3d Printing
3d Printing
                                                                                                                                                                      PRACTICE
A. Dawood,* B. Marti Marti, V. Sauret-Jackson and A. Darwood
                  1                        1                           2                           3                 in dentistry.
                                                                                                                  	 Suggests these technologies could be
                                                                                                                     used in daily practice.
3D printing has been hailed as a disruptive technology which will change manufacturing. Used in aerospace, defence,
art and design, 3D printing is becoming a subject of great interest in surgery. The technology has a particular resonance
with dentistry, and with advances in 3D imaging and modelling technologies such as cone beam computed tomogra-
phy and intraoral scanning, and with the relatively long history of the use of CAD CAM technologies in dentistry, it will
become of increasing importance. Uses of 3D printing include the production of drill guides for dental implants, the
production of physical models for prosthodontics, orthodontics and surgery, the manufacture of dental, craniomaxil-
lofacial and orthopaedic implants, and the fabrication of copings and frameworks for implant and dental restorations.
This paper reviews the types of 3D printing technologies available and their various applications in dentistry and in
maxillofacial surgery.
INTRODUCTION
The term 3D printing is generally used to
describe a manufacturing approach that builds
objects one layer at a time, adding multiple
layers to form an object. This process is more
correctly described as additive manufacturing,
and is also referred to as rapid prototyping.1,2
   3D printing technologies are not all new;
many modalities in use today were first devel-
oped and used in the late 1980s and 1990s3 the
author first treated a patient with the help of
3D printing in 1999 (Fig.1).
   The term 3D printing, however, is relatively
new, and has captured the public imagina-
tion. A great deal of hype surrounds the use            Fig. 1 The first patient treated by the author with the help of 3D printing in 1999. (a) Frontal
of 3D printing which is hailed as a disruptive          view of the 3D printed medical model, printed with FDM technology, which shows the complex
technology that will forever transform manu-            anatomy of the patients cleft palate, before implant placement. (b) A recent image of the
                                                        patient with implant supported bridgework in place
facturing. We have seen headlines in the inter-
national press describing the use of 3D printing
to produce everything from fashion wear and
architectural models to armaments (Fig. 2).
However, the reality is different; 3D printed
underwear would today be uncomfortable and
3D printed guns are dangerous  to the indi-
vidual firing them. While we are very many
1
 Dawood and Tanner Dental Practice, 45 Wimpole St,
London, W1G 8SB; 2Cavendish Imaging, London, 109
Harley St, London, W1; 3University of Nottingham
Medical School, Queens Medical Centre, Nottingham,
NG7 2UH
*Correspondence to: Dr A Dawood,
Email: andrewdawood@hotmail.com                         Fig. 2 (a) A 3D printed colour plaster architectural model of one of the most iconic
                                                        examples of twentieth-century religious architecture designed by Le Corbusier. Model
Refereed Paper                                          printed by digits2widgets.com. Photograph Chris Sullivan. (b) 3D printed gun. Production
Accepted 6 October 2015                                 file controversially disseminated on the internet by American Cody Wilson, produced by
DOI: 10.1038/sj.bdj.2015.914
 British Dental Journal 2015; 219: 521-529
                                                        digits2widgets.com for Londons Victoria and Albert Museum collection
years away from seeing the production of via-         of creativity and an understanding of tech-                      APPLICATIONS OF 3D PRINTING
ble 3D printed organs, dentistry and oral and         nology, including engineering and materi-                        IN DENTISTRY AND ORAL AND
maxillofacial surgery have used 3D printing           als skills that extend well beyond that of                       MAXILLOFACIAL SURGERY
for years, and have whole-heartedly embraced          many others working in individual fields of
the use of digital manufacturing technologies,        endeavour.                                                       Medical modelling
notably, the use of computer-aided design and            Dentistry has a long association with                         One of the earliest applications of 3D printing
manufacturing. This article sets out to explore       subtractive manufacturing6 more usually                         in surgery, medical modelling, may be thought
why 3D printing is important to dentistry, and        described as milling. Subtractive manufac-                     of as the production of an anatomical study
why dentistry motivates development in 3D             turing is the removal of material to form an                     model.12 This has been made all the more
printing applications.                                object. CAD CAM for the milling of crown                         accessible by another important technology
                                                      copings and bridge frameworks is now syn-                        that has become mainstream in dentistry in
3D PRINTING TECHNOLOGY                                onymous with modern dental technology.5                          recent years; CBCT has become widely avail-
From a mechanical perspective, 3D print-              Modern dentistry has a familiarity with                          able in dental practices13,14 and has trans-
ers are often quite simple robotic devices.           materials designed to work with CAD CAM                          formed diagnosis and treatment in implant
The apparatus would be nothing without                and to substitute for the more traditional                       dentistry15,16 and in endodontics.17-19 Ready
the computer-aided design (CAD) software              precious metal casting alloys,7 which have                       access to CT, which provides similar data and
that allows objects, and indeed whole assem-          been subject to exponential price increases                      is more prevalent in a hospital setting, or CBCT
blies to be designed in a virtual environment.        in recent years. This use of technology                          means that it is possible to provide volumetric
CAD software is commonplace in industrial             facilitates the use of materials, which would                    image data to a 3D printer before surgery20
design, engineering, and manufacturing                otherwise be hard to work with, and elimi-                       and to make detailed replicas of the patients
environments, and is also common in the               nates labour intensive artisanal production                      jaws. This allows anatomy, particularly com-
dental laboratory; it is even becoming a fea-         techniques,8 allowing the dental technician                      plex, unusual, or unfamiliar anatomy, to be
ture of many dental surgeries (Fig. 3).               to focus his manual skills on more creative                      carefully reviewed and a surgical approach
   Developments in computer technology and            aspects of the manufacturing process, for                        planned or practised before surgery.21,22
software applications are very much a part of         example the aesthetic layering of porcelain.                        This has led to the development of new
the groundswell of technological change that             Of course every time that a dentist oper-                     procedures and approaches to surgery23 and
has taken 3D printing to where it is today.           ates to provide a restoration or reconstruc-                     along with the production of drilling or cut-
For 3D printing to have value we need to be           tion, the procedure is unique to that patient,                   ting guides using 3D printed technology or
able to create objects to print; CAD software         that jaw, that tooth, or that implant. The                       conventional laboratory technology, can
allows us to create objects from scratch,4,5          reconstruction or restoration will also have                     lead to expedited, less invasive, and more
but in dentistry and surgery we also have             innate complexity requiring the reproduc-                        predictable surgery24,25 (Fig.4).
ready access to volumetric data in the form           tion of convoluted geometry with a high                             For medical modelling, accuracy will
of computed tomography (CT) data, cone                level of precision.9 Although multi-axis CAD                     often be constrained by the original imag-
beam computed tomography (CBCT) data,                 CAM milling processes will allow this to an                      ing modality and the presence of artefact26
and intraoral or laboratory optical surface           extent,10 the process is slow and wasteful as                    caused by metal structures such as teeth,
scan data. Recent developments in CBCT and            the material is milled from an intact block,                     restorations or implants; the level of inac-
optical scan technology, in particular, have          and accuracy is limited by the complexity                        curacy is unlikely to be clinically relevant for
revolutionised, and are profoundly chang-             of the object, the size of the tooling, and                      many surgical applications. A wide variety
ing many aspects of restorative and implant           the properties of the material. 3D printing,                     of 3D printers and 3D printing materials can
dentistry. These powerful technological tools         however, comes into its own for the accurate                     be used to print medical models, but as it is
are at the disposal of a class of individu-           one-off fabrication of complex structures in                     useful to have such models in the operating
als  dentists and dental technicians  who           a variety of materials with properties that are                  room, materials that can be sterilised, such
are often polymaths, having a broad level             highly desirable in dentistry and in surgery.11                  as nylon, are particularly interesting.27
Fig. 4 Models and drill guides printed in resin for simultaneous Full lower arch implant rehabilitation and mandibular reconstruction. (a) Implant
drill guide over the 3DP model. (b) Bending the osteosynthesis plate on the sterilised medical model. (c) Plate in place.
                                                 best attributes of printing  complex geom-                 or even CBCT to capture patient data. The
                                                 etry with little waste  with milling  high                Invisalign, system digitally realigns the
                                                 precision mechanical connecting surfaces.                   patients teeth to make a series of 3D printed
                                                    While it may be somewhat wasteful in                     models for the manufacture of aligners,
                                                 material, milling has the advantage that the                which progressively reposition the teeth over
                                                 material used is intrinsically homogeneous                  a period of months/years.45,46 An example
                                                 and unaffected by operating conditions.                     of printing with multiple materials is in the
                                                 There is little need for post-processing, and               manufacture of 3D printed, indirect bracket-
                                                 the equipment is considerably less costly.                  bonding splints, printed in rigid and flexible
                                                                                                             materials for precise bracket placement using
                                                 Dental models for restorative                               orthodontic CAD software (3Shape).47
Fig. 7 SLS printed prepared teeth, printed       dentistry                                                     As data travels through the internet, and
from data from an intra oral scanner
                                                 The trend towards the use of intraoral scanners             smile design takes place in software, there
                                                 means that dentists need 3D printing in order               are huge potential savings in time. Again,
                                                 to make a physical model of the scanned jaw.                patient data may be digitally archived, and
                                                    Although today, it is not always strictly                only printed when needed, with great savings
                                                 necessary to print a master model at all,44 the             in physical storage-space requirements.
                                                 3D printed master model (Fig.7) may be used
                                                 for conventional aspects of the fabrication                 Dental implants
                                                 of a restoration, such as adding a veneering                Manufacturers have used 3D printing technol-
                                                 material, and we are accustomed to seeing                   ogy to create novel dental implants32 with a
                                                 restorations displayed on a model  even                  porous or rough surface.48 We must be careful,
                                                 if they have been directly fabricated digi-                 however, not to be seduced by the attraction of a
                                                 tally. Patient model data may be digitally                  rough or porous surface; over the years we have
                                                 archived, and only printed when needed,                     seen many dental implants appear with rough or
                                                 easing storage requirements.                                porous surfaces only to disappear as problems
                                                                                                             became evident some years later.4951 However,
                                                 Digital orthodontics                                        as a method for producing batches of complex
                                                 In orthodontics, treatment may be planned                   dental implants, 3D printing has the ability to
Fig. 8 Cranioplasty and orbital rim implants     and appliances created, or wires bent roboti-               produce complex geometries, such as a bone-
in titanium or PEEK fitted to a 3D printed SLS   cally based upon a digital workflow using                   like morphology, which may not be produced
model (Courtesy of www.cavendishimplants.com)
                                                 intra oral or laboratory optical scanning                   by milling alonealthough milling/machining
                                                                                                             may also be used to refine the printed formfor
                                                                                                             example, the implant platform. There is also the
                                                                                                             opportunity to create implants which have com-
                                                                                                             plex geometry, although ultimately inserting a
                                                                                                             dental implant using a screw type form seems
                                                                                                             like a well proven approach.
                                                                                                             OMF implants
                                                                                                             Much has been made of the ability to print in
                                                                                                             titanium or in implantable polymers (notably
                                                                                                             Poly ethyl ether ketone [PEEK]52) to create max-
                                                                                                             illofacial implants53,54 (Fig.8). 3D printing is capa-
                                                                                                             ble of producing complex geometries, however,
                                                                                                             most OMF implants are actually quite simple in
                                                                                                             form; pressing and milling technologies have
                                                                                                             several distinct advantages, such as reduced post-
                                                                                                             processing, quick production, and the predict-
                                                                                                             able use of homogeneous and uniform materials.
                                                                                                             3D printing may be used to print the implanted
                                                                                                             structure directly, or as a tool for indirect manu-
                                                                                                             facture using a conventional pressing process.
caught the publics imagination, whereas                    disadvantages (Table 1). Unfortunately, a                       Supports must be generated in the CAD
rapid prototyping never seemed that excit-                common feature of the more functional and                      software, and printed to resist the wiping
ing, is that while the technology allows                    productive equipment is the high cost of the                   action and to resist gravity, and must later
the surgeon-designer to move rapidly from                   equipment, the materials, maintenance, and                     be removed from the finished product. Post-
concept to prototype product, the actual                    repair, often accompanied by a need for messy                  processing involves removal of excess resin
printing process itself is rather slow and                  cleaning, difficult post-processing, and some-                 and a hardening process in a UV oven.
costly when working with materials with                     times onerous health and safety concerns.                        The process is costly when used for large
useful mechanical properties.                                                                                              objects, but this technology is commonly
   The authors have used 3D printing to pro-                Steriolithography (SLA, SL)                                    used for the industrial production of 3D
duce several prototype designs for innova-                  A stereolithography apparatus (Fig. 1055)                     printed implant drill guides.
tive or mundane instruments or devices used                 uses a scanning laser to build parts one
in everyday practice (Fig.9).                              layer at a time, in a vat of light-cured pho-                  Photopolymer jetting (PPJ)
                                                            topolymer resin. Each layer is traced-out by                   This technology uses light cured resin materials
3D PRINTING TECHNOLOGIES AND                                the laser on the surface of the liquid resin,                  and print heads rather like those found in an
MATERIALS                                                   at which point a build platform descends,                    inkjet printer (but considerably more costly),
Many different printing technologies                        and another layer of resin is wiped over the                   to lay down layers of photopolymer which are
exist, each with their own advantages and                   surface, and the process repeated.                             light cured with each pass of the print head.
 Sintered powder
 Selective laser sintering (SLS) for polymers.         Range of polymeric materials including nylon, elas-
 Object built layer by layer in powder bed. Heated     tomers, and composites. Strong and accuracte parts.
                                                                                                                       Significant infrastructure required, eg. compressed air,
 build chamberraises temperature of material to        Self-supported process.
                                                                                                                       climate control. Messy powders. Lower cost in bulk.
 just below melting point. Scanning laserthen          Polymeric materials  commonly nylon may be auto-
                                                                                                                       Inhalation risk. High cost technology. Rough surface.
 sinters powder layer by layer in a descending         claved. Printed object may have full mechanical func-
 bed.                                                  tionality. Lower cost materials if used in large volume.
 Selective laser sintering (SLS) - for metals and                                                                      Elaborate infrastructure requirements. Extremely costly
 metal alloys. Also described as selective laser                                                                       technology moderately costly materials. Dust and
                                                       High strength objects, can control porosity.
 melting (SLM) or direct metal laser sintering                                                                         nanoparticle condensate may be hazardous to health.
                                                       Variety of materials including titanium, titanium alloys,
 (DMLS). Scanning laser sinters metal powder                                                                           Explosive risk. Rough surface. Elaborate post-processing
                                                       cobalt chrome, stainless steel. Metal alloy may be recy-
 layer by layer in a cold build chamber as the                                                                         is required: Heat treatment to relieve internal stresses
                                                       cled. Fine detail possible.
 build platform descends. Support structure used                                                                       in printed objects. Hard to remove support materials.
 to tether objects to build platform.                                                                                  Relatively slow process.
 Electron beam melting (EBM, Arcam). Heated                                                                            Extremely costly technology moderately costly materi-
                                                       High temperature process, so no support or heat treat-
 build chamber. Powder sintered layer by layer                                                                         als. Dust may be hazardous to health. Explosive risk.
                                                       ment needed afterwards. High speed. Dense parts with
 by scanning electron beam on descending build                                                                         Rough surface. Less post-processing required. Lower
                                                       controllled porosity.
 platform.                                                                                                             resolution.
Thermoplastic
 Fused deposition modelling (FDM)                      High porosity. Variable mechanical strength. Low - to
                                                                                                                       Low cost but imited materials - only thermoplastics.
 First 3DP technology, most used in 'home' print-      mid-range cost materials and equipment. Low accuracy
                                                                                                                       Limited shape complexity for biological materials.
 ers. Thermoplastic material extruded through          in low costequipment. Some materials may be heat
                                                                                                                       Support material must be removed.
 nozzle onto build platform.                           sterilised.
   The ability to 3D print in metals is incred-         used for bioprinting71  a popular area                  Although 3D printing apparatus and
ibly exciting in the dental world. There are            for research in tissue engineering. Building              technologies have been readily available
a broad range of metals and metal alloys                complex geometries usually necessitates the               for more than a decade, it is developments
available including titanium, titanium                  laying down of support structures which                   in, and access to scanner technology, com-
alloys, cobalt chrome alloys, and stainless             may be either formed from the same mate-                  puter-aided design software and raw com-
steel. 3D printed partial dentures and pros-            rial, or from a second material laid down                 putational power, that has started to make
thesis frameworks are already being made in             by a second extruder  which, for example,                the use of the technology practical, while
this way, and for implant bridge frameworks             might extrude a water soluble support mate-               commercial and public interest has raised
technology may be combined with milling                 rial. Accuracy will depend upon the speed of              awareness and improved access to resources.
processes to provide high precision connec-             travel of the extruder, as well as the flow of               With the introduction of milling tech-
tions. The technology is broadly the same as            material and the size of each step.                     nology, a plethora of new material options
that described for polymers above, but these               This is the process that is used by most               became available for the production of
apparatus may also be described by different            low cost home 3D printers. It allows for                restorations; similarly, new generations of
manufacturers as, selective laser melting, or         the printing of crude anatomical mod-                     dental restorative materials for 3D printing
direct metal laser sintering.                         els without too much complexity,57  for                  are under development and appearing on a
   The 3D printing process itself may be                example, printing an edentulous mandible                  regular basis.
straightforward, but post-processing is                 might be possible, though printing a detailed                Taking into account the range of indica-
definitely not straightforward, and the fine            maxilla would be a tall order. More costly,               tions for 3D printing in dentistry, and the
metal powders and even finer nanoparticle               more accurate FDM printers are available,                 professions long experience of scanning
waste represents quite a significant health             and have application in anatomical study-                 and milling technology, it might be said
and safety challenge. While the printer itself          model making, but little else in dentistry or             that dentists and dental technologists have a
may be readily accommodated in the dental               in surgery.                                               broader experience of these 3D manufactur-
laboratory, the associated post production                                                                        ing technologies than any other profession.
equipment takes up at least as much space.              DISCUSSION                                                   CAD software is still the domain of the
While in theory the use of one machine to               The profession is already accepting of digi-              well-trained and computer literate, but this
print in different materials may seem fea-              tal manufacturing technologies; much of the               will not faze new generations of operator,
sible, in practice it is extremely difficult to         laboratory work that was once produced by                 and the software is becoming smarter and
fully clean down a machine, and certainly               artisan processes is now produced digitally,              more user-friendly all the time. Key future
switching between an implantable metal and              leaving only the final finishes of restorations           developments that would drive forwards our
a restorative material is not at all practical.         to be applied by hand. The use of CAD CAM                 usage of the technology beyond the obvious
   In small batch production the technology             technology has become commonplace in the                  benefits of reduced costs, increased speed of
is costly and casting continues to have many            dental laboratory, and may be seen more and               manufacture, and faster, less invasive treat-
attractions. However, in a large dedicated              more in the dental surgery. Whereas early                 ments for our patients, include the potential
machine it is possible to simultaneously                approaches to scanning and the production                 to 3D print in ceramic materials with digital
print 400500 crown copings in a 24hour                of digitally manufactured restorations relied             colouration and staining, the reduction of
period. Furthermore, copings may be printed             upon the use of centralised scanning and                  the post-processing needed for metal parts,
in lower cost materials that are tradition-             manufacturing facilities, many laboratories               and the integration of machining/milling of
ally harder to work with than gold alloys,              now have their own laboratory scanners, and               3D printed metal parts into the metal print-
such as cobalt chrome, but which offer good             many also have their own milling units. In                ing workflow.
porcelain bonding strengths and excellent               the dental practice environment, intra oral                  All of this means that the slowly evolving
mechanical properties.                                  and CBCT scanners are becoming more and                   use of digital technologies in dentistry has
   In surgical applications, the technology             more common.                                              gathered momentum to the point that we are,
allows for the straightforward batch pro-                  All this means that dentists and dental                in the opinion of the authors, long past the
duction of implants for orthopaedic appli-              technicians are becoming well acquainted                  point of early adoption, with the opportunity
cations,66 and for dental implants,67 and has           with, and adept at working with large vol-                for mainstream use of 3D printing technol-
been considered for use in the production of            umes of digital data. 3D printing offers                  ogy in the orthodontic and dental laboratory,
titanium cranioplasties in oral and maxil-              another form of output device for dental                and in surgery. There is scope for so much
lofacial surgery.68,69                                  CAD software; making it possible to materi-               more development; while there is a great
                                                        alise intricate components and objects in a               focus on individual items of equipment, it is
Fused deposition modelling (FDM)70                      variety of different materials. It comes into             the overall integration of the equipment with
FDM is one of the earliest 3D printing tech-            its own when structures are unique, bespoke,              the planning and design software to create a
nologies and was used by the author to                  have intricate geometry, and where 3D scan                smooth, rigorous and streamlined workflow
produce his first medical model in 1999.An             data is easily obtained.                                  that is of key importance, and will make all
FDM printer is essentially a robotic glue gun;             In dentistry, 3D printing already has                  the difference to the uptake and acceptance
an extruder either traverses a stationary plat-         diverse applicability, and holds a great deal             of these disruptive technologies.
form, or a platform moves below a stationary            of promise to make possible many new and                     Along with this new technology comes
extruder. Objects are sliced into layers by           exciting treatments and approaches to man-                new opportunity; the challenge that we face
the software and coordinates transferred to             ufacturing dental restorations. The national              is to not look at 3D printing as a new tool to
the printer. Materials must be thermoplastic            regulatory bodies have not yet implemented                do what we have always done, but to look
by definition. A commonly used material is              guidance in the use of 3D printing in sur-                at it as a technology that will allow us to be
the biodegradable polymer polylactic acid;              gery,72 or in dentistry, but at some stage there          more creative, to develop new materials and
this or similar materials have been used                will be a need for regulators to focus on this            new more predictable, less invasive and less
as key components of scaffold structures                technology to set appropriate standards.                  costly procedures for our patients. We must
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