OpenLIMS

our mission is to provide a professional and complete lims for the laboratory complement

comprehensive solution for the laboratory complement

OpenLIMS is the new generation of the Laboratory Information Management System, equipped with open architecture. This LIMS supports several local laboratories, as well as domestic laboratory chains. OpenLIMS new generation development began in 2003. The new generation development is based on the great experiences reached during the long period of providing the first generation of LIS (more than 250 installations in the Czech Republic and 100 installations in the Slovak Republic). The works on the first generation of LIS started in 1985, and the first PC-version was installed in 1991. Two laboratories in the Czech Republic started to work with OpenLIMS in 2005 as pilot projects. From 2006 the system is being released for commercial use in any types of laboratories, and it is capable of managing a wide range of laboratory chains requirements. OpenLIMS supports the following laboratory qualifications: biochemistry, hematology, virology, parasitology, immunology, cytology, bacteriology, microbiology, genetics and pathology.

openlims characteristics

OpenLIMS is a modern and flexible system, which uses the newest available technologies. OpenLIMS has completely secure access to the data. OpenLIMS is suitable not only for small laboratories with a single workstation, but also for wide laboratory chains with thousands of workstations. (The biggest installation: 200 workstations with 60 on-line connected analysers). OpenLIMS enables management of the laboratory chain with joint data sources. OpenLIMS enables communication with all types of analyzers and can easily define the communication interface with external systems (HIS). OpenLIMS includes many functions for lab assistants, chemists and laboratory managers. OpenLIMS has important operational modules, which are accessible via WWW interface. WWW interface enables on-line laboratory examination ordering and result-viewing.

 OpenLIMS supports language modification and enables easy module customization according to any specific legislation. OpenLIMS has the user friendly interface responding to Microsoft Windows standards. The important work forms are fully configurable and adjustable. OpenLIMS is directly connected to Stapro HelpDesk application. An experienced team of specialists is ready to help with the laboratory processes optimalization. OpenLIMS can be constantly monitored from the remote centre in Stapro, Czech Republic. It enables accessibility to the critical parts of the system database, applications and communication server.

OpenLIMS capabilities
analytical capabilities
Reference range mechanism - It allows the method evaluation in nine intervals differentiated by various parameters such as sex, age, diagnosis, collection time and other common conditions (i.e. the dependence on the other method result). The reference range has its own history, and it is possible to change it through time. Except for the reference range (physiological range, pathological range), it is possible to define the intervals of the feasible ranges for the numerical values entrance. Delta Check - Once Delta Check mechanism is configured and activated, every value over the given limits (growth/drop) of test results are checked. The evaluation may be defined by age, sex, diagnosis or other common conditions. Calculated tests - Common calculated mechanism enables the immediate calculation of the results according to the given results methods and related information. Inconsistency and automatic evaluation - According to pre-defined rules, it is possible to evaluate the methods and their results between them, together with other patient data.

Result history - All previous patient results may be viewed on-line, including all evaluation and text descriptions. The result history may be used when the results have been automatically or manually validated, when the cumulative report has been printed and when Delta Check has been proceeded.

Definition of calculated test

Redundant methods - The redundant examinations are indicated, which can produce reduction in lab costs. Automatic result approval - According to the reference range evaluation, Delta Check, QC results and other conditions are the automatic result approval provided. Manual result approval - Manual result approval may be provided in several levels lab assistant, chemist, doctor, etc. QC Internal quality control - The QC archives all samples results manually inserted, or online information received from the analyzers. It enables its graphic presentation (Levey-Jennings graph, Younden graph) and the comparison of the atest and aberrations. QC includes on-line evaluation of the Westgards rules. The part of QC is also the monitoring of the result averages, where extremes are excluded. TAT (Total Around Time) - TAT is used for the monitoring and evaluation of the period necessary for the manipulation with all different types of samples.

Security

Result database - The user access policy can be defined separately for some users, and integrated for others. Access rules - The users definition and allocation to the access rights groups enables to set different access to the modules. It also manages the access to the operational parts or to the methods for each user. Logging system - Keeps history of all changes in the system and its authors, including the list of cancelled results/records.

Submission of requests, identifications and results

Print records

Standard reports - All different kinds of working protocols, main books, name lists, extreme result books, result list, etc. Report generator - Flexible parametric reports and scripts, colour printing. Automatic report creation on the background

Communication

OpenLIMS has a separate communication component. It communicates with analyzers, devices and external subjects (such as HIS, IS for general practitioners, etc.) The communication component does not depend on the core. It enables communication with analyzers even during possible temporary failure of the connection with OpenLIMS central database. The communication has been tested on more then 300 analyzers and devices. It supports one-way and two-way communication within the batch mode and also through online mode. It supports POCT analyzers. It provides on-line control transfer to the QC system. It enables transfer of the failure codes from analyzers. Also, there is the possibility upon requirement for the automation of repeated or additional examinations according to the measurement results. It communicates with analyzers through USB, RS 232 or TCP/IP protocol. It communicates with external systems in data standard (Ministry of Health of the Czech Republic), HL7 interface. The XML format is supported.

Results distribution

Result lists - The format of result lists can be defined by users according to the type of the applicants. Print reports archive - All print reports are archived, if needed with the electronic signature and time stamp. Electronic distribution - The selected applicants may received the results in electronic format, such as TXT, XML and data standard (Ministry of Health of the Czech Republic). The guaranteed and secure transfer is provided by product called MISE.

Remote access

WWW interface for examination requirement input. WWW interface for displaying results.

Work automation

Barcodes - The barcodes are used for the patient identification, sample identification and for communication with analyzers. OMR (Optical Mark Reading) - The one-way and two-way automation optical mark reader can be connected. Central entry - All requirements enter the system in one place and are automatically distributed to the operational parts of laboratories.

View of result history

Sample tracking mechanism - for each sample, a track is kept in the analytical process and in the storage room. Sequence - Often repeated activities can be predefined and manually or automatically run, when defined conditions are fulfilled. Sequences may be activated on the background as server processes. Work management - Specifically defined rules help to automatically modify work when defined conditions occur.

Statistics and finance

Statistics module - Statistics reports are generated according to the applicants, type of method and working parts or its groups. Financial module - It is the separate component, which represents the legislative needs of specific country. Invoicing - The user is able to make the invoice for the examination (preliminary or final) and also aggregate invoice for the applicant/department.

Result report

Additional functions

Daily operation - It enables the creation of reports about all samples in specific parts of the system. Daily statistics - Continuous report about the numbers of samples, daily averages and aberrations. Daily operation control - Continuous control of the daily work, such as duplicity and misspells.

Technology
System architecture
OpenLIMS uses the newest available development technologies. The system is developed with following basic parameters: component solution in Microsoft.Net and C# technology n-tier architecture database independents national independents (language and application) www interface for the system administration and for the specific components operation

The verified databases are Microsoft SQL v2000 and Oracle v9

N-tier architecture represents the strict database separation, application logic and clients presentation tier. The database tier fully respects the rules of SQL databases. It enables to choose the specific database according to the customer need and possibilities. The operation system on which is the database installed can be UNIX, LINUX or Microsoft servers. For the OpenLIMS client part, Microsoft Windows is used. OpenLIMS works on one PC or on larger networks. The work on large networks has a definite advantage; the database and application server may be separated, and the output is divided according to the operation needs. The possible OpenLIMS methods of installation: on one workstation with OS Windows-run database, application tier and client tier on server-run database and application tier; workstations run client tier the individual server is used for database and application tier, on workstation-run client tier According to the needs, the application tier may be installed on more servers/workstations. This enables division of the load among more workstations while several workstations are in use. For higher accessibility, it is possible to use the cluster solution for the database/application tier. For the communication with analysers and devices, it is possible to use the individual server. Its work is independent to the other parts of the system. This enables communication with analysers, including during possible temporary failure of the main OpenLIMS database.

system characteristic

OpenLIMS is developed as a component system. The basic services are run by the core of the system. Other components are added according to the laboratory needs. The core provides: the access rights and the system security the documentation of all changes made within the system the access to the identification register and to the results database the codes administration and users configuration administration the system versions list and possible upgrade administration The main components working over the core are: the access to the identification, examination requirements and results input the communication with analyzers and devices the results presentation the print component the statistics including QC and financial components (invoicing, billing) In OpenLIMS more laboratories can be defined, using the same list of patients applying for the examination. Each laboratory can use its own code lists (methods, texts, etc.) and its work can be divided into independent parts. They may have their own parameters for work with numerical lines of samples and for examination requirements, for results validation, for results distribution, etc.

System setup

the processes over the register and results database: calculation, validation, print reports, etc.

The design of the entrance window for each operational laboratory part may be adjusted according to laboratory needs.

Workstation requirements

Pentium 4 (or equivalent) PC Standard 512 MB RAM, optimal 1 GB RAM 1024x768 VGA 17 color monitor 20 GB Hard Disk RS232 or USB for connectivity with lab analyzers Depending on the size of the laboratory, it is recommended that a single processor or dual processor server with min. 2GB RAM, equipped with disk array for data storage. For data back-up, tape or DVD RW is used. The server accessibility will increase, when the two servers in the cluster connected to the disk array would be installed.

Server requirements

Software and operation systems requirements

Server - UNIX or Linux or Microsoft SQL 2000/2005 Server Database - possibilities: Oracle v9, Microsoft SQL v2000/2005 Application server - Microsoft SQL server 2000/2005 or Windows 2000/XP Workstation - Microsoft Windows 2000/XP and Microsoft .Net Framework Remote administration - RDP (Remote Desktop Protokol) and active Internet

STAPRO s. r. o.
Pernstynske nam. 51 530 02 Pardubice Czech Republic Phone: +420 467 003 111 Fax: +420 467 003 119 E-mail: stapro@stapro.cz

www.stapro.cz
Holder of quality management certificate under ISO 9001:2000 and environmental management certificate under ISO 14001:2004

Block schema of n-tier architecture

OpenLIMS Small Laboratory

OpenLIMS Standard Configuration

OpenLIMS The Laboratory Chain

The List of Connected Analyzers and Devices

Producer Biochemical analyzers Abbott Abbott Abbott Abbott AL Instruments AL Instruments Baker Bayer Bayer Beckmann Beckmann Beckmann Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Ciba Corning Ciba Corning Ciba Corning Ciba Corning Ciba Corning Dade (Du Pont) Dade (Du Pont) Dade (Du Pont) DPC Eppendorf Eppendorf Eppendorf Hoffmann-La Roche Hoffmann-La Roche Type Liasys Alcyon Spectrum CCx Spectrum EPx Aeroset Alixia Mascott + ENCORE ADVIA 1650 ADVIA 1200 Synchron CX 4, CX 5 Synchron CX 7 LX 20 Hitachi 704 Hitachi 705 Hitachi 717 Hitachi 737 Hitachi 902 Hitachi 911 Hitachi 912 Hitachi 917 Modular Alliance CL -7000 Express +, 550, 560, Merck Mega Merck Selectra, Selectra 2,VIVA Flexor F Dimension AR Dimension SMS, ES Dimension XL, XPAND Primus CLC 385 Primus PDQ ELAN ELAN DUO EPOS Cobas Mira Cobas Mira S

Hoffmann-La Roche Hoffmann-La Roche Hoffmann-La Roche Hoffmann-La Roche Instrument Laboratory Instrument Laboratory Johnson&Johnson Johnson&Johnson

Cobas Mira+ Cobas Integra 400 Cobas Integra 700 Cobas Integra 800 ILAB 600 ILAB 900 Vitros (Ektachem) 250 Vitros (Ektachem) 500, 950 Johnson&Johnson Vitros Eci Johnson&Johnson Vitros (Ektachem) 700, 700XR, 800 Orto clinical diagnostic Vitros Fusion Kone Konelab 30i Kone Konelab 60i Kone Konelab 20i Olympus AU 400, AU640 Olympus AU 560 Olympus AU 600 Olympus AU 800 Olympus AU 2700 Technicon Axon Technicon RA 1000 Technicon RA XT Tosoh G5, Tosoh G7 Minerals, ASTRUP, ELFO, ... Variant II BioRAD D10 ECA 180 Super G, Super GL AVL AVL 945, 995 AVL AVL Compact 1 AVL AVL Compact 2 AVL AVL Compact 3 AVL AVL OMNI AVL AVL 9181 AVL AVL OMNI C Biorad Variant Ciba Corning Chiron 248 Ciba Corning Chiron 348 Ciba Corning Chiron 644

Ciba Corning Ciba Corning Eppendorf Eppendorf Eppendorf fotometr - reader Instrumentation Lab. Instrumentation Lab. Instrumentation Lab. Labsystm Nova Nova Nova Olympus Radiometer Radiometer Radiometer Radiometer Radiometer Radiometer Radiometer Instrumentation Lab. Sebia Sebia Sebia Sebia Beckman Coulter Instrumentation Lab. Arkray Bayer BD Urine analyzers Arkray Arkray Arkray Bayer Lachema Bayer Boehringer Mannheim

Chiron 850 Chiron 865 EBIO EFIX EFOX 5053, EFIX 5055 BTS 230 EasyLite IL 1306 ILAB 900 FP 901 Nova STP 8 Nova STAT PROFILE M Nova CCX Biomedical HiTe320 ABL 50 ABL 300 ABL 330 ABL 500, 510 ABL 520 ABL 625, ABL 620 ABL 7xx - 725,730,740 GEM Premier 3000 DVS - denzitometr Hyris - denzitometr Preference - denzitometr Foresys. Capillaris Paragon cze 2000 Easy Blood Gas Osmometr OM6050 Rapidlab 855 Sedi-15 Instrument AUTION JET 4270 AUTION JET 4280 Poket Chem Clintec 50 Laura Uriscan Pro+ Clintec 500 Miditron M

Boehringer Mannheim Boehringer Mannheim DOT Lachema Nova Roche Roche Roche Toa Medical E.CO.

Urilux S Miditron Junior Supertron LabUReader Uriphan Nucleus Urisys 2400 Urisys 1800 Urisys 1100 Sysmex UF-50, 100 Quidel UrineQuick IQ 200 IRIS program LIANA Vidas Architect AxSYM Commander PPC IMx ADx LCx Centaur Access Unicel DXI 800(=Access) Array System Immage LS 6500 Nephelometr BN 100 Nephelometr BN2 Nephelometr BNA Opus BN Prospec ES 300 (TWIN 300) Elecsys 1010 Elecsys 2010 ACS 180 DCP Imullite DCP Imullite 2000, 2500

Immunological analyzers

Abbott Abbott Abbott Abbott Abbott Abbott Bayer Beckmann Beckmann Beckmann Beckmann Beckmann Behring Behring Behring Behring Behring Boehringer Mannheim Boehringer Mannheim Boehringer Mannheim Ciba Corning Diagnostic Products Corp. Diagnostic Products Corp.

Diagnostic Products Corp. Diagnostic Products Corp. Dynex Dynex technologie Hoffmann-La Roche Hoffmann-La Roche Johnson&Johnson KIM soft KIM soft Relevation Technologies Stratec Electronic DiaForin

MAXM RAS Dynatech MRX + SW Dynex DSX Cobas Core Cobas Core 2 Ammerlite program KIM-E, T, Q, ... program KIM-W PHAMAS Capsystem Stratec Etimax 3000 Adaltis Kryptor Laison AIA 600 AIA 360 Evolis BRIO DELTA ALISEI ABI PRISM 700

Biorad RADIM(SEAC) RADIM(SEAC) RADIM(SEAC) RIA analyzers Berthold

LBIS, LB 2104 (fluorescence) Berthold LB 958 Hewlett-Packard Cobra II PharmaTech Wizard 1480 RIA LABECO JNG-402,403 with program RIA LABECO Stratec Electronic Stratec RIA with program TSRINV Data submission (differential, ...) Elstasit UPD Eola Blood picture analyzers HY CELL + (14-16) Abbott Abbott CellDyn 1200 Abbott Abbott CellDyn 1600 Abbott Abbott CellDyn 1700

Abbott Abbott Abbott Abbott Abbott Abbott Abbott Bayer Bayer Bayer Bayer Ciba Corning Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Coulter Dannam Diatron Hoffmann-La Roche Hoffmann-La Roche Hoffmann-La Roche MS Labboratories MS Labboratories Nihon Kohden Nihon Kohden Nihon Kohden MUREX

Abbott CellDyn 1800 Abbott CellDyn 3000 Abbott CellDyn 3200 Abbott CellDyn 3500 Abbott CellDyn 3700 Abbott CellDyn 4000 Abbott Sapphire Advia 60 Advia 120 ADVIA 70 Centrallink Workcell Chiron 850 Counter M-530 (4) MAXM (3-5 p Diff) HMX GENS (5p diff) MD 18, MD II -18 MD 8 Onyx (3-5 p Diff) S560 (5) STK-S (5 p Diff) STKR (5p? diff) T540 (5) T660 (6) T840 (8) T890 (8) ACT, ACT 8, ACT 2 ACT 5 diff LH750 Excell 16 Abbacus Cobas Micros Cobas Minos, STX, STEL Cobas Vega (5 p Diff) MS 8 II (diff) MS 4 Celltac alfa(MEK6318) Celltac F, Celltac E Celltac F - double Minilyser 2001

Serono Serono Tecan Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO. Melet Schloesing lab. Diamond Diagnostics DiameD AG Mythic 18 Coagulometers Behnk Electronik Behnk Electronik Behnk Electronik Behnk Electronik Behring Behring Behring Instrumentation Lab. Instrumentation Lab. Instrumentation Lab. Instrumentation Lab. Instrumentation Lab. Stago Stago Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO.

Serono Baker System 9000 Serono Baker 9018 Miniswift Sysmex F-500 (5) Sysmex F-800 (8) Sysmex K-1000 Sysmex KX-21 (3 p Diff) Sysmex K-4500 Sysmex K-800 (8) Sysmex NE-1500 Sysmex SE-9000 Sysmex SF-3000 Sysmex XT 1800i Sysmex XT 2000i Sysmex XE 2100 MS 95 AU Micros 60 Pentra 80 Diamed, SW Maestro Biosen C-line CL 4 CM 2 CL 2 Trombostat Fibrintimer A Fibrintimer BF10 BCF ACL 100-300 ACL Futura ACL Advance ACL 9000 ACL 7000 ST4 Compact Sysmex CA-500,CA540, CA-560 Sysmex CA-1000 Sysmex CA-1500

Toa Medical E.CO. Toa Medical E.CO. Toa Medical E.CO.

Sysmex CA-5000 Sysmex CA-6000 SYSMEX CA 7000 AMAX Rack Rotor Organon technika Coag a Mate Organon technika Thrombolyser Compact X Interpretive programs, LIS connection ALPHA Hem-Himas interpretation Bianta Hem-Himas interperetation Cractes Immunotech Winliana Roche PSM without result transfer Roche PSM with result transfer Roche PSM direct regime Beckman Remisol