Industrial Training

At

DEY’S
“Care You Can trust”
Dey’s Medical Stores (Mfg) Pvt. Ltd.
62 Bondel Road, Kolkata-700019
West Bengal.

Training from 1st July to 30th July 2009.

Report submitted in partial fulfillment of the

requirement for the degree of bachelor of pharmacy
By

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 ACKNOWLEDGEMENT
The industrial training work is undertaken as a part of the curriculum of
the bachelor of pharmacy (B.Pharm) course of department of pharmaceutical
science of Dibrugarh University, Assam.
The accomplishment of this work require the help and effort of many
people and the work is indifferent. I am grateful to Dr. A. Bhattacharyya the
head of the department of Pharmaceutical science of Didrugarh University for
givin me the opportunity to undergo the industrial training at Dey’s Medical
Stores (Mfg) pvt. Ltd.
It has been a pleasure to undergo training at Dey’s. In spite of its short
duration (01.07.09-30.07.90), the practical experience of industrial work
environment will be a valuable asset to me and will go a long way in enhancing
my prospects in the pharmaceutical field.
I want to convey my sincere thanks specially to Mr. Deepak Banik for his
helping hand in every step here and also to each and every personal of Dey’s
for helping me the formulation industry in a better way. I want to specially
thank the supervisors and in-charges and support.
I express my deep gratitude to the below named persons for their
support and valuable information.
1. Mr. Tapash Benerjee (Personal Manager)
2. Mr. Santanu Roy & Mr. Sanjay Dutt (In-charge tablet dept.)
3. Mr. Arijit Dutta (In charge capsule)
4. Mr. Saradindu Mondal (Supervisor capsule)
5. Mr. Subhankar Biswas (In-charge liquid)
6. Mr. Amarnath Roy (In-charge I-tone)
7. (In-charge Q.C.)
8. Mrs. Sikha Roy (Librarian)

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 SOMETHING ABOUT THE COMPANY
Dey’s Medical Stores (Mfg) Pvt. Ltd. Is a private company dealing with the
production of many pharmaceutical products. It was established in 1958. It has
four manufacturing units-three at Kolkata, W.B and other one at Naini,
Allahabad, Uttar Pradesh.
The beginning of Dey’s is fascinating. In 1941, Late Mr.B.N.Dey, the then
Managing Director of this organization, from a mere urge to serve the society,
started a small retail medical store in Kolkata through his unique character
comprising high capabilities with honesty. Soon he was able to gain the
confidence of the medical profession including the stalwarts in the field. During
the 2nd world was, when the supply of essential drugs was uncertain and
much hampered, Dey’s come forward in the field of agency to ensure and
maintain a steady supply of left Saving drugs and appliances to the medical
profession and also to the ailing people of the country.
In 1957 Dey’s took sold step in establish a manufacturing units in the city
of Kolkata its own indigenous know how various dosage forms of drugs-
capsules, tablets, granules, powders, oral liquid, drops etc of all the important
categories of medicines-antibiotics, antiasthma ties, antihypertensive, ant
dysentery, anti-inflammatory. In the year 1971 Dey’s opened a second
manufacturing company at Naini, Allahabad, in the state of Uttar Pradesh.

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 CONTENT

1. Tablet......................................................................................................5

2. Capsule……………………………………………………………………………………………….10

3. Liquid ( I & II)……………………………………………………………………………………….14

4. Quality Control…………………………………………………………………………………….18

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 TABLETS

Tablets may be defined as solid pharmaceutical dosage form containing

drug substances with or without suitable diluents and prepared by either
compression or moulding methods.

The compressed tablet has a number of advantages as a dosage form. It

enables an accurate dosage of medicament to be administed simply.

Tableting Methods

Dry Granulation Wet Granulation

General Procedure For Production Of Non β-αActum Tablets :

It is devided into two

I. Wet Granulation Method

II. Dry Granulation Method

WET GRANULATION METHOD:-

Weighing of materials

Dissolution in solvent (water of organic solvent)

Addition of binding material

Mixing in steam jacketed vessel till formation of dough

Drying in tray dryer

Granulation

Addition of excipients

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 Mixing in planetary mixer

Compression

Coating QUALITY CONTROL

Packing, striping or blistering VACCUM LEAD TEST

Packing

DRY GRANULATION METHOD:-

Weighing of materials

Addition of fillers & binders

Sifting and granulation for proper mixing

ADDITION OF EXCIPIENTS

Mixing in planetary mixer

Compression

Coating QUALITY CONTROL

Packing, striping or blistering VACCUM LEAD TEST

Packaging

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 DURING ONE WEEK OF TRAINING FOLLOWING TABLETSWERE
PROCESSED

PRODUCT PROCEDURE DRUG USE

solacid w.G(wet Dried Antacid, Ant

granulation) aluminiumhydroxid flatulent,
e gel I.P, Mg. Adsorbent.
trisilicate I.P,
Mg(OH)2 I.P,
simethicone I.P
Entero-mycetin w.G chloram phenicol I.P Typhoid
caplet

Horn-o Dry Ornidazole I.P, Infection

granulation(D.G)
Ofloxacin I.P,

Horn-500 W.G Ornidazol I.P

Brotzv D.G Cepha doxyl Cough & Cold

Avicel pH101
Milk Of W.G Antacid
Magnesia &Laxative
Etformin W.G Metformin Diabetis
hydrochloride I.P
Liz-M W.G Gliclazide Diabetis
Metformin
hydrochloride
Zovax-500 Amoxycillin Antibiotic
Trihydrate

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Tablet Coating:- Tablet coating is a process of application of a coating
composition to a moving bed of tablet with a concurrent use of a heated air to
facilitate evaporation of the solvent. The distribution of coating is
accomplished by the movement of the tablets either perpendicularly (coating
pan) or vertical (air suspension coater) to the application of the coating
composition.

Tablet coating may be divided into→

-Film coating

-Sugar coating

- Enteric coating

Machine used→
→Name – UNICOTA- 36

→Capacity of pan – 50 kg

→It is an automatic coating machine with 3 coating hozzles (Guns)

→RPM of machine – 6 CPS

→Spraying on timer – 8 sec.

→spraying off timer – 8sec

→Temperature of coating pan – 37.7° C

Composition of coating solution→

Polymer – HPMC, CAP, HPMC Pthalate, Shellac.

Plasticizer – PEG-6000, DBP, DEP

Solvents – Water, Isopropyl Alcohol, Ethyl Alcohol, Acetone, Methyl chloride

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Colouring Agents – Titanium dioxide, Brilliant blue, Erythrosine lake colour,
Yellow oxide of Iron

Polishing agent – Talcum, PG

For enteric coating tablets ‘OPAR DYE’ is used along with other materials.

Other machines used or associated with UNICOATA - 36

→3 SPRAYING GUNS

→PERISTALTIC PUMP

→VESSEL CONTAINING COATING SOLUTION FIXED GWITH STIRRER

→AIR INJECTOR

→PRESSURE GAUGE

FIGURE of UNICOTA-36

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 CAPSULES
Capsules are solid pharmaceutical doses forms consisting of solids,
semisolids and liquid enclosed in a gelatin shell.

Capsules are of two types:

→HARD GELATIN CAPSULES

→SOFT GELATIN CAPSULES

The capsule filling materials may be

→ Dry solid – powder, granules and pellets

→Semisolid – thinotropic mixtures, thermosoftening mixtures, pastes

etc.

→Liquid – oily liquid suspension, solutions

TYPES OF CAPSULE PRODUCED IN DEY’S MEDICAL

1. AYURVEDIC CAPSULE
2. ALLOPATHY CAPSULE

Size of capsules – there are various types of capsules 000, 00, 1, 2, 3, 4, 5.

Machines required in the production of various capsules :-

1. Granulator,
2. Double cone blender,
3. Dough mixer,
4. Cube blender,
5. Impex pulveriser,
6. Shifter,
7. Automatic blister machine(packing),
8. Automatic capsule filling machine(PAM)

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 -: Manufacturing Procedure for Capsules:-
WEIGHING → SEIVING → BLENDING & LUBRICATION ← LACTOSE, STARCH,Mg.STEARATE

IN PROCESS TESTING, POLISHING & STORING

QUALITY CONTROL
eg:WEIGHT VARIATION TEST
STRIP/BLISTER PACING

PACKING

Machines used in different area of production of capsules:

AREA NAME OF MACHINE

CHARGING AREA 1. Weighing machine
2. Oscillating granulator
3. Double cone blender
4. Tray drier
5. Cube blender

FILLING AREA 1. Semi automatic filling

machine - PAM
2. Automatic filling machine –
Zenasis

PACKAGING AREA 1. Strip packing machine

-Four track
-Two track
2. Blister packaging machine
-PHARMAPACK 240 CH

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ALLOPATHY CAPSULE:

ENTERMYCETIN CAPSULE – Constituents → Chorophenicol

Category → Typhoid

AYURVEDIC CAPSULE: There are 3 in number

1. LIVINA CAPSULE
a. ACTIVE INGREDIENTS – Kalmegh,Kakamachi,Sarapunkha,
Guduchi,Haritaki,Katuka,Saptapura
b. EXTRACTS OF THE INGREDIENTS – Bhumium laki, Kakilakshy a Indrayva,
Daruharidra,Kasni
c. LUBRICANTS – DCP,Starch, SiO2, Magnesium stearate,Talcum powder
d. PRESERVATIVES – Sodium benzoate
e. USES – In liver ailments, helps and protects liver from hepatotonic
substances, promotes appatite, clear constipation
f. PROCEDURE :-

Mix all active potential ingredients – Sieve (mesh 60)

→Mix LIVINA extract + distilled water

→ Dryer (1st at 100°c for few hours and then at 60°c)
→Granulation (by passing double zero net Fitz mill
→Dry charge (by adding lubricants)-Filling
→Polishing →Blister packing

g. Capsule colour: Light green- Dark green

h. Size/Fill capacity: 0/0.75 ml

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2. PROSTINA CAPSULE:

a) ACTIVE INGREDIENTS: Vapusha, Pravala (Sea coral), Purified silajit,

Kababchini, Ushira, Chandan oil.
b) LUBRICANTS : DCP, Starch, SiO2, Deprogel,Mg Stearate,Talcum powder
c) USE: In problem of prostrate glands.
d) PROCEDURE : Mix active potential ingredients+lubricants→Sieve(mesh
60)→Filling→Polishing→Polishing→Blister→Packing
e) CAPSULE COLOUR → Orange-Orange
f) SIZE / FILL CAPACITY → 0/0.75 ml

3. TRASINA CAPSULE:

a) ACTIVE INGREDIENTS → Ashwagandha, Tulsi, Purified silajit, Guduchi,

Katuka, Bhringraj
b) LUBRICANTS →Starch, SiO2, Mg Stearate,Talcum powder.
c) PRESERVATIVES →Sodium Benzoate
d) USE→As an adaptogenic formulation recommendedfor management of
diverse types of strain and as an adjuvant therapy in stress induced
diseases.
e) PROCEDURE →Mix active potential ingredients lubricants →Sieve (mesh
60) →Filling→Polishing→Blistering→Packing.
f) CAPSULE COLOUR →Yellow-Dark yellow
g) SIZE/FILL CAPACITY →0/0.75 ml

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 LIQUID
Liquid formulation are intended for oral administration and external
administration.

Those liquids intended for oral administration or into body cavities

should be sufficiently sterile

Liquid department is divided into:

i. LIQUID 1 → ENTEROMYCETIN SYRUP, KARPIN LOTION 1&2.

ii. LIQUID 2 →LIVINA SYRUP, HERBODIL SYRUP, KEOKERPIN BODY
OIL(LAVENDER), KEOKARPIN BODY OIL(SANDAL)
iii. OTHERS →I-TONE EYE DROP

This department has only one charging room and one storage room for
the finished product. Every section has one washing room attached with the
packing room which washes the bottle of that particular product.

GENERAL PROCEDURE FOR LIQUID PREPARATION:-

Charging →Filtration →Storage vat →Filling →Capping & Sealing → Labelling →

packing.

LIQUID 1:
1. ENTEROMYCETIN SYRUP

This is the main product of liquid 1 section. It is a chloramphenicol oral

suspension.This antibiotics is milky white in colour. As chloramphenicol is a
drug of choice in typhoid.So thinSyrup is used in typhoid.

PREPARATION PROCEDURE :- Distilled water taken → raised to boiling

temperature → Methyl paraben &Propyl paraben is added and stirred
continuosly → required amount of sugar is added →add bromopol and sodium
benzoate → sieved → kept overnight at room temperature → next day syrup is

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filtered through sparkler filter → filter in charge VAT → chloramphenicol and
isopropyl alcohol in stream VAT → clear solution formed at 62°c-65°c → above
solution in four containers containing water with stirring → amorphous form of
chloramphenicol palminate is formed and is collected → transferred to ball mill
and operated for 2 hrs. with little water to make a slurry → slurry sent to
quality control for intermediate infrared test → after report add TWEEN 20 →
add water and stir for 20-21 hrs. → transfer to mixing VAT in syrup → add ice
cream flavours → volume makeup → sent sample to quality control → then for
I.R. test → filling → capping → labeling →packing.

2. KARPIN LOTION.

A pack of KARPIN lotion consists of Karpin lotion 1 & Karpin lotion 2.

PROCEDURE FOR PREPARATION OF KARPIN LOTION 1:- In charge VAT add

water, sodium thiosulphate + sodium benzoate + sodium hydroxide
+cetramide one by one →stir volume make up →filter →storage VAT → sample
to quality control(I.R. TEST) →filling →capping → labeling → packing.

PROCEDURE FOR PREPARATION OF KARPIN LOTION 2:- In charge VAT add

water + tartaric acid + phenol one by one → volume makeup → filter →
storage VAT → sent sample to quality control(I.R.TEST) → filling → capping →
labeling → packing.

USE – For application in skin diseases

KARPIN LOTION 1. → For cleaning the affected area

KARPIN LOTION 2. → Therapeutic effect.

Karpin lotion is doubly filtered. 1st through HYFLOW SUPERCEL POWDER (filter
aid powder) dissolved in water and then through sparkler filter (2 beded).

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LIQUID 2.
It is mainly ayurvedic section.

The products manufactured here are

1. LIVINA SYRUP, 2. KEOKARPIN BODY OIL (LAVENDER), 3. KEOKARPIN BODY

OIL (SANDAL), 4. HERBODIL SYRUP.

1. LIVINA SYRUP

INGREDIENTS: - Kakamachi,Indrayava, Sarapunkha, Kalmegh, Bhumiumlaki,

Guduchi, Harataki, Hakila-Ushya, Saptaparna, Daruharidra, Kasni, Katuka.

ACTIVE INGREDIENTS: - Sodium benzoate, Methyl paraben, Propyl paraben.

ADDITIONAL: - Sugar syrup &alternative sweetners, Sorbitol, sodium saccharine.

USE :- Protects liver from hepatotonic substances, promote appetite, clears

constipation.

2. KEOKARPIN BODY OIL (SANDAL)

INGREDIENTS :- Daruharidra, Haridra, Manjistha, Arjuna

In oil base containing karpoor,camphor, vaishakh, isopropyl alcohol,lanolin,

olive oil, neem oil, arachis oil, light liquid paraffin(for volume make up),
butylated hydroxylated anisole (as preservatives) and sandal(as perfume).

USES :- Herbal body oil.

3. OTHERS → I-TONE EYE DROP:-

It is an unique preparation derived from the ancient ayurveda,rediscovered

through extensive in-house research. In Bhirgutantra Sushtruta & Charaka
samhita succesful treatment of various occular dieseases have been recorded.
Taking lead I-TONE eyedrop has been prepared.It is invaluable in protecting the

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eyes from all pollutants and adverse environment of modern life. It also helps
to maintain the activity of vision and is very useful in treatment of various eye
ailments.

INGREDIENTS :- Aqueous distillate of nimba, shobhanjana, bhringaraj,

punarnava, nirgundi, tulsipatra, satapatri, yamani, haritaki, bibhitaka,
dhatriphala, haridra, karpuram, pudina, satwa, madhu, ela, sweet chandan,
mukta, saindhava, labau.

AS PRESERVATIVES :- Phenyl ethyl alcohol USP, benzalkonium chloride solution

I.P.

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 QUALITY CONTROL (QC)
Quality control department is a must for every pharmaceutical industry. There
are several aspects of quality control department

1. Q.C. ensures good quality of finished products.

2. Q.C. fixes the expiry date of the products.
3. Q.C. helps the organisation to discover new drugs.
4. Q.C. promotes the drug delivery, production rate etc.
5. Q.C. department has the sole authority to reject even finished products,
if it is seen to be not up to the mark.
6. Q.C. helps to maintain a consistency in producing good products.

A good Q.C. department helps to increase marketability of drug & the profit of
the respective organisation.

Q.C. department generally consists of the following departments:

1. Chemical Laboratory
2. Pharmacological Laboratory
3. Microbiological Laboratory

CHEMICAL DEPARTMENT:-

Different types of instruments in chemical department are:

1. pH meter
2. Dissolution test apparatus
3. Disintegration test apparatus
4. Friabilator
5. Phase separator apparatus
6. TLC apparatus
7. HPLC apparatus
8. Karl Fischer apparatus
9. Automated Karl Fischer apparatus
10. I.R. Spectroscope
11. Spectrophotometer
12. Centrifuge
13. Viscometer
14. Digital balance with printer.

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 Different types of tests done in chemical department are:

1. Dissolution test
2. Disintegration test
3. Hardness test
4. Weight variation test
5. HPLC
6. TLC
7. Titration
8. Friability
9. Absorbance test
10. Solubility test

MICROBIOLOGY LABORATORY:

Instruments which are used in this laboratory are:-

1. Colorimeter.
2. Double door autoclave
3. Water bath
4. Microscope
5. Incubator

Following experiments are performed in this laboratory:

1. Antibiotic assay
2. Vitamin assay
3. Amino assay
4. Microbial limit test
5. Sterility test
6. Spore test

PHARMACOLOGICAL LABORATORY:

In this laboratory the drugs are tested on animals. The tests are:

1. Pyrogen test
2. Toxicity test
3. Eye irritation test
4. Skin irritation test

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20
 Mr. Arijit Dutta (In charge capsule)
 Mr. Saradindu Mondal (Supervisor capsule)
 Mr. Subhankar Biswas (In-charge liquid)
 Mr. Amarnath Roy (In-charge I-tone)
 (In-charge Q.C.)
 Mrs. Sikha Roy (Librarian)

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