Salt
Worldwide Action
Graham A MacGregor
Professor of Cardiovascular Medicine
Chairman of WASH
Wolfson Institute of Preventive Medicine,
Barts and The London School of Medicine & Dentistry, UK
Salt Reduction
WHY?
Salt is the major cause of raised BP
(Biggest cause of death)
Very cost-effective to implement
BP - Major Cause of Death Worldwide
Raised Blood Pressure
7 million
Tobacco
Developed region
High cholesterol
Developing region
Underweight
Unsafe sex
Millions of Deaths
62% of all strokes
Raised BP
49% of all heart disease
Ezzati et al. Lancet 2002:360:1347-60.
Systolic BP and Risk of Death
Stroke Deaths
Risk
Heart Deaths
32
16
16
Risk
1
120 125 135 148
168
120 125 135 148
168
Systolic Blood Pressure (mmHg)
The risk starts in the normal range;
at systolic 115 mmHg (83% adults)
MacMahon et al. Lancet 1990;335:765-74
Brain (cross section)
Mid line shift due to
raised pressure
Cerebral
haemorrhage
Atheroma in Carotid Artery
Plaque
Ulcerated
Plaque
Fissured Plaque
with Thrombosis
Evidence for Salt BP
Epidemiology
Over 50 population studies and Intersalt
Migration
e.g. Kenya
Intervention
Portuguese villages. New born babies
Genetic
All defects impair ability of the kidney to excrete Na
Mechanisms
Plasma Na, corrected volume expansion
Animal
BP caused or aggravated by salt (e.g. chimpanzees)
Treatment
Trials, Meta-analysis. Dose response
Mortality studies
Finland (24h UNa)
Outcome trials
TOHP, Taiwan (mineral salt: high K, low Na)
He & MacGregor. Prog Cardiovasc Dis. 2010;52:363-382
Salt Intake 5-6 g/day
Stroke 24%
UK
CHD 18%
35,000 deaths prevented
per year
Worldwide 2.5 million deaths
prevented per year
He & MacGregor. Hypertension 2003;42:1093-99
How to Salt Intake
Measure amount and sources of salt
Plan
Added
Cooking/Table
Sauces
Public health
campaign
Food industry
Processed food
Eating out
Set targets for each
food group
Campbell, et al. JHH. 2011
CASH Strategy for Reducing Salt in UK
Salt intake
Source
g/day
Reduction
needed
Target intake
g/day
Table/Cooking (15%)
1.4 g
40% reduction
0.9 g
Natural (5%)
0.5 g
No reduction
0.5 g
Food industry (80%)
7.6 g
40% reduction
4.6 g
Total 9.5 g
Target 6.0 g
The food industry needs to slowly reduce salt
content of all foods by 40% over the next 5 years
www.actiononsalt.org.uk
The voluntary carrot and stick
approach
food
industry
www.actiononsalt.org.uk
UK Success by 2008
Salt intake has fallen within 3 yrs
from 9.5 to 8.6 g/d salt (10% )
i.e. 26,000 tons/yr salt removed
6000 deaths/yr strokes, heart attacks prevented
www.actiononsalt.org.uk
UK Success 2011
Processed food products 20-50%
1. No taste problems
2. No technical problems
Food outside home now being tackled
Table and cooking salt sales 40-50%
Salt intake should reach less than 6 g/d target
around 2014 (i.e. within 7 yrs)
www.actiononsalt.org.uk
Cost-effective Analysis
UK (NICE)
Cost of salt campaign 5 million per year
Healthcare savings 1.5 billion per year
http://guidance.nice.org.uk/PH25
Salt Reduction vs. Tobacco Control
(low & middle income countries)
15% salt
Number of
CVD deaths
averted in
10 yrs
(millions)
20% smoking
10
9
8
7
6
5
4
3
2
1
0.40
0
0.30
Annual
cost per
person
(US$)
0.20
0.10
0.00
Asaria et al.
Lancet.
2007;370:2044.
Worldwide Action
1.
USA, Canada, Australia following UK model
2.
Europe (ESAN) 16% reduction over 4 yrs
3.
PAHO: Brazil sets targets, Chile, Argentina, Mexico following
4.
Asian-Pacific: Salt intake is very high, e.g. China, Japan, Korea.
Urgent need to reduce salt
Global Food Industry could play a much more prominent role
Unilever & Pepsico worldwide salt reduction across their products
Kelloggs, Nestle about to reduce salt globally to UK levels
www.worldactiononsalt.com
WASH Action Groups
www.worldactiononsalt.com
Hidden Salt in Food
e.g. processed, fast, takeaway, restaurant food
Food industry slowly reduce
- No rejection by public
Fantastic for Public Health
Very little
cost
BP
No need to
change diet
www.worldactiononsalt.com
Salt - Summary
Every country in the world must now
1. Set up salt reduction plan
2. Implement the plan
This is the single most
cost-effective public health measure
It would be negligent for any
government not to take action now
www.worldactiononsalt.com