Accepted Manuscript

Title: An Appeal For The Integrity Of Science And Public

Policy
PII:
DOI:
Reference:

S0300-483X(16)30190-1
http://dx.doi.org/doi:10.1016/j.tox.2016.08.015
TOX 51734

To appear in:

Toxicology

Please cite this article as: An Appeal For The Integrity Of Science And Public Policy,
Toxicology (2016), http://dx.doi.org/10.1016/j.tox.2016.08.015
This is a PDF file of an unedited manuscript that has been accepted for publication.
As a service to our customers we are providing this early version of the manuscript.
The manuscript will undergo copyediting, typesetting, and review of the resulting proof
before it is published in its final form. Please note that during the production process
errors may be discovered which could affect the content, and all legal disclaimers that
apply to the journal pertain.

Our concern is motivated by the importance of adhering to the self-evident

precepts of the scientific method in arriving at defensible conclusions.
Those precepts require observational and experimental data that are
authentic and of known measurement error; experimental variables that are
relevant to the hypotheses being tested; the control of externalities that may
confound observations and experimental results; and reproducibility or
counterfactual verification by other performers.

ip
t

Anders, M. W., DVM, PhD

Professor Emeritus,
Department of Pharmacology and Physiology
University of Rochester Medical Center
Rochester, NY, USA
Email: mw_anders@urmc.rochester.edu
Aschner, Michael, PhD
Professor
Department of Molecular Pharmacology
Albert Einstein College of Medicine
Bronx, NY, USA
Email: michael.aschner@einstein.yu.edu

Autrup, Herman, PhD, ATS

Professor Emeritus, Institute of Public Health,
University of Aarhus,
Aarhus, Denmark
Email: ha@ph.au.dk

Ac
ce
pt
e

Unlike unbiased science, the spurious science of our concern starts off from
arbitrary default assumptions that inevitably yield biased and
uninterpretable results, unable to quantify or estimate putative human
hazards. Similar concerns apply to advocating premature experimental
accounts that are not sufficiently tested and controlled. Examples are found
in animal, in vitro and in silico tests of presumed risk factors for human
cancer and endocrine disturbances, and in many epidemiologic surveys and
environmental impact assessments.
We agree that precautionary policies and regulations may be called for in
the absence of firm scientific evidence that would permit an assumption of
certainty. However, such precautionary regulations and policies should not
be imposed as if grounded on objective science, but should result from
public debates on wider issues including economic trade-offs between
desirable uses and cautious restrictions on exposure. Rather than being truly
precautionary, what might be called pseudo-science is a subterfuge to gloss
over arbitrary policies and regulations while claiming to be supported by the
impartial objectivity of the scientific method. Indeed, on such shaky
grounds the lifestyles, choices, and behaviors of nations are directed,
substantial segments of national economies are regulated, and unfortunate
transgressors face criminal charges, massive fines and detention.

Allen, Sandra L., BSc, PhD, MRSB,

Consultant Toxicologist
Regulatory Science Associates
Grantham, UK
Email: Sandra.allen@regulatoryscience.com

cr

We, scientists and signatories of this appeal assert our concern for the
erosion of scientific principles in the purported validation of experimental
evidence, which is manifest in arguments disguised as true science. Such
arguments are used to simulate and exaggerate hazards and risks that justify
official intervention policies in health, safety and environmental issues. This
erodes public confidence in science and government, leads to misallocation
of public resources, cause massive economic distortions, and strains court
adjudications.

SIGNATORIES OF THE APPEAL

us

An Appeal For The Integrity Of Science And

Public Policy

* Corresponding author:
Dr. Gio Batta Gori
Bethesda, Maryland
Email: gorigb@msn.com

an

Editorial

Science is synonymous with factual representations, and only close

adherence to the evidentiary standards of the scientific method has allowed
the multiple discoveries that sustain current understanding of the world and
related technologies. Remarkably, those standards are not binding in most
national and international statutes that discipline the development of public
policies and regulations.
Reflecting a tradition of wide administrative discretion, such existing
statutes are non-prescriptive on how evidence is to be obtained and
considered, at odds with anticipations of clear checks and balances to
inform delegated legislative authority. Change seems in order, and we urge
legislators to embed the rules of evidence of the scientific method in
statutes governing administrative policy and regulations. Such rules would
only apply when testable scientific evidence is available where this is not
the case, considerations between precaution and desirable uses would
determine policies and regulations.
We believe it is necessary to affirm the reliable and evidence-based power
of science to ensure the rational and ethical integrity of public policies and
regulations, and of legal proceedings. Not only is science in play, but also
those ideals of justice and rationality that sustain free intellects, free persons
and free societies.

Baker, Kenneth M., MSc. (Hons), PhD

Chairman, World Agricultural Forum
Brussels, Belgium
Email: ken.baker@worldagforum.com

Bartholomaeus, Andrew PhD

Professor of Pharmacy and Toxicology
School of Pharmacy, University of Canberra
Canberra Australia
Email: bartcrofts@gmail.com

Basketter, David A., BSc, DSc, FRCPath

Director, DABMEB Consultancy Ltd
Sharnbrook, UK
Email: dabmebconsultancyltd@me.com

Berry, Colin L., Sir, MD, PhD, DSc

Professor Emeritus of Pathology,
Queen Mary
London, UK
Email: colin@sircolinberry.co.uk

Berube, David M., PhD

Director Public Communication of Science
and Technology Project
North Carolina State University
Raleigh, NC, USA
Email: drdmberube@gmail.com

Page 1 of 12

President & Principal Scientist

Applied Pharmacology and Toxicology, Inc.
Gainesville, Florida, USA,
email: cjborgert@APT-PHARMATOX.com

Beth-Hbner, Maren, MD
Secretary General MEDICHEM BG RCI
German Social Accident Insurance Institute
for Raw Materials and Chemical Industry
Heidelberg, Germany
Email: maren.beth-huebner@bgrci.de

Borzelleca, Joseph F., PhD

Professor Emeritus,
Department of Pharmacology and Toxicology
Virginia Commonwealth University
School of Medicine, Richmond, VA, USA
Email. josephfborzelleca@comcast.net

ip
t

Bigelow, Sanford, PhD, D.A.B.T.

Principal, Vanguard Global Associates LLC
Tucson, AZ, USA
Email: vanguardglobal@yahoo.com

cr

Brent, Jeffrey, M.D., PhD

Distinguished Clinical Professor of Medicine
University of Colorado
Denver, CO, USA
Email: Jeffrey.Brent@ucdenver.edu

us

Bjerrum, Ole J., MD, DMSc

Professor emeritus,
Department of Drug Design
and Pharmacology
University of Copenhagen
Copenhagen, Denmark
E-mail addres: ojb@sund.ku.dk

Bridges, James Wilfried, PhD, DSc, Hon DSc

Professor Emeritus of Toxicology
and Environmental Health
University of Surrey, Guildford, UK
Email: j.bridges@surrey.ac.uk

Ac
ce
pt
e

Bolger, P. Michael, PhD, D.A.B.T.

Senior Managing Scientist, Exponent
Center for Chemical Regulation
and Food Safety
Washington, DC, USA
Email: pmbolger33@gmail.com

Brock, William J., PhD, DABT, Fellow ATS

Brock Scientific Consulting
Gaithersburg, MD, USA
Email: billbrock@comcast.net

Blum, Winfried E.H., Dr. Dr.h.c.mult.

Professor emeritus of Soil Sciences
Vienna, Austria
Email: winfried.blum@boku.ac.at

an

Blaauboer, Bas, PhD

Professor Emeritus of Toxicology,
Institute for Risk Assessment Sciences
Utrecht University
Utrecht, The Netherlands
Email: b.blaauboer@uu.nl

Bolt, Hermann, PhD

Professor, Leibniz Research Centre FOR
fWorking Environment and Human Factors
University of Dortmund, Dortmund, Germany
Email: h.m.bolt@t-online.de

Boobis, Alan R., OBE, PhD, FRSB

Professor of Biochemical Pharmacology
Department of Medicine, Imperial College
London, UK
Email: a.boobis@imperial.ac.uk

Borden, John H., PhD

Professor Emeritus
Simon Fraser University
Burnaby BC, Canada
Email: John.Borden@contech-inc.com

Borgert, Christopher J., PhD,

Brusick, David, PhD, ATS

Toxicology Consultant
Bumpass, VA, USA
Email: brusick41@aol.com

Carvalho, Flix, PharmD, PhD

Professor, Department of Biological Sciences
Faculty of Pharmacy, University of Porto
Porto, Portugal
Email: felixdc@ff.up.pt

Casse, Francine R., Prof. Dr.

Ermeritus Professor, Science and Technology
University of Lille, Lille, France
Email: francine.casse@wanadoo.fr

Cirpus, Petra, Dr.

BASF SE
Limburgerhof, Germany
Email: petra.cirpus@basf.com

Cohen, Samuel M., MD, PhD

Professor
Department of Pathology and Microbiology
University of Nebraska Medical Center
Omaha, NE; USA
Email: scohen@unmc.edu

Cohen, Steven D., D.Sc., ATS

Distinguished Professor Emeritus of Toxicology

Page 2 of 12

University of Connecticut, School of Pharmacy

Storrs, CT, USA
Email: cttoxdoc@gmail.com

Corney, Stephen J., BSc, MRSB, ERT

Head of Toxicology
Bayer Crop Science
Sophia Antipolis, France
E-mail: stephen.corney@bayer.com

Dietrich, Daniel, PhD, FATS, ERT

Professor
Human and Environmental Toxicology
Faculty of Biology, University of Konstanz
Konstanz, Germany
Email: Daniel.Dietrich@uni-konstanz.de

Corsini, Emanuela, PhD

Associate Professor,
Department of Pharmacological
and Biomolecular Sciences
University of Milan, Milan, Italy
Email: emanuela.corsini@unimi.it

us

cr

Doerge, Daniel R., PhD

National Center for Toxicological Research
U.S. Food and Drug Administration,
Jefferson, AR, USA
Email: daniel.doerge@fda.hhs.gov

Costa, Lucio G., PhD

Professor, Environmental
and Occupational Health Sciences
University of Washington
Seattle, WA, USA
Email: lgcosta@u.washington.edu

an

Dostal, Lori A., PhD, DABT

Lori Dostal Consulting, LLC
Brighton, MI, USA
Email: LoriDostal@gmail.com

Ac
ce
pt
e

Cushman, Janette R., Dr., D.A.B.T.

Toxicologist, Retired from Chevron
Orinda, CA, USA
Email: jancushman@comcast.net

Domingo, Jose L., PhD

Professor, Toxicology and
Environmental Health, School of Medicine,
Universitat "Rovira i Virgili". Reus, Spain
Email: joseluis.domingo@urv.cat

Creppy, Edmond E., Prof. Dr.

Head of Toxicology Department
Universit Bordeaux Segalen
Bordeaux, France
Email: edmond.creppy@u-bordeaux.fr

Dayan, Anthony, D. MD, FRCP, FRCPath

Consultant Toxicologist
Queen Marys University
London, UK
Email: a.dayan@toxic.u-net.com

de Camargo, Joo Lauro V., M.D., PhD, FIATP.

Professor of Pathology, Botucatu Medical School
UNESP - State Univ of So Paulo
So Paulo, Brazil
Email: decam@fmb.unesp.br

Degen, Gisela H., Prof. Dr.

Leibniz Research Centre for
Working Environment and Human Factors
University of Dortmund. Dortmund, Germany
Email: degen@ifado.de

Dekant, Wolfgang, PhD, SOT, DGPT

Professor of Toxicology
Department of Toxicology
University of Wuerzburg
Wuerzburg, Germany
Email: dekant@toxi.uni-wuerzburg.de

ip
t

Dencker, Lennart, MD
Professor Emeritus,
Department of Pharmaceutical Biosciences
Uppsala University, Uppsala, Sweden
Email: lennart.dencker@farmbio.uu.se

Doull John, MD, PhD, FAACT

Professor Emeritus, Pharmacology
Toxicology and Therapeutics
University of Kansas Medical Center
Kansas City, KS, USA
Email: jdoull@kumc.edu

Dourson, Michael L., PhD, DABT, ATS

Professor and Director, TERA Center
Department of Environmental Health
University of Cincinnati
Cincinati, OH, USA
Email: Michael.dourson@uc.edu

Duffus, John, PhD DSc FRSC

The Edinburgh Centre for Toxicology
Edinburgh, Scotland, U.K.
Email: j.h.duffus@blueyonder.co.uk

Eisenbrand, Gerhard, PhD

Emeritus Professor
Food Chemistry and Toxicology,
Department of Chemistry
University of Kaiserslautern
Kaiserslautern, Germany
Email: eisenbra@rhrk.uni-kl.de

Esdaile, David J.
Director of Science and Regulatory Affairs
CiToxLAB Hungary
Veszprem, Hungary

Page 3 of 12

Assistant Provost
Professor of Molecular Toxicology
Surgery and Cancer, Imperial College London
London, UK
Email: n.gooderham@imperial.ac.uk

Fawell, John, BSc, MRSB, DipRC Path

Professor, Water Science Institute
Cranfield University, Cranfield, UK
Email: john.fawell@johnfawell.co.uk

Goodman, Jay PhD

Professor of Pharmacology and Toxicology
Michigan State University
East Lansing, USA
Email: goodman3@msu.edu

Fellous, Marc, PhD

Professor Emeritus, Genetique Humaine
Universit Denis Diderot
Universit Paris Descartes
Paris, France
Email: marc.fellous@inserm.fr

cr

*Gori, Gio Batta, DSc, MPH, FATS

Editor-in-Chief
Regulatory Toxicology and Pharmacology
Bethesda, MD, USA
Email: gorigb@msn.com

us

Fred Martz, PhD

Professor Emeritus
Animal Sciences Faculty
University of Missouri
Columbia, MO, USA
Email: fredmartz@reagan.com

an

Gottesbren, Bernhard, Dr.

BASF Environment, Global Modelling,
Agriculture. Ludwigshafen, Germany
Email: bernhard.gottesbueren@basf.com

Fukushima, Shoji, M.D.,PhD

Director, Japan Bioassay Research Center
Japan Industrial Safety & Health Association
Hadano, Kanagawa, Japan
E-mail: s-fukushima@jisha.or.jp

Grasl-Kraupp, Bettina, MD, ERT

Assoc. Professor
Institute for Cancer Research
Medical University of Vienna
Vienna, Austria
Email: bettina.grasl-kraupp@meduniwien.ac.at

Ac
ce
pt
e

Gadagbui, Bernard K., PhD, ERT, DABT

Senior Toxicologist, UK/EU Registered
Toxicology Excellence for Risk Assessment
Cincinnati, OH, USA
Email: gadagbui@tera.org

Galli, Corrado Lodovico, PhD, ERT

Professor, Department of Pharmacological
and Biomolecular Sciences
University of Milan, Milan, Italy
Email: corrado.galli@unimi.it

Giavini, Erminio, PhD, ERT

Emeritus Professor, Comparative Anatomy
and Developmental Biology
University of Milan, Milan, Italy
Email: erminio.giavini@unimi.it

Gibson, James E., PhD

Emeritus Professor
Pharmacology and Toxicology
Brody School of Medicine
East Carolina University
Greenville, NC, USA
Email: GIBSONJ@ecu.edu

Ginevan, Michael, PhD

M.E. Ginevan & Associates, LLC
Silver Spring, MD; USA
Email: michael@ginevan.com

Gooderham, Nigel J., PhD, C.Chem, FRSC

ip
t

Email: david.esdaile@hu.citoxlab.com

Greim, Helmut, PhD

Professor Emeritus
Technical University of Munich
Munich, Germany
e-mail: helmut.greim@lrz.tum.de

Hansen, Steen Honor, D.Sc.

Professor, Department of Pharmacy
Faculty of Health and Medical Sciences
University of Copenhagen
Copenhagen, Denmark
Email: steen.honorehansen@sund.ku.dk; shh@farma.ku.dk

Hard, Gordon C., DVSc, PhD, DSc,

DACVP, FRCPath, FRCVS, FAToxSci.
Private Consultant in Toxicologic Pathology
Tairua, New Zealand
Email: gordonhard@msn.com

Hartung, Thomas, MD, PhD

Doerenkamp-Zbinden Professor
Chair for Evidence-based Toxicology
Johns Hopkins University
Bloomberg School of Public Health
Baltimore, USA
Email: thartun1@jhu.edu

Haselbach, Joachim, PhD, ERT, DGPT

Managing Director
ATC GmbH - Applied Tox-Consult
Krefeld, Germany

Page 4 of 12

Senior Scientific Researcher,

Email: joachim.haselbach@tox-consult.de

Toxicology Department
Hastings, Kenneth L. DrPH, DABT, Fellow ATS
Hastings Toxicology Consulting LLC
Mount Airy, MD, USA
Email: kennethhastingus@gmail.com

Carol Davila University of Medicine

and Pharmacy. Bucharest, Romania

ip
t

Email: mihaela.ilie@umf.ro
Heistracher, Peter, MD
Professor Emeritus
University of Vienna
Vienna, Austria
Email: peter.heistracher@univie.ac.at

Iscan, Mumtaz, Prof., ERT

Hellman, Bjrn, PhD

Professor of Toxicology
Head of Department of
Pharmaceutical Biosciences
Uppsala University. Uppsala, Sweden
Email: bjorn.hellman@farmbio.uu.se

cr

Department of Toxicology
Faculty of Pharmacy, Ankara University

us

Ankara, Turkey

Email: Mumtaz.Iscan@pharmacy.ankara.edu.tr

an

Hengstler, Jan G., MD.

Professor, Leibniz Research Centre for
Working Environment and Human Factors
Technical University of Dortmund
Dortmund, Germany
Email: Hengstler@ifado.de

Jene, Bernhard, Dr.

BASF Environmental Modelling, Agriculture

Email: bernhard.jene@basf.com

Ac
ce
pt
e

Hoffmann-Drr, Simone, Dr.

Toxicologist, Manager Product Safety
HSA Corporate Scientific Services
Henkel AG & Co. KGaA
Dsseldorf, Germany
Email: simone.hoffmann-doerr@henkel.com

Ludwigshafen, Germany

Hollnagel, Heli M., PhD, DABT, ERT

Oberwil-Lieli, Switzerland
Email: helihollnagel@gmail.com

Honeycutt, Michael E., PhD

Director, Toxicology Division
Texas Commission on Environmental Quality
Austin, TX, USA
Email: Michael.Honeycutt@tceq.texas.gov

Honkakoski, Paavo, PhD

Professor in Biopharmacy,
Adjunct Professor in Biochemical Toxicology
University of Eastern Finland
Kuopio, Finland
Email: paavo.honkakoski@uef.fi

Johnen, Bernhard G., PhD

Emeritus Director
International Regulatory Policy
CropLife International
Brussels, Belgium
Email: Bernhard.Johnen@croplife.org

Joudrier Philippe, Dr.

Ex Director of Research INRA
Montpellier, France
Email : philippe.joudrier@neuf.fr

Huang, Xuemei, MD, PhD

Professor of Neurosurgery, Pharmacology,
Radiology, & Kinesiology, Penn State University
Milton S. Hershey Medical Center
Hershey, PA, USA
Email: xuemei@psu.edu

Jungblut, Dieter, Dr.

Director, Head of Global Consumer Safety
BASF SE

Ilie, Mihaela, PhD, ERT

Page 5 of 12

Limburgerhof, Germany
Kellert, Marco, Dr., ERT

Email: hans-dieter.jungblut@basf.com

Kacew, Sam, PhD, ATS

Wacker Chemie AG

Professor

Burghausen, Germany

McLaughlin Centre for Risk Assessment

Email: marco.kellert@wacker.com

University of Ottawa. Ottawa, Canada

cr

Kelman, Bruce J., PhD, DABT, ATS, ERT

Email: skacew@uottawa.ca

ip
t

Toxicologist Corporate Product Safety

Principal and President, Veritox, Inc.

Redmond, WA, USA

Professor, Pharmacology & Toxicology

Email: bkelman@veritox.com

us

Kaminski, Norbert E., PhD

an

Michigan State University

East Lansing, MI, USA

Klaassen, Curtis D., PhD

Email: kamins11@msu.edu

Affiliate Professor

Kamrin, Michael A., PhD, SOT, AAAS

Dept of Environmental and Occupational Health

University of Washington

Institute for Integrative Toxicology

Ac
ce
pt
e

Michigan State University

Seattle, Washington, USA

Professor Emeritus

Email: curtisklaassenphd@gmail.com

East Lansing, MI USA

Klaunig, James, PhD

Email: kamrin@msu.edu

Professor, Department of Environmental Health

University of Indiana

Karakaya, Ali Esat, PhD, ATS, ERT

Ellettsville, IN, USA

Professor of Toxicology, Faculty of Pharmacy

Email: jklauni@indiana.edu

Gazi University, Ankara, Turkey

Email: karakaya@gazi.edu.tr

Klein, Jochen, Prof. Dr.

Direktor, Pharmakologisches Institut

Keller, Detlef, Dr.

fr Naturwissenschaftler

Senior Toxicology, Corporate Scientific Services

Goethe-Universitt Frankfurt

Henkel AG & Co.

Frankfurt am Main, Germany

Dsseldorf, Germany

Email: klein@em.uni-frankfurt.de

Email: detlef.keller@henkel.com

Page 6 of 12

Knowles, Michael E., PhD

and Carcinogenesis

Former Chief Scientist, Fisheries & Food

Dept of Veterinary and Biomedical Sciences

UK Government

Pennsylvania State University

Email : mek59100@gmail.com

University Park, PA; USA

Komulainen, Hannu, PhD

Lauterbach, John H., PhD, DABT

National Institute for Health and Welfare

Department of Plant Sciences

Kuopio, Finland

University of Oxford, UK

Email: hannu.komulainen@thl.fi

Email: chris.leaver@plants.ox.ac.uk

Kurtz, Perry J., PhD

Leber, Philip, PhD, DABT

Retired Senior Director, Drug Safety

Akron, OH, USA

Wyeth/Pfizer Research

Email: toxsci@sbcglobal.net

us

an

Chazy, NY, USA

Email: pkurtz@twcny.rr.com

cr

Research Professor (Emeritus)

ip
t

Email: eml17@psu.edu

Leist, Marcel, Prof. Dr.

Lamb, James C., IV, PhD, DABT, ATS

Ac
ce
pt
e

Principal Scientist, Center for Toxicology

Doerenkamp-Zbinden Chair
Faculty of Mathematics and Sciences
University of Konstanz

and Mechanistic Biology, Exponent

Konstanz, Germany

Alexandria, Virginia, USA

Email: marcel.leist@uni-konstanz.de

Email: jlamb@exponent.com

Leonard, Paul K., BSc, MSc, MBA

Lash, Lawrence H., PhD

Head of Innovation and Technology Policy,

Professor and Associate Chair,

BASF, Brussels, Belgium

Department of Pharmacology

Email: paul.leonard@basf.com

School of Medicine, Wayne State University

Detroit, MI, USA

Lerchl, Alexander, PhD

Email: l.h.lash@wayne.edu

Professor of Biology, Department

of Life Sciences and Chemistry

Laurenzana, Elizabeth M., PhD

Jacobs University, Bremen, Germany

Center for Molecular Toxicology

Email: a.lerchl@jacobs-university.de

Page 7 of 12

Lewis, Steven C., PhD, DABT

Marinovich, Marina, PhD
Professor, Department of Pharmacological
and Biomolecular Sciences
University of Milan, Milan, Italy
Email: marina.marinovich@unimi.it

President and Principal Scientist

Integral Policy & Science, LLC

Marone, Pam, PhD

Director, Regulatory Pharmaceutical
and Food Safety, Toxcel, LLC
Gainesville, VA, USA
Email: pamarone@verizon.net;
pam.marone@toxcel.com

Email: stevencraiglewis@comcast.net

cr

Lilienblum, Werner, Dr.

Marquardt, Hans W.J.

Professor Emeritus
Experimental and Clinical Toxicology
University of Hamburg Medical School
Hambug, Germany
Email: marquardt@uke.uni-hamburg.de

Retired, independent researcher

us

Hemmingen/Hannover, Germany
Email: Werner.Lilienblum@t-online.de

an

Matthiessen, Peter, Professor

Independent consultant in ecotoxicology
Backbarrow, UK
Email: peter@matthiessen.freeserve.co.uk

Lotti, Marcello, MD
Emeritus Professor of Medicine

Ac
ce
pt
e

e-mail: marcello.lotti@unipd.it

Mayes, Brian A., PhD, DABT, SOT

Senior Toxicologist (semi-retired)
Albany Medical College (AMC)
Selkirk, NY, USA
Email: bamayesmtf@gmail.com

University of Padua, Padua, Italy

Department of Cardiological,
Thoracic and Vascular Sciences

Lux, Jrgen Alfred, PhD

ip
t

Washington, NJ, USA

McAllister, Ray S., PhD

Senior Director, Regulatory Policy
CropLife America
Email: RMcAllister@croplifeamerica.org

Vice President Global Regulatory

Affairs Crop Protection

BASF SE. Limburgerhof, Germany

Email: juergen-alfred.lux@basf.com

Mailman, Richard B., PhD

Professor, College of Medicine
Penn State University
Hershey PA, USA
Email: rmailman@psu.edu

Mally, Angela, PhD, SOT, DGPT

Professor, Department of Toxicology
University of Wuerzburg
Wuerzburg, Germany
Email: mally@toxi.uni-wuerzburg.de

McClellan, Roger O., DVM, MMS, DSc (Hon.),

Toxicology and Human Health Risk Analysis
Albuquerque, NM, USA
Email: roger.o.mcclellan@att.net
Menegola, Elena, PhD
Section of Toxicology and Risk Assessment
Department of Pharmacological
and Biomolecular Sciences (DiSFeB),
University of Milan, Milan, Italy
Email: elena.menegola@unimi.it

Montgomery, Stephen B., PhD, ACT, SOT, STP

Consultant in Nonclinical Safety Assessment
Alpharetta, GA, USA
Email: sbmont@comcast.net

Moretto, Angelo, MD, PhD, Fellow ATS

Assoc. Professor, Department of Biomedical
and Clinical Sciences
University of Milan, Milan, Italy
Email: angelo.moretto@unimi.it

Page 8 of 12

Mostert, Volker, Dr.

European Registered Toxicologist (DGPT)
Langenfeld, Germany
Email: vmostert@extera-vm.com

Poole, Nigel J., Professor, OBE

Ambassador of the International
Crops Research Institute
for the Semi-Arid Tropics" (ICRISAT)
Hyderabad, India
Email: Sekona@btopenworld.com

Nebert, Daniel W., BA, MS, MD

Professor Emeritus, Dept of Environmental Medicine
Professor Emeritus, Dept of Pediatrics & Molecular
Developmental Biology, Human Genetics
University of Cincinnati Medical Center
Cincinnati OH, USA
Email: danielwnebert@gmail.com

us

Raunio, Hannu, MD, PhD

Professor, School of Pharmacy
University of Eastern Finland
Kuopio, Finland
e-mail: hannu.raunio@uef.fi

Oesch, Franz, Prof. Dr.

Institute of Toxicology
University of Mainz
Mainz, Germany
Email: oesch@uni-mainz.de

an

Ac
ce
pt
e

Pasanen, Markku, MD, PhD

Professor
Drug Toxicology, School of Pharmacy
University of Eastern Finland
Kuopio, Finland
Email: markku.pasanen@uef.fi

Roberts, Ruth A., PhD, FRCPath,FRSB

Professor. Director Apconix Inc.
Alderley Edge, UK
Email: ruth.roberts@apconix.com

Orisakwe, Orish Ebere, PhD, ERT, FRSC

Professor of Pharmacology & Toxicology,
Faculty of Pharmacy, University of Port Harcourt
Rivers State, Nigeria
Email: orish.orisakwe@uniport.edu.ng

Reeve, Lesley M., PhD, MSc Reg Aff, MTOPRA

Director, Regulatory Strategy
Covance
Harrogate, UK
Email: Lesley.Reeve@covance.com

Orhan, Hilmi, PhD, ERT, TST

Professor, Department of Toxicology
Faculty of Pharmacy, Ege University
35040 Bornova/zmir, Turkey,
E-mail: hilmi.orhan@ege.edu.tr

Pelkonen Olavi, MD, PhD

Professor Emeritus,
Department of Pharmacology and Toxicology
University of Oulu, Oulu, Finland
Email: olavi.pelkonen@oulu.fi

Philbert, Martin A., PhD, ATS

Professor and Dean
University of Michigan School of Public Health
Ann Arbor, MI, USA
Email: philbert@umich.edu
Pira, Enrico, MD
Full Professor of Occupational Medicine
Department of Public Health and Paediatrics
Turin University, Turin, Italy
Email: enrico.pira@unito.it
Pohjanvirta, Raimo K., DVM, PhD, FTS
Professor
Toxicology, Department of Food Hygiene
and Environmental Health
University of Helsinki, Helsinki, Finland
Email: raimo.pohjanvirta@helsinki.fi

cr

Quill, Terry F., MS, JD

Director, Quill Law Group, LLC
Washington, DC, USA
Email: tquill@quilllaw.com

Odum, Jenny, PhD

Consultant toxicologist
Regulatory Science Associates
Renfrewshire, UK
Email: jenny.odum@regulatoryscience.com

ip
t

Powell, Chris J., Dr., FRCPath

Vice President Safety Assessment
GlaxoSmithKline, David Jack Research Centre
Hertfordshire, UK
Email: christopher.j.powell@gsk.com

Rogiers, Vera, PhD,

Professor of Pharmacology
Vrije Universiteit Brussel
Bruxelles, Belgium
Email: Vera.Rogiers@vub.ac.be
Ross, John H., PhD, DABT
Risksciences.net, LLC
Carmichael, CA, USA
Email: jhross@surewest.net
Rumsby, Paul, PhD ERT
National Centre for Environmental
Toxicology, Swindon, UK
E-mail: paul.rumsby@wrcplc.co.uk
Rydzyski, Konrad, Prof. Dr. med.
Director, Nofer Institute of
Occupational Medicine
Lodz, Poland
Email: konrad@imp.lodz.pl
Santonen, Tiina, MD, PhD, MSc
Team Leader, Chemical Safety
Finnish Institute of Occupational Health
Helsinki, Finland
Email: Tiina.Santonen@ttl.fi

Sargent, Edward, MPH PhD DABT

Adjunct Full Professor
School of Public Health
Rutgers University
Piscataway, NJ, USA
Email: evsargent@gmail.com

Page 9 of 12

Email: ksolomon@uoguelph.ca

Starr, Thomas B., PhD

Principal, TBS Associates
Raleigh, NC, USA
Email: tbstarr@mindspring.com

Scala, Robert A., PhD, DABT, FACT

Retired, Senior Scientific Advisor
Willow Street, PA, USA
Email: bobscala@earthlink.net

cr

Streeter, Anthony, PhD, DABT

Scientific Director
Preclinical Development & Safety
Janssen Research & Development
Johnson & Johnson
Spring House, PA, USA
Email: TSTREETE@its.jnj.com

us

Schlatter, Josef R.
Dr. sc nat ETH Retired
Zurich, Switzerland
Email: Josef.schlatter@bluewin.ch

Swenberg, James, DVM, PhD, DACVP

Kenan Professor, Environmental Science
and Engineering
School of Global Public Health
University of North Carolina
Chapel Hill, NC, USA
Email: jswenber@email.unc.edu

Tardiff, Robert G., PhD, MA, ATS

Prizm Synergies, LLC
Vienna, VA, USA
Email: tardiffrg@alumni.uchicago.edu

Ac
ce
pt
e

Schupp, Thomas, PhD

Professor, Chemical Engineering
Muenster University of Applied Science
Steinfurt, Germany
Email: thomas.schupp@fh-muenster.de

an

Schrenk, Dieter, MD PhD

Professor of Toxicology,
Food Chemistry and Toxicology
University of Kaiserslautern
Kaiserslautern, Germany
Email: schrenk@rhrk.uni-kl.de
Schulte-Hermann, Rolf, Dr.h.c., MD, PhD
Emeritus Professor of Toxicology
Emeritus Director
Institute of Cancer Research
Medical University of Vienna
Vienna, Austria
Email: schulte-h@aon.at

Seulberger, Harald, Dr.

BASF SE, Vice President
Global Environmental and Consumer Safety
Crop Production
Ludwigshafen, Germany
Email: harald.seulberger@basf.com

Sharpe, Richard M, MSc PhD FRSE

Honorary Professor, University of Edinburgh
Edinburgh, Scotland, UK
Email: r.sharpe@ed.ac.uk
Sipes, Glenn I., PhD, Fellow ATS and AAAS
Professor Emeritus, Pharmacology
University of Arizona
Tucson, AZ, USA
Email: Sipes@email.arizona.edu
Sogorb, Miguel A., PhD
Professor of Toxicology
Bioengineering Institute
Miguel Hernndez University
Elche, Spain
Email: msogorb@umh.es

Solomon, Keith R., PhD, ATS, SETAC

Professor Emeritus, School of
Environmental Sciences, University of Guelph
Guelph, ON, Canada

ip
t

Stahlmann, Ralf, Prof. Dr. med.

Institut fr Klinische Pharmakologie
und Toxikologie
Charit Universittsmedizin
Berlin, Germany
Email: ralf.stahlmann@charite.de

Savolainen, Kai, MD, PhD

Research Professor, Work Environment
Finnish Institute of Occupational Health
Helsinki, Finland
Email: Kai.savolainen@ttl.fi

Tasheva, Maria, PhD

National Centre of Hygiene
Medical Ecology and Nutrition
Sofia, Bulgaria
Email: mtasheva@aster.net
Taylor, David, PhD, FRSC, FIWEM
Chairman, WCA Environment Ltd.
Faringdon, UK
Email: david.taylor@wca-environment.com
Teeguarden, Justin, PhD, DABT
Senior Scientist,
Pacific Northwest National Laboratory,
Department of Environmental &
Molecular Toxicology. Oregon State University
Richland, WA, USA
Email: jt@pnl.gov
Testai, Emanuela, Dr.
Senior researcher, Environment
& Primary Prevention Dept.
Istituto Superiore di Sanit
Rome, Italy
E-mail: emanuela.testai@iss.it
Tilbury, Lorraine, Dr.
American Board-Certified Toxicologist
Regulatory Affairs Leader
Global Regulatory Communications EIRL
Email: globalregcom@gmail.com
Tinkler, Jeremy J.B., BSc ERT
Director of Regulatory Consultancy
and Quality Assurance
MedPass International, London, UK
Email: jeremytinkler@medpass.org

Page 10 of 12

Wallace, Heather M., PhD FRCPath FRSC FSB

Professor
Biochemical Pharmacology and Toxicology
University of Aberdeen, Aberdeen, Scotland, UK
Email: h.m.wallace@abdn.ac.uk
Wallace, Kendall B., PhD, DABT, ATS
Professor & Associate Dean
University of Minnesota Medical School
Duluth, MN, USA
Email: kwallace@d.umn.edu

Tsatsakis, Aristidis M., MSc, PhD, DSc, ERT

Director Dept Forensic Sciences & Toxicology
Medical School, University of CRETE
Heraklion Voutes, GREECE
Email: aris@med.uoc.gr

Whysner, John, MD, PhD, DABT

Vice President
Washington Occupational
Health Associates, Inc.
Washington DC, USA
Email: whysner@gmail.com

cr

Tuomisto, Jouko, MD, PhD

Professor Emeritus
Department of Environmental Health
National Institute for Health and Welfare
Kuopio, Finland
Email: jouko.tuomisto@thl.fi

us

Wiebel, Frederike A., PhD, ERT

Director Toxicology
Corporate Scientific Services
Henkel AG & Co. KGaA
Dsseldorf, Germany
Email: frederike.wiebel@henkel.com

an

van Ravenzwaay, Bennard, Prof. Dr.

Experimental Toxicology and Ecology
BASF SE
Ludwigshafen, Germany
Email: bennard.ravenzwaay@basf.com

Ac
ce
pt
e

Vilanova Gisbert, Eugenio, Prof.

Professor of Toxicology
Director Institute of Bioengineering
University "Miguel Hernndez" of Elche
Alicante, Spain
Email: evilanova@umh.es

Wiebel, Friedrich J., Prof. Dr.

Ehem. Leiter der AG Molekulare
Zelltoxikologie, Institut fr Toxikologie
Helmholtz Zentrum Mnchen
Neuherberg/Mnchen, Germany
Email: wiebel@helmholtz-muenchen.de

Vermeulen, Nico P, PhD

Chemistry & Pharmaceutical Sciences
Vrije Universiteit
Amsterdam, The Netherlands
Email: n.p.e.vermeulen@few.vu.nl
Vighi, Marco, PhD
Principal Investigator
IMDEA Water Institute
Alcala' de Henares (Madrid), Spain
Email: marco.vighi@imdea.org

Viluksela, Matti, PhD, DABT

Professor
Department of Environmental
and Biological Sciences
University of Eastern Finland
Kuopio, Finland
Email: matti.viluksela@uef.fi

Vos, J. Chris, PhD

Dept. of Chemistry & Pharmacochemistry
AIMMS-Section of Molecular Toxicology
Vrije Universiteit
Amsterdam, The Netherlands
Email: j.c.vos@vu.nl

Wallace, David R., BS, PhD

Professor of Pharmacology & Physiology
Center for Health Sciences,
Oklahoma State University
Tulsa, OK, USA
Email: david.wallace@okstate.edu

ip
t

Trainer, Maria, PhD

Managing Director
Science and Regulatory Affairs, Chemistry
CropLife Canada
Ottawa, ON, Canada
Email: trainer@croplife.ca

Wilks, Martin F., Prof., MD PhD ERT

Director, Swiss Centre
for Applied Human Toxicology
Professeur, Facult de Mdecine
Universit de Genve
Universitt Basel, Basel, Switzerland
Email: martin.wilks@unibas.ch
Williams, Gary M., MD
New York Medical College
Department of Pathology BSB 413
Valhalla, NY, USA
Email: gary_williams@nymc.edu
Witorsch, Raphael J., PhD
Professor Emeritus
Department of Physiology and Biophysics
Virginia Commonwealth University
Richmond, VA, USA
Email: raphaelwitorsch@comcast.net
Yamazaki, Hiroshi, PhD
Professor, Laboratory of Drug
Metabolism and Pharmacokinetics
Showa Pharmaceutical University
Machida, Tokyo, Japan
Email: hyamazak@ac.shoyaku.ac.jp
Yokel, Robert A., PhD
Provost Distinguished Service Professor
College of Pharmacy
University of Kentucky
Lexington, KY, USA
Email: ryokel@uky.edu

*Corresponding author

Page 11 of 12

Page 12 of 12

Ac
ce
pt
e
us

an

cr

ip
t