Raa 085 Aen
Raa 085 Aen
1. Foreword..................................................................................................1
1.1. Revisions.................................................................................................... 1
2. Connection..............................................................................................2
2.1. Serial Connection (RS232)............................................................................ 2
2.2. Ethernet Connection.....................................................................................3
3. ASTM Format......................................................................................... 5
3.1. Introduction.................................................................................................5
3.2. Connection Specifications (LIS01-A2)............................................................ 6
3.3. Records General Format Specifications (LIS2-A2)........................................... 8
3.4. Special Characteristics for HORIBA Medical Data......................................... 16
3.5. Curves and Matrix Transmission..................................................................21
3.6. Example of Data Frame.............................................................................. 24
4. HL7 Format........................................................................................... 46
4.1. Protocol Description...................................................................................46
4.2. Message Segments....................................................................................49
4.3. Special Characteristics for HORIBA Medical Data......................................... 60
4.4. Laboratory Testing Workflow Examples........................................................65
4.5. References................................................................................................ 67
5. Appendices........................................................................................... 68
5.1. Error Management..................................................................................... 68
1. Foreword
1.1. Revisions
2. Connection
2.1.2. To Configure the RS232 Connection Mode
2.1. Serial Connection (RS232) Access: Home > Settings > System > General Communication > Host
The RS232 connection mode is available only for the ASTM format on the
Yumizen H500 OT/CT.
Communications can use the RS232 communication protocol, based on the Electronics
Industries Association (EIA) standard RS232-C. As part of the conformance to this
standard, the Yumizen H500 OT/CT Data Management System is configured as Data
Terminal Equipment (DTE).
The Yumizen H500 OT/CT should be connected to the Host via the DB-9 connector of
the instrument computer connection.
Pin (DB-9) data management Host port configuration Host cable must provide
2 RXD TXD
3 TXD RXD
5 Ground Ground 1. Press Edit in the contextual toolbar.
2. Select the ASTM connection format and select the RS232 connection mode.
3. Configure the instrument communication port in the RS232 Settings area.
Option Function Default value 2.2.2. To Configure the Network Connection Mode
Stop bit Stop bit selection 1
Protocol Protocol selection None Access: Home > Settings > System > General Communication > Host
4. Press Validate in the contextual toolbar.
The network connection mode is available for the ASTM and HL7 formats on
the Yumizen H500 OT/CT.
6. From the Network tab, in the Analyzer Settings area, configure the instrument
network settings:
■ Connection Mode
■ Analyzer Name
■ IP address
■ Subnet mask
■ Default gateway
■ Primary DNS (optional)
■ Secondary DNS (optional)
7. Press Validate in the contextual toolbar.
3. ASTM Format
Term Definition
The HORIBA Medical analyzers format corresponds to the ASTM specifications Communications All framing required for transmission of data. This framing includes:
LIS01-A2 & LIS2-A2: packet <STX>[frame number][DATA] [<ETB> or <ETX>][C1][C2] <LF>
■ LIS01-A2: Standard specification for low level protocol to transfer messages Component Field One of several related pieces of information within a field.
between clinical and laboratory instruments and computer systems. Field
A specific location within a record for a piece of information, indicated by
■ LIS2-A2: Standard specification for transferring information between clinical and a field delimiter and position.
laboratory instruments and computer systems. Frame A complete communications packet.
LIS Laboratory Information System
A collection of related information; a group of records that begins with a
"Header" record and ends with a "Terminator" record. A single record
Message
3.1. Introduction could theoretically constitute a message, but within this context, a
message always contains multiple records.
<EOT> End of transmission (ASCII decimal 4)
A connection between a computer (host) and a HORIBA Medical instrument can be <CR> Carriage return (ASCII decimal 13)
performed when the protocol, the format description and the connection mode have
In reference to the low level protocol, a record is the message data
been properly setup. (shown as [DATA]) as described within the communications packet. If the
data is longer than 240 characters, then it must be split in two (or more)
Term Definition parts and sent in two (or more) communications packets. The
<ACK> Acknowledgment (ASCII decimal 6) Record intermediate packet uses the <ETB> character, and the ending packet
uses the <ETX> character. No single communications packet contains
[C1] The most significant character of checksum more than one record. In reference to the message layer, a record can be
[C2] The least significant character of checksum one of the following codes: H (header), P (patient), O (order), R (result), L
(terminator), C (comment).
[DATA] The data contents of the record
A total unit of communication activity used in this standard to indicate the
<ENQ> Inquire (ASCII decimal 5)
Session events starting with the establishment phase and ending with the
End of transmission block (ASCII decimal 23). For use only when a single termination phase.
<ETB>
record is too large to fit into one frame.
A determination of a single analyte or a combination of values from other
<ETX> End of text (ASCII decimal 3). Required at the end of each record. Test determinations or observations from which a variable or gradable result is
[frame number] Single digit frame number "0" to "7", starts with "1". derived.
The default format for emitted character is 1 bit start, 8 data bits, No parity, 1 bit stop. Typical discussion between the instrument and the host
The default communication speed is 38400 bauds.
Instrument <> Host
Hardware settings of the interface:
<ENQ> >
■ RS232 connection via a DB9 connector < <ACK>
■ Ethernet connection via an RJ45 cable
<STX>1...Data...<CR><ETX>xx
>
<CR><LF>
< <ACK>
<STX>2...Data...<CR><ETX>xx
>
3.2.2. Output Data Characteristics <CR><LF>
< <ACK>
■ Characters: ASCII <EOT> >
■ Maximum message length: 247 characters
■ Xon/Xoff protocol
Typical discussion between the host and the instrument
Discussion with conflict between the instrument and the host 3.2.4. ASTM Data Frame Format
No answer from Host for an <ENQ>
A sequential number located after the <STX> character is inserted into each data frame.
■ Timeout: 15 seconds
The frame number is set to 1 when the transfer phase is initialized and is incremented by
■ In case of conflict: 1 second before a new transmission, up to 3 transmissions. Host
1 for each frame up to 7 and then returns to 0.
timeout: 20 seconds
■ In case of negative answer <NAK>: No time before a new transmission, up to 6 The frame number allows the receiver to distinguish new and re-transmitted frames. In
transmissions case of re-transmitted frame (after a <NAK> response from the host), the frame number
is not incremented: <STX>1...Data...<CR><ETX>xx<CR><LF>.
Instrument <> Host
<ENQ> > Frame format
< <ENQ>
ASTM field Definition Transmitted data # of bytes Comments
Wait 1 second Wait 20 seconds
0 STX $02 1
<ENQ> >
Frame number is
<
set to 1,
... incremented by 1
1 Frame number 1 to 7, 0, ... 1
<EOT> > for each frame up
to 7, and then
returns to 0
Defect packet during discussion between instrument and host Header, Patient,
Order, Result and
2 Data message 240 max.
Instrument <> Host Comment
messages
<ENQ> >
End of data
< <ACK>
3 message 1
<STX>1...Data...<CR><ETX>xx ETX if end frame
>
<CR><LF>
4 Checksum 2
< <NAK>
5 CRLF $0D $0A 2
<STX>1...Data...<CR><ETX>xx
>
<CR><LF>
Frame checksum
< <ACK>
<STX>2...Data...<CR><ETX>xx According to LIS01-A2, the frame checksum (<STX>1...Data...<CR><ETX>xx<CR><LF>)
>
<CR><LF> is defined as modulo 256 of ASCII values sum between <STX> not included and <ETX>
< <ACK> included characters: 1...Data...<CR><ETX>.
<EOT> >
3.3. Records General Format Specifications (LIS2-A2) Structure of records for result transmission
■ H (Header)
■ P (Patient)
Data frames encapsulate records defined by the LIS-A2 norm, records themselves ■ C (Patient Comments) optional
encapsulate ASTM fields. ■ .. O (Order)
■ .. C (Order Comments) optional
Record ID ASTM Definition ■ .. C (Run Alarms) optional
H Header ■ .. M (Curves and Matrix points)
P Patient ■ .. M (Curves and Matrix points)
■ ... .... R (Result)
O Order
■ ... .... C (Flag Result) optional
R Result ■ ... .... R (Result)
C Comment ■ ... .... C (Flag Result) optional
Q Query (Request information order)
■ ...............
■ ...............
M Manufacturer information ■ ... .... R (Result)
L Terminator record ■ ... .... C (Flag Result) optional
■ L (Terminator)
When alphanumeric data is sent, all the characters below 0x20 are replaced by an 3.3.2.4. Header Record
escape sequence with the following format: &Xhhh&.
"hhhh" is the hexadecimal value of ASCII character completed with zero on 4 digits. ASTM Definition Transmitted Field Input type Repeat Mandatory
For example, <ETB> should be replaced by: <&X0017&>. field data max. delimiter
length
When alphanumeric data is received, the escape sequence &Xhhhh& is converted to the
6.1 Record Type H 1 Fixed No Yes
corresponding characters.
idem standard:
When alphanumeric data is transmitted, all delimiters characters they can contain must
be replaced by their corresponding escape sequence as below: ■ | field
delimiter
■ \ Repeat
Delimeter Escape sequence
6.2 Delimiters definition delimiter 4 Text No Yes
Field delimiter &F& ■ ^
Component delimiter &S& Component
delimiter
Repeat delimiter &R& ■ & Escape
Escape delimiter &E& delimiter
6.3 Message Control ID
6.4 Access Password
For more information about errors and messages, refer to the Appendices > Error InstrumentCod
42 Alphanumeric^
Receiver ID (from e^SerialNumbe
Management chapter. 6.10 (15^15^ Alphanumeric^ No No
host to instrument) r^Software
10) Alphanumeric
version
Comments or
6.11
Special Instructions
ASTM Definition Transmitted Field Input type Repeat Mandatory ASTM Definition Transmitted Field Input type Repeat Mandatory
field data max. delimiter field data max. delimiter
length length
P: Patient Patient Name
message This field is not
Q: Quality transmitted if the
6.12 Processing ID 1 Fixed list No Yes
control Anonymous patient Name^First 41
7.6 Alphanumeric No No
message check box is name (20^20)
D: Technician selected in the
6.13 ASTM Version Nb LIS2-A2 9 Fixed No Yes General Communication
screen.
Date and Time of YYYYMMDDH
6.14 14 Date and time No No Mother's Maiden
message HMMSS 7.7
Name
There should not be the field delimiter between 6.1 and 6.2 fields (as it is in the 6.2 field YYYYMMDD^A
GE^U
value).
■ YYYYMMD
In case of a response to a request (query, ...), the field 6.5 should be an exact copy from
D: Date of
the 6.10 field sent in the request.
birth
■ AGE: 20 Date^Numeric^
7.8 Birth date Patient age (14^3^1) No No
Fixed List
3.3.2.5. Patient Record ■ U: Unit of
Age (Y, M,
D or H for
ASTM Definition Transmitted Field Input type Repeat Mandatory Year,
field data max. delimiter Month, Day
length or Hour)
7.1 Record Type P 1 Fixed No Yes M = Male
7.2 Sequence Nb 1, 2, ... 2 Numeric No Yes 7.9 Patient Sex F = Female 1 Fixed list No No
U = Unknown
Practice Assigned
7.3 Patient Race-Ethnic
Patient ID 7.10
Origin
Laboratory Assigned
7.4 Patient Id 25 Alphanumeric No No 7.11 Patient Address
Patient ID
7.5 Patient ID No 3 7.12 Reserved
Patient Telephone
7.13
Nb
Attending Physician PhysicianID^Ph Alphanumeric^
7.14 20^30 No No^No
ID ysicianName Alphanumeric
7.15 Special Field 1
ASTM Definition Transmitted Field Input type Repeat Mandatory ASTM Definition Transmitted Field Input type Repeat Mandatory
field data max. delimiter field data max. delimiter
length length
7.16 Special Field 2 7.34 Hospital Institution
7.17 Patient Height CHILD1,
7.18 Patient Weight CHILD2,
CHILD3,
Patient's Known or 7.35 Dosage Category CHILD4, 20 Fixed list No No
7.19 Suspected CHILD5,
Diagnosis CHILD6,
Patient Active CHILD7
7.20
Medication
7.21 Patient's Diet
7.22 Practice Field 1 3.3.2.6. Order Record
7.23 Practice Field 2
Admission and ASTM Definition Transmitted Field Input type Repeat Mandatory
7.24 field data max. delimiter
Discharge Dates
length
7.25 Admission Status
8.1 Record Type O 1 Fixed No Yes
Alphanumeric
7.26 Location No No 8.2 Sequence Nb 1, 2, ... 2 Numeric No Yes
Max length: 20
Nature of Alternative 8.3 Sample ID SampleID 16 Alphanumeric No No
7.27 Diagnostic Code Instrument
8.4
and Classifiers Specimen ID
Nature of Alternative From
7.28 Diagnostic Code instrument
and Classifiers to Host: yes
^^^Testname 13
7.29 Patient Religion 8.5 Universal Test ID Fixed list Yes From Host
(CBC or DIF) (^^^10)
to
7.30 Martial status instrument:
7.31 Isolation Status no
7.32 Language R: routine
8.6 Priority 1 Fixed list No No
S: STAT
7.33 Hospital Service
Requested/Ordered YYYYMMDDH
8.7 14 Date and time No No
Date and Time HMMSS
Specimen Collection YYYYMMDDH
8.8 14 Date and time No No
Date and Time HMMSS
ASTM Definition Transmitted Field Input type Repeat Mandatory ASTM Definition Transmitted Field Input type Repeat Mandatory
field data max. delimiter field data max. delimiter
length length
YYYYMMDDH 8.21 Laboratory Field 1
8.9 Collection End Time 14
HMMSS 8.22 Laboratory Field 2
8.10 Collection Volume Date and Time
8.11 Collector ID 8.23 Results reported or
last modified
From
instrument to From Instrument Charge
8.24
Host: not used instrument to Computer System
From Host to to Host: no Instrument Section
8.12 Action Code instrument: 1 Fixed list No From Host 8.25
ID
A: add on to
existing order instrument: From
N: new order yes instrument to
C: cancel order Host:
F: final
8.13 Danger Code X: order cannot
Relevant Clinical be done
8.14
Information From Host to
Date/Time YYYYMMDDH 8.26 Report Types instrument: 1 Fixed list No Yes
8.15 14 Date and time No No Q: response to
Specimen Received HMMSS
request
SpecimenType information
^^SpecimenLiq Z: no record for
uid this patient
SpecimenType: Y: no test for
■ this record
BLOOD
Specimen ■ CONTROL 42 Fixed 8.27 Reserved
8.16 No No^^No
Descriptor SpecimenLiqui (20^^20) list^^Fixed list Location or Ward of
8.28
d: Specimen Collection
The order must follow the following conditions, otherwise, the received order is ignored: ASTM Definition Transmitted data Field Input type Repeat Mandatory
field max. delimiter
■ Sample ID data of Specimen ID field (8.3) match the Sample ID data of the pending
length
query
■ At least one of Universal Test ID field (8.5) shall contain a TestName data From instrument to
Host:
■ In case of several Universal Test ID field (8.5), with at least one with a "DIF"
Ranges^RangeDe
TestName, and at least another one with a "CBC" TestName, the requested analysis scription
is set to DIF Ranges: lower limit
■ Action code field (8.12) is "N" (New order) to upper limit
■ Report Types field from Host (8.26) is one of the following values: Q, Z, Y RangeDescription:
Alphanumeric^
9.6 Reference Ranges 20^15 Yes No
If a received order contains a Universal Test ID (field 8.5) with a TestName different from ■ REFERENCE_ Fixed list
CBC or DIF, the Yumizen H500 OT/CT will send back the order with the record type field RANGE
■ CRITICAL_RA
set to "X" and the received order will be ignored.
NGE
From host to
instrument: not
3.3.2.7. Result Record used
From instrument to
ASTM Definition Transmitted data Field Input type Repeat Mandatory Host:
field max. delimiter L: below low
length normal
H: above high
9.1 Record Type R 1 Fixed No Yes normal
9.2 Sequence Nb 1, 2, ... 2 Numeric No Yes LL: below panic
normal
^^^English result HH: above panic
name^LOINC normal
LOINC: Result Abnormal <: below absolute
From instrument to 9.7 Fixed list No Yes
Flag low
Host: code 24 ^^^Open >: above absolute
^^^Yes^N
9.3 Universal Test ID associated with (^^^10^ list^Open No high
o^No
the result frame, if 10) list^Numeric A: rejected
available N: normal
From host to X: invalid value
instrument: not >>: above
used absolute visibility
Data or Test result or --- or From host to
9.4 16 Alphanumeric No No
Measurement Value +++ instrument: not
used
Yes but No
Unit text (ISO 2955
9.5 Unit or Set of units 10 Open list No if Nature of
or specific) 9.8
observation Abnormality Testing
ASTM Definition Transmitted data Field Input type Repeat Mandatory 3.3.2.8. Comment Record
field max. delimiter
length
ASTM Definition Transmitted data Field Input type Repeat Mandatory
From instrument to field max. delimiter
Host: length
W: warning
(suspicion on 10.1 Record Type C 1 Fixed No Yes
validity) 10.2 Sequence Nb 1, 2, ... 2 Numeric No Yes
9.9 Result Status X: order cannot be 1 Fixed list No Yes
I: Clinical
done (result) 10.3 Comment Source 1 Fixed list No Yes
instrument system
F: final result
From host to From instrument to
instrument: not Host:
used For result 200 Alphanumeric Yes Yes
comment (after R
Date of Change in
frame): alarm
9.10 Normative Values
or Units For order
comment (after O Open
From instrument to 103
frame): list^Open Yes^No^Y
Host: Login^^User (20^20^ Yes
AlarmType^Measu list^Open es^No
profile or 30^30)
10.4 Comment Text rementType^Alarm list^Open list
LastName
Main^AlarmDetail
FirstName^^User
profile 63 Alphanumeric For patient
Operator
9.11 User profile: (41^^20 ^^ No Yes comment or
Identification
TECHNICIAN / ) Alphanumeric sample comment 200 Alphanumeric Yes Yes
LABMANAGER / (after P or O
USER frame): free text
From host to From Host to
instrument: not instrument: 200 Alphanumeric No Yes
used comments
Date/Time Test YYYYMMDDHHM I: Instrument flag
9.12 14 Date No Yes 10.5 Comment Type 1 Fixed list No Yes
Starting MSS comment
Date/Time Test YYYYMMDDHHM
9.13 14 Date No No
Completed MSS
From instrument to
Host:
Device 9380BDED579C
9.14 15 Alphanumeric No Yes
Identification From host to
instrument: not
used
Alarms specifications ASTM Definition Transmitted Field Input type Repeat Mandatory
field data max. delimiter
The Comment Text (10.4) field can contain an alarm type data as follows: length
■ CONDITIONS for alarms linked to analysis conditions such as blank failed, reagent 11.6 Time limits
expired, … 11.7 Time Max limits
■ D or S for alarms linked to the calculation of data such as Unstable Count, High
11.8 Time Min limits
linearity. D (Device) indicates an alarm linked to an instrument technical problem. S
(Sample) indicates an alarm linked to the blood sample. 11.9 Physician Name
■ SUSPECTED_PATHOLOGY for suspected pathologies alarms such as Leukocytosis 11.10 Telephone Number
or Large Immature Cells. 11.11 Reserved for User
■ CONTROL_FAILED for alarms due to bad control result.
11.12 Reserved for User
The Comment Text (10.4) field can contain a measurement type data as follows: Request Information O: request for
11.13 1 Fixed No Yes
■ Status Codes test information
WBC if the alarm is linked to the white blood cells count.
■ DIFF if the alarm is linked to the white blood cells differential.
■ PLT if the alarm is linked to the platelets measurement.
■ RBC if the alarm is linked to the red blood cells measurement. 3.3.2.10. Traceability record
■ RBC_OTH if the alarm is linked to other measurements such as HGB and HCT.
The Comment Text (10.4) field can contain an alarm data as follows: ASTM Definition Transmitted Field Input type Repeat Mandatory
field data max. delimiter
■ One of the analytical alarms or suspected pathologies specified in Analytical Alarms length
in case of D, S or SUSPECTED_PATHOLOGY alarm type. 14.1 Record type M 1 Fixed No Yes
■ The default condition in case of CONDITIONS alarm type.
14.2 Sequence number 1..99 2 Numeric No Yes
■ The reason of the control failure in case of CONTROL_FAILED alarm type.
"REAGENT"
"QC"
14.3 Message type "XB" 10 Closed list No Yes
3.3.2.9. Request Information Record "STARTUP"
"SETTING"
ASTM Definition Transmitted Field Input type Repeat Mandatory 3.3.2.11. Terminal record
field data max. delimiter
length
ASTM Definition Transmitted Field Input type Repeat Mandatory
"REAGENT": field data max. delimiter
reagent name length
(CLEANER,
DILUENT, 12.1 Record type L 1 Fixed No Yes
14.4 Traceability name LYSE) 20 Open list Yes Yes 12.2 Sequence number 1 1 Fixed No Yes
"SETTING":
12.3 Termination code N: Normal 1 From From From
setting name
instrument to instrument instrument
(RUO,
host: fixed to host: to host: Yes
WBCDIFF)
From host to No From host
"REAGENT": instrument: not From host to
ReagentID^Loa used to instrument:
ded date/ instrument not used
time^Expiration : not used
Date
120130H1*^20
120327151737
^20120727 39 Alphanumeric^
Yes^No^Ye
"QC", "XB", (15^14^ Date and Yes
Traceability s
14.5 "STARTUP": 8) Time^Date Yes
Information Yes
status 20 Open list Yes
"SETTING": 20 Alphanumeric
Yes
3.4. Special Characteristics for HORIBA Medical Data
setting value
■ RUO:
TRUE,
FALSE
■ WBCDIFF:
5, 6 3.4.1. Data Presentation
The CBC and DIF codes correspond to the Universal Test ID field 9.3 and the units
correspond to the Unit field 9.5.
3.4.1.1. Parameters
CBC Codes LOINC Code Definition DIF Codes LOINC Code Definition
RBC 789-8 Red Blood Cells BAS% 706-2 Basophils percentage
HGB 718-7 Hemoglobin Concentration IMG# 53115-2 Immature Granulocytic cells absolute value
HCT 4544-3 Hematocrit IMG% 71695-1 Immature Granulocytic cells percentage
MCV 787-2 Mean Corpuscular Volume IMM# X-IMM# Immature Cells Medium granulometry absolute
value
MCH 785-6 Mean Corpuscular Hemoglobin
IMM% X-IMM% Immature Cells Medium granulometry
MCHC 786-4 Mean Corpuscular Hemoglobin Concentration
percentage
RDW-SD 21000-5 Red Distribution Width Standard Deviation
IML# X-IML# Immature Cells Low granulometry absolute value
RDW-CV 788-0 Red Distribution Width
IML% X-IML% Immature Cells Low granulometry percentage
MIC X-MIC Microcytic Red Blood Cells percentage (versus
ALY# 43743-4 Atypical Lymphocytes absolute value
RBC)
ALY% 42250-1 Atypical Lymphocytes percentage
MAC X-MAC Macrocytic Red Blood Cells percentage (versus
RBC) LIC# 55432-9 Large Immature Cells absolute value
PLT 777-3 Platelets LIC% 55433-7 Large Immature Cells percentage
PCT 51637-7 Plateletcrit
PDW 51631-0 Platelets Distribution Width
MPV 32623-1 Mean Platelet Volume
3.4.1.2. Units
P-LCC 96354-6 Platelets - Large Cell Count
CBC Codes SI (international) Conventional mmol/L Japan China
P-LCR 48386-7 Platelets - Large Cell Ratio
RBC 1012/L 106/mm3 1012/L 104/µL 1012/L
WBC 6690-2 White Blood Cells
HGB g/L g/dL mmol/L g/dL g/L
DIF Codes LOINC Code Definition HCT L/L % L/L % %
LYM# 731-0 Lymphocytes absolute value MCV fL fL fL fL fL
LYM% 736-9 Lymphocytes percentage MCH pg pg fmol pg pg
MON# 742-7 Monocytes absolute value MCHC g/L g/dL mmol/L g/dL g/L
MON% 5905-5 Monocytes percentage RDW-SD fL fL fL fL fL
NEU# 751-8 Neutrophils absolute value RDW-CV % % % % %
NEU% 770-8 Neutrophils percentage MIC % % % % %
EOS# 711-2 Eosinophils absolute value MAC % % % % %
EOS% 713-8 Eosinophils percentage PLT 109/L 103/mm3 109/L 104/µL 109/L
BAS# 704-7 Basophils absolute value PCT % % % % %
CBC Codes SI (international) Conventional mmol/L Japan China 3.4.2. Alarms and Pathologies
PDW fL fL fL fL fL
MPV fL fL fL fL fL
P-LCC 109/L 103/mm3 109/L 104/µL 109/L 3.4.2.1. Suspicion and Reject
P-LCR % % % % %
When a result is suspected of being abnormal or false, it is not reliable and the
WBC 109/L 103/mm3 109/L 102/µL 109/L instrument returns a flag in field 9.9.
Refer to Description of Records.
DIF Codes SI (international) Conventional mmol/L Japan China
LYM# 109/L 103/mm3 109/L 102/mm3 109/L
LYM% % % % % % 3.4.2.2. Normal and Panic Ranges
MON# 109/L 103/mm3 109/L 102/mm3 109/L
MON% % % % % % Flags when result exceeds normal or panic ranges are transmitted through field 9.7, they
NEU# should be compared, to obtain a full result information, to the ranges set by the user.
109/L 103/mm3 109/L 102/mm3 109/L
NEU% % % % % % Refer to Description of Records.
EOS# 109/L 103/mm3 109/L 102/mm3 109/L
EOS% % % % % % 3.4.2.3. Analytical Alarms
BAS# 109/L 103/mm3 109/L 102/mm3 109/L
BAS% % % % % % Analytical alarms and suspected pathologies are transmitted in field 10.4.
IMG# 109/L 103/mm3 109/L 102/mm3 109/L Transmitted analytical alarms list:
IMG% % % % % %
Measurement
IMM# 109/L 103/mm3 109/L 102/mm3 109/L Alarm type Transmitted data Description
type
IMM% % % % % %
D DIFF ANA_ERR^BUBBLE_DIFF Optical Noise
IML# 109/L 103/mm3 109/L 102/mm3 109/L S DIFF WBC_ABN_MAT^ABN_NEU Abnormal NEU
IML% % % % % % S DIFF WBC_ABN_MAT^BLAST Blasts?
ALY# 109/L 103/mm3 109/L 102/mm3 109/L Presence of a significant large
ALY% % % % % % population of cells located on
S DIFF WBC_ABN_MAT^NEU_NOISE
the left-hand side of the
LIC# 109/L 103/mm3 109/L 102/mm3 109/L neutrophil area
LIC% % % % % % S DIFF WBC_ABN_MAT^NRBC NRBC?
Separation threshold is not
S DIFF WBC_ABN_MAT^SEP_LYM_MON found between the lymphocytes
and monocytes areas
Measurement Measurement
Alarm type Transmitted data Description Alarm type Transmitted data Description
type type
Presence of a significant large Presence of a significant large
population of cells located in WBC_ABN_MAT^SUSP_NB_IMM population of cells in the middle
S DIFF WBC_ABN_MAT^SEP_LYM_MON S DIFF
the separation area between WBC_ABN_MAT^SUSP_P_IMM part of the large immature cells
lymphocytes and monocytes area
WBC_ABN_MAT^SEP_LYM_MON WBC_ABN_MAT^SUSP_NB_LIC0
S DIFF MON Interference Presence of a significant large
WBC_ABN_MAT^SEP_MON_IMM WBC_ABN_MAT^SUSP_NB_LIC1
S DIFF population of cells in the large
Separation threshold is not WBC_ABN_MAT^SUSP_NB_LIC2
immature cells area
S DIFF WBC_ABN_MAT^SEP_LYM_NEU found between the lymphocytes WBC_ABN_MAT^SUSP_P_LIC
and neutrophils areas D PLT ANA_ERR^CLOG_PLT No count
Presence of a significant large D PLT ANA_ERR^CLOG_PLT Low Count
population of cells located in
S DIFF WBC_ABN_MAT^SEP_LYM_NEU D PLT ANA_ERR^UNST_PLT Unstable Count
the separation area between
lymphocytes and neutrophils D PLT ANA_ERR^UNST_PLT Background noise
Separation threshold is not Result out of LoQ (Limit of
S PLT OOR_PLT^LOQ
S DIFF WBC_ABN_MAT^SEP_MON_NEU found between the monocytes Quantitation)
and neutrophils areas S PLT PLT_INTERF^PLTAGR PLT aggregates?
Presence of a significant large S PLT PLT_ABN_HIST^ABN_PDW Abnormal PDW
population of cells located in
S DIFF WBC_ABN_MAT^SEP_MON_NEU S PLT PLT_ABN_HIST^SEP_RBC_PLT RBC PLT Interference
the separation area between
monocytes and neutrophils S PLT WBC_ABN_MAT^NRBC_PLTAGR PLT aggregates or NRBC?
Separation threshold is not D RBC ANA_ERR^BAL_RBC_HGB Abnormal MCH
S DIFF WBC_ABN_MAT^SEP_NEU_EOS found between the eosinophils
D RBC ANA_ERR^BAL_RBC_HGB Abnormal MCHC
and neutrophils areas
D RBC ANA_ERR^CLOG_RBC No count
Presence of a significant large
population of cells located in D RBC ANA_ERR^CLOG_RBC Low Count
S DIFF WBC_ABN_MAT^SEP_NEU_EOS
the separation area between D RBC ANA_ERR^UNST_RBC Unstable Count
neutrophils and eosinophils
S RBC OOR_PLT^LINEARITY High linearity
WBC_ABN_MAT^SUSP_NB_ALY0
WBC_ABN_MAT^SUSP_NB_ALY1 S RBC OOR_PLT^VISIBILITY High visibility
Presence of a significant large
WBC_ABN_MAT^SUSP_NB_ALY2 S RBC OOR_RBC^LINEARITY High linearity
S DIFF population of cells in the
WBC_ABN_MAT^SUSP_NB_ALY3
atypical lymphocytes area Result out of LoQ (Limit of
WBC_ABN_MAT^SUSP_NB_ALY4 S RBC OOR_RBC^LOQ
WBC_ABN_MAT^SUSP_P_ALY Quantitation)
Measurement Measurement
Alarm type Transmitted data Description Alarm type Transmitted data Description
type type
RBC_ABN_HIST^INTERF_RBC_W S WBC OOR_WBC^VISIBILITY High visibility
S RBC Nucleated cells interference
BC S WBC WBC_ABN_MAT^INTERF_TNC Counted WBC abnormally low
HGB blank measurements out S WBC WBC_ABN_MAT^INTERF_WBC WBC Interference
D RBC_OTH ANA_ERR^UNST_HGB
of the intensity ranges
WBC_ABN_MAT^NEU_EOS_NOIS
Intensity instability during the S WBC Background noise
D RBC_OTH ANA_ERR^UNST_HGB E
three HGB blank measurements
Presence of a significant large
Intensity instability during the population of cells located in
D RBC_OTH ANA_ERR^UNST_HGB WBC_ABN_MAT^SEP_LYM_NRB
nine HGB measurements S WBC the separation area between
C
HGB_MEAS_BIAS^INTERF_HGB_ the background noise low and
S RBC_OTH HGB/WBC Interference
WBC lymphocytes areas
S RBC_OTH OOR_HCT^LINEARITY High linearity
Transmitted suspected pathologies list:
Result out of LoQ (Limit of
S RBC_OTH OOR_HCT^LOQ
Quantitation) ■ Leukocytosis
S RBC_OTH OOR_HCT^VISIBILITY High visibility ■ Leukopenia
S RBC_OTH OOR_HGB^LINEARITY High linearity
■ Lymphocytosis
■ Lymphopenia
Result out of LoQ (Limit of ■
S RBC_OTH OOR_HGB^LOQ Neutrophilia
Quantitation)
■ Neutropenia
S RBC_OTH OOR_HGB^VISIBILITY High visibility ■ Extrem Neutropenia
PLT_ABN_HIST^SCH_MACRO_PL ■ Eosinophilia
S RBC_OTH Schistocytes/Macro PLT?
T ■ Monocytosis
S RBC_OTH RBC_ABN_HIST^ABN_DISTRI Abnormal distribution ■ Basophilia
■ Large Immature Cells
S RBC_OTH RBC_ABN_HIST^DBL_POP RBC double population
■ Atypic Lymphocytes
D WBC ANA_ERR^CLOG_DIFF No count ■ Pancytopenia
D WBC ANA_ERR^LIGHT_BEAM_DIFF Optical bench light error ■ Aplasia
D WBC ANA_ERR^UNST_DIFF Unstable Count ■ Erythrocytosis
■ Anemia
Low correlation between the
D WBC ANA_ERR^UNST_DIFF resistive and optical
■ Macrocytosis
measurements on the matrix ■ Microcytosis
■ Hypochromia
D WBC ANA_ERR^UNST_DIFF No cells counted in the flowcell
■ Anisocytosis
S WBC OOR_WBC^LINEARITY High linearity ■ Poikilocytosis
Result out of LoQ (Limit of ■ Cold Agglutinins
S WBC OOR_WBC^LOQ
Quantitation) ■ Thrombocytosis
■ Thrombocytopenia
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Y4z9rP18jXs64hXzc/J7+WwjZm6Q+az8ZIwbMybPmtv6B PyppKzBlyFc75RjLMGSKJ3CRRmy/+B8zNSfrnuTMT0VBnOMM
+q6WftwYtKTzvaEG9z9nLi2ScLMn+7/8H +o2fTurlodN5Ed38DKro7zzjHsB+Z5BiG6V7GvUy/NeN145x5I/27xuB/vj0WHLSwv/m8/
tcx3x6m52Hqb+H9/gY=
M|2|HISTOGRAM|PLT|PLTALONGRES|FLOATLE-stream/
deflate:base64^Y2AAAQ4nMMXQA6IdgMjhxW9P+1dqO+3f1Yg7QuQa7EFyAA==|
FLOATLE-stream/deflate:base64^rZV/TJVVGMevcGdQUTBpREYDh0jmiJgSCfE
+z3szxqChozF02DBZMhZOpkjGQERTAhKDVAwKEkI0qGui/
AgIDEUwSIiQoC4E8cOgIDSEwur7cs9d1xvjnzrju
+d9z3me83z3Oe89qFTKsJDngiodMYnwADmySpUPTbB M|3|HISTOGRAM|WBC|WBCALONGRES|FLOATLE-stream/
+TZnbq4nWrfCdtT3uW7+221ejfUBy0bhLFp0bpNHIndJwQqoU6pcjNVmXSN7d1VJJQYv deflate:base64^Y2AAgX9OYIohygVIOIBYAA==|FLOATLE-stream/
kEK2TMjzHJaW+MsKCYpqsaaWbPQ1kOlHO7cfpxTAPsqpfS5eWaygxNYCeHg deflate:base64^ddUBiN1zHADwH45tHDsc22zj2GxnDmfONu7Yu7s3NjvzZjc7MzzMDMN
+m8eAwKq6IoC0O0WSfHEvtQwlY30/LQg8hJ426qzOQl0VZTtnIzaXAg/ hGMZeEkeXLkkj6YW4JF1raUl6sXRJurS0tPSSNJKWLl1a+Ly937/+vebq0/
nILyT1aDFqSqkm6CzqztPuskrU1pCb/UVKDbhMwwnNpNG2Ul5/ d7v///vd/v/3+/7/
O83aXqdQvx4q29NLNiUDFK0bpibrMXLRTFBy7C3SnZom7+5Z7K3i1/ cXQuXvn64jIazPhlDIhDDaGcJyY68zGq8F4892u760mmcy1XuLlCgTfK6BJlrJkCNPPwUG
PMuLhCzZ1ti1k9asEe6vt4i4MVZ3g GGInRYYZYQ+lzurcY
+yDVBNjwauYTtkx9ivxw73l1mz4UtS7l9yIEVhjeXLOPBFc7c5e3CV4NcuXbrStbGreKCND +ynzEEOMUGwljomU08DjUxnFk3MpZkWWmljCR1kyHZVn62HHL30sYE8G9nMFvrZyja2
c+lufOKec8OL5xNW/v8eTwcS8ONvfm5+2e5WeekBh//Fiwhm22rWPzeD U+A5nucFBniZQV5hiFd5Lb67nbzJW7xNkXd4j/cZ5kM+4mNG2MVuPmEPn/IZn1PiC/
+eOuzPN04GcM+FF7i1OYjrdRu4bDKYixaH8IlHQjndbRMnymEcE/ISR0SFc0jiy+yfGcE byVfxtvuYbvmWM79jH9+znBw7wI2V+4md+4SC/8Tt/cIg/GecvJvibw11xj/j9j
+Ra/wk1WR7NQaxbb9r/ +FYjqOO4zmBSUxmCidyEvWczClMpYFTOY3TaeQMzmQa05nBWcxkFrM5m3No4lzOY
I9U9t5xjKGxxx2cu9Tsdy2Lo4bNu7h8uh4PrMvgXOP7uXGjiTsv4+rRpLRYz w5zOZ95zKeZC1jAhbRwERdzCa1cykIuo43LWcRilnAFV9JOB1dxNUvJ0EkX3WRZxjVcy
+Xzh5An4Ocb30IvVI40/lN9EvlN7zS0DOdXwt8C30Pc1R4Bnof4c273kb/ 3JWcB0r6eF6VnEDOVZzI2voZS03sY4+bmY9t7CBW7mN28lzB3dyFxu5m03cw2bu5T7u
TF6fkgUP77CcexQ+jvEa7XF4yWbXhhPw8y4v7cqBp1y2GnsPvt6f+ ZwsP8CAP0c/DPMKjbOUxHucJtvEkT/
+ZmLD8At5PwVwB2hfD4IfgVwecpMCyG19PgeAZ+PwLLEnguBc E023mmu1r3lfrOx1qti3XWEeuoJ9ZUNtZaUnPN8b6mWKuV
+P4fsTMNVyxumz4PopJ9ecA9sy3tV2Hnwv8LbBcjCu4E0zleD8GQdaVYN1DUtOteD9OX +p2INT6SUoz9YCj2iVyMabnYVyr9JRxFKfahYlSoySv9KqRkUjF9b+33pMeT/
usqQPzel7ufxHcv2C7zQ1gf4nvjbkM/o1858AVnEETj2c34xyucn/ pb0tnxc83B8pnLsUfWp99Mbe8lgrPlSrMkQa2NG3LPtcW9siu/+xe5QeEN8V9zFl
JlziLFv6mrhXn8RWYXQOzNjBrB7OvwawDzDrB7DqYdYHZt2DWDWY9YPYdmH0PZjow +yjbGxc/FeclA2ZqdlQatS3ZzJHPl9cwMJsKCwW241l5CvlOfka+brskV5f6kNe6PX/
6wWzPjD7Acz6wWwAzH4Es0EwGwKzYTAbAbMbYPYTmI2C2RiY/ avkqVsiXiT5XWCS2iPOMNYmE2eacZty8hSkcto5fOcAYJWvbLX5QXX/hJfmOuD/
Qxmv8z9RmcsfwWzSTC7CWa3wOw3MJsCs9tgNg1mM2D2O5j9AWazYHYHzP4Es7+w XxrppizVcqf9K3xiPfWk09rrh2DMHY7+t9OVcfJ9tcT81RnVxT5XjubEn7qeheNYkkvMmvdc
rpIbO1Ryw8ZFcr1ukVy71UyuGjGTy6PN5bJJc1kbp5ZLZ9Xijvi/RhLuBMKdsgP KKUOpsfSey6fGau9L58kcyXzpNSTzJvcka6mN/3cujtRIrhVr5j/
+i6FsERXZKr2ElHlnxD7WS1nrQlyN+DBkDblDavHuCk2LvEeh+yEfUaO8O8r6tedErpesv aGTucUvvcAzXz7Y3nTeWsqPTsEP4D
+PUIt9HrE+IfGV+lejTJTyMQNdYf29eEe8VJtKK
+zMFqoOOiBgu5taLHBJ52UIk5C5YKHGHiEpNHZj1kf7ZUeTW0T/
4. HL7 Format
Each segment is identified by a unique three-character code known as the Segment ID.
HL7 content is enclosed by special characters to form a block. Two or more segments may be organized as a logical unit called a segment group. A
The block format is <SB> HL7 Message <EB> <CR>. segment group may be required or optional and might or might not repeat.
The characters below shall surround the HL7 TCP message: Each message is defined in special notation that lists the segment IDs in the order they
would appear in the message.
Element Description Value Comment ■ Braces { . . . }, indicate one or more repetitions of the enclosed group of segments.
<SB> Start Block character (1 byte) <0x0B> / <VT> Vertical Tab The group may contain only a single segment.
HL7 Message This is the HL7 data content of The data can contain any ■ Brackets [ . . . ], show that the enclosed group of segments is optional.
the block single-byte values greater than
If a group of segments is optional and may repeat it should be enclosed in brackets and
0x1F and the ASCII carriage
return character <CR> braces [{ . . . }].
<EB> End Block character (1 byte) <0x1C> / <FS> File Separator
Fields
<CR> Carriage Return (1 byte) <0x0D> / <CR> Carriage
Return A field is a string of characters.
HL7 does not take into account how systems store data within an application.
When fields are transmitted, they are sent as character strings.
4.1. Protocol Description
Separators
The HL7 messages must be created by using the separators below:
Separator Name
4.1.1. Overview \ Escape character
| Field separator
Messages ~ Repetition separator
A message is the atomic unit of data transferred between systems. It consists of a group ^ Component separator
of segments in a defined sequence. Each message has a message type that defines its & Sub-component separator
purpose.
The numerical values must use the character "." as decimal separator. Message Description
Order information (related to a single patient and a single specimen) used
Low level protocol OML^O33 to send a request from an external system to Yumizen H500 OT/CT
(request downloading).
Two sockets are used. The first socket is dedicated to orders messages and their
acknowledgments. The second socket is dedicated to results messages and their Acknowledgment / Rejection of a request message sent from
ORL^O34
Yumizen H500 OT/CT to an external system.
acknowledgments.
Result information (related to a single order) used to send a test result
OUL^R22
from Yumizen H500 OT/CT to an external system (result uploading).
Records to send
Acknowledgment / Rejection of a test result message sent from an
ACK^R22
Fields that are not used are sent empty. external system to Yumizen H500 OT/CT.
When sending records, the HL7 sends only non-empty components, ie. without
component delimiters for the last empty components of the field.
The application must respect the following attribute descriptions to create and process Segment Meaning Usage Card.
the HL7 messages: OBR Observation Request R [1..1]
■ Segment: the segment ID [{NTE}] Notes and comments O [0..1]
■ Meaning: the contain of this segment --- Observation Request end
■ Usage: whether the segment is required (R) or optional (O)
■ --- ORDER end
Card: whether the segment may repeat
--- SPECIMEN end
Card. Description
[0..1] Element may be omitted and it can have at most one occurrence
[1..1] Element must have exactly one occurrence 4.1.2.2. ORL^O34^ORL_O34 / ACK^R22^ACK_R22
[0..*] Element may be omitted or repeat for an unlimited number of times
Element must appear at least once and may repeat for an unlimited The following table lists the detailed structure for messages ORL^O34 and ACK^R22
[1..*]
number of times used to acknowledge a message reception by both Yumizen H500 OT/CT and an
external system:
Segment Meaning Usage Card. Fields and components must contain a value that complies with the specified input type.
Observation Result (for The input types are listed in the table below:
[OBX] O [0..2]
specimen)
Input type Name Description
--- ORDER begin
The corresponding fields and components must contain only this
OBR Observation Request R [1..1] F Fixed
fixed value.
[ORC] Order Common O [0..1]
The corresponding fields and components must contain only the
CL Closed list
[NTE] Notes and comments O [0..n] predefined values.
{ --- RESULT begin The corresponding fields and components must contain only the
OL Open list
OBX Observation Result R [1..1] values specified in the Yumizen H500 OT/CT.
} --- RESULT end The corresponding fields and components must contain a free
AN Alphanumeric
text.
--- ORDER end
The corresponding fields and components must contain a
--- SPECIMEN end N Numeric
numerical positive data including 0 (zero).
The corresponding fields and components must contain a date
DT Date and time
and time formatted as follows: YYYYMMDDhhmmss
The corresponding fields and components must contain a date
D Date
formatted as follows: YYYYMMDD
4.2. Message Segments
Messages consist of segments of various types that are listed in the table below:
4.2.1. MSH - Message Header Segment
Segment Type Name
MSH Message Header The MSH segment defines the intent, source, destination, and some specifics of the
syntax of a message.
PID Patient Identification
The Message Header segment contains general information and identifies the sender.
NTE Notes and comments
The Message Header segment is always the first record in a transmission.
SPM Specimen
ORC Order Common
OBR Observation Request
4.2.1.1. From Host to Yumizen H500 OT/CT
OBX Observation Result
MSA Message Acknowledgment
Input
SEQ LEN OPT Element name Example
ERR Error type
0 3 R F Segment ID MSH
1 1 R F Field Separator | (Pipe)
Input Input
SEQ LEN OPT Element name Example SEQ LEN OPT Element name Example
type type
41 Doe^John Patient Comment
Depends on the associated
5 20 O AN Patient Name Doe: family name
3 200 O AN Comment segment:
20 John: given name
■ PID: patient comment
19800926000000 ■ OBR: order comment
7 14 O D Date/Time of Birth YYYYMMDDhhmmss: date and time
of birth G
4 1 R CL Comment Type G (General): patient comment, order
M comment
M (Male)
8 1 O CL Administrative Sex
F (Female)
U (Unknown) Example of a message sent by Host:
NTE|1||the patient is afraid of needles|G
Example of a patient identification segment sent by Yumizen H500 OT/CT:
PID|1||PID0002^^^^PI||Doe^John||19800926000000|M
4.2.3.2. From Yumizen H500 OT/CT to Host
Input
SEQ LEN OPT Element name Example
type
4.2.3. NTE - Notes and Comments Segment
0 3 R F Segment ID NTE
1 1 R N Set ID - NTE 1
The NTE segment is defined here for inclusion in messages defined in other chapters. It
is commonly used for sending notes and comments. The NTE segment can be linked to L
2 1 R F Source of comment
a PID or an OBR segment. L (Filler)
Depends on the comment content
3 R Comment
(refer to the table below).
4.2.3.1. From Host to Yumizen H500 OT/CT G
G (General): patient comment, order
4 1 R CL Comment Type comment
Input I (Device Flag): analyzer and
SEQ LEN OPT Element name Example
type analytical alarms
0 3 R F Segment ID NTE
1 1 O N Set ID - NTE 1
Input Input
SEQ LEN OPT Element name Example SEQ LEN OPT Element name Example
type type
2 16 O AN Specimen ID 0123456789 21 ^Hematology_Department
WB 17 O AN Entering Organization Hematology_Department:
4 20 R CL Specimen Type 20
WB (Whole Blood) department name
P
11 1 R F Specimen Role
P (Patient) Example of a common order segment sent by Host:
20161012145110 ORC|NW|||||||||||||||||^Hematology_Department
Specimen Collection
17 14 O DT YYYYMMDDhhmmss: date and time
Date/Time
of the specimen collection
Specimen Received
20161012181002 4.2.5.2. From Yumizen H500 OT/CT to Host
18 14 O DT YYYYMMDDhhmmss: date and time
Date/Time
of the specimen reception
Input
SEQ LEN OPT Element name Example
type
Example of a specimen segment sent by Yumizen H500 OT/CT:
0 3 R F Segment ID ORC
SPM|1|0123456789||WB||||||P||||||20161012145110|20161012181002
SC
1 2 R F Order Control
SC (Status Change)
21 ^Hematology_Department
17 O AN Entering Organization Hematology_Department:
4.2.5. ORC - Common Order Segment 20
department name
The Common Order segment (ORC) is used to transmit fields that are common to all
Example of a common order segment sent by Yumizen H500 OT/CT:
orders.
ORC|SC|||||||||||||||||^Hematology_Department
However, the Yumizen H500 OT/CT manages only one order at a time.
The Universal Service Identifier field corresponds to any parameters or compatible Input
SEQ LEN OPT Element name Example
panels: type
DIF
CBC Test panel:
Universal Service
4 10 R OL
DIF Identifier ■ CBC
■ DIF
51 789456^JOHN DOE
4.2.6.1. From Host to Yumizen H500 OT/CT 16 20 O AN Ordering Provider 789456: physician ID
30 JOHN DOE: physician name
Input
SEQ LEN OPT Element name Example 20161012161021
type Results Rpt / Status
22 14 R DT YYYYMMDDhhmmss: date and time
0 3 R F Segment ID OBR Chng Date
of the result delivery
1 1 O N Set ID - OBR 1 F
25 1 R F Result Status
CBC F (Final)
Universal Service Test panel: LoginName
4 10 R OL 34 41 R AN Technician
Identifier ■ LoginName: user login name
CBC
■ DIF
51 789456^MISTER PHYSICIAN Example of an observation request segment sent by Yumizen H500 OT/CT:
20 789456: physician ID
OBR|1|||CBC|||||||||||789456^MISTER PHYSICIAN||||||20161012161552|||F|||||||||LoginName
16 O AN Ordering Provider
MISTER PHYSICIAN: physician
30
name
Input
SEQ LEN OPT Element name Example
type
0 3 R F Segment ID OBR
1 1 R F Set ID - OBR 1
4.2.7. OBX - Observation Result Segment 4.2.7.2. From Yumizen H500 OT/CT to Host with the SPM Segment
The OBX segment is used to transmit a single observation or observation fragment. It For the Patient Age
represents the smallest indivisible unit of a report. The OBX segment can be linked to a
SPM or an OBR segment. Input
SEQ LEN OPT Element name Example
type
4.2.7.1. From Host to Yumizen H500 OT/CT with the SPM Segment 0 3 R F Segment ID OBX
1 1 R F Set ID - OBX 1
Input NM
SEQ LEN OPT Element name Example 2 2 R F Value Type
type NM (Numeric)
0 3 R F Segment ID OBX 35659-2^Age at specimen
40
collection^LN
1 1 O N Set ID - OBX 1
10 35659-2: LOINC code
NM
2 2 O CL Value Type 3 R F Observation Identifier Age at specimen collection: name of
NM (Numeric) 26
the transmitted observation
35659-2^Age at specimen
24 LN: Logical Observation Identifiers
collection^LN 2
Names and Codes (LOINC)
10 35659-2: LOINC code
3 O F Observation Identifier 35
Age at specimen collection: name of 5 3 O N Observation Value
10 35: patient age
the transmitted observation
d
LN: Logical Observation Identifiers
2 Unit:
Names and Codes (LOINC)
6 2 O CL Units ■ a (Year)
35
5 3 O N Observation Value ■ m (Month)
35: patient age
■ d (Day)
d ■ h (Hour)
Unit:
Observation Result F
■ 11 1 R F
6 2 O CL Units a (Year) Status F (Final)
■ m (Month)
■ d (Day)
■ h (Hour) Example of an observation result segment sent by Yumizen H500 OT/CT:
OBX|1|NM|35659-2^Age at specimen collection^LN||36|a|||||F
Observation Result F
11 1 O F
Status F (Final)
Input Input
SEQ LEN OPT Element name Example SEQ LEN OPT Element name Example
type type
F 150520M11^20200915000000^202
39
F: result status 01115
■ 15 R AN Traceability 150520M11: reagent ID
Z (Warning: suspicion on 5
Observation Result Information
11 1 R CL validity, reject or out of linearity 14 O DT 20200915000000: loaded date/time
Status range)
■ X (Order cannot be done: invalid 8 R D 20201115: expiration date
value or out of visibility range) REAGENT
■ F (Final) 6 7 R F Traceability type
REAGENT: traceability type
LoginName Observation Result F
16 41 R AN Responsible Observer 11 1 R F
LoginName: user login name Status F (Final)
17 30 O AN Observation Method Laboratory name
Date/Time of the
20210707172928 Example of an observation result segment sent by Yumizen H500 OT/CT:
19 14 R DT YYYYMMDDhhmms: date and time OBX|3|ED|LYSE||150520M11^20200915000000^20201115|REAGENT|||||F
Analysis
of the analysis
For Reagent Traceability The MSA segment contains information sent while acknowledging another message.
Input
SEQ LEN OPT Element name Example
type 4.2.8.1. From Host to Yumizen H500 OT/CT
0 3 R F Segment ID OBX
3 Input
Incremented by one at each OBX SEQ LEN OPT Element name Example
1 4 R N Set ID - OBX type
segment in the OBR segment,
0 3 R F Segment ID MSA
starting with 1.
AA
ED
2 2 R CL Value Type Acknowledgment AA (Accept)
ED (Encapsulated Data) 1 2 R CL
Code AE (Error)
LYSE AR (Reject)
3 20 R OL Traceability Name
LYSE: reagent name
2016101214500200002
Message Control ID of the
2 20 R AN Message Control ID
corresponding message sent by the
Yumizen H500 OT/CT.
Input
SEQ LEN OPT Element name Example
type Example of a message sent by Host:
0 3 R F Segment ID MSA ERR|||203|E||||The Version ID is not supported
AA
Acknowledgment AA (Accept)
1 2 R CL 4.2.9.2. From Yumizen H500 OT/CT to Host
Code AE (Error)
AR (Reject)
2016101214500200002 Input
Message Control ID of the SEQ LEN OPT Element name Example
2 20 R AN Message Control ID type
corresponding message sent by the
0 3 R F Segment ID ERR
Host.
101
3 20 R CL HL7 Error Code
Error code
Example of a message sent by Yumizen H500 OT/CT:
E
MSA|AA|2016101214500200002 4 1 R CL Severity
E (Error)
A required field is missing from a
8 250 O AN User Message segment
Error message
Message Unsupported
201 The Event Code is not supported. MSH-9
Input rejected event code
SEQ LEN OPT Element name Example
type
Message Unsupported
202 The Processing ID is not supported. MSH-11
0 3 R F Segment ID ERR rejected processing id
203
3 20 R CL HL7 Error Code
Error code
When?
Error
Name Context
Concerned 4.3. Special Characteristics for HORIBA Medical Data
code Segment / Field
Message Unsupported
203 The Version ID is not supported. MSH-12
rejected version id
Message Unknown key
204 The order to delete does not exist. SPM
rejected identifier
Message Duplicate key The ID of the patient, order, etc., already 4.3.1. Data Presentation
205 SPM
rejected identifier exists.
The analyzer is not be able to manage The CBC and DIF codes correspond to the parameter English name in field OBX.3 and
Message Application
206 the message because of an error at the Not applicable the units correspond to the Units field OBX.6.
rejected record locked
application storage.
Message Application A catch-all for internal errors not
207 Not applicable
rejected internal error explicitly covered by other codes.
4.3.1.1. Parameters
The message segments were not in the
Message Segment
100 proper order, or required segments are Not applicable
error sequence error LOINC Code: Logical Observation Identifiers Names & Codes
missing.
A required field is missing from a
Message Required field CBC Codes LOINC Code Definition
101 segment or a required component is Not applicable
error missing RBC 789-8 Red Blood Cells
missing in the field.
Message The field contains data of the wrong HGB 718-7 Hemoglobin Concentration
102 Data type error Not applicable
error input type. HCT 4544-3 Hematocrit
A field (that must contain only MCV 787-2 Mean Corpuscular Volume
Message Table value not predefined value) was compared
103 Not applicable MCH 785-6 Mean Corpuscular Hemoglobin
error found against the corresponding table, and no
match was found. MCHC 786-4 Mean Corpuscular Hemoglobin Concentration
Message RDW-SD 21000-5 Red Distribution Width Standard Deviation
104 Value too long A value exceeded the normative length. Not applicable
error
RDW-CV 788-0 Red Distribution Width
MIC X-MIC Microcytic Red Blood Cells percentage (versus
Example of a message sent by Yumizen H500 OT/CT: RBC)
ERR|||101|E||||A required field is missing from a segment
MAC X-MAC Macrocytic Red Blood Cells percentage (versus
RBC)
PLT 777-3 Platelets
PCT 51637-7 Plateletcrit
PDW 51631-0 Platelets Distribution Width
MPV 32623-1 Mean Platelet Volume
P-LCC 96354-6 Platelets - Large Cell Count
ALY# 43743-4 Atypical Lymphocytes absolute value LYM# 109/L 103/mm3 109/L 102/mm3 109/L
LIC# 55432-9 Large Immature Cells absolute value MON# 109/L 103/mm3 109/L 102/mm3 109/L
LIC% 55433-7 Large Immature Cells percentage MON% % % % % %
NEU# 109/L 103/mm3 109/L 102/mm3 109/L
NEU% % % % % %
EOS# 109/L 103/mm3 109/L 102/mm3 109/L
EOS% % % % % %
Measurement Measurement
Alarm type Transmitted data Description Alarm type Transmitted data Description
type type
Presence of a significant large D RBC ANA_ERR^CLOG_RBC No count
population of cells located in
S DIFF WBC_ABN_MAT^SEP_NEU_EOS D RBC ANA_ERR^CLOG_RBC Low Count
the separation area between
neutrophils and eosinophils D RBC ANA_ERR^UNST_RBC Unstable Count
WBC_ABN_MAT^SUSP_NB_ALY0 S RBC OOR_PLT^LINEARITY High linearity
WBC_ABN_MAT^SUSP_NB_ALY1 S RBC OOR_PLT^VISIBILITY High visibility
Presence of a significant large
WBC_ABN_MAT^SUSP_NB_ALY2
S DIFF population of cells in the S RBC OOR_RBC^LINEARITY High linearity
WBC_ABN_MAT^SUSP_NB_ALY3
atypical lymphocytes area
WBC_ABN_MAT^SUSP_NB_ALY4 Result out of LoQ (Limit of
S RBC OOR_RBC^LOQ
WBC_ABN_MAT^SUSP_P_ALY Quantitation)
Presence of a significant large S RBC OOR_RBC^VISIBILITY High visibility
WBC_ABN_MAT^SUSP_NB_IML population of cells in the lower
S DIFF S RBC PLT_CONCENT PLT Concentrate Mode
WBC_ABN_MAT^SUSP_P_IML part of the large immature cells
area S RBC RBC_ABN_HIST^INTERF Interference?
Presence of a significant large RBC_ABN_HIST^INTERF_RBC_W
S RBC Nucleated cells interference
WBC_ABN_MAT^SUSP_NB_IMM population of cells in the middle BC
S DIFF
WBC_ABN_MAT^SUSP_P_IMM part of the large immature cells HGB blank measurements out
area D RBC_OTH ANA_ERR^UNST_HGB
of the intensity ranges
WBC_ABN_MAT^SUSP_NB_LIC0 Intensity instability during the
Presence of a significant large D RBC_OTH ANA_ERR^UNST_HGB
WBC_ABN_MAT^SUSP_NB_LIC1 three HGB blank measurements
S DIFF population of cells in the large
WBC_ABN_MAT^SUSP_NB_LIC2
immature cells area Intensity instability during the
WBC_ABN_MAT^SUSP_P_LIC D RBC_OTH ANA_ERR^UNST_HGB
nine HGB measurements
D PLT ANA_ERR^CLOG_PLT No count
HGB_MEAS_BIAS^INTERF_HGB_
D PLT ANA_ERR^CLOG_PLT Low Count S RBC_OTH HGB/WBC Interference
WBC
D PLT ANA_ERR^UNST_PLT Unstable Count S RBC_OTH OOR_HCT^LINEARITY High linearity
D PLT ANA_ERR^UNST_PLT Background noise Result out of LoQ (Limit of
S RBC_OTH OOR_HCT^LOQ
Result out of LoQ (Limit of Quantitation)
S PLT OOR_PLT^LOQ
Quantitation) S RBC_OTH OOR_HCT^VISIBILITY High visibility
S PLT PLT_INTERF^PLTAGR PLT aggregates? S RBC_OTH OOR_HGB^LINEARITY High linearity
S PLT PLT_ABN_HIST^ABN_PDW Abnormal PDW Result out of LoQ (Limit of
S RBC_OTH OOR_HGB^LOQ
S PLT PLT_ABN_HIST^SEP_RBC_PLT RBC PLT Interference Quantitation)
S PLT WBC_ABN_MAT^NRBC_PLTAGR PLT aggregates or NRBC? S RBC_OTH OOR_HGB^VISIBILITY High visibility
D RBC ANA_ERR^BAL_RBC_HGB Abnormal MCH PLT_ABN_HIST^SCH_MACRO_PL
S RBC_OTH Schistocytes/Macro PLT?
T
D RBC ANA_ERR^BAL_RBC_HGB Abnormal MCHC
S RBC_OTH RBC_ABN_HIST^ABN_DISTRI Abnormal distribution
Measurement ■ Macroplatelets
Alarm type Transmitted data Description
type ■ PLT aggregate?
S RBC_OTH RBC_ABN_HIST^DBL_POP RBC double population ■ NRBC?
■ PLT aggregate or NRBC?
D WBC ANA_ERR^CLOG_DIFF No count
■ Low PLT Count
D WBC ANA_ERR^LIGHT_BEAM_DIFF Optical bench light error ■ Leukocytosis
D WBC ANA_ERR^UNST_DIFF Unstable Count ■ Leukopenia
Low correlation between the ■ Lymphocytosis
D WBC ANA_ERR^UNST_DIFF resistive and optical ■ Lymphopenia
measurements on the matrix ■ Neutrophilia
D WBC ANA_ERR^UNST_DIFF No cells counted in the flowcell
■ Neutropenia
■ Eosinophilia
S WBC OOR_WBC^LINEARITY High linearity ■ Monocytosis
Result out of LoQ (Limit of ■ Basophilia
S WBC OOR_WBC^LOQ
Quantitation) ■ Large Immature Cells
S WBC OOR_WBC^VISIBILITY High visibility ■ Atypic Lymphocytes
S WBC WBC_ABN_MAT^INTERF_TNC Counted WBC abnormally low ■ Left Shift
■ Extrem Neutropenia
S WBC WBC_ABN_MAT^INTERF_WBC WBC Interference
■ Pancytopenia
WBC_ABN_MAT^NEU_EOS_NOIS ■ Blank Cycle
S WBC Background noise
E ■ Malaria P. falciparum?
Presence of a significant large ■ Malaria P. vivax?
population of cells located in ■ Dengue?
WBC_ABN_MAT^SEP_LYM_NRB
S WBC the separation area between
C
the background noise low and
lymphocytes areas
4.4. Laboratory Testing Workflow Examples 4.4.2. Yumizen H500 OT/CT to Host acknowledgment
Message Accepted
-> <VT>
4.4.1. Host to Yumizen H500 OT/CT standard test request -> MSH|^~\&|H500^112YADH47745^3.0.0.3b|HORIBA_MEDICAL|Application|Facility|
20210726134529||ORL^O34^ORL_O34|MCID12345678|P|2.5||||||UNICODE UTF-8<CR>
4.4.3. Yumizen H500 OT/CT to Host standard result -> OBX|12|NM|21000-5^RDW-SD^LN||38.1|fL|37.0 - 56.0^REFERENCE_RANGE|N|||F|||||
LabMan_111|||20210707172907<CR>
-> OBX|13|NM|777-3^PLT^LN||218|1E03/mm3|150 - 400^REFERENCE_RANGE|N|||Z|||||
-> <VT>
LabMan_111|||20210707172907<CR>
-> MSH|^~\&|H500^112YADH47745^3.0.0.3a|HORIBA_MEDICAL|Application|Facility|
-> OBX|14|NM|51631-0^PDW^LN||16.8|fL|11.0 - 20.0^REFERENCE_RANGE|N|||Z|||||LabMan_111|||
20210707180555||OUL^R22^OUL_R22|21070718072400001|P|2.5||||||UNICODE UTF-8<CR>
20210707172907<CR>
-> PID|1||0565^^^^PI||NAME^FIRSTNAME||19900518000000|M<CR>
-> OBX|15|NM|51637-7^PCT^LN||0.327|%|0.150 - 0.400^REFERENCE_RANGE|N|||Z|||||
-> SPM|1|0566||WB<CR> LabMan_111|||20210707172907<CR>
-> OBX|1|NM|35659-2^Age at specimen collection^LN||31|a|||||F<CR> -> OBX|16|NM|32623-1^MPV^LN||9.2|fL|7.4 - 12.0^REFERENCE_RANGE|N|||Z|||||LabMan_111|||
-> OBX|2|ST|^Dosage category||MAN||||||F<CR> 20210707172907<CR>
-> <VT>
-> MSH|^~\&|Application|Facility|H500^112YADH47745^3.0.0.3b|HORIBA_MEDICAL|
20210726193805||ACK^R22^ACK_R22|21072618365400001|P|2.5<CR>
-> MSA|AA|21072618365400001<CR>
5. Appendices
Message Definition
LL_RESPONSE_TIMEOUT_ERROR Timeout occurs while expecting a control character
from Host
5.1. Error Management LL_FRAME_TIMEOUT_ERROR Timeout occurs while expecting a data frame or a frame
control character (EOT) from Host
H01 Invalid data at order reception HL_UNEXPECTED_RECORD_ERROR An unexpected (at wrong place in the frame) record has
been received and ignored
H02 Contextual error at order reception
HL_NOT_MANAGED_RECORD_ERROR A record not manageable has been received and
H03 Host connection error ignored
H04 Communication protocol error (low level) HL_IGNORED_RECORD_ERROR A record has been ignored (following a previous error)
Only for ASTM
HL_IGNORED_MESSAGE_ERROR A message has been ignored due to:
H05 Communication protocol error (high level)
■ an erroneous field value in a mandatory segment
H06 Communication protocol error at sending ■ a mandatory segment absent
H07 Host software error
Only for HL7
Low Level Protocol Errors (Only for ASTM) HL_BYPASSED_RECORD_ERROR A record of upper level has been ignored (following a
previous error)
Message Definition HL_TERMINATOR_MISSING_ERROR The Terminator record of a message is missing
Only for ASTM
LL_ENQ_ERROR Establishment phase conflict ENQ - ENQ
HL_INVALID_ORDER_RECORD_ERROR Order in response to a query is invalid, record ignored
LL_NAK_ERROR NAK control character received from Host
HL_INVALID_FIELD_ERROR Invalid field type or value, mandatory field absent,
LL_FRAME_STRUCT_ERROR Invalid frame structure record ignored
LL_LENGTH_ERROR Invalid frame length HL_FIELD_LENGTH_ERROR Invalid field length, field truncated or record ignored
LL_FRAME_NUMBER_ERROR Invalid frame number HL_FIELD_REPEAT_DELIMITER_ERROR Not allowed field repeat delimiter, record ignored
LL_CHECKSUM_ERROR Invalid frame checksum HL_FIELD_COMPONENT_DELIMITER_E Not allowed field component delimiter, field truncated
LL_UNEXPECTED_CTRL_ERROR Invalid control character received while expecting a RROR
specific one inside a set