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28 Jul.y 1955

SUBJEC'r: ADDENDUM TO S~PROJECTS 8 M.d -10

. .·.
-,;:;...•.

1. The purpose of this addendum is to set- forth the mutual

o.drn.!nistra.tive responsibilities of-the contractor e.r.d. sponsor.·---~
I
_ rl The above- subprojects -represent the resea.rch program-------
2.
v -or ....Jil:lllt~~~ated~t the V"'Z7Mf.lW$1_1......, .8
Boston, H.as-sa.chusetts 1 coverJ.ng-:t_he::-~r~of _9 June 1953 through --
.l5 Sep'Wmber 1955 • ___ ----

3· The
Hospital to
reques . • • --
·accounting of monies received.
·--~-.8 •
from the Fund. Also~-- they req,uested- the return of _e.ny J.mexpendecl._
funds received ~under a sra.nt~J):_o_m_ the_FUil_d~-~~==~- ---.
.
4. 'l'itle to-any ;pei-ma.nent eQ:I.l.i.pment purchased by tund..e -----~-­
granted the Hospital s·nall-be retained by theHospital in-lieu of - ·
hig.}}el' overhead :t'ates. _ - - -- - -- -- - -

6. It was_a.greed._tha.t te~lmi._c~.l_:_':t"_epQL"tS .!'~~:,.ecting _the__ ~-----~-=~--=---

progress o~ the research prg~am shall be submitted at mutually ____ ___ _
e.oceptabl.e in~rvals. ,.,.,.,._--- - - - - -----~/r~,

,-/t' ~Dl!EY OOI'I'LIEB - -- -

! Chief
~- · TSS/Chemical Division
· APPROVED:----~-----

·Distribution:
Orig. & 2 - 1r."SS/CD
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CERTIFICATE -
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Tbis 1_a_~9 certify that I have today received
Cat~hier's check-No~ Ml38328-of the . . . . . JUillT?nt
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Payment due !or grant to

• ••••••••• $26,333.33
••••..•••. ~526.67
Service charge ot 2% !or •••••••_,_••_$26, sJ.;O. co
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August .31, 1953 •

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 FRO!ot: Budg~t Office) TSS ...
. . SUBJECT: 'I'w checks.

I hereby ae~nodedge receipt of the following: .

Cbsci< I K1.33786 in the omouni of $263.33 and check I Ml.)J78$ in the
amount ot m.),l.66.67 as ~ent::!or_~!Oiee I} 11 Subpt"Oj~ot 8
Proje~t HKtJLTM. -- . ....
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Please return_~_aignod topy(ies) of this receipt

To-~~-~---
FORM NO. li·U
MAR 1949

MEMORANDUM RE:CE 1er ~===

TO: :(!;, .. 28 August 195.3 -•·
OAT£

SUBJECT: Two checks ,

.·• '

I hereby acknc.\Vledge-receipt -or the following·

Check II Z.UJJ786 in- the-~ - · · ·
amount or $13,166,67- as a:~t_ ~tt$ 263 ·}3 and check II Ml.JJ785 in the
Proje£t MK'tJLTRA, ·_ ·· 1ll•~n. · or invoice # 1, Subproject 8

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Please rtt11rn ~~~ 1 1g:o,..:t eopy(lea) of thlt reulpt

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 ,_. .August. 1S 1 1953
-
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Paym..;nt D'iA. :or grant.to~~········~l3!._166~67

Service Chare,e or 2% ••• ·-·-·--'~-~--~ ~ _~:!.~-~-'-~-'-.___ • ••••••••• , •• ,. . . . . . . . . . . . . . . • ~263.-33
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1J MEMORANDUM FOR TRE RECORD

·•
SUBJECT:

1. Subproject 8 is being-set up as a means the--

present work in the general field-of L.S.D. at • •l
- u n t i l l~ Sept~mber 1954.
2. This project will-include e.ccontinuatie;>n or" a atudy of the
biochemical, neurophysiologicalj~s(£iological) -- ~d clinical psychiatric
·aspects of t.s.D;; o.nd::JJ..J.::sq_:::a.-]ltudy-of _!,._~._!). antagonists and· drugs ..
related to t.s.D., such as L.A.E.-- A detailed proposal is attached-.':--~--- -- ---
--The iple investigator~ vnl::.-co~{in~"f t~~ /3 •

---/3
,. ~ :

111111• vi l l se l"Ve as a j.3

sh the above_funds
~- grant for - - i3 :-:- - j

of the_estimated- -
for this servic-e.- /3·. . -
.~·

4. Thus the total-cbe.rges-forcthis project vill uot:exceed ·

. $40,290.00 for a P'~r~9dc~ndi1lg se:Pt~llllJ~~ H·Lt25~·--------- ---------- ·-_---,
5. · (Director of the
hospital) are cleared through TOP and are-a\!a.re of the true
purpose of the project.~~_---~~.- -~-- -0-~z::?/2.. '/1 ~A
.- . ~~~
l;s
l'v~
ratifl-
C~emiea.l Div1s1on/TSS

APPROVED:-
 :-,:
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APPROVED FOR OBLIGATION

PROORAl..f APPROVED
OF FUNDS:
AN.D RECOt-~NDED:

A- .
A'
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.
..·.
-~···.

Date:

Attachment:
Proposal
Original Only. .

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 (1. . ·.
ri:···rcs 1o·oa co~·!'l'I~;UATio~• oF RE~.s.. PROJECt III
t:'i· r... s.n. • d•L'lSi:'.tliliC ACID Dihl'H'lLAHIDE 'i.'JUlTP.ATE.
J ~includo Stud7 otn::.s.D. Antagonists and
Related Dr'tl!~s such as L.A.E. • Lys~reic Acid
Eth,:rlumide,-~-- ---- - ----- ----

Too pro€>'Peetuo tor next, yeal"_ i~ in general~_ continuation or :the--

'
L.~.D. -pro.,ect aloog sWlar lines t<l that Qt this ~ear •. Ea~b aspo.c_t. or th~

··· - - -project (l>io~he'..rlcal., nfi'IU'Ophysiological, sociological, clinical psy~hiatric)

-to bf' continued.

The princip,tl nrJdit.ion-1t1 tn3 bl'O_{l<j e.rus_o_f ~~~d,y is that or a I
. ...
E.._aycholoyical section t4_}!it;h__consists ot. Y_()r'tC_ ~ot ou~lin~ in~bst yoar ts __ -·- ...
..._, "::J

.,..... .
prot-ocol cat ~hieh. nevertheleas ~iff-been-going on ()uring t-ha y~a.~ and~-

hao brought forth substan~ial !indin~s sufficient to poin~ out, the neccesity
bohll of its contirr..tation ll."td ext>Msio.n• -
~~~==~====~=======

E=.ch scietltiflc aspect_of_t."l~-P~rojoct haa le-i -to the developtt\ent

o! procedtu'C~ ~nd ~thod.o. which are no~-1 ol flrom_ use!ulr.eos in the study
...
of lyaergic and other e:!.illar _dr\lg_x-~action~~--I.~-isthe-rurt.her...:.!ipplic:ation..::.:cc_--~-...__~_ -=~

o£ the ~;:ct't.-ods vhich have be~n--dlilvelopcd_d~:r.~g thO ~st year. ot oxperi.lllentnU011

tha·(, will bG ona ot the ·p:oineipal fo~es ot n~~y~ar 1 s-work • -- - -- : --

such as L.A.S. and 1m'/ otlwr drugs~1-.iehl?'Ake t.~eir ~ppea.rance,. and to tha ______ _
st'ldf o£ oth"-r drug~ in conjur.eUon tJith L-;s.D. with the goa1 of asoert...,i.ning

cntagonistic·~rt~ct.s.

rio would al8o like to exp~.nd the baso o! the experiment by rsppl.:fi.ng

ttese methods t~ the stud.y_o! patimt.~ b'itll_@.c_t,.ojlnl. psycliof1eS not

nttrl~utabla to dru~ r~~etiona. Thio~-~ill not onlT teAt ~10 4pplicability

of the znethod(J O~l 8. broad~r basis but will dt"..Uonstra to lliOre pr~cisely tha

--. --decree to "t;h.ich tr.e fi.>1~.i:')~~~ of tho studies or the lysergic p9yehosis can

.. . .;.-
 .

'!'he past.
- ,I
reor•s reeuroh hss dealt to a
determln.i.ne the s:,•~,ptoio prodv.e~d by~differen.t do'a~e~ o! L.s.n•. and the
'
ere~t <>~tGnt with
- . -
-~

degr-ea to which U:.eeo ~tO!its CM be de~rr.dned by tho ooeial. situation in

which too cubjeet finds 1-..Luel£ and by-tM banic Pe.l'Gon~tty and aoeb.l
.-..
~

attribu.tcs or tho :;ub.jec~ h.i:".nelf. _¥or tho study of' th$ use of other drugs-
-.
- --necessar.r to develop moN precise measuront>lnts or t.s.D. etf'~o.t--t.ll.an-allY'--:---:---:-~-c.._

uhlch wo h~vo ll;;ld 1-.eroto!ore. This const.it.utas- an esocntially n~" fJ.~l4 og' 1
.....,.
imost1~at.io.:1, r-.M.cl.Y ~that_o:i.'_Q.eV"f)l_oPJ,.ng~_c;u.w.t.i~t~vo roeaw.re:teflts- ot
..
lysug:1o effect.
-~·

-- Front our baekground_o.f__e_li.._!rl.cal ~..nd social obeervatiotu"Lof_i.l'ttL ___

...... ------- :~,
c_

lysergic psychosis \lhich bsvo been carx'i~d (\n throughout tho pa.st year,· rore

p-rooise and objecti~e inst~e_n_ts oflieam~~m~nt Will bo dovolopad along the.

stmsitivity to sp~citic phj'sj.col otimuli su.ch ~s nash:!ng_lizht;

J.?S"YCholoi.d~ ne.asur~zwn~ ()f fArsistenee, no~~~~~-l~n _l.ll~, distractibilityl

r~or1 1 t""....allt;v pe~cept1oni--ric'l"-.neaa or a:~:5ociat.:!.onsJ ~o~j.ol~1-cal nfid soc~a.!

t,.~chol~~~··tJ. .rn~~s-Ursmen,...~J\teh 3S _G\lalit.1~an~_quaritity_~f verbal production

· in diffe::~nt struct.ured social &it.u.at.ions ouch as prcblcm sol\'i:tlcr group

, ~ . .
discussion nnd occupatiorcl taa~ s!.tuationsj P.~~chi3t.ric ·ctetorninntions_o£
r:~ntal otatus (which is esoentially 4 continuation or the pre&ent. JM:thod of

clin1C8l evaluation).

Part I. Etc-che<7lical Stud~--- _

'fhesa studies w~re c1.1rl'iod out at tho 8

-j} '&t I fJM81M-. _Diroctor1
M

~elve vol\L"lt.ears vera chosen. On the control dq, merezy.tho urinQa

I
were c?llected at pre-dotermir.ed int;;l"'Vllls, ~nd at 3.00 o'clock in tho ai'~rnoon,
an injection ot ACTH, 25 ltg· I \>tlS given to teat the l'E!Spondvit.y of tho
---- -- - --_ adrenal conex.•

.cJ'he urlne vas oxami,ned as to ·.vollllUOj raw per lllinu.teJ a.nd, chomic.ally,
•e to tha c-ontec.t o! Creatinine (det.cl'!llined in r.rar:ts per 2u hours) J 17-Ketost.eroids •

(deter'mlW<l by :.nilliv:-am p~J".._hour)J So<U\.Qlt (dtJtemined by:ldUigl"al:l~per-~ur); _

t-ota.isiu.-11 (dot~J.Md byll\illi~~ per- ~our); Uric Acid (de"w..ined b:r m..Uligra.'!l
}:1."1" Jlli.--1ut~) J fhosphat'3~ (detct'ni.ned b7 n.Ulit;.--ram per .lllLI'\u:te).

On the experl:mmtt.U day,-=-_!ha~~_o}_\i!l~~~-reeeivcd t.s.D. early- in.

tho mornL"lft at· a def1trlt~_.hQ_Q_r.- The u_li.ne again was co~ccted at exactly tba
G.?J<ta titoo intawals as on- tM- c:ont.rol oay. ·

----- --~--

Fro~ the data_o:r__t~_(ilic.mical-dotel.":ltin:ltions

--- -----~--------
c~llect~d, f!Q.. ~~tir.ite
___ _[--------

conclusions OG.n b.? draw-at the pres~nt. time. Soma or ~e roault.s 'W\~re not-

Cl}nsistent. 'l'"acN &eems to have been some technical d1.:£':fieu.lties, sucn as--~ ~
----~·

errors possibly ll'Ada by the ~bjecta themselve1 wit.~ rer~nrd to tho ~.l!ct ti:":Ie,

,
sotte errors in cheJ:'"•.fcal deuminationa. Hol."''V~?r 1 frOi!l tho overall picture of

lend taaoclves-to eruuat.ion, UIG imprassion WS.l) gained by_:::_::_____:c_.:.:_ __ --::-

. • • e... -- -·c~ - •

as well es .b.i that L.s.D. ~e.~ to causa

o.n. inhibitory crtect upon tho adreno.l cort~x. _ !~ i~~!lt tha.~ it is or ut1~oat
' .

-- .
tho t.eeh•"11qua are conteillplatod in ordo.r-to es~.;J.blish c:bta \'lhich will allow a
-··
 f-/J
.i
-I
I

· .A number ot antidote ~erJJq,ents ,.~ero ct-.rrlod out end more are

...
cOntemplGted tor the tuturo.
In the ooursQ ot these-experiroen~s, the i~rtaaionwas gain;d that ~·

_·:the :nolecular .rt.ru<rbure ot th& egent ~sed had a d0.finita rela.t1onellipvith

•
re~~ t.o tho effect. or L.s.D. In ~a iA~t.nnces, too ert4fct-:or t.s.D. aeel'led

to h:lve been enr.anced, as fol" in:lta.'1ce tho expel'1Jil\lnt.a: vith ergotA'dne, while

definite Deutraliz~ et!ects wit.'\· other agents were ~t. 7et ~ot.ablished. =~I

A ~l'' drug,-t.A .. ~. ,- bee.ame &.vaihble for us .and 'WEtprop~&e__t.Q__ _

•
inveet.igste, it .more thoroughly in the cor.l.1.nr:._1_ea.r, _This dl'ug-:waa_dcveloj:'Ed·

. .
Etr~14s. This clioocal io clO,~l7 relAted. to J.,.s.o.. the. difterenee Wr.g

~~~lily. U'.a.t one e~yl group,~ C~}!s has 'bt-1):. Sl.1bstit-ut-Od b7 bydrogc'' (21) atom.
From th"e.prelUd.f;..u<Y reMrt. ot the ---~- ·.,? ·•
we. ·ba..>·'n3d the rollol/L"lg·( ~ .L29 L-qle-ri:u6nto wot-e carried
,~ .
®t.~on 28 riOi'iJI.al per-'ons ·$P4_ aoma poycf::\)tics.
- - · - - - _- -
~TOO-:o.r'Ug.l-ias
.-
----------
giveri.-in.-.doses
.-.-------::----.;:- --

.....
ir.dividu.ala cnq::-erieneod
,. a achizophrcrd.a•li..~o condition l:hiclt. u.1s characterized

by ~a;,·n2.my, inGifterenco, i.":lpai.N<\ volitionj r.rid phen0I11ena

. ---
o£ depersonalization.
~ schizop!U"~tli r..AE colm~crn-cted -p&rat1oi4 b:lll'Jci[!JltorJ

. excitation. That is to- a.s.y, t.'\e echizophren.ics did not. loso thqiJ' pera.n¢id
delusions ~r hall.ueir~tiona, but b~!Wte ir.diffO.rant. to til~uJ a pheno!7lt-non
tihich appear'!~ U> tho invost!gat6r as a~.ll\Uar to tho l)f.tect of' prefrontal
lobo~o~, end therc!oro1 h~ ~on31cler~ tha ottcet or LAE as that o£ a
.. •--
,
 .....,.;. ~--,. ~ .

Oa the pasis of their ob~ervnt.ions., the invoatig~tors coosid~ro4 _

L\E as a n~~ ki.fl.d or '1 ~ed.lt1vo 11 J o. ;edativa which in ita of!ect 13 neither - ...
·.·41w.

rela~d to the @"Oup o£ hypnot.ica E>.nd J'.Sr~ot.ica ot t-he l;lax-'QituriC 0~ __ _

morphl.na typ-e, nor ~o tho eroup ot tho sympa.th!co• or p.lra~thicolytic

chemicals. .- '
•
Tho tbcor~tical problera prasent.~ _it.selt to_ the· ~\lsstion e3 to hov _ :__ ___ _
it i.s possible that s cb~micalwhl.ch, _in_n~nru_ ~-opl~_})d-ngs a.Cout o.
-- disint..e~tion into a scbi!opbrantc-H.ke con.UtionJ is, on. tM othGr hand, -
capable of tu.nitl6 dQ~1n or r.autralizing too _e.."<:Cii~!ion of a. sebieophronic_ _
ps7chot.ic.
- '
Q4,.ber proble'-m:s prese·nt tllc!'llselves., the rco~t. inlpo;rtant_of vnich uil~ •

be tM i.'1ter~tion or LAE and L.s.o.- u-is JjOsaiblo t<,- thin.tc tMt LAE_ night __

flr.:siolodcal_Stnd!!!s
.., . 'a ....;....,._..,.- • A - -- .....,...,.-_:_ __-- --

(C2a:ibil".OO Physio-pG"Jcho.. &l>ciologlcal otudios) · _

- ' ; ~
"'
.. Tho p.'lysiolozicaJ.·Changt>.s durir.g b. lyacrgic psychosilLWly_:_be_~--~---~.-.·.-----

6xplo.red by. use o_f t.b.G polygra.p}l_.__ Tltia awa_ratu-s ~ab-it possible ·to stud;r
·- . . . . •.
ltiNJ:i" p~aiolo.r,ical ~~r~t.ers~simulianeoualy•=-In addition a tape reeord.ing
o! tho verbal inhr-:h~n~e 'between tho~ly3~r~;:i.:ed eubject .Ql'lf} the ~xa"'1iner
~ ' -

is eynchroni~ed liit:'l t:.e physiolog:Lcat=-r¢cord•~ Soci<i"'l~tric clessi.!'ieation.

ot int~c:Uons (Dol~! int.0rt\ction.-mGthod) is carried out 4lso by an ob613rver
and recor-Jed. on the po:t:rgraph record. -

Thus tho r:-olygraplr proccduro-can be u~od to obt.:U.n in.fon.'ll~tion et. the

(a) phyeiological 1 {b) ps-;ohologic~ and (o) noeiolosical level .. nll :runnelo-d

into ono record.

batl:een th•J l'e!lt.inr, physiologicu values pre-!ltfrtll. -cmd durin:; lyacrgtc

~ ¥

ps;yc~tcisl_:;. (a) ti!.ter~nce between at.nss p!w~:~tologie.U valuaa pre and du:rine. . ~~
~;;:

~·
• Mii'I!N 6 ••m~ ~· · · ~--~··a=•b.
 '

-~·
. -6· t, . . ,.
~*
;
-
i:'.
,,,..
Tvo classes ot otrcs3 are ueod (a) £ssentially p~Jsieal (ie~ appli~ation ~~d .... .,..·.
J
_rlie1(ering li~~ht,) and (b) psyeholog:lcal &tress (pBYch.btric interview and

sp~cific psycholocie~ tQ~t).

F~rt~~r analyei6 related oocial clGssificati~n of Y~rbaliration

tturin.G -the peyc.rdatric interview 'h'ith physiologic~ facto~ D. Thua it is

possible to determin~ whethar p"t\lsa, tentperaturo, Nspirat.ion, .GSR, muscle ..
··- activity, oto.wn."Y ss a ~nction of-pooit1v"11 oriented 5ocial_~rbaliz<tt1o.:1_, _.·
-- negativol.7 o:'iented vcl"balizc:.tion, o.t' r.<tutral.· This study is don<l both befot:'
and du.rl~ lysergic psnho~is.. -------------.---_-·.,_c ....._______ _

An interaction cl'.l'0003raph is-n<f.l being dovelope4. b;r_Q_\ll."_glo~}_l"!C~

omgineer which vill do Uta tollo-wi.ngr~ (1) Record on polygraph p~pcr vr~n
.,.
eubjcct is tilling arut tmen e~J.ner is talldnJ1. · (2) Aecltitulllte tAG talking~~-

interval~,. (3) G!w crude estir'..ato-or decibel ait.rer..t~th of tD.lki.ng _oi_eithc~

&U.'bject Ot' C2:a..clnel"e Dlirl.ns _!1."ly"SA_r~~psyci·:oSiS it r.aS been noted cliniea.llY•

•
!'>.as alra~ bl3en shown that "t9rl;)!l-pt"Qdttctivity dr~a dur~~.:..t.t:~-'--ly5erg!~---=-=c
- -:

psychosis.

Further psycho-p.'lj...siol9gte~l ~loration \-:hieh va thin:-: ed.£;ht

hold proni~e would b~ to d~ter::!\ine the n.'lture and ~ee:Ne ~r '.Ps~rchologica.l, ··..

:stress induced b;r .fliekerj.ng Jight. in rc~aUon to tho disGo:rg~mizing and

obso....ved thst a l$ ~r l$econ~ loll intcn.:tity flicker \.'ill produce e. feeling ·

ot great tension or irritability in ono aubjset \\her~as-it will 'bo ~.3

A.'id ~ci!ying to anilther. 'l'h.b study is also w l::·e done beroro e.nd during

lfsilrgic paychosi.s.

Ml~n:r~plrl._c, clcct.;.•o:;n:,¢t*:~logra.phic ar:J clt"ctroc~·cliogrcphi.<l traei.lt:::3 ~r~:~rc taken.

· remWPt zmm:km:n Iii... · •
 ".~-------
1.~
'tid
.. ~. .
.. ·1· . )1-/J
Til$ rN;J<br~ ot e:<perilu~nts 1s r.ot yat suttieient to eMble us to
srriva nt cl~finit~ co~clueione. Some of the conternplatod e~erimonts, for
~~lll!nistrative re2soo3, have not yet. been curled out.
'l'h-a autooomlc Ml'l'OU.S sysi.e!~ lUIS tested on B"..l'ojectfl vho had received~

t.s.D. orolly, in the anoWl~ o! one ga.."l~, orte·half gam.'l'la, a,n1 or..e..qu~or ~~

g~a pt;)l." l:Uo,s.a borly wotght. Tne gNate'st-mm"b~r of_fi.Kper:Utent~ wero_ ..,
carri£d ot.l.t on subjects vho h:ld received--=-~~-l'5'_l_y-or.e~ao.rtel' gar~ per
kilogram ~body ...'e'lght.· I

1-:'hen t.s.D. in the Mtount or ono £~llil!'U1 pt.>r kUogr~ body. weight W3.S

given, the injectiOn or Er.~inephrlJ'W, as cgm_par~1 to tho control, sh.owod a

COD.$iderabl~ inhibition. l~'hen oM;o,q~t<r g~ per kilogrf'l body weight of

~ ~ r...s~ D. ~~i given, a nWilbvr of the Bubjects sho~Gd a do!inite in.."rl.bition of

tha a'ltonomo uel"'VVUS syot~ on lnin.ir:ll!l f!-'!lOunts of Epi.nephr_1ns and ~~ac:holyl.
' .
In these insi:.t:Jnce3, Spin~pti~iTlO was ~ven in tho tmQ\lllt or .• e~5 <;c. or c. SOl;.It.icn------~-·

1:1000, nn.1 Hecholyl t;:.us g1v~n in t.ha auount ot 2S ~tg. intrs:nuscilirl.y)wh.ieh-::_--==-=-- -

.
~

.
io one-quarter of t-he ordii'Vl.r'J amount ot 10 lilU11£ra.'lts.---As: we
~
~d anticipat.ed,
. --: . - ---

worki.ng with those mniroal--dg_se3__Q_~ t.s;n., au v~U 83 ot. Epin~phrin~ !ind

~ . ---- ---------------·-- ' .~ \

/ .
At a recent,
.
eon.tor~r.ce, it was deeid(.-d that the !utul•eu;,~erimcnttt
' . ,
should be carried orit \iith-t=;s;D.=-ln tho-~unt of one..;h.~lf' c.run.~ 'por'
·!'~

-.---~-

·~ observ~d.

l~o G)q>oriment:S'i ·ror s&"11rtist.l."a.tivo rMsc.-ns, ha.va y€!t. bcon. carried ·

. I
. .
_ ou.:t; vi~h wgua otimulc.tion ~nd ndrcnol~'tic c.nd Wg\tG•bloc!c1nf1 e;:ento,

··'
·~~t~
 _----~ ---_. --· Y-73

by ll!ethod!l ho r..1s fad3pted to lo~er vnrtobroto.a. Briefly, he will. &>et up

fj at. - -(~ ~oll<>.bor~ tine wi~ '1l1JiltW$1lllrl8_
Jl t1<10 laboratories to study chronically mentauy- ill -
patients•. responso to award conditioriing in terna ot thE~ir ability to
.
_1ievelop decired bii:b..·wior '&nd to contili.u.o 8\lCh be:M.viQr OVfjt" long perioda- ot

beh4v:tor dovalopoo in
'·
t.u.'l\~ll3 j,n. colla.6oration Wi we pls.n e
to teat effect of J.Ysergic &C:ld on thtJ bchp.v±_or CUl""t-:e3e

Part V. Clinical Fsych.tntr:to St'.:.dies _·c------ _ _'_· ___________ _

..
(l) We wUl cont.im;vrM ~n the ~·st ye~.r- to ~o a clinie3l psychiatric
evalt:.at.ion a.t tho hel~ht o_r-the rcact.io_..rt ot_~_ll_ ~ubjects :who rt~ccive-L-.S.D. ~

. .
th.a eva:tu.:1tion of antagon1stio-eff'ects.-----

doao ot or.s and halt dose of th-9 other.

This ideal- 31t.u_ation 1~, l1owver, ll•'llitcd by t-he 4t•sire ot t-he
GU'oJ.eot to have the O":POri.'-n&nt rap~ted on hi1~sel! D.r.d M--St. e~rienee woul~

indioa.t~ t~J3.t very few robjeot:s voul.d suhd.t to r.er-o than two or t..l-troe tosta

during. the e}ll.!';;~e o"i• G. :fll~r. fa.s n X"etiult the co."t.bi~-ations of cl:~ and L.S.D,

will b"J decided in e~.ch. in:it:Ine.., \tlt.i. reference to tho avai.U<b1l1t7 of tho
cru.bject iir.d .. ~-ho
- - ;., . m.~Ui.ll u~ilizat,~c,m·
. .
ot each :i.nd!vichwl ·$r.p~ril~~at.. ...
'_1
 (3) Ue arp particuhrly intereawd in the psychiatric ttffocte ot ....· :-

ch.el:dcal variants oi lyu~rglc acid o1' which t.A.G. iG presently. availQble, ~~

Thera is also int.erGst tn ~om.blr.atlons ot~theset-eb~~--~~to w"ith otheru · .· t~~;·
d.I-ugs~ the goal; ?S in (2) ~eins doi'ixt~· u-Jbstanoea having antagonistic of.fccta. ·.

.. . (4) i':o have eh.'!la interest i."l tM a~inist.ration ot t.D.D. alono ,or

in QOm.bi.tll\tioa with <trugs al!d.~t.QeJ- -~iants of t•s. D. molec~e to patients · :;..

Vi th vui~us ps;yc.'Ut!tric rflldrorr.es. Tlle=eoa.J. ill this as~et of the wor!-c

~~;·t·:·;:
I
t-rhich russ •dds re:adi'ieations 1~ there.peutic- psychiatric e.!f'eoh. The .
~ i:~~:-:·~==

o'bservaticna h~re as. in tho 40J:.Qcts ~~ ~& in toms ot \"ru"it\t1<ms in the

cliniea.l psychi~tric pictu:.re.
·--~---·-

inc.;.•e.aoo in "ppetite in tOr..l!S ot 4 plus sign. ··

. Inwgrntio~ of_ cliniw pS'Jchiatric i'indings ~nd
.ot fin!ir.gs of
. . ,:· ' .,
altered ::.,clAl beha'ri.or. \rill= be i'u.rther ~devGlep;Jd~Only as tho change in th~

lysQrgbro o\lbjeet 'o abUity to f®ctio];::_ln _wt-ie:d social ·suuat1e>na is

. r~lete<.i t.o th-o <:hnnaes in hi$ t&~ntd st:atua em t.l-10 ~aicdyr~li1ics or

psycho~ss bs eseert~..ined. ao--!ar the-abnon,..alit.ie~ clotero.ldned by clinicru.

ps~--ch!atric evduotion and tn!'~e fot~l in hour-to•hour social obser-vation

l'..e.ve t.o to~:.e. ext.~nt been vi\lve.d indepe~~tl'l~_l.t__&.nd o..'C_t~naive intoe;.rativa

enslyaia i:s rcquit"ed to co;r:bin~ tl;o~s £,;r.di.l'l;?;tl•

·~
 .Q - .... v rc:;::;a $ .,

~~{~!::~·~;~
i~.~.~~.t';'
..'£11

- ---
rsycholoe;ie~ ra'!~e'!

Tho dra.J·e.•person teat (n.A. p.,} C~hould be eon.t.irr.;.cd ao a regular

- pa.:rt of the ps-.rcbolo€ieal program oinca it- notl Llppearo to bo " particularly
'I (·~,:.•.·

~.::~·
~-~·--
~~}~
.fr\.litful ef>pro.ach in -giving le.'ldll about the subject 1 :s self <lvnc~pt and his
$"tt1t.udes toflard· oth~rs
.
in an indireet but. mea.""l.ing!\11 "Wa¥•
.
adrieable to add to t.':lo moro <t"re.Ving tcch.~Gue a $~t ot routine questions .o~--
It might bo .-i~ ::~~~;

. ....· .
~-;z
J:f.;
~

ask the subje(lt to aseo.o14te fMfJly' to the f1guro he h~-~ draun. Th18 woul~ gi~'"~·___
SOl;le 1d.e:1 of richness ot ost~ooiation L'l re~~.rd to ~oplo at'td in re~ to his 1 . ::,, .
,:)';~·.f

~. ;:;. ~ ::
own creati.ons. ~:
~.)-·
,.~

'l'lte T.A. T. s.'lould be <lontinued r..nd poseioly enlarged to induda ten ···-
ca.--d~. !nt.t;.nsive nnalysb or one e~sa ha.!l-shotm th8t thore hu been a deel"Case :.•

in the nu:ID.er or worda used when g!~_;l__S.~r".{ \l.fl\ier t•S•P· in eontr:tstJ9 __ _

· tha nuaber o! ~l:'lrd~J used in th'! norm.!ll- st..at~; tho uubj oct .!Jl~o _spent_ lfl~_s -time

on each picture. Th.a .riclmess of asGociatton covld be in'g'ostigated more

... " l!!t:4 • - - - • -- -- ~---

thoroughly \16ing t.,_is proj~ctin donee by-not only eounting the woru bu.t _
- :_t -;_ -- "- --~ ~"::

l!Wkif!..g on aoo11sh ot_t_ba ~eJ.~to~t~orda (nouna end verbs) .ruld deeer1pt.1ve

- -

phraaes (a~ccUves and a.dverba) in

.. the t'W'o et<1tes and the h!-TrOth~d:~ could
f.
- -------
i:'
•
ber-o
.-..,.._
~
.t-1) £o..-mulated that ~or the-l,'serG!~ed
. / - -
sUite
-
the.~~'~.A,l.>ject
;
would ba l;3ss

c..re.aUvely r-rod:uctive an<f_ gi-'N_J.oss rioiMess in h13 -~torieJ.

.
It is suegested that sinco only th.r'Se ot tbe ten
.
'l1orschMh c~ds

a.-.oa beine gi ve.'l. t.nd since the Rorf'eM.ch is apparcn~l;r b\ling u~ed. in full by

e.no"l!'ler group, t.hat wo diseont.inu'l th•' ·paitial_Ro_l'sel-)ll~h and l.'O~ with other · . --~
i
t~-pes or tE::sts. It,. ia su~cesto-.1 t!Ult. in placo ot tho Ro1•seho.ch we usa tho
VisotStV• The t~st has, in th'l 1i t~rnture, a re.porl of tho f>(lrfon~anco o£ I
~Chitophrerrt.cs •

ad"".til~strat:i.on

· ot the: !dent.!on
'lhl.a is OS&.o.Dt.inlly

or lt. ths cxamL'ler can

an~ tlle hypot~"t!'d2il'1~~

D. te~t

t~a~ily
ot nb$tr~etion l'itrJ

insist on
that h goir.g on while
~r demar.d
in the

wxb~l.

t17ine to do the
reports i
...
·. •U•

This pal!tieular teat n.:cms to be on& which is a challe• to

~
-·
-------------

thos-& peopla or oupe:-ri.or intclligoneo and :ls one which aluo createo-a -somewhAt ..
-natural stresa s1tu!.lt1on. Be®usa of the ..fonr.llation .and reject.io-.1 ot

_ ~oth.esu Which io involved i.J\· the situaticn or this test. tr..o ottbject.ta
!~i_l4tz: to cot:eE'ntr'~te M.d. function in a str$ss sit.u!l.tion can be ob~ervcd•

Hie ohiUty to eh.i:rt hiu t.hirking and hie ability to respon-i to the ox.t'..:d\:l$1"

'-1lO can incr:ease or decrease the st1·oss situation b:t behavicr_and_cow~nts ______ _
. I
e..m alSo be observed. It seeM as thout;\ this teat may prorl.da ~ g4·eat~ toealtl:l__

of [l"..ahnal which should. allow to~ corrslation With beha\"iornl obut'vstions-:-~ ~--~~:-:.=

made in o·l:.her th.-~"1 .the -ust.ir.g o1 tunt.ion•--. --:-- - ----

_It. will fbo the e~"'liMr'zrrGspor..sibility_ on tUs ts,t to suec~ssf'ully

longer tol~:O!t t.e th:e fl-ue t.rs.tion _f:XP~l'ionce i.!l_i_tsel:i'. __S_ince this ia a ztoto~ • ~-

f'(\rcentuel..
distort1on3 could fll3o 'be as.'{od about ~ttcr the t\'St ia QOll!pleted. -cIt. woUld -
be ·U!portant. to a me at the end or thlif test if the~ subject could rev1sw h1s
mental pl'OCCf:Se3 on tl\is ta~ Which is irttal'lgible_S_Ild wh~N it is OOVious·ttult.

there is a solution e.nd an ans-.,or.- f.:bQth~r he bl~r..l':es

-
the e-;CE.tr:.in!lr-ror his
. . . . . oo:o.l!!4>- - · -~-..---------

dif!icu.lty, bl.e:i~~•._h_!-3_Se_}._£,_sh.2VEUdthdruVsluOf'~ hostilit.V' Ut, rtt>ponse te>

.
m- u

otross r..nd so oo co~·i bc-oatu~u-d or-evalu.SXo-..rr.:.ore directly.

It is su.ggc3tedcthnt t.he p:Nverbs oo-::discontinued in tid~ nf:W

c;;:porlreent. This is ·~seentiallybQe&us.,_o.t~_th6_nppa.t'(mt in~bility of tho

be dealt tilth in th~ Vigo·t~k1 both in n yerbal and non verbal level, it uotrld
. "
. ·~
. ?-73

&yond tJlO drawing of thl:J tes~ it r~tight be pooaiblc aleo to uso

it for ricbneaa or asuociat.ion in U1at tho subject. wo~ld bo e.s!<od to tell a.s
man;r t..ldngo as each d~sicn z:.o.de them thin.!C or, or one pould see how l'..a!lY t:ords

vas suggestod tc the subject. by the givon design 1n one r.dnuts ot time. .
..
.

. There vill be_a pro~leili_C~~ially l-lit.h .~~ Vlgot,sq about .eivin.~

the test to t'he person in the no mal state before he has h.~(\ L.S. D. eineo

oncg this teet h~HI b~n so1v~.d_:_1t_1s_r.Q_lo~ng~r_ a-ch.~:lller.:;e to any- individUal.

It. ia DUEgested that i'or t.l'o.is ~st-thG-·su.bjects Ul 'ba given .it !irut whilo __J
Wlder L.a.n. and the..'\ nav~rt.'tflr>l ta.tco it a second tuo..e in their r,.or:nalet.ate
at which tina intensive-LnvesUgation be made ot their raoUngs, attit~das,

reactions, etc. ...

.•

D.tring tha put roar·th& ~t~aplny ~3t:e~ori~s ~ve been: applied

pri.m.:lrily at a time wb.en-distortions occur within tl!o.liidt or social .

ritul-\tions !!tat. or sought. out by t."le subjoot. FUrther exten~ion-or t.ne_applic~­

tion ol this rn~:thod are. to ineludo ·&yrnp~<t c~ngo~ · ot ~. subject. a a tel~ ted

to in~~rGOnal rela.Uon.ships and v.id~r-variety or-social situations~-

\
SOt..~ of tb.a si t.u..'ltioM- in wnicn fUrther study i3. indicated c~re 1

1. Oroup problem•solrln,g-oituationa. Lys~rgie su'bj~cw are

~Eked to wotk on proble-ms or social. an;i Gt.hics.l nature,

instrtunent.a as Bales In~raetion P.roccos Ana.lyois s.nd

the ·rntera'ct.1on Chrono;z;r~ph, in e.dditiol\ to t.'1c nine

·2. Subjects put. to bed and giv~n supportive nw-si."lg Md

..

In conjuttction with thcso stu~ies vo \~ish to npply tho interple.y

catci:;orie:s in a comp~rativo exploration of therapeut.ic techniques Yi~b

lyserr).zcd s®jects, ~nd nonal psyo~ll>tics. J'udgir.g or the ll'.any extant

ineorclud~e and. oi'ten_contr_g.dietory_]'~port_! ~n_ p_sychothcrapentic techniques,
---- - Qt\ ift\.ei\sive stud7_~1,'j.}lec pt!;(Chother~l!>CUtie sitU..:'\tion, \dt.h the aid Of the

interplay catcg:lriea, is needed,-- Little·±~ knmrn, tor example., o:t"_llowr

~uately or 1-<QW cl.oa~ly t.'·u~rapists' solf~~ct-ation. about their roles ~a __
-. - - .· . I
therapists are ~et in :!n ectual-=-tnerapeuti<f intorvi~.l. Moreov~r.f _with_thia _

erm ba eJ>:plored .. _

..
cnst.ing at th~ t.1.rae \>lhen diat-ort1ono oc;clrr in psschotics and L~s.n.-subje<:js•-::-::--

Suth a atudy is eA.·ptH::Wd to-l~utd t.() a tl!"\r':el'U~~~~~\1 _l!-¢qro~.nd1.ne ot •the mean.iitg"'

of these distortiona to tl\Ja PaJ.ient. nnd_}bair intportance-1n psychiat~ic-------~---

. . . ..;. .
,
. ), CoclinU£\"tion MdJ;xt<:l!don-of }ktnods cr rcrMmllt.7
- - - - . 5
Evd!H~.t..ion
:1!--.. ---
'i -.....-

tho re1~tcdr~.~3-~-pro£!12,--(S~(J_Q-~~rt,erl;{n1!_epo:;ot. #2) .fOCl.!SeG on the -

dot'l.iY...nt kind or relateir.sos, tm- lot-eroi' i1arti¢1pn.tiou nnd the d~r.Ns o!

'Tho cllnic?.l social

••• - A
sunn.-~rv
,.....,.,.. - - . . •

scores tho (1"!'-ality__ o!_t.ho__in~U.vir~ual 'a {;en~~~l.:!~~~~dl'lesa pattern in ter.ns

of "zpont.aneit:r vs •. control" anJ so fo1."th (Quarterly Report fi2) • A :rt·port
or t.'l)e u~g of the profile t'\r.d clint~ ~.>r:nl.y~>is w~ll
. .
aFl!ein' in tbo thir-J
 ..
·:--
_SQJ -

. -lh-
.·
eaaentially a eo~nrison
between th~ basio ~rsonaU.t.y and tho social behavior
I
befoN ani at tlHt height of tho L.S.D. roactioth

. ~part fro~ oxt.end1ng thi3 typo ot.analysis to tq.e tot.nl avail.ablea ~.....
i'~ -
nUlllh<lr or cases, further studies ot this nature nro &~<1 at elucidating mon ~:·
clearly tbe psycho-social cl.t~ratJ.ons ot.-----=-tho L.S.D. subjeo.t•s conduct. on a ··~ ~··
"li

chronological hour--by-hour (and perhapG even minute•bt....-rl.n~.th) bo.Gis. ·It is

expected that this procedure -would giva a rr.ore-1nte."lsivo cyr.areic appraisal ot

the e:~qu.et!.ce o! s:r.npto."'ll. The tindings_j~·r.~_t}l~ application ot these metho~$

wlll bo intc;;grated both with caeb. oth#Jr and ltith clirJ.cal and p~;chological - . =t

4. A Co~rat.iw Stu~.., ot_the fr4{7fs.t1es, Syntsctics and Se-.n,al}.tico in L.S.Di

and GerrJ.ir.-.3 ?.:ij:2ilosi~ _ ·

. ;

This 13 cq_uilly tl"ue With the pcy_~_otics. For

- ------ -~--- -~-..!

C¢~unicate very lit.Ue to a b~oi~_ u~~rot..an-..Un,~ ot the deturiorat.ion ot tnour.ht

snd. emot.iotul proe0ss
.
which is taking placo in the i..'"1Ciividllall- Unless
-- -- -
feelings
------ -
--- . -

ara translated into a vocabulart o!.r:-.ot,iyos vhich is meardngi\ll both to t.te

su"!)ject, e}"::p.al"i.encin.e the to~lin~s C..'"ld to the other tl7iOt1 to undoratru-1<1 tllo
.
....
.·
;
. , . . -

£~elinzs, tha ba;.'rief to CO:""Wunleation cont.i.riu~o to -e.."'dst. and llttlo aid c:;.n

1. AP.al:rt>itl of: ~ra~.at/1.es, th.:'l.t i:-.1, a ctudy or th3 inwntiot"'S 1

attitu.'de~, flr-:t of t.!~9 c.xprcssive ~r'lAvier inrolvcd in

 2.

b.\.JS ol aasociation..)

A."l.al.ysis of ~e. .n~ntics, that is, a study or eontE-'Ut. meaning.--

--~~------·---~-----~------~-----
. - -- I
This t,ype of' eor:.te!\t ar.alyd:r-d~ala.- vi th. _tho "eani.ng ol tl$1gs - -----
..
"-'---~

and ev~M'its M.d people, e~"terMl to the subject, ·that: is, ~h....'lt -

seems most Bigniticent- trJ tho aubjeet aoout these thi."lgu,

wheth~~ ~~01 be prosaic, conventional-or L~girAtive,

s~;mbolic an;..j inte_n>re~:tV<,J.-_---:-~-c----- ~~

~
~;:~
. In this type or a1wlysis, ve-expect t-o b~ guided l.'}"
..
thll e.dMt
--- .
------------ -~::'',
:··..-
1~-
llt.eratil..'""ll on this
..,
suhj~et,-tn p~.rt.icula:r,t-a rilc~nt-al't1cl~ .
on "!.al1frll&ge-
_,..........
--------

-------------·
De~v1or in l~ics" b7 ·g.: Lorenz 1n t.ha-Arc.hJ_yes ·or 1J6uro1.5!.& t\nd Psyc.'"liat!"::r,

Janu-:try, 1953.

- --- ____ --

Studie3 otc t.h.o p~$t ;year resulted in th3 acci.wulation or cnffieient '
--

.. "
the point· of vi~>~ ot its capaeit-.r to- increase -their ability to UJ."Kle-r~~nd r.ml

o.id ~1atient.s. 1:"3ta Ued ~f!§,.l.y~is oi'- this~ in£or.nat1on hao yot to ba made on
-~----------

opplied by personnel in patient care.

 Two erd.Ip e~cri~noos aro ple:o.~d ror-turtter Gtud;Yt
1. Group Sf:53iens \fill be l~eld t..r.\.th pcrsonnal who have had . -
t.'te e~ri~n<;e to d_,tur.Uno the extent ot the knowlodgo
thoy b.~ve gdned in_the_Mnage:tnt3ilLO!'_ps:ychotio patients.
2. There lolill be group meet.ings L-cwhich p~l"sonnel-who have

11

..

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A. Technicol
... 281000.
2,500.
-:?··•.
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Oh~t:ala 1 tru.&s 1 ~~·
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A. :· .....
B~ Recorda t..l1d. Ft.otograpiq
llOO,
C. _Ot!'ic~ Supp11o~ __

600.
---------
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--.....· .
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tho responsible res:esrch.ers ldll cot.tinuo cu:; or

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. presertt year-

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