Mechanical ventilation

Hosam m Atef ; MD

SUEZ CANAL UNIVERSITY

 Introduction
• Indications
• Basic anatomy and physiology
• Modes of ventilation
• Selection of mode and settings
• Common problems
• Complications
• Weaning and extubation
 Indications
• Respiratory Failure
– Apnea / Respiratory Arrest
– inadequate ventilation (acute vs. chronic)
– inadequate oxygenation
– chronic respiratory insufficiency with FTT
 Indications
• Cardiac Insufficiency
– eliminate work of breathing
– reduce oxygen consumption
• Neurologic dysfunction
– central hypoventilation/ frequent apnea
– patient comatose, GCS < 8
– inability to protect airway
 Basic Anatomy
• Upper Airway
– humidifies inhaled gases
– site of most resistance to airflow
• Lower Airway
– conducting airways (anatomic dead space)
– respiratory bronchioles and alveoli (gas
exchange)
 Basic Physiology
• Negative pressure circuit
– Gradient between mouth and pleural
space is the driving pressure
– need to overcome resistance
– maintain alveolus open
• overcome elastic recoil forces
– Balance between elastic recoil of chest
wall and the lung
 Basic Physiology

http://www.biology.eku.edu/RITCHISO/301notes6.htm
 Normal pressure-volume
relationship in the lung

http://physioweb.med.uvm.edu/pulmonary_physiology
 Ventilation
• Carbon Dioxide
PaCO2= k * metabolic production
alveolar minute
ventilation

Alveolar MV = resp. rate * effective tidal vol.

Effective TV = TV - dead space
Dead Space = anatomic + physiologic
 Oxygenation
• Oxygen:
– Minute ventilation is the amount of fresh gas
delivered to the alveolus
– Partial pressure of oxygen in alveolus (PAO2) is the
driving pressure for gas exchange across the
alveolar-capillary barrier
– PAO2 = ({Atmospheric pressure - water
vapor}*FiO2) - PaCO2 / RQ
– Match perfusion to alveoli that are well ventilated
– Hemoglobin is fully saturated 1/3 of the way thru
the capillary
 Oxygenation

http://www.biology.eku.edu/RITCHISO/301notes6.htm
CO2 vs. Oxygen
 Abnormal Gas Exchange
• Hypercarbia
Hypoxemia can
canbe
bedue
dueto:
to:
– hypoventilation
– V/Q mismatch
– shunt
– diffusion impairments

Due to differences between oxygen and CO2 in their

solubility and respective disassociation curves, shunt and
diffusion impairments do not result in hypercarbia
 Gas Exchange
• Hypoventilation and V/Q mismatch are the
most common causes of abnormal gas
exchange in the PICU
• Can correct hypoventilation by increasing
minute ventilation
• Can correct V/Q mismatch by increasing
amount of lung that is ventilated or by
improving perfusion to those areas that are
ventilated
 Mechanical Ventilation
• What we can manipulate……
– Minute Ventilation (increase respiratory rate, tidal
volume)
– Pressure Gradient = A-a equation (increase
atmospheric pressure, FiO2, increase ventilation,
change RQ)
– Surface Area = volume of lungs available for
ventilation (increase volume by increasing airway
pressure, i.e., mean airway pressure)
– Solubility = ?perflurocarbons?
 Mechanical Ventilation
Ventilators deliver gas to the lungs
using positive pressure at a certain
rate. The amount of gas delivered
can be limited by time, pressure or
volume. The duration can be cycled
by time, pressure or flow.
 Nomenclature
• Airway Pressures
– Peak Inspiratory Pressure (PIP)
– Positive End Expiratory Pressure (PEEP)
– Pressure above PEEP (PAP or ΔP)
– Mean airway pressure (MAP)
– Continuous Positive Airway Pressure (CPAP)
• Inspiratory Time or I:E ratio
• Tidal Volume: amount of gas delivered with
each breath
 Modes
• Control Modes:
– every breath is fully supported by the ventilator
– in classic control modes, patients were unable to
breathe except at the controlled set rate
– in newer control modes, machines may act in
assist-control, with a minimum set rate and all
triggered breaths above that rate also fully
supported.
 Modes
• IMV Modes: intermittent mandatory
ventilation modes - breaths “above” set rate
not supported
• SIMV: vent synchronizes IMV “breath” with
patient’s effort
• Pressure Support: vent supplies pressure
support but no set rate; pressure support can
be fixed or variable (volume support, volume
assured support, etc)
 Modes
Whenever a breath is supported by the
ventilator, regardless of the mode, the limit
of the support is determined by a preset
pressure OR volume.
– Volume Limited: preset tidal volume
– Pressure Limited: preset PIP or PAP
 Mechanical Ventilation
If volume is set, pressure varies…..if
pressure is set, volume varies…..
….according to the compliance…...

COMPLIANCE =
 Volume /  Pressure
 Compliance

Burton SL & Hubmayr RD: Determinants of Patient-Ventilator Interactions:

Bedside Waveform Analysis, in Tobin MJ (ed): Principles & Practice of Intensive
Care Monitoring
 Assist-control, volume

Ingento EP & Drazen J: Mechanical Ventilators, in Hall JB,

Scmidt GA, & Wood LDH(eds.): Principles of Critical Care
 IMV, volume-limited

Ingento EP & Drazen J: Mechanical Ventilators, in Hall JB,

Scmidt GA, & Wood LDH(eds.): Principles of Critical Care
 SIMV, volume-limited

Ingento EP & Drazen J: Mechanical Ventilators, in Hall JB,

Scmidt GA, & Wood LDH(eds.): Principles of Critical Care
 Control vs. SIMV
Control Modes SIMV Modes
• Every breath is supported regardless of “trigger”
• Vent tries to synchronize
• Can’t wean by decreasing ratewith pt’s effort
• Patient may hyperventilate if
• agitated
Patient takes “own” breaths
• Patient / vent asynchrony possible and may need
in between (+/- PS)
sedation +/- paralysis
• Potential increased work of
breathing
• Can have patient / vent
asynchrony
 Pressure vs. Volume
• Pressure Limited • Volume Limited
– Control minute
– Control FiO2 and MAP (oxygenation)
ventilation
– Still can influence ventilation somewhat
(respiratory rate, PAP) – Still can influence
– Decelerating flow pattern (lower PIP for same
oxygenation
TV) somewhat (FiO2,
PEEP, I-time)
– Square wave flow
pattern
 Pressure vs. Volume
• Pressure Pitfalls • Volume Vitriol
– tidal volume by change – no limit per se on PIP
suddenly as patient’s (usually vent will have
compliance changes upper pressure limit)
– this can lead to – square wave(constant)
hypoventilation or
overexpansion of the flow pattern results in
lung higher PIP for same
– if ETT is obstructed tidal volume as
acutely, delivered tidal compared to Pressure
volume will decrease modes
 Trigger
• How does the vent know when to give a
breath? - “Trigger”
– patient effort
– elapsed time

• The patient’s effort can be “sensed” as a

change in pressure or a change in flow
(in the circuit)
 Need a hand??
Pressure Support
• “Triggering” vent requires certain amount of
work by patient
• Can decrease work of breathing by providing
flow during inspiration for patient triggered
breaths
• Can be given with spontaneous breaths in IMV
modes or as stand alone mode without set rate
• Flow-cycled
 Advanced Modes
• Pressure-regulated volume control
(PRVC)
• Volume support
• Inverse ratio (IRV) or airway-pressure
release ventilation (APRV)
• Bilevel
• High-frequency
 Advanced Modes
PRVC
A control mode, which delivers a set
tidal volume with each breath at the
lowest possible peak pressure. Delivers
the breath with a decelerating flow
pattern that is thought to be less injurious
to the lung…… “the guided hand”.
 Advanced Modes
Volume Support
– equivalent to smart pressure support
– set a “goal” tidal volume
– the machine watches the delivered
volumes and adjusts the pressure support
to meet desired “goal” within limits set
by you.
 Advanced Modes
Airway Pressure Release Ventilation
– Can be thought of as giving a patient two
different levels of CPAP
– Set “high” and “low” pressures with release
time
– Length of time at “high” pressure generally
greater than length of time at “low” pressure
– By “releasing” to lower pressure, allow lung
volume to decrease to FRC
 Advanced Modes
Inverse Ratio Ventilation
– Pressure Control Mode
– I:E > 1
– Can increase MAP without increasing PIP:
improve oxygenation but limit barotrauma
– Significant risk for air trapping
– Patient will need to be deeply sedated and
perhaps paralyzed as well
 Advanced Modes
High Frequency Oscillatory Ventilation
– extremely high rates (Hz = 60/min)
– tidal volumes < anatomic dead space
– set & titrate Mean Airway Pressure
– amplitude equivalent to tidal volume
– mechanism of gas exchange unclear
– traditionally “rescue” therapy
– active expiration
 Advanced Modes
High Frequency Oscillatory Ventilation
– patient must be paralyzed
– cannot suction frequently as disconnecting the
patient from the oscillator can result in volume
loss in the lung
– likewise, patient cannot be turned frequently so
decubiti can be an issue
– turn and suction patient 1-2x/day if they can
tolerate it
 Advanced Modes
Non Invasive Positive Pressure Ventilation
– Deliver PS and CPAP via tight fitting mask
(BiPAP: bi-level positive airway pressure)
– Can set “back up” rate
– May still need sedation
 Initial Settings
• Pressure Limited • Volume Limited
– FiO2 – FiO2
– Rate – Rate
– I-time or I:E ratio – I-time or I:E ratio
– PEEP – PEEP
– PIP or PAP – Tidal Volume
These choices are with time - cycled ventilators.
Flow cycled vents are available but not commonly
used in pediatrics.
 Initial Settings
• Settings
– Rate: start with a rate that is somewhat
normal; i.e., 15 for adolescent/child, 20-30
for infant/small child
– FiO2: 100% and wean down
– PEEP: 3-5
– Control every breath (A/C) or some (SIMV)
– Mode ?
 Dealer’s Choice
• Pressure Limited • Volume Limited
– FiO2 – FiO2
– Rate – Rate
– I-time – Tidal Volume MV
– PEEP – PEEP
MAP
– PIP – I time

Tidal Volume ( PIP ( & MAP)

& MV) Varies Varies
 Adjustments
• To affect oxygenation,• adjust:
To affect
ventilation,
– FiO2 adjust:
– PEEP – Respiratory
– I time Rate MV
– PIP MAP
– Tidal Volume
 Adjustments
• PEEP
Can be used to help prevent alveolar
collapse at end inspiration; it can also
be used to recruit collapsed lung spaces
or to stent open floppy airways
 Except...
• Is it really that simple ?
– Increasing PEEP can increase dead space,
decrease cardiac output, increase V/Q
mismatch
– Increasing the respiratory rate can lead to
dynamic hyperinflation (aka auto-PEEP),
resulting in worsening oxygenation and
ventilation
 Troubleshooting
• Is it working ?
–Look at the patient !!
–Listen to the patient !!
– Pulse Ox, ABG, EtCO2
– Chest X ray
– Look at the vent (PIP; expired TV;
alarms)
 Troubleshooting
• When in doubt, DISCONNECT THE
PATIENT FROM THE VENT, and begin
bag ventilation.
• Ensure you are bagging with 100% O2.
• This eliminates the vent circuit as the
source of the problem.
• Bagging by hand can also help you gauge
patient’s compliance
 Troubleshooting
• Airway first: is the tube still in? (may need
DL/EtCO2 to confirm) Is it patent? Is it in the
right position?
• Breathing next: is the chest rising? Breath
sounds present and equal? Changes in exam?
Atelectasis, bronchospasm, pneumothorax,
pneumonia? (Consider needle thoracentesis)
• Circulation: shock? Sepsis?
 Troubleshooting
• Well, it isn’t working…..
– Right settings ? Right Mode ?
– Does the vent need to do more work ?
• Patient unable to do so
• Underlying process worsening (or new
problem?)
– Air leaks?
– Does the patient need to be more sedated ?
– Does the patient need to be extubated ?
– Vent is only human…..(is it working ?)
 Troubleshooting
• Patient - Ventilator Interaction
– Vent must recognize patient’s
respiratory efforts (trigger)
– Vent must be able to meet patient’s
demands (response)
– Vent must not interfere with patient’s
efforts (synchrony)
 Troubleshooting
• Improving Ventilation and/or Oxygenation
– can increase respiratory rate (or decrease rate if
air trapping is an issue)
– can increase tidal volume/PAP to increase tidal
volume
– can increase PEEP to help recruit collapsed
areas
– can increase pressure support and/or decrease
sedation to improve patient’s spontaneous effort
 Lowered Expectations
• Permissive Hypercapnia
– accept higher PaCO2s in exchange for limiting
peak airway pressures
– can titrate pH as desired with sodium
bicarbonate or other buffer
• Permissive Hypoxemia
– accept PaO2 of 55-65; SaO2 88-90% in
exchange for limiting FiO2 (<.60) and PEEP
– can maintain oxygen content by keeping
hematocrit > 30%
 Adjunctive Therapies
• Proning
– re-expand collapsed dorsal areas of the lung
– chest wall has more favorable compliance curve
in prone position
– heart moves away from the lungs
– net result is usually improved oxygenation
– care of patient (suctioning, lines, decubiti)
trickier but not impossible
– not everyone maintains their response or even
responds in the first place
 Adjunctive Therapies
• Inhaled Nitric Oxide
– vasodilator with very short half life that can be
delivered via ETT
– vasodilate blood vessels that supply ventilated
alveoli and thus improve V/Q
– no systemic effects due to rapid inactivation by
binding to hemoglobin
– improves oxygenation but does not improve
outcome
 Complications
• Ventilator Induced Lung Injury
– Oxygen toxicity
– Barotrauma / Volutrauma
• Peak Pressure
• Plateau Pressure
• Shear Injury (tidal volume)
• PEEP
 Complications
• Cardiovascular Complications
– Impaired venous return to RH
– Bowing of the Interventricular Septum
– Decreased left sided afterload (good)
– Altered right sided afterload
• Sum Effect…..decreased cardiac output
(usually, not always and often we don’t
even notice)
 Complications
• Other Complications
– Ventilator Associated Pneumonia
– Sinusitis
– Sedation
– Risks from associated devices (CVLs, A-
lines)
– Unplanned Extubation
 Extubation
• Weaning
– Is the cause of respiratory failure gone or
getting better ?
– Is the patient well oxygenated and
ventilated ?
– Can the heart tolerate the increased work
of breathing ?
 Extubation
• Weaning (cont.)
– decrease the PEEP (4-5)
– decrease the rate
– decrease the PIP (as needed)
• What you want to do is decrease what
the vent does and see if the patient can
make up the difference….
 Extubation
• Extubation
– Control of airway reflexes
– Patent upper airway (air leak around tube?)
– Minimal oxygen requirement
– Minimal rate
– Minimize pressure support (0-10)
– “Awake ” patient