methods used for passive and
active surveillance.
P.T.O.
Q3) Solve any EIGHT : [8 × 5 = 40]
a) Write a importance of Communication in pharmacovigilance.
b) Write the role of pre-clinical and clinical phase in safety data generation.
c) Write a note on Schedule Y.
d) Explain Narinjo scale.
e) Explain Vaccine safety surveillance.
f) Write a short note on ICH guidelines
g) Discuss WHO drug dictionary and coding in pharmacovigilance.
h) Write a short note on WHO causality assessment.
i) Discuss adverse effects after immunization.
j) What is the role of preclinical and clinical phase in safety data
generation?
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[6019]-8015 2
Total No. of Questions : 3]
SEAT No. :
P894 [6019] - 8016
[Total No. of Pages : 2
Fourth Year B. Pharmacy
QUALITY CONTROL AND STANDARDIZATIONS OF HERBALS
(2019 Pattern) (Semester - VIII) (Theory) (BP806ET)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Figures to the right indicates full marks.
3) Draw well labelled diagram whenever necessary.
Q1) Solve the following. (Answer 5 out of 7) [5x3=15]
a) Brief physical evaluation of crude drugs.
b) Write about ‘personnel’ from GACP.
c) Write in short ‘Record of market complaints’ as per schedule T.
d) Note on biological evaluation of crude drugs.
e) What are basic tests for identification in herbal dosage forms.
f) Note on ‘Foaming Index’as per WHO for quality control of crude drugs.
g) Write in short ‘Stores’ as per schedule T.
Q2) Solve long answers (Answer 2 out of 4) [2x10=20]
a) Write in detail research guideline for evaluating safety of herbal drugs.
b) Elaborate list of recommended machinery, equipment and space
requirement of premises required for manufacturing of herbal medicines
as per schedule T.
c) Explain stability testing of herbal drugs in detail.
d) Write in detail regulatory requirement for herbal medicines.
P.T.O.
Q3) Solve Short answers (Answer 8 out of 10) [8x5=40]
a) What are post harvesting processing as per GACP?
b) Brief parameters of quality control of herbal drugs as per EU guidelines.
c) Write about cultivation parameter as per GAP for medicinal plants.
d) Write a note on comparison of monograph studies of herbals in Indian
Herbal pharmacopoeia and American herbal pharmacopoeia.
e) Brief safety in laboratories as per GLP.
f) Explain application of TLC & HPTLC for standardization of herbals.
g) Write ICH guidelines for quality control of herbal drugs.
h) Explain WHO guidelines on safety monitoring of herbal medicines in
pharmacovigilance systems.
i) Write in detail about various types of licensing forms needed for herbal
drug industry for regulation aspects under D & C Act.
j) Discuss on preparation of documents for new drug application.
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[6019] - 8016 2
Total No. of Questions : 3] SEAT No. :
P3162 [Total No. of Pages : 2
[6019]-8017A
Fourth Year B.Pharmacy
COMPUTER AIDED DRUG DESIGN
(2019 Pattern) (Semester-VIII) (BP807ET) (Theory)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Figures to the right indicate full marks.
Q1) Objective types questions (Answer 5 out of 7) [5×3=15]
a) Write a note on Taft steric constant,
b) Write a note on Lipinski Rule of 5.
c) Compare SAR and QSAR.
d) Write a note on chemoinformatics in the drug discovery process.
e) Define Bioinformatics. Mention applications of bioinformatics.
f) Discuss the role of molecular and quantum mechanics in drug discovery
g) Applications of QSAR.
Q2) Long answer (Answer 2 out of 4) [2×10=20]
a) What is QSAR? Explain in detail the history and development of QSAR
Explain the Hansch analysis and Free Wilson analysis and the relation-
ship between them.
b) What do you mean by Drug Discovery & Development? Explain various
steps & approaches to lead discovery.
c) Explain in detail Ligand -based & Structure-based drug design by taking
suitable examples.
d) What is Molecular docking? Enlist various types of Molecular docking
and explain any one of them. Write a note on the concept of Virtual
screening.
[6019]-8017A 1 P.T.O.
Q3) Short answers (Answer 8 out of 10) [8×5=40]
a) Write a note on molecular mechanics.
b) Classify the bio-isosterism approach with examples. Discuss of
bioisosteric replacement strategy with one case study.
c) Discuss various databases used in drug design and discovery.
d) Explain in detail Quantum mechanics.
e) Physicochemical parameters involved in QSAR.
f) Write a note on databases used in bioinformatics.
g) Discuss COMFA & COMSIA.
h) Explain different methods in the determination of energy minimization.
i) Write a note on docking and explain about docking-based virtual screening.
j) 2D-QSAR
[6019]-8017A 2
Total No. of Questions : 3] SEAT No. :
P-895 [Total No. of Pages : 2
[6019]-8018
Final Year B. Pharmacy
BP-808ET : CELL AND MOLECULAR BIOLOGY
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Figures to the right indicate full marks.
2) Draw well labeled diagrams wherever necessary.
Q1) Attempt any Five : [15]
a) Write functions of cell membrane
b) Define the term meiosis
c) What do you mean by catabolism
d) Elaborate cell adaptation
e) Explain the structure of protein
f) Draw double helical structure of DNA
g) Write the types of RNA
Q2) Attempt any Two : [20]
a) Write different types of receptors. Describe G-Protein coupled receptor
in detail.
b) What are the different steps involved in translation process?
c) What is cell signaling? Explain the mechanism of cell signaling in
detail.
d) Discuss cellular reproduction process in ova and sperm formation.
P.T.O.
Q3) Attempt any Eight : [40]
a) What are the steps of GPCR signal transduction pathway?
b) What are the different checkpoints in the cell cycle?
c) What are the applications of proteomics in disease?
d) Define cell organelles and write its functions.
e) What is the mechanism of DNA replication in eukaryotes?
f) Explain the principles of gene expression?
g) What means by meiosis? What are the four process of meiosis?
h) Why is it important to regulate protein synthesis?
i) What is the division of somatic cells to form gametes?
j) Write the functions of GPCRs?
[6019]-8018 2
Total No. of Questions : 3] SEAT No. :
P-1465 [Total No. of Pages : 2
[6019]-8019
Final Year B. Pharmacy
BP809ET : COSMETIC SCIENCE
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Neat labeled diagrams must be drawn wherever necessary.
3) Figures to the right indicate full marks.
Q1) Attempt any five out of seven of the following : [15]
a) Discuss the formulation of Hair oils.
b) Compare antiperspirants and deodorants.
c) Define SPF, Give Classification of sunscreen.
d) Discuss the causes for the hair fall.
e) Discuss the role of antioxidants in cosmetic products.
f) Explain the role of fluoride in toothpaste formulations and its benefits
for dental health.
g) Discuss applications of Amla in hair care.
Q2) Answer any two out of four of the following. [20]
a) Define cosmetics and cosmeceuticals and outline their classification.
b) Discuss the cosmetic problems for skin and add a note on products
prepared to address these problems.
c) Discuss the forniulation aspects of oral care products.
d) Discuss in detail formulation aspects of antidandruff shampoo and add
a note on its evaluation.
P.T.O.
Q3) Answer in brief on any eight of the following. [40]
a) What are the different types ofsurfactants used in cosmetic formulations?
Discuss the examples and function of each type.
b) Write a note on formulation aspects of mouthwash.
c) Discuss the analytical methods for toothpaste.
d) Discuss in detail BIS Specifications and analytical methods for skin
cream.
e) Explain the role of polymers and thickeners in cosmetics.
f) Write a note on evaluation of sunscreen products.
g) Describe the formulation and manufcturing process of a hair dye
product.
h) Write a note on neem and clove in oral care products.
i) Write a note on soap and syndet bars.
j) Write in brief about formulation of hair conditioners.
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[6019]-8019 2
Total No. of Questions : 3] SEAT No. :
P-896 [Total No. of Pages : 2
[6019]-8020
Final Year B. Pharmacy
BP810ET : EXPERIMENTAL PHARMACOLOGY
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Draw neat and well labelled diagram wherever necessary.
3) Figures to the right side indicate full marks.
Q1) Solve any Five out of seven questions : [15]
a) Explain principle and working of Eddy's hot plate method for
evaluation of analgesic activity.
b) Discuss animal models for evaluation of nootropic activity.
c) Explain the principle of screening methods for anti-dyslipidemic drugs
.
d) Elucidate 3 'R' principles of CPCSEA.
e) Enlist the methods and discuss any one method for evaluation of skeletal
muscle relaxant activity.
f) Define epilepsy and explain evaluation of anti-epileptic activity in
experimental animals.
g) Discuss euthanasia techniques for laboratory animals.
Q2) Solve any Two out of Four : [20]
a) Discuss the evaluation of anti-diabetic activity in laboratory animals.
b) Explain preclinical evaluation of anti-hypertensive activity.
c) Describe preclinical methods for evaluation of anti-ulcer activity.
d) Elucidate evaluation of anti-depressant activity of compound in
experimental animal.
P.T.O.
Q3) Solve any Eight out of Ten : [40]
a) Explain preclinical data analysis using students 't' test.
b) Describe acute oral toxicity as per OECD guidelines.
c) Explain evaluation of sympatholytic activity in experimental animals.
d) Discuss preclinical screening of coagulants.
e) Explain preclinical evaluation of sedative and hypnotics.
f) Discuss evaluation of anti-inflammatory activity.
g) Discuss any two methods for screening anti-arrythmic drugs.
h) Explain evaluation of local anesthetics in experimental animals.
i) Discuss methods for making transgenic animals.
j) Explain screening methods for anti-pyretic activity.
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[6019]-8020 2
Total No. of Questions : 3] SEAT No. :
P-3375 [Total No. Of Pages : 2
[6019]-8021
Final Year B.Pharmacy
BP811ET: ADVANCED INSTRUMENTATION
TECHNIQUES
(Semester-VIII) (2019 Pattern)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates :
1) All questions are compulsory.
2) Figures to the right indicate full marks.
3) Draw well labelled diagrams wherever necessary.
4) Do not write anything on question paper except seat number.
Q1) Answer following questions (Any Five) : [15]
a) What is Chemical Shift? How it is measured?
b) Explain Spin-Spin splitting rule with reference to NMR.
c) Enlist names of matrix used in MALDI along with their functions.
d) How system Precision is evaluated for calibration of HPLC?
e) Discuss procedure to evaluate accuracy of Electronic balance.
f) What are applications of Thermogravimetric Analysis?
g) Differentiate between Proton NMR and 13C NMR
P. T. O
Q2) Answer following questions in detail (Any Two) : [20]
a) Discuss exhaustively on RIA with its applications.
b) Suggest suitable chemical structure for following spectroscopic data:
Molecular Formula C7H5N
IR : 3100 cm-1, 2200 cm-1, 1600 cm-1, 1400 cm-1
Proton NMR: 7.2 (m, 5H)
Mass (m/z): 103,77
c) Give an exhaustive account of Differential Thermal Analysis.
d) Write in detail about different components of Mass Spectrophotometer.
Q3) Write short notes on following (Any Eight) : [40]
a) Time of Flight Mass Analyzer
b) LC-MS
c) Differential Scanning Calorimetry
d) Calibration of UV Spectrophotometer
e) Solid Phase Extraction
f) Fragmentation pattern in Alcohols
g) Gel Electrophoresis
h) Chemical Ionization
13
i) C NMR
j) Powder Crystal method
[6019]-8021 2
Total No. of Questions : 3] SEAT No. :
P897 [Total No. of Pages : 2
[6019]-8022
Fourth Year.B.Pharmacy
BP812ET : DIETARY SUPPLEMENTS & NUTRACEUTICALS
(2019 Pattern) (Semester - VIII)
Time : 3 Hours] [Max. Marks : 75
Instructions to the candidates:
1) All questions are compulsory.
2) Neat labelled diagrams must be drawn wherever necessary.
3) Figures to the right indicate full marks.
Q1) Objective Type Questions (Answer 5 out of 7) [5×3=15]
a) What food standards does AGMARK specify?
b) What are reactive oxygen species? Give examples.
c) What are complex carbohydrates? Give examples.
d) Enlist factors that reduce endogenous antioxidant enzymes.
e) Write health benefits of Xanthophylls.
f) Define functional foods. Give examples.
g) List out nutraceuticals for child health.
Q2) Long Answers (Any 2 out of 4) [2×10=20]
a) Define Functional foods and Classify Nutraceuticals. Explain in detail the
significance of Nutraceuticals in prevention & management of heart disease
and hypertension.
b) Explain in detail the role of free radicals in Diabetes. Comment on the role
of - Lipoic acid and tocopherol in management of free radicals.
c) Explain in detail the GMP in manufacturing of nutraceuticals and food.
d) Explain in detail the regulation of FSSAI and FDA.
[6019]-8022 1 P.T.O.
Q3) Short Answers (Any 8 out of 10) [8×5=40]
a) Explain the biological source, phytoconstituents and medicinal benefits
of Flaxseed.
b) Add a note on Biological Source, chemical composition and medicinal
application of Sea foods.
c) Explain in detail the damaging effects of free radicals on protein.
d) Role of free radicals in causing Diabetes.
e) Explain the documents and requirements for obtaining FDA approval.
f) Add a note on Biological Source, chemical composition and medicinal
application of Lycopene and Lutein.
g) Explain the biological source, phytoconstituents and medicinal benefits
of Soybean.
h) Explain in detail the damaging effects of free radicals on Lipids.
i) Comment on the role and concentration of BHT and BHA in food
products.
j) Significance and Role of minerals as functional food.
[6019]-8022 2
