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Meropenem

Meropenem is a carbapenem antibiotic used to treat various bacterial infections including intra-abdominal infections, bacterial meningitis in pediatric patients over 3 months, and other infections like soft tissue infections and urinary tract infections. It works by inhibiting bacterial cell wall synthesis. Common side effects include diarrhea, nausea, rash and headache. Safety and efficacy have not been established for children under 3 months of age. Dosing is 1g every 8 hours with adjustment for renal impairment. It comes in 1000mg and 500mg intravenous formulations under the brand name Meronem.

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Muhammad Arsalan
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275 views1 page

Meropenem

Meropenem is a carbapenem antibiotic used to treat various bacterial infections including intra-abdominal infections, bacterial meningitis in pediatric patients over 3 months, and other infections like soft tissue infections and urinary tract infections. It works by inhibiting bacterial cell wall synthesis. Common side effects include diarrhea, nausea, rash and headache. Safety and efficacy have not been established for children under 3 months of age. Dosing is 1g every 8 hours with adjustment for renal impairment. It comes in 1000mg and 500mg intravenous formulations under the brand name Meronem.

Uploaded by

Muhammad Arsalan
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Meropenem

Therapeutic Category Antibiotic Pharmacologic class: Carbapenem Use\ Indications Intra-abdominal infections (complicated appendicitis and peritonitis) caused by viridans group streptococci, E. coli, K. pneumoniae, P. aeruginosa, B. fragilis, B. thetaiotaomicron, and Peptostreptococcus sp; also indicated for bacterial meningitis in pediatric patients >3 months of age caused by S. pneumoniae, H. influenzae, and N. meningitidis; meropenem has also been used to treat soft tissue infections, febrile neutropenia, and urinary tract infections Pharmacological Effects Inhibits bacterial cell wall synthesis by binding to several of the penicillin-binding proteins, which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis; bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested Adverse Reaction Central nervous system: Headache Dermatologic: Rash, pruritus Gastrointestinal: Diarrhea, nausea/vomiting, constipation Local: Pain at injection site, phlebitis, thrombophlebitis Respiratory: Apnea

Precautions/Warnings/Contraindication Pseudomembranous colitis and hypersensitivity reactions have occurred and often require immediate drug discontinuation; thrombocytopenia has been reported in patients with significant renal dysfunction; seizures have occurred in patients with underlying neurologic disorders. safety and efficacy have not been established for children <3 months of age; superinfection possible with long courses of therapy Pregnancy category: B Interactions: Increased effect: Probenecid competes with meropenem for active tubular secretion and inhibits the renal excretion of meropenem Dosing Adults: 1 g every 8 hours Dosing adjustment in renal impairment: Brand Available: Meronem 1000mg I.V Meronem 500mg I.V

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