Pelvic Mass
Benign ovarian tumors  unilateral, 99% cystic, mobile, 
smooth
Malignant ovarian tumors  bilateral, cystic & solid, fixed, 
irregular, 50% have ascites, cul-de-sac nodules, rapid growth
rate
!" & endometriosis  fixed li#e malignant ovarian tumors
$%, !", & liver d&  can present w' ascites
( )0% of abd masses in #ids * + years are renal in origin
Pelvic kidney occurs in ( ,5% of girls w'o vagina or uterus
-drenal-renal tumors are partially cystic, partially solid  
do ultrasound first, .$ scan second
elvic mass in pre-pubertal female /0 age +1
 21% ovarian/tubes
o 100% neoplastic
 20% benign3 )0% malignant
o 95% are germ cell tumors
 !% bladder/renal
o 95% adrenal-renal tumors
 MC presentation = palpable mass (85%), abd pain 
& discomfort (55%)
 All ovarian masses in pre-pubertal females 
require surgery
elvic mass in young reproductive age female /,5-+0yo1
 0% ovarian/tubes
o "0% p#ysiologic
o ,5% neoplastic
 $!% benign 
 95% of neoplasms are germ cell 
tumors
 2$% uterus
o ,00% pregnancy related
elvic mass in pre-menopause female
 !!% ovarian/tubes
o +5% physiologic
o 55% neoplastic
 !% benign3 +5% malignant
 40% of neoplasms are epithelial 
tumors
 45% of those are lo% 
malignant potential
o 5% endometriosis
o 4% !"
o 5% 6ctopic precnancy
 &0% uterus
o 45% pregnancy related
o ,5% leiomyomata
 &% bo%el
,
elvic mass in post-menopause female
 &"% ovarian/tubes
o 100% neoplastic
 20% benign3 )0% malignant
o 90% are epit#elial tumors
 99% of those are invasive ca
 &0% uterus
o !!% cancer of uterus
o +5% cancer of cervix
o +0% leiomyomata
 10% bo%el
o )0% infection3 &0% cancer
 Most require surgery
 Always investigate tmor mar!ers
o '() * colon cancer
o ')12! * ovarian cancer
o )+P * germ cell cancer
 alpable ovary
o .ystic, * 5 cm, and normal .-,+5  0-
,% chance of malignancy
o 7ulticystic w' echoes, * 5 cm, normal 
.-,+5  -10% chance of malignancy
o .ystic, 0 5 cm, and normal .-,+5  -
10% chance of malignancy
o 7ulticystic w' echoes, 0 5 cm, normal 
.-,+5  2!-,0% chance of malignancy
Mullerian epithelium tumors of ovary  M' in 
reproductive age - post-menopausal females  derived 
from coelomic epithelium /peritoneum is too1  cause lower 
abd pain and abd enlargement3 can cause massive ascites3 
may have elevated Osteopontin 
 .erous cystadenocarcinomas 8 M' tumor of 
ovary3 45% benign3 us9 bilateral & unilocular
o $issue resembles fallopian tube 
epithelium
o Psammoma bodies
o Papillary pro/ections
o ')-12!
 Mucinous cystadenomas 8 +
nd
 7. ovarian 
neoplasm3 50% benign3 5% bilateral3 us9 
multilocular3 tissue resembles cervical epithelium
o :ining of tall columnar epithelial cells w' 
apical mucin and absence of cilia
o 7iddle adult life
o Pseudomyxoma peritonei 8 extensive 
mucinous ascites, cystic epithelial 
implants on peritoneum
 (ndometrioid carcinomas 8 ;
rd
 7. ovarian 
neoplasm3 )0% bilateral3 tissue resembles 
endometrial epithelium
o ,5% assoc9 w' endometriosis
o ')-12!
 'lear cell adenocarcinoma  occurs w' 
endometriosis or endometrioid carcinoma of ovary 
 'ystadenofibroma  proliferation of fibrous 
stroma
 0renner tumors  adenofibromas w' nests of 
transitional cells  glandular spaces lined by 
columnar mucin secreting cells
Germ cell tumors of ovary  M' in pre-puberty and 
young reproductive age females
 1eratomas  M' germ cell tumors
o Mature 2benign3 teratomas 2dermoid 
cysts3  hair, cheesy sebaceous material, 
thyroid tissue  cystic & solid
 1x * laparoscopy %/ unilateral 
salpino-oop#orectomy
o Monodermal teratomas 
 Struma ovarii 7. type, 
composed entirely of thyroid 
tissue, causes #ypert#yroidism 
 <varian .arcinoid type 
/'arcinoid syndrome1
o 4mmature 2malignant3 teratomas  hair, 
cartilage, bone, calcifications3 fetal tissue 
 solid tumors
 5ysgerminomas  ovarian counterpart of 
seminoma of testis  M' malignant germ cell 
tumor
o -ll are malignant3 no endocrine function
o !nfiltration w' mature lymphocytes, 
occasional granulomas
 (ndodermal sinus 2yolk sac3 t umors  2
nd
 M' 
malignant germ cell tumor  fatal w'in + yrs  pts 
present w' rapidly developing pelvic mass w' abd 
pain
o   -fetoprotein 2)+P3
o   1-antitrypsin
o .c#iller-5uval bodies  characteristic 
glomerulus structure w' central blood 
vessel enveloped by germ cells lined by 
germ cells
 6varian c#oriocarcinoma  #ig# #'7
o =nresponsive to therapy  fatal
o .ompare to trophoblastic choriocarcinoma
Sex cord stromal tumors of ovary
 7ranulosa-1#eca cell tumors  extremely rare  
elaborate lots of (2  endometrial hyperplasia, 
endometrial ca, cystic d& of breast3 us9 solid3 us9 
unilateral3 acidophilic 'all-(xner bodies3 all 
potentially malignant3 high levels of inhibin
o Can case complete psedoisose"al 
precocity
 +ibroma-1#ecomas  us9 unilateral3 elaborate lots
of (2
o Meigs syndrome 8 nonspecific pain and 
pelvic mass w' or w'o ascites and right-
sided hydrothorax3 benign condition
 .ertoli-8eydig cell tumors 2adrioblastomas3  us9
unilateral3 masculini9ation3 pea# incidence in +
nd
-
;
rd
 decades3 tumors may bloc# normal female sex 
development /breast atrophy, amenorrhea, sterility1
+
 :ilus cell tumors 2mature 8eydig cell tumors3  
unilateral3 large lipid laden cells3 ;einke 
crystalloids3 high 1-ketosteroid excretion
 7onadoblastoma  mixed tumors /germ cells and 
stromal cells13 occurs w' hermaphroditism
Metastatic tumors of ovary
 7. mets are from contralateral ovary, derived from
mullerian system neoplasms
 7. extramullerian primaries 8 breast and >! tract
o <rukenberg tumor  >! mets to ovaries3 
mucin production3 signet-ring cells
5-,0% of women in =? will have surgery for suspected 
ovarian neoplasm during lifetime
 ,5-+0% of these will have malignant ovarian 
neoplasm
Most adnexal masses are benign
4nfant female /age * + years1  7. pelvic mass due to 
transient elevation in circulating gonadotropins after birth 
/p#ysiological ovarian cyst1
P#ysiologic 2functional3 ovarian cysts in reproductive age 
female /age ,5-+01  repeat ultrasound in 2 wee#s b'c 5% 
chance of neoplasm
Paratubal fallopian tube cysts 8 M' primary lesions of 
fallopian tubes /tiny, translucent cysts filled w' clear serous 
fluid13 develop from cranial portion of mesonephric duct
 !ydatids of Morgagni 8 larger paratubal cysts near
fimbriated end
"eiomyomas #fibroids$  45% of reproductive age females 
M' tumor in humans  %#orled bundles of smooth muscle 
cells  red degeneration
 #enign metastasi$ing %eiomyoma  extremely rare 
 7. to lung
 &isseminated peritoneal leiomyomatosis  multiple 
small nodules on peritoneum
    ris# for spontaneous abortion /esp9 if 
submucosal1
 7ost are -?x
"eiomyosarcoma  us9 arise de novo /not from leiomyomas1
 invade uterine wall <@ proAect into uterine lumen  lots of 
atypia  pea# incidence )
th
-2
th
 decades  50% mets to lungs, 
bone, brain via bloodstream
 Bibroid 6C:-@>!C> in a post-menopausal female
us9 indicates malignancy
erimenopausal female passing large clots, very irregular, 
very heavy bleeding, enlarged uterus  cancer of t#e 
endometrium
%aginal carcinoma  always @'< cervical carcinoma
 ( 95% are ?.. assoc9 w' :P=
 >reatest ris# factor 8 previous carcinoma of cervix 
or vulva
 7. along upper posterior %all of vagina
;
&ervical carcinoma ( "0% are .'' assoc9 w' high-ris# 
DE /esp9 type 1>1
 7. variant 8 fungating /exophytic1
 ?tage , confined to cervix3 ?tage + extends beyond 
cervix but not onto pelvic wall3 ?tage ; extends 
onto pelvic wall3 ?tage ) extends beyond true 
pelvis or involves bladder'rectum
o .an obstruct and cause hydronephrosis, 
dilated ureter
 ?ymptomatic early on  post-coital bleeding  foul
smelling disc#arge
&ervical carcinoma ? 20% are adenocarcinomas 
/endocervical gland origin3 assoc9 w' :P= type 1"1 <@ 
adenosFuamous carcinomas /mixed3 less favorable 
prognosis1 <@ poorly differentiated /oat cell carcinomas3 
poor prognosis due to early lymphatic spread1 <@ clear cell 
adenocarcinomas /5(. exposure1
 '!ip lesions
)cute Pelvic Pain
:-P @uick and to t#e point
Pregnancy-related
 6ctopic pregnancy
 -bortion
Gynecologic
 -cute !"
 <varian cyst /torsion, hemorrhage, rupture1
 6ndometriosis
'ongynecologic
 -cute appendicitis
 =$!  cystitis, pyelonephritis
 "iverticulitis
(ctopic pregnancy 
 7. implantation is in fallopian tubes 2$!%3
 7. predisposing condition is P45 
 7. cause of #ematosalpinx 
 7. cause of 1
st
 trimester maternal mortality
o .auses 2% of all maternal deaths
 (riad of symptoms = amenorr)ea, vaginal 
bleeding, lower abd pain
 Possible (ctopic pregnancy 8 7. clinical 
presentation3 ultrasound shows no !=3 -h.> 
level below discriminatory &one
 Probable (ctopic pregnancy 8 lower pelvic pain, 
spotting'bleeding, adnexal'cervical motion 
tenderness, absence of != on ultrasound, -#'7 
level 1!00-2000 25iscriminatory Aone3
 )uptured (ctopic pregnancy * surgical 
emergency3 severe abd pain, di&&iness, unstable 
vital signs
 "iagnostic tests 8 #'7 should double every )5 
hours /if not, thin# 6ctopic or abortion13 
transvaginal ultrasound should show gestational 
sac by wee# 5 of amenorrhea
 $reatment of 6ctopic pregnancy
o !f pt has no evidence of acute abd & 
pregnancy is * ;95 cm w' no fetal heart 
activity  90% cure w' met#otrexate
o 7ethotrexate is a chemotherapeutic agent 
 embryo dies & is resorbed
o !f pt is in -.=$6 pain, is spotting, has 
lower left Fuadrant tenderness  
laparoscopy
;isk factors for (ctopic pregnancy * previous (ctopic 
pregnancy 2B13, Dx of !", cigarette smo#ers, Dx of tubal 
ligation, Dx of tubal reconstructive surgery, use of assisted 
reproductive technology
Cormal #'7 levels
 5 wee#s  gestational sac on sono  h.> level ,500
!=':
 2 wee#s  fetal pole on sono  h.> 5+00
 4 wee#s  fetal cardiac motion on sono  h.> 
,4,500
+hreatened abortion  no $x, bed rest
 ?'? 8 GpainlessH bleeding before +0
th
 wee# /can 
have cramping1
,nevitable abortion  empty gestational sac past 5-4 wee#s
 %leeding, cramping, cervical dilation
 $x 8 5-'
,ncomplete abortion  passage of tissue3 some retained
Missed abortion  dead fetus, retained
 Co bleeding, cramping, or passage of tissue
    ris# of coagulopat#y
 $x 8 5-( /dilation and evacuation1
&omplete abortion  all products of conception passed  
severe bleeding w' large clots, severe lower abdominal 
cramping, cervix dilated
( ;0% of pregnant women will bleed in ,
st
 trimester
 half will abort 2? 1!%3
 half will continue w' normal pregnancy
)uptured ovarian cyst
 =ltrasound  free fluid in pelvis
 ?urgical intervention if orthostatic & anemic
 <bservation and C?-!"s if not orthostatic and 
anemic
Ovarian +orsion 8 twisting of vascular ovarian pedicle or 
fallopian tube3 bigger cysts are more li#ely to twist
 <ccludes lymphatic & venous drainage of adnexa
 )bsence of blood flo% on "oppler
 =ltrasound  presence of adnexal mass
)
 7ust be treated surgically
 Digh index of suspicion in female w' repeat 
episodes of abd pain and Dx of "E$Is w' oral 
contraceptive use
Pelvic ,nflammatory -isease #P,-$  upper reproductive 
tract infection, us9 ascending
 7. bilateral
 7. etiologic agents 8 gonococcus, c#lamydia
 S.S * fever/ pelvic mass/ tenderness/ acute abd/ 
high 0B&/ mucopurulent cervicitis
 .an cause pyosalpinx, hydrosalpinx, 
infertility
 .omplications
 2J  ris# for 6ctopic pregnancy
 ,)J  ris# for infertility
 2-,0J  ris# for pelvic pain
 +it9-:ug#-'urtis syndrome  =@K pain 
due to infection of liver capsule
 "x by laparoscopy
 "iagnose and treat empirically in sexually 
active female w' ris# factors & 
uterine'adnexal'cervical motion tenderness
 $x 8 antibiotics
 4npatient if pregnant, failed oral $x, 
unreliable pt, severe illness, tubo-ovarian 
abscess
 .an be caused by Actinomycosis assocD %/ 4E5  
us9 unilateral in this case
(ndometriosis 8 presence of endometrial glands outside of 
uterus
 .lassic triad 8 dysmenorr#ea, dyspareunia, 
dysc#e9ia
o "ysmenorrhea ,-+ days prior to menses 
early in clinical course
o "yspareunia  deep thrust penetration
 ?'? 8 tenderness, echogenic ovarian mass, fixation 
of uterus w' nodularity of uterosacral ligaments, 
chocolate cysts
 7. in pre-menopause female
 7. cause of secondary dysmenorr#ea
 7. cause of cul-de-sac nodularity
 "6B!C!$!E6 "!->C<?!? 8 biopsy at time of 
laparoscopy
 "6B!C!$!E6 $x 8 surgical /total abdominal 
hysterectomy w' bilateral salpingo-oophorectomy3 
laparoscopy w' ablation and excision of implants1
 7edical $x 8 oral contraceptives, C?-!"s, >n@D 
agonists /bserelin, leprolide acetate3 temporary 
$x for ( , year1, "ana&ol
Appendicitis * 7. intestinal source of acute pain in women
 ?'? 8 abd pain, anorexia, vomiting, normal %, 
normal pulse,  temp ,00-,0,95
 )cute abdomen  pain starts periumbilical, shifts 
to @:K w'in hours
 L%. ,+,000-,5,000 /normal ;,000-,0,0001
 !f L%. 0 +0,000, thin# about rupture
 $x 8 surgical
Acute abdomen 8 rebound & guarding
 "ue to blood, pus, or chemicals irritating 
peritoneum
%owel problems that can present as pelvic mass 8 
inflammatory or neoplastic bo1el d2/ ulcerative colitis/ 
regional ileitis/ diverticulitis
 Bluctuant adnexal mass could be inflamed bowel in 
pelvis
 ?tool guaiac positive for occult blood
 $x 8 corticosteroids
5ysmenorr#ea
:-P more broad and in dept#
Primary dysmenorrhea 8 pain w' menses3 no defined 
pathology3 us9 starts w'in 2-,+ mos9 of menarche
 elvic cramping, pain radiating to bac# or thighs, 
diarrhea, headache, nausea, vomiting
Secondary dysmenorrhea 8 pain w' menses due to defined 
pathology /7. due to endometriosis1
 <ther causes 8 adenomyosis, fibroids, ovarian 
cysts, pelvic congestion syndrome, congenital 
malformations
,
st
 line $x for dysmenorrhea 8 C?-!"s M oral contraceptives
 C.)45s bloc# prostaglandin release
o Caprosyn, -leve, .elebrex, 7otrin, -dvil
 6ral contraceptives suppress endometrial growth
o -novulation  prostaglandin levels
!f ,
st
 line $x fails  laparoscopy and ultrasound to loo# for 
secondary cause of dysmenorrhea
'#ronic Pelvic Pain
:-P very meticulous
&hronic pelvic pain 8 non-specific pain 0 2 mos9 duration 
unrelieved by C?-!"s3 pain affects Fuality of life
 ,'; have no apparent pathology on laparoscopy
 ,'; have endometriosis
 N-,'; have adhesions Ofrom prior surgeryP or 
remnants of chronic !"
>ynecologic causes 8 endometriosis, adenomyosis, 
adhesions, chronic !", leiomyomata, pelvic congestion, 
ovarian remnant syndrome
Pelvic congestion syndrome 8 dilated veins in pelvis3 assoc9 
w' post-coital aching
5
Ovarian )emnant Syndrome 8 previous hysterectomy but 
some ovarian cortex left behind
>astrointestinal causes of chronic pelvic pain 8 !%?, 
inflammatory bowel d&, hernia
=rologic causes of chronic pelvic pain 8 interstitial cystitis 
/common1, urethral syndrome
 %ladder 8 most neurally sensitive organ in the body
7usculos#eletal causes of chronic pelvic pain 8 abd wall 
defects, incisional neuroma, pelvic diaphragm ?'"
 <nly +-4% of all afferents passing thru each dorsal 
root ganglion are visceral & 9;-95% are somatic 
cross-tal#  viscerosomatic pain referral
o @eason for referred pain to pelvic floor
sychiatric causes of chronic pelvic pain 8 depression, 
somati&ation, hypochondriasis
6 incl9 chec# abd wall, F-tip test for vestibulitis /indicates
referred pain1, abd wall trigger points, ovarian point 
tenderness /suggests pelvic congestion syndrome1, pelvic 
floor myalgias /transvaginal single digit exam1, piriformis 
screen, traditional bimanual exam /last portion of pelvic 
exam1
Pelvic 6rgan Prolapse
Cormal, standing female  bladder, upper +'; of vagina, and 
rectum are #ori9ontal  urethra, lower ,'; of vagina, and 
anal canal are vertical
Primary support of pelvic organs 8 pelvic diaphragm 
muscles
 +ailure of primary support  7. due to term 
labor and delivery3 also caused by  intra-
abdominal pressure /chronic cough, heavy lifting, 
constipation, etc1 and iatrogenic factors /surgery1
 7uscles of pelvic diaphragm incl9 levator ani 
/pubococcygeus & iliococcygeus1, 
ischiococcygeus, pubovaginalis, puborectalis, 
piriformis, obturator internis
Secondary support of pelvic organs 8 endopelvic fascia
,1 .ardinal-uterosacral ligament complexes 
/suspensory3 apical axis1
a9 Dold bladder and vagina up
+1 aravaginal supports /hori&ontal axis3 paravaginal1
a9 ubocervical fascia  holds uterus up
b9 @ectovaginal fascia  holds rectum down
;1 Eertical orientation of urethra, vaginal outlet, anal 
canal
+ailure of cardinal-uterosacral ligaments  apical 
vaginal prolapse /vagina drops out1
+ailure of pubocervical fascia  anterior vaginal prolapse 
 cystocele 8 bladder bulges thru ant9 wall of vagina
+ailure of rectovaginal fascia  posterior vaginal prolapse
 rectocele 8 rectum bulges thru post9 wall of vagina
 enterocele 8 loop of bowel bulges thru post9 wall of
vagina
Splinting 8 placement of finger in vagina to have bowel 
movement3 7. if pt has rectocele
"x of prolapse 8 speculum exam, rectal exam
Consurgical $x 8 Qegel exercises, pessaries
?urgical $x 8 lots3 can only repair brea#s in continuity of 
endopelvic networ# /fixes secondary failures, not primary1
4ncontinence
Genuine stress incontinence #GS,$ /50-40% of cases1  lea#
w' coughing, laughing, snee&ing3 no detrusor contraction
 !ypermobility of bladder nec3  due to wea# 
pelvic diaphragm muscles and connective tissue 
/pubocervical fascia1  7. after c#ildbirt#
o Bire hose in muddy ground
 ,ntrinsic sphincter deficiency #,S-$  severe form 
of >?!3 Gstove pipeH uret#ra
 +x = estrogens, Qegel exercises, pessaries, surgery 
/suburethral sling1
-etrusor ,nstability #-,$ /,0-;0% of cases1  urgency, 
freFuency /voiding 0 5 times per day3 nocturia 0 + times per 
night1, overactive bladder
 Enin#ibited detrusor contraction assoc9 w' strong
urge to void
 =n#nown etiology
 .ommonly assoc9 w' triggers /i9e9 running water, 
etc91
 +x 8 timed voiding, oxybutynin /"itropan1, 
tolterodine /"etrol1, tri-cyclic antidepressants
Mixed ,ncontinence /,0-;0% of cases1 8 >?! M "!
 revalence increases w' age
 $reat urge ,
st 
Other #overflo1/ neurogeneic$ incontinence /,0% of cases1 
 result from detrusor areflexia or hypotonic bladder
 7. in pts w' prolapse
 :7C d&, spinal cord inAuries, autonomic 
neuropathy /"71
 7anagement 8 intermittent self-catheteri&ation
'limacteric
2
Climacteric 8 phase in female reproductive life when 
gradual decline in ovarian function results in  sex steroid 
production and assoc9 seFuelae
 -verage onset ( 5, years old
 <varies lose ability to respond to >n@D
    estrogen production
 <vulation ceases
Menopase 8 last menstrual period3 made in retrospect, us9 
after  ( ,yr w'o menses
7ost women ovulate ( )00 times btwn menarche & 
menopause  the rest of the eggs are lost
 %orn w' ( ,95 million primary ovarian follicles
 @each menarche w' ( )00,000
(arly effects of estrogen deficiency * Perimenopausal 
symptoms 8 heavy menses, endometrial hyperplasia,  
mood and emotional changes, hot flashes, night sweats, 
shortened cycle length, irregular menses, breast tenderness
 7ay last ;-5 yrs before complete loss of menses
 -vg9 age of onset of perimenopausal ?'? 8 )495 
years
    freFuency of anovulation
Premature ovarian failure #premature menopause$ 8 
menopause before the age of )0
:ormone c#anges
 (2 2estradiol3 declines but (1 2estrone3 may be 
higher
    androgen production but lost opposition by 
estrogen causes  sensitivity to androgens  
e"cessive facial )air growt),  breast si$e
o $estosterone  ( +0%
o -ndrostenedione may  ( 50%
 )ndrostenedione from ovary and adrenals is 
converted to estrone in peripheral fat tissues  
capable of maintaining vagina, s#in, and bone in 
reasonable cellular tone and reducing incidence of 
flashes
o    6, may be responsible for  
incidence of endometrial or breast 
cancer among obese women /unopposed 
estrogen1
    progesterone  levels too low to induce 
en&ymes that convert 6+ to 6,, too low to induce 
secretory activity in endometrium  irreglar 
vaginal bleeding, endometrial )yperplasia, celllar
atypia,  incidence of endometrial cancer
    +.: - 8: due to more >n@D released by 
arcuate nucleus and paraventricular nucleus in 
hypothalamus  due to low circulating estrogen 
levels
Cormal vagina  very sensitive to estrogen  produces thic# 
moist epithelium w' acidic secretion /pD ( )901
4ntermediate effects of estrogen deficiency 2age !!->!3
 Atrophic vaginitis  loss of estrogen results in thin, 
dry epithelium w' al#aline secretion /pD 0 4901
o ?'? 8 dysuria, dyspareunia, vaginal 
pruritis
o    elastic capacity of bladder  
freFuency, urgency, nocturia
 "yspareumia
 =rge incontinence
 ?tress incontinence
 ?#in atrophy
4
8ate effects of estrogen deficiency 2age >!I3
 -therosclerosis
 -l&heimerIs d&
 .ancer
 Osteoporosis
o 6strogen loss  osteoclast activity far 
exceeds osteoblasts activity  osteopenia 
 osteoporosis
o .linical sign 8 loss of 0 ,95H height due to 
vertebral compression fracture
o 7ost .a
+M
 lost from trabecular bone  
M' fractures are spinal column and 
femoral neck
o ?creening 8 dual-energy x-ray 
absorptiometry /5(J)1 measurements of 
total hip and spine
o @educe ris# of fracture w' ,+00-,500mg 
calcium and )00-200= vit" daily, 
wal#ing, weight-bearing exercise
o $x 8 estrogen, selective estrogen receptor 
modulators /?6@7s, li#e raloxifene1, 
biphosphonates /alendronate1, calcitonin, 
$D
(strogen replacement therapy
    ris# of coronary artery d&, stro#e, thrombosis, 
breast cancer
    ris# of -l&heimers, colon cancer, osteoporosis
 4ndicated primarily for relief of significant 
menopausal symptoms 2fre@uent #ot flas#es, 
genitourinary discomfort, ot#er @uality-of-life 
issues3
 .ontinuous estrogen  0 )0% incidence of 
endometrial hyperplasia
 >ive cyclic estrogen M progesterone  reduced ris#
of endometrial hyperplasia
o 7onitor endometrium annually w' 
ultrasound3 thic#ness should be * 5mm
 .ontraindications 8 pregnancy, breast cancer, 
estrogen-dependent neoplasia, undiagnosed -%C 
vaginal bleeding, thrombophlebitis
 -lternatives 8 progesterone, clonidine D.l, 
methyldopa, phenobarbital, paroxetine D.l /axil1, 
venlafaxine D.l /6ffexor1
;adiology of Pelvis
Eltrasound is usually the initial imaging exam of the 
female pelvis, transabdominal then transvaginal
 -dvantages
 >ood tissue differentiation
 :ow cost, portable, easily available
 7ultiple imaging planes
 .tudy of c#oice
 "isadvantages
 ?mall field doesnIt give global view
 <perator-dependent
'1 excellent for detection of calcification or fat within 
pelvic masses9  .an be used for staging ovarian cancer but 
not very useful for endometrial or cervical cancer9
 -dvantages
 6xcellent tissue differentiation
 7ultiple imaging planes
 8arge field of vie%
 "isadvantages
 Digh cost and less available
M;4 can be used for staging uterine cancers and ovarian 
cancers9  -lso used for further characteri&ation of benign 
uterine or ovarian masses9
 -dvantages
 7lobal vie%
 6xcellent anatomic resolution
 "isadvantages
 @adiation
 7ainly used to eval metastatic malignancy
and abscesses
!ndications for imaging referrals
 =aginal 0leeding
 Pelvic Mass
 Pelvic Pain
 *nitial e"am is ltrasond+  %ocali$es a mass as 
terine, ovarian or tbal, identifies potential 
sorce of pelvic pain, sefl in determining t)e 
case of vaginal bleeding+  A patient wit) a !nown 
)istory of cancer will be imaged by C( or M-*+ 
=ltrasound !mages
 Cormal uterus
 4-5cm length in nulliparous menstruating 
female
 Cormal ovary
 -verage 2-,0cc volume in normal 
menstruating female
 Eolume determined by l J w J h J 095+;
7@! !mages
 6ndometrium
 remenopause, variable
 ost 7  5 mm
 Runctional &one /dar# rim around endometrium1
 +-5 mm
 <uter myometrium
 .ervixS mucosa, stroma
.auses of vaginal bleeding
 (ndometrial
 (ndometrial atrophy  7. 
 (ndometrial hyperplasia or polyp
 6ndometrial thic#ening
o K ! mm /post 
menopausal13 
#ypoec#oic
5
o "iffuse T cystic change
 6ndometrial polyps typically 
demonstrate cystic change
 (ndometrial carcinoma
 !rregular border after giving 
contrast  shows infiltration into 
myometrium
 All e"cept atrop)y re.ire biopsy to 
differentiate
 Eterine 8eiomyoma 2especially submucosal3
 %ocations for leiomyoma = intramral, 
sbmcosal, sbserosal (can be 
pednclated) and cervical
 'ervical 'ancer
 =ltrasoundS Cot very useful
 7@!S Study of choice to evaluate local 
mass
 .$S (valuate adenopathy and distant 
metastasis
)dnexal Pat#ology
 !nitial evaluation 8 =:$@-?<=C"
 7@! 8 problem solving modality
 <varian vs adnexal
 ?olid vs cystic
 Ceoplastic vs non neoplastic
 Simple Ovarian &yst
 =:$@-?<=C"
 Bollicular cyst or corpus luteum 7. 
 .U?$ 8 larger t#an 2 cm
 Co internal echoes, nodules, or septations 
 -lmost always benign 
 B'= in 2 wee#s
 /5% resolve spontaneosly
 %right on 7@!
 !emorrhagic &yst
 :ypoec#oic on ultrasound due to blood
 "ar# on 7@! due to blood
 (ndometriosis
 G?tring of pearlsH on 7@!
 Ovarian 'eoplasms
 0(C47C  dermoid 2teratoma3 M'
 .omposed of varying amounts of 
endoderm, mesoderm, & 
ectoderm
 <ccasionally unilocular /lined w' 
ectoderm1 filled w' desF9 #eratin '
sebum
 1orsion * M' complication
 +% malignant transformation
 M)847C)C1 8 .omplex cystic masses 
w' internal echoes, septations, and nodules
 4ltrasound for initial eval
 B'= with M), or &+
6varian 1umor 1ypes
 .urface (pit#elium 2>!-!%3L  mucinous and 
serous cystadenoma'adenocarcinoma
 rimary criteria for malignancy
 0 ) cm
 ?olid mass /bilateral1
 Lall & septations thic# /0 ; mm1
 Eegetations and nodules
 0enign 'ystadenoma * M' surface 
epit#elial tumor
 %enign features 8 simple cyst or 
few thin septations, little or no 
free fluid, unilateral or bilateral
 7erm 'ell 21! M 20%3L  cystic teratomas, 
germinomas
 .ex 'ord 2!-10%3L  granulosa cell, thecoma, 
fibroma, androblastoma
 Metastatic 2!-10%3L  breast, colon or gastric 
carcinoma /Qru#enberg tumor1, lymphoma
Pelvic 4nflammatory 59
 Bever, elvic pain, vaginal discharge
 =ltrasound 8 initial evaluation
 .linical evaluation critical
 .$ useful if larger field of view needed to evaluate 
abscess
 ?evere adnexal tenderness
 1ubo-6varian abscess 8 7. reason to evaluate 
pts w' !"
(ctopic Pregnancy
 =ltrasound w' clinical correlation reFuired
 .$ and 7@! have little value
9