1.
Haloperidol is classified structurally as a;
benzodiazepine
phenothiazine
butyrophenone
diphenylbutylpiperidine
2. Which local anaesthetic is also given intravenously to treat arrhythmias?
Tetracaine
Mepivacaine
Lignocaine
Bupivacaine
3. Which laxative acts by a detergent-like effect?
Psyllium
Polycarbophil
Phenolphthalein
Docusate sodium
4. Which of the following will increase the half-life of theophylline?
Carbamazepine
Cimetidine
Phenobarbital
Smoking
5. Beta-lactam antibiotics kill bacteria as a result of;
a detergent effect on the bacterial cell membrane
destruction of the bacterial cell nucleus
inhibition of bacterial protein synthesis
inhibition of bacterial cell wall synthesis
6. How much salt is contained in a 0.5% w/v solution
0.5 g in 1 mL
0.5 g in 1 Litre
0.5 g in 100 mL
5g in 100 mL
7. Diphtheria, Tetanus and Pertussis vaccine (DPT) should be stored;
at room temperature
at 2 - 8 C
at -4 C
at -25 C
8. Pyrogens are;
derivatives of pyrogallol
used as preservatives in parenteral solutions
products of the growth of microorganisms
released by the immune system in response to bacterial infection
9. When a patient is prescribed Glyceryl trinitrate (nitroglycerin) tablets they must;
store them in a tightly closed glass bottle
keep a couple of tablets in their pocket or purse for emergency use
swallow them whole with a glass of water
take them regularly e.g. 8 hourly
10. Which of the following metals has no therapeutic use?
Lead
Lithium
Gold
Platinum
The effects observed following systemic administration of levodopa in the treatment of Parkinsonism
have been attributed to its catabolism to dopamine. Carbidopa, can markedly increase the proportion of
levodopa that crosses the blood-brain barrier by:
increasing penetration of levodopa through BBB by complexation with it
decreasing peripheral metabolism of levodopa
decreasing metabolism of levodopa in the CNS
decreasing clearance of levodopa from the CNS
Drugs in suspensions and semi-solid formulations always degrade by
first order kinetics
zero order kinetics
second order kinetics
non-linear kinetics
Tropane alkaloids are NOT present in
Datura stramonium
Erythroxylum coca
Duboisia myoporoides
Lobelia inflata
In nucleophilic aliphatic substitution reactions the ability of the following leaving groups:(P)
Fluoride (Q) Iodide (R) Chloride (S) Bromide follows the order
P>Q>R>S
R>S>Q>P
Q>S>R>P
P>R>S>Q
In sequence rules, the priority of the following atoms attached to chiral carbon is to be decided for
designating its absolute configuration:
(P) Oxygen (Q) Carbon (R) Nitrogen (S) Hydrogen Priority of the atoms is to be decided on
the basis of their:
electronegativity
atomic mass
atomic number
atomic size
In the four major constituents of vitamin B complex, thiamine, riboflavin, pyridoxal and cynocobalamine:
(p) riboflavin contains ribose sugar ; (q) thiamine contains pyridine ring ;(r) pyridoxal contains
pyrimidine ring ; (s) cynacobalamine contains porphyrin ring The given statement is correct:
r is true, s is false, p is true, q is false
r is true, s is true, p is true, q is true
r is false, s is true, p is false, q is false
r is true, s is false, p is false, q is true
7. The thickness of tablets are measured by
Sliding caliper scale
Rotating disc technique
Microscopic Technique
Techincon Auto analyser
8. Hardness of tablet is measure by
pfiser tester
Strong Cobb
Erweka tester
All the above
9. The mesh size of USP disintegrator is
5-6
2.5
28-32
10
10. Aspartame has the main disadvantage as
Carcinogenic
Less sweeter than sucrose
Hygroscopic in nature
Bitter after taste
Which filler can NOT be used for the preparation of tablets for amine containing basic drugs to avoid
discoloration of the tablets?
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Dicalcium Phosphate
Microcrystalline cellulose
Starch
Lactose
The ability of human eye using illuminated area to detect a particle limited to
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0.4 micron
50 micron
10 micron
25 micron
What quantities of 95% v/v and 45% v/v alcohols are to be mixed to make 800ml of 65% v/v alcohol?
Dr. Qurrat Ul Ain Awan corrected the question 01-09-2015
480 mL of 95% and 320 mL of 45% of alcohol
320 mL of 95% and 480 mL of 45% of alcohol
440 mL of 95% and 360 mL of 45% of alcohol
360 mL of 95% and 440 mL of 45% of alcohol
The role of borax in cold creams is
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anti-microbial agent
to provide fine particle to polish skin
in-situ emulsifier
antioxidant
Choose the right combination:
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Quinine, antimalarial, isoquinoline alkaloid
Reserpine, antihypertensive, indole alkaloid
Quantitative microscopy, stomatal number, myrrh
Palmitic acid, salicylic acid, fatty acids
Triterpenoids are active constituents of
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Jaborandi
Rhubarb
Stramonium
Brahmi
Alkaloids are not precipitated by
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Mayer's Reagent
Dragendroff's reagent
Picric acid
Millon's reagent
Anisocytic are present in
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Senna
Digitalis
Belladonna
Coca
Bacopa monnieri plant belongs to the family
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Scrophulariaceae
Leguminosae
Polygalaceae
Rubiaceae
Tropane alkaloids are NOT present in
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Datura stramonium
Erythroxylum coca
Duboisia myoporoides
Lobelia inflata
Guggul lipids are obtained from
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Commiphora molmol
Boswellia serrata
Commiphora wightii
Commiphora abyssinica
An example of N-glycoside is
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Adenosine
Sinigrin
Rhein-8-glucoside
Aloin
One mg of Lycopodium spores used in quatitative microscopy contains an average of
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94,000 spores
92,000 spores
90,000 spores
91,000 spores
Select the correct combination of drugs for the treatment of patients suffering from Hepatitis C
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Interferon with Ribavirin
Interferon with Zidovudine
Interferon with Stavudine
Interferon with Lamivudine
Aliskiren acts by
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Inhibiting the conversion of Angiotensin I to II
Inhibiting the release of Rennin
Inhibiting the binding of Angiotensin II to the receptor
Inhibiting the action of Aldosterone
Digitalis toxicity is enhanced by co-administration of
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Potassium
Quinidine
Diuretics
Antacids
The rate limiting step in cholesterol biosynthesis is one of the following
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LDL-receptor concentration
VLDL secretion
Mevalonic acid formation
Co-enzyme A formation
Which one of the following drugs is withdrawn from the market due to torsade de pointes?
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Chlorpromazine
Astemizole
Haloperidol
Domperidone
Ganciclovir is mainily used for the treatment of infection caused by
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Cytomegalovirus
Candida albicans
Herpes Zoster virus
Hepatits B Virus
Identify the one rational combination which has clinical benifit
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Norfloxacin - Metronidazole
Alprazolam - Paracetamol
Cisapride - Omeprazole
Amoxycillin - Clavulanic acid
Stevens Johnson syndrom is the most common adverse effect associated with one of the following
catagory of drugs
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Sulphonamides
Macrolides
Penicillins
Tetracyclines
Amitryptyline is synthesized from the following starting material :
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Phthalic anhydride
Terephthalic acid
Phthalamic acid
Phthalimide
The common structural feature amongst the three categories of anticonvulsant drugs barbiturates,
succinimides and hydantoins is
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Ureide
Imidazolidinone
Dihydropyrimidine
Tetrahydropyrimidine
Nicotinic action of acetylcholine is blocked by the drug
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Atropine
Carvedilol
Neostigmine
d-tubocurarine
Chemical nomenclature of procaine is
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2-Diethylaminoethyl 4-aminobenzoate
N, N-Diethyl 4-aminobenzoate
4-Aminobenzamidoethyl amine
4-Amino-2-diethylaminoethyl benzoate
Barbiturates with substitution at the following position possess acceptable hypnotic activity :
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1,3-Disubstitution
5,5-Disubstitution
1,5-Disubstitution
3,3-Disubstitution
Selective serotonin reuptake inhibitor is
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Imipramine
Iproniazide
Fluxetin
Naphazoline
Proton pump inhibitors like omiprazole and lansoprazole contain the following ring system:
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Pyrimidine
Benzimidazole
Benzothiazole
Oxindole
A metabolite obtained from Aspargillus terreus that can bind very tightly to HMG CoA reductase enzyme
is ________
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Fluavastatin
Cerivastatin
Lovastatin
Somatostatin
Cyclophosphamide as anticancer agent acts as
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Alkylating agent before metabolism
Alkylating agent after metabolism
Phosphorylating agent after metabolism
DNA intercalating agent
Artemisinin contains the following group in its structure
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An endoperoxide
An exoperoxide
An epoxide
An acid hydrazide
Indicate the HPLC detector that is not sensitive to change in temperature
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PDA detector
Refractive index detector
Electrochemical Detector
Fluorescence detector
One of the following statements is NOT true
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Accuracy expresses the correctness of measurement
Precission represents reproducibility of measurement
High degree of precision implies high degree of accuracy also
High degree of acuracy implies high degree of precession also
In thiazides following substituent is essential for diuretic activity
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Chloro group at possition 6
Methyl group at possition 2
Sulphamoyl group at possition 7
Hydrophobic group at possition 3
Streptomycin can NOT be given orally for treatment of tuberculosis because
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it gets degraded in the GIT
it causes severe diarrhoea
it causes metalic taste in the mouth
it is not absorbed from the GIT
In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelength lower
than
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350 nm
200 nm
300 nm
250 nm
Glass transition temperature is detected through
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X-Ray diffractometry
Solution calorimetry
Differential scanning calorimetry
Thermogravimetric analysis
In Gas-Liquid chromatography, some of the samples need to be derivatized in order to increase their
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volatility
solubility
thermal conductivity
polarizability
Oxidative phosphorelation involves
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Electron transport system
Substrate level phosphorelation
Reaction catalyzed by succinic thiokinase in TCA cycle
None of the above
Coulter counter is used in determination of
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particle surface area
particle size
particle volume
all of the Above
Drugs following one compartment open model pharamacokinetics eliminate
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bi-exponentially
trii-exponentially
non-exponentially
mono-exponentially
The temperature condition for storage of drug products under cold temperature is given as :
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temperature between 8 - 25 Degree Celsius
temperature below 2 Degree Celsius
temperature at 0 Degree Celsius
temperature between 2 - 8 Degree Celsius
Many xenobiotics are oxidized by cytochrom P - 450 in order to
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increase their biological activity
increase their disposition in lipophilic compartments of the body
increase thier aqueous solubility
all of the above
The following protien/polypeptide has a quaternary structure
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α-Chymotrypsin
Hemoglobin
Insulin
Myoglobin
Drugs in suspensions and semi-solid formulations always degrade by
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First order kinetics
Second order kinetics
Zero order kinetics
Non-linear kinetics
In nail polish, following polymer is used as a film-former :
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Nitrocellulose
Polylactic acid
Hydroxypropyl methyl cellulose
Cellulose acetate phthalate
Rabies vaccine (living is prepared by using
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Sheep blood
Meice lymph
Horse plasma
Fertile eggs
A drug (200mg dose) administered in tablet form and as IV injection (50 mg dose) showed AUC of 100
and 200 microgram hr/mL respectively, The absolute availability of the drug through oral administration
is :
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125 %
250 %
12.5 %
1.25 %
Geriatric population should be included in the following phase of clinical trails
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Phase I
Phase II
Phase III
Phase IV
Class 100 area is referred to
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Manufacturing area
Aseptic area
Clean area
Ware area
Many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution?
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750 mL
1000 mL
1250 mL
1500 mL
The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL
instantaneous concentration in plasma shall be
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10 L
100 L
1.0 L
0.10 L
It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having
half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be
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600 mg
300 mg
30 mg
60 mg
Which one of the following is NOT an ex-officio member of Pharmacy Council of India?
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The direactor general of Health services
The direactor of Central Drugs Laboratory
The Drugs Controller General of India
The Director of Pharamacopoeia Laboratory
In which of the following technique the sample is kept bellow triple point?
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Lyophilization
Spray drying
Spray congealing
Centrifugation
The vitamin essential for tissue culture medium is
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Pyridoxine
Thiamine
Nicotinic acid
Inositol
Gingkgo biloba is used for its
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Expectorent acitivity
Lipid Lowering activity
PAF antagonistic acitivity
Antidepressent activity
Sildenafil is used for the treatment of the following disoders:
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Systolic hypertension
Unstable angina
Pulmanary Hypertension
Hypertension due to eclampsia
Cadiac glycosides have the following configuration in the aglycone part of the steroid nucleus :
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5α, 14α
5α, 14β
5β, 14α
5β, 14β
Eugenol is present in
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Fennel
Tulsi
Cardamom
Corriander
whiich one of the following drug is prescribed for the treatment of Philadelphia chromasome positve
patients with Chronic myeloid Leukemia
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Pantostatin
Methotrexate
Imatinib
L-Asparaginase
Which of the following monochlonal antibodies is prescribed for patients with non-Hodgkin's
Lymphoma?
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Infiximab
Abciximab
Gemetuzumab
Rituximab
Identify the drug which is not used in the treatment of Malaria caused by Plasmodium falciparum
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Artemisinin
Primaquine
Quinine
Mefloquine
Which one of the following drugs does NOT act through G-Protien coupled receptors
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Epinephrine
Insulin
Dopamine
TSH
Which one of the following drugs is most effective in preventing transmission of HIV from the mother to
foetus?
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Lamivudine
Zudovudine
Indinavir
Ribavirin
Improvement of memory in Alzheimer's disease is brought about by durgs which increase transmition in
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Cholinergic Receptors
Dopaminergic Receptors
GABAergi Receptors
Adrenergic Receptors
Which one the following is a non-opoid analgesic is a prodrug
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Piroxicam
Celecoxib
Nebumetone
Ketorolac
Which of the following drugs is NOT a typical anti-psychotic agent?
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Chlorpromazine
Haloperidol
Resperidone
Flupentixol
Myasthenia gravis is diagnosed with improved neuromuscular function by using
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Donepezil
Edrophonium
Atropine
Pancuronium
Which one of the following drugs specially inhibits calcineurin in the activated T Lymphocytes?
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Daclizumab
Prednisone
Sirolimus
Tacrolimus
The chimical behaviour of morphine alkaloid is
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Acidic
Basic
neutral
amphoteric
which one of the followingis used as a mood stabilizer for bipolar disorders and also in certain epilieptic
convulsions?
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Phenytoin
Lithium
Sodium valproate
Fluoxetine
An isosteric replacement for carboxylic acid group is
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Pyrrole
isoxazole
phenol
Tetrazole
For glyburide, all of the following metabolic reactions are logical EXCEPT
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O-demethylation
aromatic oxidation
benzylic hydroxylation
amide hydrolysis
The effects observed following systemic administration of levodopa in the treatment of Parkinsonism
have been attributed to its catabolism to dopamine. Cabidopa, can markedly increase the propotion of
levodopa that cross the blood-brain barrier by
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Increasing penetration of levodopa through BBB by complexation with it
Decreasing peripheral metabolism of levodopa
decreasing the metabolism of levodopa in the CNS
decreasing the clearance of levodopa from the CNS
Ethambutol molecule has
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two chiral centers and 3 stereoisomers
two chiral centers and 4 stereoisomers
two chiral centers and 2 stereoisomers
one chiral centers and 2 stereoisomers
A compound will be sensitive towards IR radiation only when one of the following properites undergo
transition on radiation
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Polarizability
Dielectric constant
Dipole moment
Refractivity
X-ray crystallographic analysis of an optically active compound determines its
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Optical rotatory despersive power
Absolute configuration
Relative configuration
Optical purity
Which one ofthe following statements is WRONG?
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A singlet or triplet state may result when one of the electrons from the HOMO is excited to higher
energy levels
In an excited singlet state, the spin of the electron in the higher energy orbital is paired with the
electron in the ground state orbital
Triplet excited state is more stable than the singlet excited state
When the electron from the singlet excited state returns to ground state, the molecule always shows
fluorescence phenomenon
Aminotransferases usually require the following for their activity :
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Niacinamide
Vitamin B12
Pyridoxal Phosphate
Thiamine
Purity of water can be assessed by determining one of its following properties instrumentally :
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pH
Refractivity
Viscosity
Conductivity
Which one of the following statement is WRONG
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Carbon NMR is less sensitive than Proton NMR
C-12 nucleus is not magnetically active
Both C13 and H1 have same spin quantum numbers
The gyromagnetic ratio of H1 is lesser than that of C13
In the TCA cycle, at which of the following ezyme-catalyzed steps, incorporation of elements of water
into an intermediate of the cycle takes place :
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Citrate synthase
Aconitase
Malate dehydrogenase
Succinyl Co-A synthase
Humectants added in cosmetic preparations generally act by
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Hydrogen bond formation
covalent bond formation
complex formation
the action of London forces
In the mixing of thymol and menthol the following type of incompatibility occurs :
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Chemical incompatibility
Therapeutic incompatibility
Physical incompatibility
Tilerance incompatibility
Bloom strength is used to check the quality of
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Lactose
Ampoules
Hardness of tablets
Gelatin
The characteristic of non-linear Pharmacokinetics includes:
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Area under the curve is propotional to the dose
Elimination half-life remains constant
Area under the curve is not propotional to the dose
Amount of drug excreted through remains constant
In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is
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Schedule M
Schedule C
Schedule Y
Schedule H
Thioglycolic acid-like compounds have applications in the following type of cosmetic formulations :
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Depilatory preparations
Epilatory preparations
Vanishing creams
Skin tan preparations
Which one of the following is a flocculating agent for negatively charged drug?
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Aluminium chloride
Bentonite
Tragacanth
Sodium biphosphate
The healing agent used in hand creams is
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soft paraffin
urea
bees wax
steryl alcohol
Measurement of inulin reanal clearance is a measure for
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Effective renal blood flow
Ranal drug excretion rate
Active renal secretion
Glomerular filtration rate
Highly branched three dimenssional macromolecules with controlled structure with all bonds originating
from a central core are known as
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Cyclodextrins
dextrans
dendrimers
liposomes
Which one of the following is the commonly used bulking agent in the formulation of freeze dried low
dose drug products
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sodium chloride
mannitol
starch
HPMC
The applicability of Noyes-Whitney equation is to describe
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First order kinetics
Zero order kinetics
Mixed order kinetics
Dissolution rate
1. Hausner ratio is calculated by
H.R. = Tapped Density/Poured Density
H.R. = Poured Density/ Tapped Density
H.R. = Bulk Density/True Density
H.R. = Bulk Density/Void Volume
2. Particle size analysis is mainly done for
Dose uniformity
Stability
Dissolution rate
All the above
3. Modified starch is
Starch 1500
Starch 1000
Starch 200
Starch 1200
4. Following lubricants, which is not used in oral tablets
Talc
Hydrogenated vegitable oils
Magnesium stearate
Boric acid
5. The concentration of polyvinyl pyrrolidone (PVP) as a binder is
2-15% w/v
0.1 – 0.5% w/v
1-5% w/v
0.5-3% w/v
6. Primary amines are incompatible with
Lactose
Mannitol
Methyl Cellulose
Acacia
7. The thickness of tablets are measured by
Sliding caliper scale
Rotating disc technique
Microscopic Technique
Techincon Auto analyser
8. Hardness of tablet is measure by
pfiser tester
Strong Cobb
Erweka tester
All the above
9. The mesh size of USP disintegrator is
5-6
2.5
28-32
10
10. Aspartame has the main disadvantage as
Carcinogenic
Less sweeter than sucrose
Hygroscopic in nature
Bitter after taste
Indian baladona is
Atropa Belladonna
Atropa Belladonna var acuminate
Atropa fastusa
Atropa succirubra
2. Opium does NOT contain the following EXCEPT -
Meconic acid
Starch
Calcium Oxalate
Tannins
3. Saponnins are characterized by
Bitterness value
Hemolytic activity
Swelling Index
All of the above
4. White ginseng is
White colored variety of ginseng roots
Obtained by washing to remove colour of ginseng roots
Washed roots without secondary roots, sun dried and oftenly peeled
None of the above
5. Bitters are used therapeutically as
Antimalarial agents
Antiamoebic agents
Antifungal agents
Appetizing agents
6. Volatile oils are extracted by using
Soxhlet apparatus
Perculator
Clavenger apparatus
All of the above
8. Opium alkaloid containing isoquinoline ring system is
Morphine
Codiene
Thebaine
Papaverine
9. Which constituents of Gugulipids is reponsible for hypolipdemic activity
Gums
Guggulsterol I and II
Guggulsterones E and Z
All of the above
10. Which one of the following is S glycoside
Digoxin
Sennoside A
Aloin
Sinigrin
Precursor for the biosynthesis of Phenanthrene alkaloid is
Tryptophan
Secologanin
Ornithine
Reticuline
2. Choose the correct statement
Quinine and Quindine are dextrorotatory, cinchonine and cinchonidine are levorotatory
Quinine and Quindine are levorotatory, cinchonine and cinchonidine are dextrorotatory
Quinine and cinchonidine are levorotatory, Quindine and cinchonine are dextrorotatory
Quinine and cinchonine are dextrorotatory, Quindine and cinchonidine are levorotatory
3. Tropane alkaloids are biosynthesized from
Ornithine
Tryptophan
Tyrosine
Phenylalanine
4. Ergotoxine is a mixture of
2 alkaloids
3 alkaloids
4 alkaloids
6 alkaloids
5. The active constituents of cassia bark consists of all of the following EXCEPT
Cinnamic acid
Caryophylline
Eugenol
Coumarin
6. Aconitine on hydrolysis gives
Benzoic acid + Acetic acid + Aconine
Cinnamic acid + Tropic acid + Aconine
Cinnamic acid + Methyl alcohol + Benzoyl Aconine
Formic acid + Methyl alcohol + Benzoyl Aconine
7. Tropane is
6, 7 epoxy tropane
3 α - hydroxy tropine
3 β - hydroxy tropine
3 apatropine
8. Bioflavanoids are earlier known as
Vitamin C
Vitamin Y
Vitamin P
Vitamin M
9. Cyanogenetic glycosides are
S - Glycosides
O - Glycosides
C - Glycosides
N - Glycosides
10. C 23 Glycosides show the following test
Baljest test
Legal test
Libermann's Sterol Test
Baljest test and Legal test
1. 5, 5 Diethyl barbituric acid is common name of
Phenobarbital
Barbitone
Thiopentanal
Pentobarbital
2. Hydrolysis of methoxy carbonyl and Benzoate group of cocaine gives an inactive compound which is
known as
Ecgonine
Tropacocaine
Atropine
Pseudo cocaine
3. Codeine differs structure from Morphine by
N - Methyl Group
- Cl group
- OC2H2 group
- OCH3 Group
4. Heterocyclic ring INDOLE is present in
Diclofenac
Flurbiprofen
Sulindac
Indomethacin
5. The aromatic nucleus present in Naproxen is
Benzene
Naphthalene
Anthracene
Pyridine
6. Procainamide differs from procaine by
Ester group
Amide Group
Chloro group
Hydroxy group
7. The active metabolite of phenyl butazone is
Sulfinpyrazone
Oxyphenbutazone
Phenazone
Azapropazone
8. Ethacrynic acid belongs to the class of
Loop diuretic
ACE inhibitor
Aldosterone antagonist
Diuretic
9. Chloroquin is an antimalarial drug which belongs to the class of
4 - amino quinoline
8 - amino quinoline
9 - amino quinoline
Acidine
10. Penicilline on hydrolysis wit alkali gives
Penicilloic acid
Penaldic acid
Penicillic acid
Penicillamine
1. One of the following drug is an alkylating agent
Allopurinol
Methotrexate
Cyclophosphamide
Buslphan
2. Anti-asthamatic agent which is not a mast cell stabillizer
Ketotifen
Terbutaline Sulfte
Nedocromil
Sodium Chromoglycate
3. The drug which was used as 'LIE DETECTOR' during the Second world war is
Nitrous Oxide
Chloroquine
Carbamazepine
Hyoscyine
4. Choose the "Cholineesterase reactivator"
Atropine
Pralidoxime
Pirenzepine
Ipratropium
5. Which one of the following is used in treatment of Ulceratice Colitis?
Sulfasalazine
Mesalazine
Olsalazine
All of the above
6. Chloroprocaine is not used for spinal anasthesia because
It is not effective in spinal anasthesia
It produces a very long duration of spinal anasthesia
It produces a very short duration of spinal anasthesia
It can damage nerve roots on intra-thecal injection
7. A source of anitcarcinogenic drug is
Belladona
Nux vomica
Vinca rosea
Cascara
8. Organic nitrates are not very usefull in acute angina attacks because they
are insoluble
Can only be given orally
Cause very severe side effects
Must be biconverted before being active
9. Which one of the following interacts with vasopressin
Chloramphenicol
Diphenylhydantoin
Chlorpropamide
Dicumarol
10. Cyanocobalamine is a
Steroid
Choline esterase inhibitor
Hallucinogen
Vitamin
1. _________ is not a chelating agent.
Ethylene diamine
Tripyridyl
Citric acid
EDTA
2. Hydroquinone, polyhydroxy phenol is mainly used as
Chelating agent
Anti oxidant
Solubilizing agent
Oxidising agent
3. The inclusion of water miscible solvents in the formulation will increase the stability by
Supressing ionization
Reducing the extremes of pH required to achieve solubility
Contributing itself to solubility
Reducing the water activity be reducing the polarity of the solvent
4. Polymorphism is important in the formulation of ________.
Ointments
Suspositories
Capsules
Solutions
5. Polymorphism is mainly exhibited by
Barbiturates
Sulphonamides
Steroids
All the above
6. the melting point of given substances can be determined by
DSC
XRD
FTIR
HPLC
7. Wood’s apparatus is mainly used in
Particle size determination
pH determination
Solubility determination
Partition coefficient determination
8. Kinetic pH profiles for preformulation are mainly done by exposing the drugs to
Base degradation
Acid degradation
Aqueous degradation
All the above
9. The solubility of the drug will be high when it is in its
Metastable form
Stable form.
Unstable form
All the above
10. Hydrophobic nonionisable substances solubility can be increased by addition of
Polar solvents
Non polar solvents
By both polar and nonpolar solvents
Galactomanne
20:-Name the world's thinnest and strongest nano material.
Correct Answer:- Option-A
A:-Graphene
B:-Titanium Nanorods
C:-Iron Nanofoils
D:-Copper Nanowires
21:-In tablet manufacturing, TALC is used as
Correct Answer:- Option-C
A:-Diluent
B:-Granulating agent
C:-Glidant
D:-Disintegrating agent
22:-SCHICK TEST is done to
Correct Answer:- Option-A
A:-Detect the degree of immunity against Diphtheria.
B:-Detect the degree of immunity against Tuberculosis
C:-Detect the degree of immunity against Typhoid
D:-identify the presence of Ketone bodies in urine
