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Biological Factors

Sarah's genetic predisposition plays a crucial role in her risk of developing chronic diseases like obesity and hypertension, influenced by her family's history. Studies indicate that specific genetic variants, particularly in the FTO and MC4R genes, are linked to obesity and hormonal imbalances that can lead to serious health issues over time. These factors contribute to altered fat storage and increased risks of conditions such as hyperglycemia and hypertension.

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10 views1 page

Biological Factors

Sarah's genetic predisposition plays a crucial role in her risk of developing chronic diseases like obesity and hypertension, influenced by her family's history. Studies indicate that specific genetic variants, particularly in the FTO and MC4R genes, are linked to obesity and hormonal imbalances that can lead to serious health issues over time. These factors contribute to altered fat storage and increased risks of conditions such as hyperglycemia and hypertension.

Uploaded by

Mfon Obot
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Biological Factors

Sarah’s genetic predisposition contributes significantly to the development of chronic


diseases like obesity and hypertension as she ages. Genetic predisposition can be
described as the increased likelihood of developing a specific disease based on the
presence of genetic variants in an individual’s family history (National Cancer
Institute, n.d). With a long-standing history of obesity present in her family, this
suggests the weight gain as a hereditary component which could influence her blood
pressure, fat storage patterns, and predisposition to chronic diseases. The study of
Poosri et al. (2024) and Cheragi et al. (2025) established that variants in genes like
Fat mass and obesity-associated (FTO) and Melanocortin 4 receptor (MC4R) genes
are connected to increased risk of obesity and overweightness. Hormonal
imbalances from obesity arises from variations in the hypothalamic-pituitary
hormones axes leading to increase in levels of leptin and decrease in adiponectin,
altering fat dissolution in the body (Ylli, Sidhu, and Parikh, 2022). With passage of
time, this dysfunction can generate to grave health conditions such as
hyperglycaemia and hypertension.

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