Scribd
Upload
2K views1 page

Antibiotics and Penicillin Allergy: Contra-Indicated Contra - Indicated Contra - Indicated

This document discusses antibiotic options for patients with different severities of penicillin allergy. Severe penicillin allergies involve anaphylaxis and occur within 1 hour, limiting treatment to non-beta-lactam antibiotics. Non-severe allergies involve rashes and occur after 24 hours, allowing cautious use of certain cephalosporins and carbapenems. Beta-lactam antibiotics are contraindicated for severe allergies but may be used cautiously for non-severe allergies due to low cross-sensitivity risk. Individual treatment decisions should involve the patient's allergy history and guidance from microbiology specialists.

Uploaded by

Jeferson Braxton
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
2K views1 page

Antibiotics and Penicillin Allergy: Contra-Indicated Contra - Indicated Contra - Indicated

This document discusses antibiotic options for patients with different severities of penicillin allergy. Severe penicillin allergies involve anaphylaxis and occur within 1 hour, limiting treatment to non-beta-lactam antibiotics. Non-severe allergies involve rashes and occur after 24 hours, allowing cautious use of certain cephalosporins and carbapenems. Beta-lactam antibiotics are contraindicated for severe allergies but may be used cautiously for non-severe allergies due to low cross-sensitivity risk. Individual treatment decisions should involve the patient's allergy history and guidance from microbiology specialists.

Uploaded by

Jeferson Braxton
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Antibiotics and Penicillin Allergy

*SEVERE PENICILLIN ALLERGY: **NON-SEVERE PENICILLIN ALLERGY:


Normally within 1 hour (up to 12 hours) Normally after 24 hours
Anaphylaxis Maculopapular/morbilliform rash
Angioedema Serum sickness (fever, rash, arthralgia,
Urticarial rash/pruritus glomerulonephritis)
Wheezing/stridor

CONTRA- Amoxicillin
INDICATED Co-amoxiclav (Augmentin®) = Amoxicillin + Clavulanic acid
CONTRA- Flucloxacillin
INDICATED Penicillin G (Benzylpenicillin)
Avoid in severe* Penicillin V (Phenoxymethylpenicillin)
and non-severe**
penicillin allergy
Piperacillin + Tazobactam (Tazocin®)
Temocillin
Ticarcillin + Tazobactam (Timentin®)
All cephalosporins including:
CAUTION* Cefalexin Cefixime Cefotaxime
Ceftazidime Ceftriaxone Cefuroxime
CAUTION All carbapenems including:
Avoid in severe* Ertapenem
penicillin allergy Imipenem + Cilastatin
Meropenem
Other beta-lactams:
Aztreonam (may be used with caution in severe penicillin
allergy – discuss with microbiology)

Amikacin Erythromycin Oxytetracycline


Azithromycin Fosfomycin Rifampicin
CONSIDERED Chloramphenicol Gentamicin Sodium Fusidate
SAFE Ciprofloxacin Levofloxacin Teicoplanin
Clarithromycin Linezolid Tetracycline
Clindamycin Metronidazole Tigecycline
Colistin Nitrofurantoin Trimethoprim
Co-Trimoxazole Norfloxacin Tobramycin
Doxycycline Ofloxacin Vancomycin
Individuals with a severe* allergy to penicillin SHOULD NOT receive a penicillin, cephalosporin or
another beta-lactam antibiotic. Individuals with a non-severe** penicillin allergy SHOULD NOT receive a
penicillin but cephalosporins, carbepenems and other beta-lactams can be used for these patients
with caution as the risk of cross sensitivity is low.

You might also like