1-M.B.B.S.

: SUMMER 2020
SUBJECT: BIOCHEMISTRY -I
Time 2.00 pm to 4.00 pm
Day Saturday Max. Marks 50
Date 24/10/2020
N.B.
1) Attempt ANY FIVE questions.
to the RIGHT indicate FULL
marks.
2) Figures
WHEREVER necessary.
3) Draw neat and labelled diagrams

and therapeutic importance of (10)

Q.1 Define enzymes. Discuss analytical diagnostic
on isoenzymes.
enzymes. Add a note

chain. Add a note on oxidative (10)

Q.2 Describe the components of Electron transport
phosphorylation.

Deseribe the sources, recommended daily

allowance (RDA), synthesis, (10)
Q.3 of Vitamin C.
manifestations
biochemical functions and deficiency

Write notes ANY TWO:

on
(10)
Q.4
a) Amphibolic role of TCA cycle
b) Lipoproteins
c) Phase II reactions of detoxification

Write notes on ANY TWO

(10)
Q.5
a) Free radicals and role of antioxidants.
b) Ketogenesis
c) Clearance tests

Write notes on ANY TWO: (10)

Q.6
a) Homopolysaccharides
tests based on excretory function
b) Liver function
c) Carcinogens
 1- M.B.B.S.: SUMMER 2020
SUBJECT: BIOCHEMISTRY PAPER - II
Time 2:00 p.m. to 4:00 p.m.
Day Monday Max. Marks: 50
Date 26/10/2020

N.B.
Attempt any FIVE questions out of SIX questions.

2) Figures to the right indicate FULL marks.

Draw neat diagrams WHEREVER necessary.
3)

Describe in detail formation and fates of ammonia. Add a note on Uremia (10)
Q.1

Discuss in detail steps of recombinant DNA technology. Add a note on (10)

Q,2
applicationsof recombinant DNA technology in medicine.

Describe synthesis and degradation of haemoglobin. Add a note on (10)

Q.3
bilirubin excretion.

Q.4 Write short notes on ANY TWO of the following: (10)

a) Genetic code
b) Applications of radioisotopes in medicine
c) Flame photometry

Q.5 Write short notes on ANY TWO of the following: (10)

a) Trace elements

b) Biologically important free nucleotides

c) Metabolic changes in late phase of starvation

Q.6 Write short notes on ANY TWO of the following: (10)

a) Blood buffers
b) Abnormal hemoglobins
Regulation of water and electrolyte balance
c)
 M.B.B.S PHASE - I (2019 NEW CURRICULUM) : SUMMER-2020
I
: BIOCHEMISTRY PAPER
-

SUBJECT

Time 1.30 p.m. to 4.30 p.m.

Day Saturday Max. Marks: 100
Date 23/01/2021

N.B.
All questions are COMPULSORY.
1)
sheet will be collected at the
2) Section- A : MCQs. Question paper and OMR
END OF FIRST 30 MINUTES.
SEPARATE answer sheets.
3) Section B and Section C should be written on
4) Draw NEAT and CLEAN DIAGRAMS wherever necessary.
5) Figures to the right indicate FULL marks.

SECTION-A (1x20-20)
Q.1 Multiple Choice Questions : Separate Question Paper

SECTION-B

TWO out of THREE) (2x10-20)

Q.2 Long Answer Questions (Attempt any
Give an outline of Hexose Mono Phosphate shunt
with its (3+4+3)
a)
significance. Add a note on Glucose 6 Phosphate
Dehydrogenase (G6PD) deficiency.
inhibition with its (3+5+2)
b) Explain the mechanism of competitive
suitable clinical applications. Add a note on suicidal inhibition.
(1+1+1+4+3)
c) Describe Vitamin A under the following headings:
i) Sources
ii) Recommended Daily Allowance (RDA)
iii) Provitamin and Active forms
iv) Biochemical functions
v)Deficiencymanifestations
Short Essay Questions (Attempt any FOUR out of FIVE) (4x5-20)
Q.3
a) Components and functions of GAGs (Glycosaminoglycan's)
b) Diagnostic and therapeutic applications of enzymes
c) Process of communication
d) Galactosemia
in hostel has been experiencing (1+1+2+1)
e) An 18 year old girl, residing
abdominal discomfort after meals. It is more after the
consumption of milk, paneer and butter. She has abdominal
cramps, flatulence and diarrhea.
i) ldentify the probable disorder.
ii) What may be the cause of the disorder?
ii) Explain the biochemical basis of above signs and
symptoms
iv) What dietary advice can be given to her?
P.T.O (1)
 SECTION -C
(2x10=20)
(2x10-20)
TW0 out of THREE)
Answer Questions (Attempt any (3+3+4)
(+3+4)
Q.4 Long
utilization of Ketone
bodies. Add a
a) Describe the synthesis and
note on ketosis. (1+1+1+4+3)
Describe Vitamin B12 under
the following headings
b
i) Sources
ii) Absorption and transport
Active forms
iii) Biochemical functions
iv) Deficiency manifestations (1+6+3)
Describe its
v Chain (ETC)?
What is Electron Transport suitable diagram.
Add a
c) flow of electrons with
components and
Chain.
inhibitors of Electron Transport
note on
(4x5-20)
FOUR out of FIVE)
Short Essay Questions (Attempt any
Q.5 a) Marasmus
and harmful effects
b) Free Radicals :generation
c) Lipoproteins
Tumour markers (1+2+1+1)
d) male, thought of volunteering for ongoing
A 25 year old healthy care teaching
e) COVID 19 vaccine at
a tertiary
clinical trial for
he had following
questions to the
hospital. However,
trial.
investigators of the
What is a vaccine?
i) a disease?
How a vaccine helps in preventing
ii) vaccination can help in controlling
a pandemic?
How
iii) completely eradicated by vaccination.
Name the disease
iv)
 M.B.B.S. PHASE-1 (2019 -NEW CURRICULUM) : SUMMER-2020
SUBJECT: BIOCHEMISTRY - PAPER - II

Day Monday Time 1.30 p.m. to 4:30 p.m.

Date 25/01/2021 Max. Marks : 100
N.B.
1) All questions are COMPULSORY.
2) Section A : MCQ Question Paper and OMR sheet will collected at the END
OF FIRST 30 MINUTES.
3) SectionB and Section C should be written on SEPARATE answer sheets.
4) Draw NEAT and CLEAN DIAGRAMS wherever
necessary.
5) Figures to the right indicate FULL marks.

SECTION - A

Q.1 Multiple Choice Questions: Separate Question Paper (1x20-20)

SECTION-B
Q.2 Long Answer Questions (Attempt ANY TWO out of THREE) (2x10-20)
a) Discuss the various metabolic fates of
disorders associated with
tryptophan. Add a note on (5+5)
tryptophan.
b) Discuss the chemistry, structure and functions of hemoglobin. (3+2+5)
c) Discuss the synthesis, catabolism and salvage of
nucleotides. Add a note on primary gout. purine (3+2+3+2)

Q.3 Short Answer Questions (Attempt ANY FOUR out of FIVE)

a) (4x5-20)
Quaternary structure of proteins and importance of
structure-function relationship
b) Porphyrias
c)Metabolic changes in starvation
d) Regulation of water and electrolyte balance
)e) A new born infant developed jaundice within 24 hours of birth. (1+l+1+1+1)
The infant was Rh
positive
Total bilirubin was 20.36
and mother was Rh negative. Serum
mg/dl,
and unconjugated bilirubin 19.43conjugated
bilirubin: 0.93 mg/dl
kept on phototherapy. mg/dl. He was immediately
Identify the probable disorder.
ii) Explain the biochemical basis of jaundice in this infant.
ii What is Kernicterus?
iv) What is the biochemical basis of
v) Enumerate any two causes of phototherapy?
congenital hyperbilirubinemia.
P.T.O. (1)
 SECTION-C

Q.4 Long Answer Questions (Attempt ANY TWO out of THREE) (2x10-20)
(1+1+5+3)
a) What is normal blood pH? Explain the need for its regulation.
Describe the role of blood buffers and lungs in its maintenance.
(7+3)
b) Discuss the steps of protein biosynthesis. Add a note inhibitors
of protein biosynthesis in prokaryotes and eukaryotes. (142+1+1+2+3)
and function
c) Discuss the sources, absorption, transport, stórage
Add overload.
note on disorders of Iron
of Iron. a

Short Answer Questions (Attempt ANY FOUR out of FTVE) (4x5-20)

Q.5
a) Components and functions of Extracellular Matrix
b) Thyroid function tests.
c) Phase II reactions of detoxification
d) Electrophoresis (1+3+1)
e) A 35 year old male patient flu OPD with complaints of
visited
fever, cough and loss of smell since last two days. The clinician
suspected COVID 19 infection and collected his throat swab.
The report was available on the next day and came positive for
COVID 19 virus.
Name the confirmatory technique of molecular biology
used for diagnosis of COVID19 infection.
) Give the principle and steps of this technique.
iii) Mention two more applications of this technique.
'***'