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Ciclo de Krebs Cadena Respiratoria Fosforilación Oxidativa

The document describes the Krebs cycle and oxidative phosphorylation. It includes diagrams of the Krebs cycle showing the key steps of citrate synthase, aconitase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. It also includes diagrams of the electron transport chain showing Complexes I, II, III, IV and ATP synthase, and mentions some inhibitors of electron transport like amytal, rotenone and antimycin A.

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MARIA FERNANDA MORALES MURUETA
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38 views47 pages

Ciclo de Krebs Cadena Respiratoria Fosforilación Oxidativa

The document describes the Krebs cycle and oxidative phosphorylation. It includes diagrams of the Krebs cycle showing the key steps of citrate synthase, aconitase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl-CoA synthetase, succinate dehydrogenase, fumarase, and malate dehydrogenase. It also includes diagrams of the electron transport chain showing Complexes I, II, III, IV and ATP synthase, and mentions some inhibitors of electron transport like amytal, rotenone and antimycin A.

Uploaded by

MARIA FERNANDA MORALES MURUETA
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PPTX, PDF, TXT or read online on Scribd
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Ciclo de Krebs

Cadena respiratoria
fosforilación oxidativa
Ciclo de Krebs
Ciclo de Krebs
Ciclo de Krebs
Ciclo de Krebs
Pyruvate
dehydrogenase
Citrate synthase Aconitase

Pyruvate Citrate

H2O
NAD NADH Aconitase
CO2 cis-Aconitate
Oxaloacetate
Malate H2O
dehydrogenase NADH

NAD Isocitrate

Malate
Citric acid cycle Isocitrate
dehydrogenase

Fumarase
H2O
NAD
NADH Oxalosuccinate
FADH2 CO2
Fumarate NADH
FAD CO2 NAD Isocitrate
dehydrogenase
Succinate
GTP GDP
dehydrogenase

-Ketoglutarate
Succinate

Succinyl-CoA -Ketoglutarate
synthetase dehydrogenase
Succinyl-CoA
Pyruvate Acetyl-CoA
dehydrogenase
Citrate synthase Cis-Aconitase

Pyruvate Citrate
NADH
CO2
NAD H2O
Pyruvate
CO2 Cis-Aconitase
carboxylase cis-Aconitate
Oxaloacetate
Malate H2O
dehydrogenase NADH

NAD Isocitrate

Malate
Citric acid cycle Isocitrate
dehydrogenase

Fumarase
H2O
NAD
NADH Oxalosuccinate
FADH2 CO2
Fumarate NADH
FAD CO2 NAD Isocitrate
dehydrogenase
Succinate
GTP GDP
dehydrogenase

-Ketoglutarate
Succinate

Succinyl-CoA -Ketoglutarate
synthetase dehydrogenase
Succinyl-CoA
Energía libre de Gibs
Regulación del ciclo de Krebs
Vía anaplerótica
Vía anaplerótica
Complejo I y II
Complejo I
4

https://www.youtube.com/watch?v=xbJ0nbzt5Kw
https://www.youtube.com/watch?v=3y1dO4nNaKY&t=56s
Mitochondrial electron transport and oxidative phosphorylation

H+ H+ H+
NADH:CoQ CoQ:Cytochrome c Cytochrome c
Oxidoreductase Succinate:CoQ
Oxidoreductase Oxidase
(Complex I) Oxidoreductase
(Complex III) (Complex IV)
(Complex II)

Q Cyt c
Q

2 e- a
Q  Mitochondrial
Succinate DH Cyt bc1 Cyt bc1
Q COX COX
b Matrix
(FAD)
Q

 
Fumarate

NADH + H +
NAD Succinate

ADP + Pi ATP
H+
Inhibitors of electron transport and oxidative phosphorylation

H+ H+ H+
NADH:CoQ CoQ:Cytochrome c Cytochrome c
Oxidoreductase Succinate:CoQ
Oxidoreductase Oxidase
(Complex I) Oxidoreductase
(Complex III) (Complex IV)
(Complex II)
Cyt c
Q Q

2 e- a
OSCP

Q
Q
Succinate DH Cyt bc1 Cyt bc1
Q COX COX
b  Mitochondria
(FAD) Matrix

  
  
Fumarate

NADH + H+ NAD Succinate

ADP + Pi ATP
H+

Amytal Antimycin A

Rotenone

Oligomycin
https://www.youtube.com/watch?v=xbJ0nbzt5Kw
https://www.youtube.com/watch?v=rdF3mnyS1p0
Anaeróbica

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