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Class - ACE Inhibitor: Captopril

Captopril is an ACE inhibitor used to treat hypertension, congestive heart failure, and diabetic nephropathy. It works by inhibiting the angiotensin converting enzyme, preventing the conversion of angiotensin I to angiotensin II and causing vasodilation and increased cardiac output. Common side effects include hypotension, cough, angioedema, and hyperkalemia. It is well absorbed orally, 30% protein bound, and eliminated renally with a half-life of 2 hours. Studies show captopril decreases mortality from congestive heart failure and improves symptoms and exercise capacity.

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26 views2 pages

Class - ACE Inhibitor: Captopril

Captopril is an ACE inhibitor used to treat hypertension, congestive heart failure, and diabetic nephropathy. It works by inhibiting the angiotensin converting enzyme, preventing the conversion of angiotensin I to angiotensin II and causing vasodilation and increased cardiac output. Common side effects include hypotension, cough, angioedema, and hyperkalemia. It is well absorbed orally, 30% protein bound, and eliminated renally with a half-life of 2 hours. Studies show captopril decreases mortality from congestive heart failure and improves symptoms and exercise capacity.

Uploaded by

ernawati
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Captopril

4/11/10
PY Drug Book
Part I Notes

Class - ACE inhibitor

Mechanism of Action

- an inhibitor of angiotensin I-converting enzyme (ACE), the enzyme responsible


for the conversion of angiotensin I to angiotensin II -> vasodiation, increased Q,
myocardial remodeling.

Pharmaceutics

- tablet
- 12.5 to 50mg

Dose

- PO: 12.5 to 50mg Q 6hrly

Indications

- HT
- CHF
- diabetic nephropathy

Adverse Effects

- hypotension
- cough
- angioedema
- anaphylaxis
- cholestasis -> hepatic failure
- hyperkalaemia

PK

Absorption 75% bioavailablity


Distribution 30% protein bound, Vd = 0.8L/kg
Metabolism - hepatic
Elimination renal, t1/2 = 2 hrs

Evidence

-> shown to decrease mortality when used in congestive cardiac failure


(myocardial and cerebral events)
-> improved symptoms
-> improved exercise capacity

Jeremy Fernando (2011)


Jeremy Fernando (2011)

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