Saurabh Argade, Int. J. of Pharm. Sci.

, 2025, Vol 3, Issue 01, 245-257 |Review

INTERNATIONAL JOURNAL OF
PHARMACEUTICAL SCIENCES
[ISSN: 0975-4725; CODEN(USA): IJPS00]
Journal Homepage: https://www.ijpsjournal.com

Review Article

Revolutionizing Pharmaceutical Packaging: A Comprehensive Review of

Current Trends and Future Directions
Saurabh Argade*, Someshwar Mankar, Suhas Siddheshwar

Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar 413736.

ARTICLE INFO ABSTRACT

Published: 06 Jan. 2025 In order to guarantee medicine safety, effectiveness, and patient compliance,
Keywords: pharmaceutical packaging is essential. This comprehensive review examines the critical
Pharmaceutical Packaging, aspects of pharmaceutical packaging, encompassing its functions, regulatory
Smart Packaging, compliance, and innovative advancements. Packaging serves as the first defense against
Sustainability, Patient contamination, degradation, and tampering, maintaining drug stability through
Compliance. specialized materials like inert glass and high-quality plastics. Moreover, it enhances
DOI: patient compliance with user-friendly designs such as blister and calendar packs. The
10.5281/zenodo.14602999 pharmaceutical packaging market is expected to increase at a compound annual growth
rate (CAGR) of 9.7% between 2024 and 2030 due to changing regulatory requirements
and technological advancements. Innovations such as smart packaging, sustainable
materials, and patient-centric designs are reshaping the industry. Smart packaging
incorporates sensors and digital tools to improve traceability and patient adherence,
while eco-friendly solutions address environmental concerns. Regulatory bodies like the
FDA and EMA ensure packaging meets safety and efficacy standards. Future trends
emphasize personalized solutions, integrating AI and IoT for enhanced medication
management and operational efficiency. This review highlights the need for continued
research and development to address emerging challenges, ensuring that pharmaceutical
packaging remains a cornerstone of healthcare innovation.

INTRODUCTION integrity of pharmaceutical products. This review

In order to guarantee medicine safety, will explore the multifaceted importance of
effectiveness, and patient compliance, pharmaceutical packaging, focusing on its
pharmaceutical packaging is essential. It serves as functions, regulatory compliance, and innovative
the first line of defense against various advancements that enhance patient outcomes.
environmental factors that could compromise the Ensuring Medication Safety-The primary function
*Corresponding Author: Saurabh Argade
Address: Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar 413736.
Email : saurabh.argade15102001@gmail.com
Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of
any commercial or financial relationships that could be construed as a potential conflict of interest.

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of pharmaceutical packaging is to protect increasingly important for tracking
medications from contamination, degradation, and pharmaceutical products throughout the supply
tampering. Packaging materials must be designed chain, thereby enhancing transparency and
to create a barrier against external elements such reducing the risk of counterfeit drugs entering the
as moisture, light, and oxygen, which can market.Regulatory bodies such as the FDA
adversely affect drug stability and efficacy. (United States), EMA (European Union), and
Moreover, sterile packaging techniques, such as WHO (World Health Organization) provide
aseptic filling for injectable medications, are guidelines that govern the design and
crucial in preventing microbial contamination manufacturing processes of pharmaceutical
during storage and transport. Tamper-evident packaging [3].
features are also essential in pharmaceutical Market Overview
packaging assuring consumers that the product is The pharmaceutical packaging market is
safe for use [1]. Maintaining Efficacy- Packaging experiencing significant growth, driven by
for pharmaceuticals is important in maintaining advancements in technology, increasing
medication efficacy by protecting drugs from regulatory demands, and evolving consumer
environmental factors and preventing interactions preferences. This overview will present key
with packaging materials. For instance, inert glass statistics on the market's expansion and highlight
containers are often used for sensitive medications emerging trends shaping its future. Statistics on
to ensure stability. Proper labeling is equally Market Growth The pharmaceutical packaging
important, providing essential information like market was estimated to be worth $139.37 billion
dosage, storage conditions, and expiration dates, globally as of 2023. From 2024 to 2030, it is
which helps prevent errors and ensures safe use by anticipated to expand at a compound annual
patients and healthcare providers [2]. Promoting growth rate (CAGR) of 9.7%, demonstrating the
Patient Compliance-Effective pharmaceutical pharmaceutical industry's strong need for creative
packaging also plays a vital role in enhancing packaging solutions. The United States remains
patient compliance with prescribed regimens. the largest pharmaceutical market globally,
Packaging solutions that facilitate easy access to supported by extensive healthcare systems, high
medications—such as blister packs or calendar per capita income, and substantial investments in
packs—are designed to help patients manage their drug development. The rising importance of
doses effectively. These user-friendly designs generic drugs and improved access to healthcare
make it easier for patients to adhere to their services are anticipated to further enhance
treatment plans by organizing doses clearly and opportunities within the pharmaceutical packaging
reducing the likelihood of missed or incorrect landscape . Emerging trends in pharmaceutical
dosages. Regulatory Compliance - The packaging packaging highlight a focus on sustainability,
of pharmaceuticals must adhere to strict smart technology, patient-centric designs,
regulations established by different health regulatory compliance, and digital integration.
authorities around the globe. These regulations Sustainability drives the adoption of eco-friendly
ensure that packaging meets safety standards while materials like recyclables and plant-based plastics,
safeguarding public health. For instance, child- with the market expected to grow significantly.
resistant packaging is mandated for certain Smart packaging, featuring sensors and RFID tags,
medications to prevent accidental ingestion by enhances traceability, prevents counterfeiting, and
children. Serialization practices have also become improves adherence through tools like reminder-

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enabled blister packs. Patient-centric designs
prioritize accessibility with easy-open and senior-
friendly features, while personalized medicine
demands customized solutions. Regulatory
compliance ensures product authenticity with
tamper-evident seals and unique identifiers.
Additionally, digital integration, such as AR and (Figure 1)
interactive QR codes, educates patients and 2. Ampoules and vials are airtight glass
enhances healthcare experiences [4] . containers primarily used for storing liquid
Types Of Packaging medications and injectables. Ampoules are
Primary Packaging: sealed by melting the neck after filling,
Primary packaging is a crucial aspect of the ensuring sterility and preventing
pharmaceutical industry, as it encompasses the contamination. Vials often come with rubber
materials that come into direct contact with the stoppers and aluminium seals to maintain
drug. This type of packaging is designed to protect sterility while allowing access via syringes.
the medication from environmental factors, ensure Both ampoules and vials are essential for
its stability, and maintain its efficacy until it parenteral drug delivery systems, where
reaches the patient. Glass and plastic are key maintaining sterility is paramount. Ampoules
materials in pharmaceutical packaging, each with and vials are airtight glass containers
distinct advantages. Glass, commonly used in vials primarily used for storing liquid medications
and ampoules, is chemically inert, protecting drugs and injectables. Ampoules are sealed by
from reactions, moisture, and light while allowing melting the neck after filling, ensuring
easy inspection of contents. However, its fragility sterility and preventing contamination. Vials
requires careful handling. Plastic, used in bottles often come with rubber stoppers and
and blister packs, is lightweight, flexible, and cost- aluminium seals to maintain sterility while
effective but less inert than glass, with potential for allowing access via syringes. Both ampoules
drug interaction or leaching. High-quality plastic and vials are essential for parenteral drug
formulations are essential to ensure safety and delivery systems, where maintaining sterility
drug stability. is paramount.
1. Blister packaging is particularly common for
solid dosage forms like tablets and capsules.
It consists of a pre-formed plastic cavity
(blister) that holds individual doses securely,
typically covered by a peelable foil layer. This
type of packaging not only protects the
medication from moisture and light but also
(Figure 2)
allows for easy access for patients. Blister
3. Syringes serve as both primary packaging and
packs can be designed with child-resistant
a delivery device for injectable medications.
features to enhance safety. The use of
They are typically made from plastics or glass
aluminum foil in blister packs provides an
and can be pre-filled or used as disposable
excellent barrier against external elements
devices. Pre-filled syringes offer convenience
while maintaining product integrity.

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for patients by eliminating the need for information to consumers and healthcare
manual filling, reducing the risk of dosing professionals. The primary function of secondary
errors. The design of syringes must ensure packaging is to provide an additional layer of
compatibility with various medications while protection for the primary packagingThis entails
maintaining sterility throughout their shelf protecting the contents from environmental
life [5]. elements like light, moisture, and temperature
changes as well as from physical harm during
storage and transit. Secondary packaging
contributes to the stability and effectiveness of
pharmaceutical items over the course of their shelf
life by strengthening the primary packaging's
durability. Furthermore, because it acts as a canvas
(Figure 3) for product information, logos, and design aspects
Secondary Packaging that aid in product differentiation in a competitive
Secondary packaging serves as the outer layer of market, secondary packaging frequently plays a
packaging that groups and protects primary critical part in branding and marketing.
packages, which contain the pharmaceutical Cartons
products themselves. This layer is essential for 1. Paperboard Boxes
ensuring the safe transport and storage of 2. Shrink Wraps
medications while also providing important 3. Trays

(Figure 4) (Figure 5)
The choice of materials for secondary packaging is Tertiary packaging
influenced by factors such as product type, Tertiary packaging is an essential component of
regulatory requirements, cost considerations, and the pharmaceutical supply chain, primarily
environmental sustainability. Common materials focused on bulk handling and shipping. This layer
include. Convenience and Handling Secondary of packaging encompasses containers such as
packaging is designed not only for protection but pallets, crates, and bulk containers that facilitate
also for convenience in handling and distribution. the transportation of multiple primary and
Features such as easy-open seals, ergonomic secondary packages. The primary function of
designs, and unit-dose packaging enhance user tertiary packaging is to provide efficient bulk
experience by simplifying access to medications. handling and transportation of pharmaceutical
Additionally, well-designed secondary packages products. By grouping multiple secondary
can facilitate efficient stacking and storage during packages together, tertiary packaging ensures that
transportation, optimizing space utilization within medications are protected during transit and
warehouses and pharmacies [6 ,7]. storage. This layer of packaging plays a vital role

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in maintaining the integrity of the products by optimizing space utilization during transportation,
preventing damage from external forces and and facilitating inventory management.
environmental conditions. Additionally, tertiary 1. Pallets
packaging enhances logistical efficiency by 2. Crates
enabling easier loading and unloading processes, 3. Bulk Containers
4. Shrink Wraps.

(Figure 6) (Figure 7)
Often used for pallets and crates due to its strength 4. By optimizing space utilization during
and availability. Wooden pallets are widely transport and reducing handling time, tertiary
utilized in the pharmaceutical industry but may packaging can lead to significant cost savings
require treatment to prevent contamination. Plastic in logistics operations.
pallets and containers are increasingly popular due Key Functions
to their lightweight properties, durability, and Containment is one of the fundamental functions
resistance to moisture. They are also easier to clean of pharmaceutical packaging, serving as the first
and sanitize compared to wooden alternatives. line of defense in ensuring that medications remain
Metal containers provide superior strength and stable, effective, and safe for use. This aspect of
durability for heavy or sensitive pharmaceutical packaging encompasses various design
products. They are often used when maximum considerations and material choices that
protection is required during transport. collectively work to prevent leakage, diffusion,
Advantages and permeation of the product. [4,8,9] .
1. By grouping multiple packages together, Protection is a fundamental function of
tertiary packaging simplifies handling pharmaceutical packaging, crucial for
processes at warehouses and distribution safeguarding medications against various
centers. This leads to faster loading times and environmental factors such as light, moisture, and
reduced labor costs. oxygen. These external elements can significantly
2. Tertiary packaging provides an additional impact the stability, efficacy, and safety of
layer of protection against physical damage pharmaceutical products. [10,11].
during transit. This is particularly important Information Delivery is a critical function of
for fragile or sensitive pharmaceutical pharmaceutical packaging, as it ensures that
products that require careful handling. essential information about the medication is
3. Standardized tertiary packaging allows for effectively communicated to healthcare
better organization within warehouses and professionals and patients. This function
facilitates easier tracking of inventory encompasses the use of labels, package inserts,
throughout the supply chain. and other informational materials that provide vital

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details regarding the drug's usage, safety, and preventing accidental ingestion of medications and
storage. hazardous substances by children. With the rising
Tamper Evidence is a crucial function of awareness of child safety, manufacturers are
pharmaceutical packaging that ensures the increasingly focused on developing packaging
integrity and safety of medications by providing solutions that are both effective in safeguarding
visible indications of any unauthorized access or children and accessible for adults, particularly
tampering. This function has gained significant seniors. Accidental poisoning remains a
importance in the wake of various incidents significant public health concern, particularly
involving product tampering, most notably the among young children aged 1 to 5 years.
Tylenol poisoning case in the 1980s, which led to According to the World Health Organization,
increased regulatory scrutiny and the medicines are a leading cause of non-fatal
establishment of tamper-evident packaging poisoning incidents globally. Child-resistant
requirements. packaging is designed to mitigate this risk by
1. Tamper-Evident Seals making it difficult for children to open containers
2. Breakable Caps that hold potentially harmful substances. The
3. Shrink Bands implementation of CRP is not just a regulatory
4. Tear Strips requirement; it reflects a commitment to consumer
5. Color-Changing Inks safety and responsible manufacturing practices.
6. Intelligent Packaging Solutions [10]. 1. Multi-Step Opening Mechanisms
Innovative Packaging Technologies 2. Locked4Kids Packaging
Smart packaging is an innovative approach that 3. Smart Packaging Techologies
incorporates advanced technologies, such as 4. Visual Distraction Technologies [8,14-16]
sensors, to monitor and enhance the safety, quality, Anti-counterfeit measures in pharmaceutical
and efficiency of pharmaceutical products. This packaging are essential for safeguarding consumer
technology is particularly crucial in the health and maintaining the integrity of
pharmaceutical sector, where maintaining the medications. With the increasing prevalence of
integrity of medications is paramount. counterfeit drugs, which pose significant risks to
1. Real-Time Monitoring public safety, innovative technologies such as
2. Active Interaction holograms, QR codes, and RFID (Radio
3. Enhanced Traceability Frequency Identification) are being adopted to
Benefits of Smart Packaging combat this growing threat.
1. Improved Product Safety 1. Holograms
2. Increased Efficiency 2. QR Codes
3. Sustainability [11-13] 3. RFID Technology
Child-resistant packaging (CRP) is a crucial
innovation in the pharmaceutical industry aimed at

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Biodegradable Materials are becoming innovations in this area is the incorporation of

increasingly important in the quest for sustainable Braille labels, which provide critical information
packaging solutions within the pharmaceutical in a tactile format. Accessibility features in
industry. As concerns about plastic waste and pharmaceutical packaging are vital for
environmental impact grow, innovative empowering visually impaired individuals to
biodegradable packaging options are emerging to independently manage their medications. The
reduce the ecological footprint of packaging ability to read labels and understand dosage
materials. Biodegradable packaging refers to instructions is crucial for ensuring that patients
materials that can decompose naturally through take their medications correctly and safely.
the action of microorganisms such as bacteria, Without accessible packaging, visually impaired
fungi, and algae. This ability to break down and individuals may face challenges in identifying
return to their natural state contributes their medications, which can lead to medication
significantly to reducing waste accumulation in errors, missed doses, or adverse health outcomes.
landfills and minimizing environmental Types of Braille Labels
pollution. Unlike traditional plastics, which can 1. Embossed Labels
take hundreds of years to decompose, 2. Screen-Printed Braille
biodegradable materials are designed to degrade 3. Integral Braille
within a much shorter timeframe—typically 4. Adhesive Labels
within a year or less—depending on 5. Marburg Braille
environmental conditions.
1. Cornstarch-Based Materials
2. Mushroom Packaging
3. Seaweed Packaging
4. Paper and Cardboard
5. Bio-Plastics
(Figure 12)
6. Bamboo [8,20-24]
Patient-Centric Designs
Accessibility Features in pharmaceutical
packaging are essential for ensuring that visually
impaired patients can safely and effectively use
their medications. One of the most significant
(Figure 13)

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Adherence Aids are essential components of packaging difficult to open. A study indicated that
patient-centric designs in pharmaceutical many older adults struggle with common
packaging, particularly for individuals managing packaging types, such as water bottles and food
chronic conditions. These aids, such as calendar containers, which can lead to frustration and non-
packs and reminder systems, are specifically adherence to medication regimens. User-friendly
designed to enhance medication adherence by packaging addresses these challenges by
providing structured, easy-to-follow systems that simplifying the opening process, thereby
help patients remember their medication promoting independence and enhancing patient
schedules. Medication adherence is a significant confidence in managing their medications.
challenge in the management of chronic diseases. 1. Easy-Open Caps and Lids
Research indicates that adherence rates often 2. Pull-Tab and Tear-Away Features
hover around 50% in developed countries, with 3. Transparent Packaging
forgetfulness being a major contributing factor to 4. Pictorial Instructions [35-38]
non-adherence . Non-adherence can lead to poor Regulatory Considerations
health outcomes, increased hospitalizations, and Compliance with Standards Strict regulatory
higher healthcare costs. Factors contributing to considerations are applied to pharmaceutical
non-adherence include complex medication packaging to guarantee safety, effectiveness, and
regimens, lack of understanding about the adherence to several standards. Guidelines
treatment's importance, and insufficient governing the packaging and labeling of
information provided during consultations. pharmaceutical items are provided by regulatory
Adherence aids address these challenges by agencies including the European Medicines
simplifying the medication-taking process and Agency (EMA) and the U.S. Food and Drug
providing reminders that encourage patients to Administration (FDA).
follow their prescribed regimens. U.S. Food and Drug Administration (FDA)
1. Calendar Packs plays a critical role in regulating pharmaceutical
2. Visual Cues packaging in the United States. The primary
3. Compartmentalization regulations governing packaging are outlined in
4. Blister Packs the Code of Federal Regulations (CFR),
5. Electronic Reminder Systems particularly 21 CFR Part 211, which addresses
• Smart Pill Bottles current good manufacturing practices (cGMP) for
• Mobile Applications pharmaceuticals. Key aspects include:
• Automated Messaging Systems [28-34] 1. Suitability for Intended Use
User-Friendly Interfaces in pharmaceutical 2. Tamper-Evident Packaging
packaging are crucial for ensuring that all patients, 3. Child-Resistant Packaging
particularly the elderly and those with dexterity 4. Labeling Requirement
issues, can access their medications safely and 5. Quality Control Procedures
easily. As the global population ages, the demand European Medicines Agency (EMA) provides
for packaging solutions that cater to these needs regulatory guidance for pharmaceutical packaging
has become increasingly important. within the European Union, emphasizing similar
The aging population often faces physical principles as those established by the FDA .
challenges such as reduced strength, arthritis, and 1. Packaging Materials
diminished fine motor skills, making traditional 2. Tamper-Evident Features

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3. Child-Resistant Packaging • Increased Adherence Rates
4. Labeling Standards • Enhanced Communication
5. Good Manufacturing Practices [39-43] • Operational Efficiency
Stability Testing Protocols are a critical aspect of • Sustainability [50-53]
pharmaceutical development, ensuring that Personalized Packaging Solutions are the future
medications maintain their quality, safety, and of pharmaceutical packaging is increasingly
efficacy throughout their shelf life. The selection leaning towards personalized packaging solutions
of appropriate packaging materials based on that cater to individual patient demographics and
stability data is essential for preserving the medication types. This trend is driven by
integrity of pharmaceutical products. advancements in technology, a greater
Stability testing is designed to evaluate how a understanding of patient needs, and the growing
pharmaceutical product behaves under various emphasis on personalized medicine. Below, we
environmental conditions over time. The primary will explore the significance of personalized
objectives include: packaging solutions, their potential applications,
1. Determining Shelf Life and the implications for patient care.
2. Defining Storage Conditions Personalized packaging refers to the customization
3. Regulatory Compliance of pharmaceutical packaging based on specific
4. Quality Assurance patient demographics, medication types, and
5. Regulatory Framework [44-49] individual health needs. This approach aims to
Future Trends enhance the overall patient experience by making
The integration of Artificial Intelligence (AI) medications easier to manage and more effective
and the Internet of Things (IoT) into packaging in promoting adherence.
is poised to revolutionize the pharmaceutical 1. Demographic-Specific Features
industry, creating smart packaging solutions that 2. Medication-Specific Customization
enhance communication between products and 3. Genetic-Based Customization
healthcare providers. This transformation not only Implications for Patient Care
improves operational efficiency but also • Enhanced Patient Engagement
significantly impacts patient care and medication • Reduction in Medication Errors
management. Below is an exploration of the
• Improved Health Outcomes
potential of AI and IoT in smart packaging, their
• Cost-Effectiveness [9,54-58]
applications, and the benefits they bring to
CONCLUSION
healthcare.
Innovative packaging plays a critical role in
1. Enhanced Data Collection and Monitoring
enhancing patient safety and compliance within
2. Communication with Healthcare Providers
the pharmaceutical industry. As the healthcare
3. Personalized Patient Engagement
landscape evolves, packaging solutions are
4. Applications of Smart Packaging in
increasingly designed not only to protect
Pharmaceuticals
medications but also to facilitate better patient
• Predictive Maintenance engagement and adherence to treatment regimens.
• Quality Control Enhancing Patient Safety
• Supply Chain Optimization 1. Tamper-Evident Features
Benefits of Smart Packaging Solutions 2. Child-Resistant Packaging
• Improved Patient Safety 3. Smart Packaging Technologies

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4. Active Packaging Solutions CHEMICAL SCIENCES ISSN: 2277 5005
5. User-Friendly Designs (Vol. 1, Issue 3). www.ijpcsonline.com1282
6. Visual and Tactile Reminders 4. Zadbuke N, Shahi S, Gulecha B, Padalkar A,
7. Electronic Reminders Thube M. Recent trends and future of
8. Personalized Packaging Solutions pharmaceutical packaging technology. J
The need for ongoing research and Pharm Bioallied Sci. 2013 Apr;5(2):98-110.
development in pharmaceutical packaging doi: 10.4103/0975-7406.111820. PMID:
technologies is becoming increasingly critical as 23833515; PMCID: PMC3697200.
the industry faces evolving challenges and 5. Jadhav, H. S., Kale, R. B., & Aher, 3akshay
opportunities. As highlighted by recent trends, H. (2022). A REVIEW ON INNOVATIVE
advancements in technology, regulatory PACKAGING OF MEDICINE (Vol. 10).
requirements, and patient expectations are driving www.ijcrt.org
the demand for innovative packaging solutions 6. Jadhav, S. P., Deore, S. D., Gajmal, G. K.,
that enhance safety, compliance, and Jadhav, S. P., Patil, D. M., & Sonawane, D.
sustainability. Here are several key reasons D. (2023). Study of different methods of
emphasizing the importance of continuous R&D in Pharmaceutical Packaging. Article in Journal
this field: of Interdisiplinary Cycle Research.
1. Advancements in Technology https://www.researchgate.net/publication/36
2. Regulatory Compliance 8445296
3. Sustainability Initiatives 7. A Review On Advancements In The
4. Personalized Medicine Packaging Of Medicines. (n.d.).
5. Combatting Counterfeiting https://doi.org/10.5281/zenodo.10389787
6. Enhancing Patient Engagement 8. Chordiya, S. v, & Garge, B. M. (n.d.).
REFERENCES Innovative packaging of medicines. In
1. Poitou P. Les missions du conditionnement en Review Article IP International Journal of
terme de sécurité et de bon usage du Aesthetic and Health Rejuvenation (Vol. 2,
médicament [The role of the packaging in Issue 4).
terms of safety and good use of medicines]. 9. Annex 9 Guidelines on packaging for
Ann Pharm Fr. 2003;61(5):300-3. French. pharmaceutical products. World Health
PMID: 13130287. Organization WHO Technical Report Series,
2. Nikam, S., Homepage, J., Nikam, S. M., No. 902, 2002
Davange, M. D., & Patil, D. M. (2023). 416- 10. Manoj Shivaji Kumbhar, Naresh Hiraram
432 | Review International Journal In Choudhary, Deepak Annasaheb Dighe, Meera
Pharmaceutical Sciences 416|Page Chandradatt Singh , TAMPER EVIDENT
International Journal In Pharmaceutical PHARMACEUTICAL PACKAGING –
Sciences A Review On Advancements In The NEEDS AND ADVANCES , International
Packaging Of Medicines. Int. J. in Pharm. Sci, Journal of Pharmaceutical Sciences Review
1. https://doi.org/10.5281/zenodo.10389787 and Research , page 141-153
3. Kunal, M., Akhilesh, D., & Shyam Kumar, B. 11. Kunal, M., Akhilesh, D., & Shyam Kumar, B.
(n.d.). Recent Trends in Pharmaceutical (n.d.). Recent Trends in Pharmaceutical
Packaging: A Review. In INTERNATIONAL Packaging: A Review. In INTERNATIONAL
JOURNAL OF PHARMACEUTICAL AND JOURNAL OF PHARMACEUTICAL AND

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES 254 | P a g e

 Saurabh Argade, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 01, 245-257 |Review
CHEMICAL SCIENCES ISSN: 2277 5005 from blister packaging for tablets and
(Vol. 1, Issue 3). www.ijpcsonline.com1282 capsules. European Journal of Clinical
12. Pandey, P., Pal, R., Chanana, A., & Pal Singh, Pharmacology, 80(1), 151–161.
R. (n.d.). THE VARIOUS TYPES OF https://doi.org/10.1007/s00228-023-03594-1
PACKAGING AND THEIR MATERIALS 21. https://www.weavabel.com/blog/from-
IN THE PHARMACEUTICAL PRODUCTS popular-to-lesser-known-types-of-
OR FORMULATIONS. biodegradable-packaging
https://www.researchgate.net/publication/36 22. https://meyers.com/meyers-blog/what-is-
9669032 biodegradable-packaging/
13. V, alFIya P., SaMuEl, M. P., mUrAlI, S., & 23. Mahe, E., Levaggi, R., Veronin, M., Ms, B.,
DElFIya, anIESranI. (2017). KERALA & #1, P. (n.d.). Packaging and Labeling of
KARSHAKAN e-journal. Pharmaceutical Products Obtained from the
14. Dailin, D. J., & Rithwan, F. (2022). A Review Internet.
on current status of plastic waste 24. RAKESH NALAM. (2023). Essentials of
Biodegradation using microbial approach. pharmaceutical packaging to prevent drug
https://www.researchgate.net/publication/36 counterfeiting. International Journal of
3263600 Science and Research Archive, 9(2), 599–
15. Nasa, P., Praveen Nasa, A., Singh Mahila 605.
Vishwavidyalaya, P., & Kalan, B. (2014). A https://doi.org/10.30574/ijsra.2023.9.2.0610
REVIEW ON PHARMACEUTICAL 25. Annex 9 Guidelines on packaging for
PACKAGING MATERIAL. In 344 Praveen pharmaceutical products. (n.d.).
World Journal of Pharmaceutical Research 26. Ran, X., Qu, Y., Wang, Y., Cui, B., Shen, Y.,
(Vol. 3, Issue 5). www.wjpr.net & Li, Y. (2023). Enhanced UV-Blocking
16. aruna, S. M., & Rao, R. N. (n.d.). A Review Capabilities of Polylactic Acid Derived from
on Packaging for Different Formulations. Renewable Resources for Food and Drug
17. Ashiwaju, B. I., Orikpete, O. F., Fawole, A. Packaging: A Mini-Review. In Journal of
A., Alade, E. Y., & Odogwu, C. (2023). A Composites Science (Vol. 7, Issue 10).
Step toward Sustainability: A Review of Multidisciplinary Digital Publishing Institute
Biodegradable Packaging in the (MDPI). https://doi.org/10.3390/jcs7100410
Pharmaceutical Industry. Matrix Science 27. https://www.europeanpharmaceuticalreview.
Pharma, 7(3), 73–84. com/article/117701/latest-innovations-in-
https://doi.org/10.4103/mtsp.mtsp_22_23 child-resistant-pharmaceutical-packaging/
18. Popović, K., Živanović, S., & Jevtić, I. 28. Fernandez-Lazaro, C. I., García-González, J.
(2024). Biopolymer Packaging Materials in M., Adams, D. P., Fernandez-Lazaro, D.,
the Pharmaceutical Industry. AIDASCO Mielgo-Ayuso, J., Caballero-Garcia, A.,
Reviews, 2(1), 46–56. Moreno Racionero, F., Córdova, A., &
https://doi.org/10.59783/aire.2024.43 Miron-Canelo, J. A. (2019). Adherence to
19. https://www.swiftpak.co.uk/insights/anti- treatment and related factors among patients
counterfeiting-in-pharmaceutical-packaging with chronic conditions in primary care: A
20. Falconnier-Williams, O. C., Taeschner, W., cross-sectional study. BMC Family Practice,
Hille, A., Falconnier, A. D., & Haefeli, W. E. 20(1). https://doi.org/10.1186/s12875-019-
(2024). Untapped options to reduce waste 1019-3

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES 255 | P a g e

 Saurabh Argade, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 01, 245-257 |Review
29. Neiman, A. B., Ruppar, T., Ho, M., Garber, 35. Bell AF, Walton KL, Tapsell LC. Easy to
L., Weidle, P. J., Hong, Y., & Mary, ; (n.d.). open? Exploring the 'openability' of hospital
Morbidity and Mortality Weekly Report food and beverage packaging by older adults.
(MMWR). Appetite. 2016 Mar 1;98:125-32. doi:
30. Association between non-adherence 10.1016/j.appet.2015.12.004. Epub 2015 Dec
behaviors, patients’ experience with 11. PMID: 26686584.
healthcare and beliefs in medications_ a 36. https://www.healthcarepackaging.com/desig
survey of patients with different chronic nmaterials/adherencedelivery/news/1328292
conditions. (n.d.). 4/aging-population-demanding-easyopen-
31. Rivera-Picón, C., Benavente-Cuesta, M. H., packages
Quevedo-Aguado, M. P., Sánchez-González, 37. Sekine, Y., Kawaguchi, T., Kunimoto, Y.,
J. L., & Rodríguez-Muñoz, P. M. (2023). Masuda, J., Numata, A., Hirano, A., Yagura,
Factors Associated with Adherence to H., Ishihara, M., Hikasa, S., Tsukiji, M.,
Treatment in Patients with HIV and Diabetes Miyaji, T., Yamaguchi, T., Kinai, E., &
Mellitus. Journal of Personalized Medicine, Amano, K. (2023). Adherence to anti-
13(2). https://doi.org/10.3390/jpm13020269 retroviral therapy, decisional conflicts, and
32. Burnier, M. (2024). The role of adherence in health-related quality of life among
patients with chronic diseases. In European treatment-naïve individuals living with HIV:
Journal of Internal Medicine (Vol. 119, pp. 1– a DEARS-J observational study. Journal of
Elsevier B.V. Pharmaceutical Health Care and Sciences,
https://doi.org/10.1016/j.ejim.2023.07.008 9(1). https://doi.org/10.1186/s40780-023-
33. Menditto, E., Orlando, V., de Rosa, G., 00277-y
Minghetti, P., Musazzi, U. M., Cahir, C., 38. https://eurpack.it/2024/04/29/developing-an-
Kurczewska-Michalak, M., Kardas, P., Costa, inclusive-senior-friendlypackaging/?lang=en
E., Lobo, J. M. S., & Almeida, I. F. (2020). 39. Pharma Packaging Guidelines & Regulations
Patient centric pharmaceutical drug product in the USA | Origin
design—the impact on medication adherence. 40. Klemenčić, M., Bolanča Mirković, I., & Bolf,
In Pharmaceutics (Vol. 12, Issue 1). MDPI N. (2023). The Influence of the Production
AG.https://doi.org/10.3390/pharmaceutics12 Stages of Cardboard Pharmaceutical
010044 Packaging on the Circular Economy.
34. Sekine, Y., Kawaguchi, T., Kunimoto, Y., Sustainability (Switzerland), 15(24).
Masuda, J., Numata, A., Hirano, A., Yagura, https://doi.org/10.3390/su152416882
H., Ishihara, M., Hikasa, S., Tsukiji, M., 41. Takahashi, K., & Aldridge, A. A. (n.d.).
Miyaji, T., Yamaguchi, T., Kinai, E., & Quality , Production, Laboratory, Materials ,
Amano, K. (2023). Adherence to anti- Facilities and Equipment Packaging and
retroviral therapy, decisional conflicts, and Labeling Regulatory Education for Industry
health-related quality of life among (REdI): Focus on CGMPs & FDA Inspections
treatment-naïve individuals living with HIV: Packaging & Labeling.
a DEARS-J observational study. Journal of 42. Guidance for Industry Container Closure
Pharmaceutical Health Care and Sciences, Systems for Packaging Human Drugs and
9(1). https://doi.org/10.1186/s40780-023- Biologics CHEMISTRY,
00277-y MANUFACTURING, AND CONTROLS

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES 256 | P a g e

 Saurabh Argade, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 01, 245-257 |Review
DOCUMENTATION (Vol. 20857). (1999). 52. Campanella, B., Simoncini, M., Passaglia, E.,
Tel. Cicogna, F., Ciancaleoni, G., González-
43. Gahtori, A. U. (n.d.). Systematic Review Rivera, J., Bernazzani, L., & Bramanti, E.
Pharmacy 5 2 2 Recent Trends in (2024). Ecofriendly Preparation of
Pharmaceutical Packaging. Rosmarinic Acid-poly(vinyl alcohol)
https://doi.org/10.31858/0975- Biofilms Using NADES/DES, Ultrasounds
8453.13.8.522-526 and Optimization via a Mixture-Process
44. Carli Lorenzini, G., & Olsson, A. (2022). Design Strategy. Materials, 17(2).
Exploring How and Why to Develop Patient- https://doi.org/10.3390/ma17020377
Centered Packaging: A Multiple-Case Study 53. https://dragonflyai.co/resources/blog/how-ai-
with Pharmaceutical Companies. Therapeutic and-iot-are-transforming-packaging-design
Innovation and Regulatory Science, 56(1), 54. https://www.packaging-
117–129. https://doi.org/10.1007/s43441- gateway.com/features/ai-smart-packaging-
021-00338-0 enhancing-customer-experience/
45. Salem, A., Abdelhedi, O., Sebii, H., 55. Goetz, L. H., & Schork, N. J. (2018).
Fakhfakh, N., Jr, M., Kechaou, H., Nasri, M., Personalized medicine: motivation,
Debeaufort, F., & Zouari, N. (2022). challenges, and progress. In Fertility and
Preparation and Characterization of Sterility (Vol. 109, Issue 6, pp. 952–963).
Ecofriendly food Packaging Material by Elsevier Inc.
Smooth Hound Skin Gelatin Films/TiO2. https://doi.org/10.1016/j.fertnstert.2018.05.0
https://doi.org/10.21203/rs.3.rs-1239574/v1 06
46. https://aurigaresearch.com/pharmaceutical- 56. https://en.wikipedia.org/wiki/Personalized_
testing/stability-testing/ medicine
47. ICH Topic Q 1 E Evaluation of Stability Data 57. https://www.nature.com/scitable/topicpage/p
Step 5 NOTE FOR GUIDANCE ON harmacogenomics-and-personalized-
EVALUATION OF STABILITY DATA. medicine-643/
(2003). http://www.emea.eu.int 58. Swarup Das, P., Saha, P., & Das, R. (n.d.).
48. Pareek, V. (2014). Pharmaceutical packaging: Pharmaceutical Packaging Technology: A
Current trends and future. Brief Outline.
https://www.researchgate.net/publication/29 HOW TO CITE: Saurabh Argade*, Someshwar Mankar,
7091323 Suhas Siddheshwar, Revolutionizing Pharmaceutical
Packaging: A Comprehensive Review of Current Trends
49. https://humiditycontrol.com/blog/what-is- and Future Directions, Int. J. of Pharm. Sci., 2025, Vol
stability-testing/ 3, Issue 01, 245-257.
50. Bhat, J. (n.d.). Role of packaging material on https://doi.org/10.5281/zenodo.14602999
Pharmaceutical product stability.
51. Kasagani, V., & Kakollu, V. (2023). Design
and Implementation of a Track n trace 2D
Multi Scanner Bulk Code Reader for
Pharmaceutical Packaging. International
Journal of Life Science and Pharma Research.
https://doi.org/10.22376/ijlpr.2023.13.2.p37-
p50

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