Tablet Coating Related Problems Page 1 of 3
Tablet Coating Related Problems
Thursday, February 21, 2013 Google+ Followers
Amit Biswas
Film coating Problems and Remedies
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Film coating Problems and Remedies
1.Blistering
2.Blushing
3.Bridging(of the intagliations)
4.Hipping
5.Cracking
6.Cratering
7.Flaking
8.Infilling
9.Orange peel
9.Peeling 1,230 have me in circles
10.Picking
11.Pimpling
12.Pitting
13.Pulling out(of a intagliation) Google Plus+ Add-me
14.Splitting
15.Wrinkling
16.Blooming
1. Blistering:
Film becomes detached from substrate forming a blister
Cause: Over heating during spraying of at end of coating run
Remedy: Milder drying condition.
2. Blooming:
Coating becomes dull immediately or after a prolong storage. Film becomes detached from substrate forming a blister
Cause: due to low molecular weight plasticizers included in the coating formulation
Amit Biswas
Remedy: Decrease plasticizer concentrations and increase molecular weight of plasticizer..
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Pharmacist/Researcher (MS Pharm Tech), IT
3. Chipping: Professional
Film becomes chipped and dented, usually at the edges of the tablet
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Cause: Excessive attrition during coating process.
Remedy: hardness of the film by increasing the molecular grade of polymer.
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4. Cracking:
Films cracks or splits
Cause: high internal stresses in film (more than the tensile strength of the film)
Remedy: Adjusting the plasticizer type and concentration; Pigment type and concentration. Use lower molecular weight polymers or Facebook Follow Me
polymeric blends.
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5. Flaking:
Film flakes off exposing the tablet surface.
Cause: Associated with cracking and splitting.
Remedy: Adjust the spray rate with drying temperature.
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6. Infilling: Amit Biswas
Intagliation filled with either particles of dried polymer or solidified foam.
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Cause: bubble or foam formation because of air spraying of polymer solution. Over drying of spray or excessive foaming of coating
solution. Hello,
Remedy: Add alcohol or use spray nozzle capable of finer atomization. I'm a Registered Pharmacist,
Researcher and IT Professional.
7. Orange peel/ Roughness:
Working Experiences:
Surface appearance similar to that of an orange or lemon
My Internship was at Beximco
Cause: poor spreading or spreading of spray droplets associated with non-optimum spray atomization.
Pharmaceuticals Ltd (One of the Leading
Remedy: Thinning the solution with additional solvent; use mild drying conditions Pharmaceutical Company in the World)
Hospital & Clinical Pharmacy (Square
Hospitals Ltd, Apollo Hospitals Dhaka
8. Peeling: Specialized Hospital)
Film peels off exposing the best tablet surface Attended "CPR" at Dhaka Medical College
Cause: Associated with cracking and splitting. Hospital
Worked as a "IT Specialist and Data Analyst"
Remedy:Adjust molecular grade of polymer. Balance spraying and drying rate
at Sonali Bank Ltd.
Hiring Manager Position at AMAZON
Publishing Company.
9. Splitting: Product Promotion Manager
Film splits usually around the edges of the tablet at AMAZON eBook Publishing Company.
Cause: High internal stress in film. Working Now as a Web Developer, CSS
Remedy:Use lower molecular weight polymers or polymeric blends. And/or adjust plasticizer type and concentration. Developer, CRM Management Specialist and
Graphics Specialist.
**Labels: Coating Tablet Defects, Cause and Remedies, Formulation, Solution, Tablet coating Problems, Tablet properties, polymers, plasticizers
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Tablet Coating Related Problems and Solutions Top Performer of my Pharmacy course as well
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Labels: Amit Biswas (RPh), Coating, Film coating Problems and Remedies, Formulations, Medical, Pharma, Pharmaceutical of-course Playing Guitar. Ohh... forgot to say
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Excipients, Pharmaceutical Technology, Tablet Coating Related Problems and Solutions
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Tablet Coating Related Problems and Solutions to contact with me for any assistance :))
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Coating Related Problems and Solutions. Skype: omit-light
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Here is a list of common defects associated with coated tablets and some likely causes https://www.facebook.com/amit.pharmacist
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Capping: https://plus.google.com/u/0/1062635016862369
This is when the tablet separates in laminar fashion. The problem stems from improper tablet compression, but it may not reveal itself 08627/posts
until you start coating. How you operate the coating system, however, can exacerbate the problem. Be careful not to over-dry the Pinterest: https://www.pinterest.com/amit80
tablets in the preheating stage. That can make the tablets brittle and promote capping. LinkedIn: https://www.linkedin.com/in/amit-
biswas-08538559?trk=hp-identity-name
Youtube:
https://www.youtube.com/user/phamit80
Chipping: Instagram:
This is the result of high pan speed, a friable tablet core, or a coating solution that lacks a good plasticizer. https://www.instagram.com/amitlight/?hl=en
LinkedIn:
Website and Blogs:
Picking & Sticking: http://amitsportfolio.blogspot.com/
This is when the coating removes a piece of the tablet from the core. It is caused by over-wetting the tablets, by under-drying, or by http://itnews-solutions-tips.blogspot.com/
http://pharmacyhelps.blogspot.com/
poor tablet quality.
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Bridging: m/
This occurs when the coating fills in the lettering or logo on the tablet and is typically caused by improper application of the solution, http://itnews-solutions.blogspot.com/
http://amitbiswaspharmacist.weebly.com/
poor design of the tablet embossing, high coating viscosity, high percentage of solids in the solution, or improper atomization
pressure.
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This can be the result of soft tablets, an over-wetted tablet surface, inadequate drying, or lack of tablet surface strength.
2013 (1)
February (1)
Mottled color:
Film coating Problems and
This can happen when the coating solution is improperly prepared, the actual spray rate differs from the target rate, the tablet cores
Remedies
are cold, or the drying rate is out of spec.
2012 (1)
Peeling & Frosting:
This is a defect where the coating peels away from the tablet surface in a sheet. Peeling indicates that the coating solution did not
lock into the tablet surface. This could be due to a defect in the coating solution, over-wetting, or high moisture content in the tablet Total Visitors
core.
Twinning:
This is the term for two tablets thats stick together, and its a common problem with capsule shaped tablets. Assuming you to change
the tablet shape, you can solve this problem by balancing the pan speed and spray rate. Try reducing the spray rate or increasing the
pan speed. In some cases, it is necessary to modify the design of the tooling by very slightly changing the radius. The change is
almost impossible to see, but it prevents the twinning problem.
Orange peel:
This refers to a coating texture that resembles the surface of an orange. It is usually the result of high atomization pressure in
combination with spray rates that are too high. T & C this photo shows multiple defects. The initial problem is erosion of the tablet
edge due to a soft or friable tablet or because the pan was turning too fast or both. Peeling and breakage also appear here. I attribute
the peeling in this photo to excessive moisture within the tablet, which preserved the coating from adhering. However, the tablet
coating also pulled the granulation out of the tablet, a picking defect. That is usually caused by over-wetting the tablet or by a tablet
that is too fast.
Just one broken tablet can distribute particles to all other tablets and mar their appearance. These tablets likely broke because they
had poor hardness. This photo shows a very porous tablet that prevented the coating from adhering to the surface. These tablets
should have been coated longer, and atomization pressure should have been reduced to decrease the slight orange peel, or
textured, surface.
**Labels: Coating Tablet Defects, Cause and Remedies, Formulation, Solution, Tablet coating Problems, Tablet properties, polymers, plasticizers
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