USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
1 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology Videos
Get our free
psychopharmacology
lectures in your inbox.
Enter your information below
to subscribe.
Email address
Profession
videos
Psychopharmacology lectures
PowerPoints
About
Select your profession
Country
Select your country
Copyright 2015 Pharmacology Corner
Click here to subscribe
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
2 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology Videos
Get our free
psychopharmacology
lectures in your inbox.
Enter your information below
to subscribe.
Email address
videos
USMLE-like pharmacology quiz. Part 3:
pharmacokinetics (drug metabolism)
Profession
r: Flavio Guzman, MD.
Select your profession
Country
Select your country
Click here to subscribe
The following are multiple choice questions in a style similar to
those included in the USMLE step 1. The main topic here is:
pharmacokinetics (drug metabolism). This quiz has been
uploaded to Scribd by medical student James Lamberg. The
correct answers can be found in link at the end of this post.
Note: the words underlined dont mean right answer but link to
another page.
6 Pharmacokinetics: Drug Metabolism
1.1) Which of the following locations is the most likely for
finding a free, unaltered drug?
a) Urine
b) Feces
c) Breast milk
d) Fat
e) Sweat
1.2) Most drugs are active in their ____ form and inactive
in their ____ form.
a) Non-polar; Polar
b) Polar; Non-polar
c) Water-soluble; Lipid-soluble
d) Lipid-insoluble; Water-insoluble
e) Neutral; Neutral
2.1) Drug biotransformation phase I makes drugs ____
polar for metabolism and phase II
makes drugs ____ polar for excretion.
a) More; More
b) More; Less
c) Less; More
Pharmacology
Topics
Pharmacokinetics
Pharmacodynamics
Autonomic
pharmacology
CNS drugs
Anticonvulsants
Antidepressants
Antipsychotics
Benzodiazepines
and
Z-drugs
Antiemetics
Cardiovascular
Antihypertensives
Diuretics
Lipidlowering
agents
Antiplatelet
agents
Antithrombotics
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
3 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology Videos
Get our free
videos
psychopharmacology
lectures in your inbox.
Enter your information below
to subscribe.
3) Which of the following reactions is phase II and NOT
Email address
Profession
Select your profession
Country
Which
Select your4)
country
of the following metabolically active tissues is the
principle organ for drug
Click here to subscribe
d) Liver
e) GI Tract
5.1) Damage at which of the following locations would
most affect the goals of phase II
biotransformation?
a) Skin
b) Kidneys
c) Lungs
d) Liver
e) GI Tract
Match the biotransformation reaction with the drug:
5.2) Hydroxylation of aromatic ring to increase polarity a)
Codeine
5.3) N-dealkylation b) Morphine
5.4) Sulfoxidation c) Thioridazine
5.5) O-dealkylation d) Nicotine
5.6) N-oxidation e) Phenobarbitol
5.7) Side chain oxidation with -OH to increase polarity f)
Pentobarbitol
5.8) Conversion to glutathione and reactive intermediate
g) Acetaminophen
6.1) What is the goal of the P450 system (microsomes
pinched off from endoplasmic
reticulum)?
a) Metabolism of substances
b) Detoxification of substances
c) Increasing pH of compartments containing substances
d) Decreasing pH of compartments containing substances
e) A & B
6.2) Regarding the microsomal drug metabolizing system,
a patient with late stage
alcoholism and liver damage would have more ETOH
available due to which of the
following concepts?
a) Increased induction
b) Decreased induction
c) Increased inhibition
d) Decreased inhibition
6.3) Regarding the microsomal drug metabolizing system,
a patient who is a chronic user
of barbiturates would need more drug to produce the
same effects due to which of the
following concepts?
a) Increased induction
Endocrine
Diabetes
drug
therapy
Pain drug
therapy
Anesthetics
Opioids
Antibiotics
Antivirals
Antiretrovirals
Cancer
chemotherapy
Vaccines
Recommended
sites
Psychopharmacology
Institute
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
4 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology
Videos
d) Decreased
inhibition
Get our free
6.4) Which of the following are the videos
drugs that induce CYP
psychopharmacology
1A2 and the drugs that have
lectures intheir
yourmetabolism
inbox.
induced by 1A2?
Enter youra)information
below & phenobarbitol; Theophyline &
Carbamazepine
to subscribe.
Email address
b) Phenobarbitol & phenytoin ; Phenytoin & warfarin
c) Carbamazepine & phenytoin; Warfarin
d) Carbamazepine; Cyclosporine
Profession6.5) Which of the following are the drugs that inhibit CYP
Select your1A2
profession
and the drugs that have
Country their metabolism inhibited by 1A2?
SSRIs; Phenytoin & warfarin
Select youra)
country
b) Amiodarone & cimetidine; Phenytoin & warfarin
c) Cimetidine, erythromycin, & grapefruit juice;
Theophyline
& warfarin
Click here
to subscribe
d) Cimetidine & erythromycin; Cyclosporine
6.6) Which of the following groups of people is the least
likely to have biotransformation
effects due to altered hepatic function?
a) Infants
b) Adults
c) Elderly
d) Chronic alcoholics
e) Acetaminophen overdoses
6.7) In what location does amino acid conjugation of
glycine (e.g. salicyclic acid) take
place?
a) Microsomal
b) Cytosol
c) Mitochondria
6.8) Where does acetylation conjugation (e.g. isoniazid)
and sulfate conjugation (e.g.
acetaminophen) take place?
a) Microsomal
b) Cytosol
c) Mitochondria
6.9) Where does glucuronide conjucation (e.g. digoxin,
bilirubin) take place?
a) Microsomal
b) Cytosol
c) Mitochondria
6.10) What is a result of conjugation of isoniazid via
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
5 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology
Videos
a) Detoxification
of liver
Get our free
psychopharmacology
b) Detoxification of kidneys
lectures in your inbox.
Detoxification
of blood
Enter yourc)information
below
to subscribe.
d) Detoxification of urine
Email address
videos
Profession
Pharmacokinetics: Principles of Eliminations
Select your7profession
1.1)
One liter contains 1,000 mg of a drug. After one hour,
Country
900 mg of the drug remains.
Select yourWhat
country
is the clearance?
Click here to subscribe
e) 1 mg/sec
1.2) To maintain a drug concentration at steady state, the
dosing rate should equal the
elimination rate. Which of the following is true? (CL = Drug
Clearance)
a) Dosing rate = CL + target concentration
b) Dosing rate = CL target concentration
c) Dosing rate = CL * target concentration
d) Dosing rate = CL / target concentration
1.3) Which of the following is most useful in determining
the rate of elimination of a
drug, in general?
a) Drug concentration in urine (renal elimination)
b) Drug concentration in stool (bilary elimination)
c) Drug concentration in blood
d) Drug concentration in brain
e) Drug oxidation rate
2.1) For first-order drug elimination, half life t(1/2) is ____
at two places on the curve
and a constant ____ is lost per unit time.
a) Equal; Amount
b) Equal; Percentage
c) Not equal; Amount
d) Not equal; Percentage
2.2) For first-order drug elimination, given the half-life
equation of t(1/2) = (0.693 * Vd)
/ CL, how many half-lives would be necessary to reach
steady state (95%) without a
loading dose?
a) 1 to 2
b) 2 to 3
c) 3 to 4
d) 4 to 5
e) 5 to 6
2.3) Which of the following is NOT a drug exhibiting
zero-order elimination kinetics?
a) Aspirin
b) Morphine
c) Phenytoin
d) ETOH
2.4) For zero-order drug elimination, half-life t(1/2) is ____
at two places on the curve
and a constant ____ is lost per unit time.
a) Equal; Amount
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
6 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology
d) Not equal;Videos
Percentage
Get our free
2.5) If a drug with a 2-hour half life videos
is given with an initial
psychopharmacology
dose of 8 mcg/ml, assuming
lectures infirst-order
your inbox.
kinetics, how much drug will be left at 6 hours?
Enter your information below
to subscribe.
Email address
Profession3.1) What are the units for steady-state concentration
Select your(Css),
profession
or infusion rate over
Country
Select your country
Click here to subscribe
3.2) What percentage of the steady-state drug
concentration is achieved at 3.3 * t(1/2)?
a) 10%
b) 25%
c) 50%
d) 75%
e) 90%
4.1) Increasing the rate of infusion changes the time
necessary to reach the steady-state
concentration.
a) True
b) False
4.2) An injection of two units of a drug once-daily (qd) will
yield the same steady-state
concentration as an injection of one unit of a drug
twice-daily (bid).
a) True
b) False
5.1) Which of the following drugs would most likely need a
loading dose to help reach
therapeutic levels?
a) Acetaminophen, t(1/2) = 2 h
b) Aspirin, t(1/2) = 15 m
c) Tetracycline, t(1/2) = 11 h
d) Digitoxin, t(1/2) = 161 h
e) Adenosine, t(1/2) = 10 s
5.2) A target concentration of 7.5 mg/L of theophylline is
required for a 60 kg patient.
What is the loading dose, given the following: Vd = 0.5
L/kg, Cl = 0.04 L/kg/hr, t(1/2) =
9.3 hr?
a) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg/h, infusion
b) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg, bolus
c) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg/h, infusion
d) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg, bolus
5.3) A target concentration of 7.5 mg/L of theophylline is
required for a 60 kg patient.
What is the steady state maintenance dose, given the
following: Vd = 0.5 L/kg, Cl = 0.04
L/kg/hr, t(1/2) = 9.3 hr?
a) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg/h, infusion
b) 0.5 L/kg * 60 kg * 7.5 mg/L = 225 mg, bolus
c) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg/h, infusion
d) 0.04 L/kg/hr * 60 kg * 7.5 mg/L = 18 mg, bolus
11/12/2015 9:36 AM
USMLE-like pharmacology quiz. Part 3: pharmacokinetics (drug meta...
7 of 7
http://pharmacologycorner.com/usmle-like-pharmacology-quiz-part-2-...
Are you a visual learner interested in learning psychopharmacology? Click here to get our
Psychopharmacology
Videos questions
USMLE pharmacology
Get our free
videos
psychopharmacology
mmended pharmacokinetics reading
lectures in your inbox.
et information
Guide: Pharmacokinetics
Made Easy (2009)
Enter your
below
Clinical
Pharmacokinetics
(2009)
to subscribe.
epts in Clinical Pharmacokinetics (2010)
Email address
al Pharmacokinetics, 4th Edition (2008)
Profession
MCQs and quizzes for USMLE, Pharmacokinetics
Select your profession
Country
Select your country
Click here to subscribe
Illustrated Psychopharmacology Lectures
in Your Inbox
Mechanisms of action, adverse effects and indications of
psychotropic medications.
Concise and illustrated presentations.
Practical tips for mental health professionals.
Email address
Profession
Select your profession
Country
Select your country
Click here to subscribe
11/12/2015 9:36 AM
