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Boric acid can exist as transparent scales, six-sided crystals, or a white powder. It is soluble in water, alcohol, glycerin, and boiling water/alcohol. Boric acid content is determined through acid-base titration with NaOH in the presence of glycerol, forming glyceryl boric acid which acts as a strong acid. It has synonyms including Sal Sedativum Hombergi. Boric acid is prepared in dosage forms such as dusting powders, solutions, suppositories, ointments, and eyewash. It is used as an antiseptic, antifungal, and emollient for skin diseases and burns.

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937 views1 page

Inorgmedlab Exp7

Boric acid can exist as transparent scales, six-sided crystals, or a white powder. It is soluble in water, alcohol, glycerin, and boiling water/alcohol. Boric acid content is determined through acid-base titration with NaOH in the presence of glycerol, forming glyceryl boric acid which acts as a strong acid. It has synonyms including Sal Sedativum Hombergi. Boric acid is prepared in dosage forms such as dusting powders, solutions, suppositories, ointments, and eyewash. It is used as an antiseptic, antifungal, and emollient for skin diseases and burns.

Uploaded by

Janice Malafu De Guia
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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QUESTIONS FOR RESEARCH:

1. What are the 3 physical occurrence of boric acid in the market?


transparent, colorless, odorless, pearly scales having a smooth feel
six-sided triclinic crystals
white, odorless, bulky powder which is unctuous to touch

2. Using the different descriptive terms to describe solubility (refer to USP) of


substance, express the solubility of boric acid.
- Boric acid is soluble in
1gram-18ml of water (soluble)
1gram-18ml of alcohol (soluble)
1gram-4ml glycerin(freely soluble)
1gram-4ml boiling water (freely soluble)
1gram-6ml boiling alcohol (freely soluble)

3. How is the boric acid assayed? What is the rationale for such procedure?
- Purpose: To determine the percentage of purity in a given amount of the
boric acid
- Procedure: It is determined by the acid-base titration, i.e. direct titration
method with 1N NaOH method.
- Rationale:
Boric acid is a weak acid and hence it cannot be determined quantitatively
in an aqueous solution with standard NaOH solution using visual indicator.
However, it can be determined by titrating with standard NaOH solution in
the presence of polyhydric alcohols, such as glycerol or mannitol because
glyceryl boric acid which is formed on treatment of boric acid with glycerol.
This glyceryl boric acid acts as a strong acid and can be titrated against a
standard NaOH solution using a visual indicator, phenolphthalein.

4. List Synonyms of boric acid.


Sal Sedativum Hombergi
orthoboric acid
boracic acid
acidum boricum
borofax

5. In what dosage forms is boric acid prepared?


Dusting powders
Solution
Suppository
Ointment
Eyewash

6. State and define the medicinal uses of boric acid.


-Antiseptic (cleanse cuts and wounds)
-Antifungal (kills bacterias and fungi)
-Emollient Indicated for skin diseases (eczema, impetigo, erysipelas) and burns

REFERENCES:
http://www.citycollegiate.com/boric_acid.htm
http://www.sigmaaldrich.com/content/dam/sigma-
aldrich/docs/Sigma/Product_Information_Sheet/b7901pis.pdf

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