J Ethnopharmacol. 2008 Feb 28;116(1):96-101. Epub 2007 Nov 17.
Pharmacological study of antispasmodic activity of Mirabilis jalapa Linn flowers.
Aoki K, Corts AR, Ramrez Mdel C, Gmez-Hernndez M, Lpez-Muoz FJ.
Source
Departamento Sistemas Biolgicos, Universidad Autnoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Colonia Villa Quietud, C.P. 04960, Mxico, D.F., Mexico. kaoki@correo.xoc.uam.mx
Abstract
INTRODUCTION: Mirabilis jalapa Linn is a well-studied plant. The indigenous people of Mexico use Mirabilis jalapa to cure many infirmities including dysentery, diarrhea, muscular pain and abdominal colic. In the present investigation, we have further characterized some pharmacological properties of an extract of Mirabilis jalapa flowers; therefore, we intend to contribute to understand the pharmacological effects and clarify the complex use of this medicinal plant. RESULTS: The extract of Mirabilis jalapa (1-1000 mug/mL) exhibits an inhibitory effect (IC(50)=18+/-0.7 micorg/mL) on gut smooth muscle contractility whereas it stimulates the contraction of rabbit aortic muscle (EC(50)=11.60+/-0.26 micorg/mL) in a concentration-dependent manner. CONCLUSIONS: These effects were not due to either ACh or HIS receptors blockage, IP(3), cAMP, cGMP, Ca(2+) release from intracellular storage, or protein kinase mediated contraction-relaxation mechanisms. The effects inducted by the Mirabilis jalapa extract may involve a serotoninergic mechanism, which, in turn, interacts with other adrenergic systems. Further studies are necessary to identify the active compounds within the extract and to elucidate the mechanism of action. PMID: 18093770 [PubMed - indexed for MEDLINE]
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at Prod Res. 2010 Nov;24(18):1681-6.
Inhibition of histamine mediated responses by Mirabilis jalapa: confirming traditional claims made about antiallergic and antiasthmatic activity.
Maxia A, Sanna C, Salve B, Kasture A, Kasture S.
Source
Department of Botanical Sciences, University of Cagliari, Cagliari, Italy.
Abstract
The roots of Mirabilis jalapa are used traditionally in allergic skin disorders and asthma. The effect of an ethanol:acetone (1:1) extract of the roots of M. jalapa was studied for antihistaminic activity using a guinea pig tracheal chain preparation and clonidine-induced mast cell granulation in mice. Its antiallergic activity was evaluated using milk-induced eosinophilia and albumininduced paw oedema in mice. The extract (0.5 mL of 100 mg mL(-1)) inhibited histamineinduced guinea pig tracheal chain contractions non-competitively. The extract (100 or 200 mg kg(-1) i.p.) inhibited milk-induced eosinophilia, albumin-induced paw oedema and protected mast cells against clonidine-induced granulation. The study justified the folkloric use of M. jalapa in the treatment of allergic diseases and asthma. PMID: 20981612 [PubMed - indexed for MEDLINE] J Ethnopharmacol. 2008 Nov 20;120(2):169-75. Epub 2008 Aug 8.
Antinociceptive activity of Mirabilis jalapa in mice.
Walker CI, Trevisan G, Rossato MF, Franciscato C, Pereira ME, Ferreira J, Manfron MP.
Source
Laboratrio de Neurotoxicidade e Psicofarmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: The infusion or decoction of Mirabilis jalapa leaves is used in traditional medicine in Brazil to treat inflammatory and painful diseases. AIM OF THE STUDY: The present study examined the antinociceptive effect of Mirabilis jalapa extracts from leaves and stems in models of pain in mice. MATERIALS, METHODS AND RESULTS: The crude hydroethanolic extract from leaves (CrdL) was more potent than the crude extract from stems (CrdS) to inhibit abdominal constrictions induced by acetic acid, with ID(50) values of 5.5 (2.3-13.1) and 18.0 (11.3-28.5) mg/kg, respectively. Among the fractions tested, the Eta fraction from leaves (Eta) was more effective (maximal inhibition of 83+/-8%) and potent (ID(50) of 1.1 (0.6-2.1) mg/kg) to induce antinociception. Eta and CrdL also possessed an antinociceptive effect in the tail-flick test. Pre-treatment with naloxone did not modify the antinociceptive effect of Eta, but co-administration with atropine completely prevented it. This suggests that the antinociceptive effect might depend on the cholinergic system. Instead, Eta was not able to alter the acetylcholinesterase activity in blood or spinal cord. Concerning side effects, Eta did not alter locomotor activity, body temperature, gastrointestinal transit and did not produce gastric lesions. CONCLUSION: Our results demonstrate that Mirabilis jalapa presents antinociceptive activity in mice, which supports its folkloric use as an analgesic. PMID: 18761072 [PubMed - indexed for MEDLINE]
