Supplemental Table 1.
Treatment effect on kidney outcomes according to category of CKD
Outcome eGFR ≥60 mL/min/1.73 m2 eGFR 45 to <60 mL/min/1.73 eGFR <45 mL/min/1.73 m2 P-
m2 interac
tion
Placebo Finerenone Placebo Finerenone Placebo Finerenone
Composite kidney outcome
(inc. ≥50% eGFR decline)
No. events (%) 27/1561 (2%) 27/1552 (2%) 12/754 (2%) 19/802 (2%) 16/683 (2%) 29/649 (4%)
Rate/100 PY (95% CI) 0.8 (0.5, 1.1) 0.8 (0.5, 1.1) 0.7 (0.4, 1.3) 1.1 (0.7, 1.7) 1.2 (0.7, 2.0) 2.3 (1.6, 3.3)
Hazard Ratio (95%CI) 0.92 (0.53, 1.58) 1.50 (0.72, 3.09) 2.00 (1.08, 3.70) 0.18
≥50% eGFR decline
No. events (%) 27/1561 (2%) 27/1552 (2%) 12/754 (2%) 19/802 (2%) 13/683 (2%) 27/649 (4%)
eGFR decline <15
mL/min/1.73 m2
No. events (%) 0/1561 (0%) 2/1552 (0%) 0/754 (0%) 3/802 (0%) 12/683 (2%) 20/649 (3%)
Dialysis initiation
No. events (%) - - 0/754 (0%) 1/802 (0%) 6/683 (1%) 6/649 (1%)
Macroalbuminuria (≥300
mg/g)
No. events (%) 192/1402 (14%) 110/1414 (8%) 93/672 (14%) 71/695 (10%) 101/540 (19%) 69/500 (14%)
Rate/100 PY (95% CI) 6.0 (5.2, 6.9) 3.2 (2.7, 3.9) 6.4 (5.2, 7.8) 4.4 (3.5, 5.6) 9.1 (7.5, 11.1) 6.6 (5.2, 8.4)
Hazard Ratio (95%CI) 0.55 (0.43, 0.69) 0.69 (0.51, 0.94) 0.74 (0.54, 1.00) 0.28
Micro- or
macroalbuminuria (≥30
mg/g)
No. events (%) 477/1004 (48%) 367/1018 (36%) 226/429 236/465 181/313 139/282
(53%) (51%) (58%) (49%)
Rate/100 PY (95% CI) 27.9 (25.5, 18.7 (16.9, 35.4 (31.1, 30.8 (27.1, 42.6 (36.8, 31.7 (26.9,
30.5) 20.7) 40.4) 34.9) 49.2) 37.5)
Hazard Ratio (95%CI) 0.69 (0.60, 0.79) 0.90 (0.75, 1.09) 0.78 (0.62, 0.98) 0.08
Supplemental Table 2. Treatment effect on kidney composite outcome according to category of baseline UACR and diabetes
Outcome UACR <300 mg/g UACR≥300 mg/g No diabetes Diabetes
Placebo Finerenone Placebo Finerenone Placebo Finerenone Placebo Finerenone
Composite kidney
outcome (inc. ≥50% eGFR
decline)
No. events (%) 34/2614 44/2609 19/282 30/292 26/1776 30/1786 29/1222 45/1217
(1.3%) (1.7%) (6.7%) (10.3%) (1.5%) (1.7%) (2.4%) (3.7%)
Rate/100 PY (95% CI) 0.6 (0.4, 0.8 (0.6, 3.7 (2.4, 5.4 (3.8, 0.7 (0.5, 0.8 (0.5, 1.1 (0.8, 1.8 (1.3,
0.8) 1.0) 5.8) 7.8) 1.0) 1.1) 1.6) 2.4)
Hazard Ratio (95%CI) 1.26 (0.80, 1.98) 1.52 (0.84, 2.73) 1.09 (0.64, 1.85) 1.56 (0.98, 2.50)
P-interaction for treatment effect according to categories of UACR (<300 or ≥300 mg/g) history of diabetes was 0.58 and 0.31,
respectively.
