12 Dmpk Jobs nearby Alappuzha

As a Coordinator for in-vivo studies, your role involves planning and coordinating the initiation of research study protocols. You will be responsible for establishing operating policies and procedures, ensuring adherence to pre-established work scope, study protocol, and regulatory requirements. Developing and maintaining recordkeeping systems, as well as coordinating multiple data collection efforts with collaborating agencies or institutions, will also be part of your duties. Additionally, you will be involved in writing and editing reports and manuscripts, maintaining financial records for in vivo studies, and ensuring the availability and preparation of necessary supplies as specified by protocols and/or SOP. Key Responsibilities: - Coordinate the preparation of labels, labeling of sample collection tubes, and other laboratory reagents - Coordinate the preparation of shipment packages for dispatching activities Qualifications Required: - Master's in Lifescience with 3-5 years of working experience in in-vivo studies - Excellent time management skills to handle multiple tasks, manage deadlines, and respond to urgent needs - Strong technical knowledge with exceptional attention to detail - Excellent data analysis and interpretation skills - High self-motivation to work independently under aggressive deadlines - Exceptional communication skills and ability to build relationships with stakeholders - Organizational skills to thrive in a fast-paced team environment The company is located in Ahmedabad, Gujarat, India.,

As a Research Associate II - In Vitro, ADME at Jubilant Biosys in Bengaluru, your role involves reading and understanding various in vitro ADME protocols. You will be responsible for conducting in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices. Additionally, you will conduct various in vitro ADME experiments including logP, logD, and pKa measurements, CYP induction and inhibition assays, permeability determinations in relevant cell lines such as Caco-2 and MDCK, CYP phenotyping in purified enzyme systems, and solubility determinations in kinetic, thermodynamic, and simulated fluids. Qualification Required: - M.Pharmacy Experience Required: - 3-5 years You will play a crucial role in conducting a variety of in vitro ADME experiments and contributing to the research and development efforts at Jubilant Biosys. As a Research Associate II - In Vitro, ADME at Jubilant Biosys in Bengaluru, your role involves reading and understanding various in vitro ADME protocols. You will be responsible for conducting in vitro stability experiments for new chemical entities in liver microsomes, plasma, and other relevant matrices. Additionally, you will conduct various in vitro ADME experiments including logP, logD, and pKa measurements, CYP induction and inhibition assays, permeability determinations in relevant cell lines such as Caco-2 and MDCK, CYP phenotyping in purified enzyme systems, and solubility determinations in kinetic, thermodynamic, and simulated fluids. Qualification Required: - M.Pharmacy Experience Required: - 3-5 years You will play a crucial role in conducting a variety of in vitro ADME experiments and contributing to the research and development efforts at Jubilant Biosys.

You will be working as a Research Scientist/ Sr. Research Scientist (L1/L2) in the DMPK department of Jubilant Biosys located in Greater Noida. Your responsibilities will include ADME representation, lab management, mentorship, and publishing results. - Understand the broader ADME requirements of various projects and guide chemistry teams towards improving duggability of the NCEs - Design DMPK strategy and implementation plan - Conduct PK and PK/PD analysis through early pre-clinical development - Interact with cross-functional teams and contribute to project progression - Design tailor-made ADME protocols for projects - Collate results and prepare presentations for internal and external meetings - Contribute to the design of the critical path for projects - Address queries from clients In terms of lab management, you will be responsible for: - Developing methods and troubleshooting analytical issues - Generating data, compiling reports, and maintaining lab records - Optimizing lab resource utilization - Tracking FTE utilization in projects - Monitoring CAPEX and OPEX requirements Your role will also involve mentorship where you will: - Guide team members on work planning and execution - Develop team skill sets for project activities - Mentor and train juniors on assays and technologies - Ensure ethical guidelines are followed in all aspects Additionally, you will be involved in publishing results by communicating scientific work to peer-reviewed journals. For Fee-for-service (FFS) projects, you will: - Understand client requirements and design appropriate experiments Qualifications required for this position are: - Ph.D./M.Sc./M.Tech in Biochemistry, Pharmaceutical Chemistry, or Biotech background Experience needed includes: - 1 to 8 years post-PhD or 10-12 years post M.Sc./M.Tech - Experience in a drug discovery industry/CRO in the DMPK department Jubilant Biosys is an equal opportunity employer, and all qualified applicants will be considered without regard to various characteristics as per local laws and regulations.,

Role Overview: As a critical member of the team, you will be responsible for driving the design, execution, and interpretation of preclinical studies to support the discovery and development of novel therapeutics for neurological disorders. Your expertise in neuroscience, pharmacology, and translational science will be instrumental in advancing drug candidates, including biologics and gene therapies, from early discovery through IND-enabling studies. Key Responsibilities: - Lead preclinical strategy and execution for neuroscience drug discovery programs. - Design and oversee in vivo and in vitro studies to evaluate pharmacodynamics, efficacy, and safety. - Guide target validation, biomarker development, and mechanism-of-action studies. - Serve as the preclinical lead on cross-functional project teams. - Collaborate with medicinal chemistry, DMPK, toxicology, and clinical teams for seamless transition from discovery to development. - Mentor and supervise a team of scientists and research associates. - Identify and manage CROs and academic partnerships for preclinical research support. - Contribute to the preparation of regulatory documents including INDs, IBs, and briefing packages. - Support IND-enabling studies and contribute to regulatory submissions. - Translate preclinical findings into clinical hypotheses and biomarker strategies. Qualifications: - Ph.D. in Neuroscience, Pharmacology, or related discipline; postdoctoral experience preferred. - 8+ years of relevant experience in preclinical drug discovery. - Proven track record in leading neuroscience programs to preclinical candidate nomination. - Expertise in neurobiology, in vivo pharmacology, and translational models of CNS disorders. - Strong leadership, communication, and project management skills. - Experience with IND-enabling studies, regulatory documentation, and biomarker discovery. - Proficiency in partnership management, publication record in high-impact journals, and hands-on experience with neurological animal models. Additional Company Details: This position operates in an office setting and requires in-person presence, with limited remote work. The job may also require availability outside regular hours for priority business needs. It is a largely sedentary role with no direct reports. Role Overview: As a critical member of the team, you will be responsible for driving the design, execution, and interpretation of preclinical studies to support the discovery and development of novel therapeutics for neurological disorders. Your expertise in neuroscience, pharmacology, and translational science will be instrumental in advancing drug candidates, including biologics and gene therapies, from early discovery through IND-enabling studies. Key Responsibilities: - Lead preclinical strategy and execution for neuroscience drug discovery programs. - Design and oversee in vivo and in vitro studies to evaluate pharmacodynamics, efficacy, and safety. - Guide target validation, biomarker development, and mechanism-of-action studies. - Serve as the preclinical lead on cross-functional project teams. - Collaborate with medicinal chemistry, DMPK, toxicology, and clinical teams for seamless transition from discovery to development. - Mentor and supervise a team of scientists and research associates. - Identify and manage CROs and academic partnerships for preclinical research support. - Contribute to the preparation of regulatory documents including INDs, IBs, and briefing packages. - Support IND-enabling studies and contribute to regulatory submissions. - Translate preclinical findings into clinical hypotheses and biomarker strategies. Qualifications: - Ph.D. in Neuroscience, Pharmacology, or related discipline; postdoctoral experience preferred. - 8+ years of relevant experience in preclinical drug discovery. - Proven track record in leading neuroscience programs to preclinical candidate nomination. - Expertise in neurobiology, in vivo pharmacology, and translational models of CNS disorders. - Strong leadership, communication, and project management skills. - Experience with IND-enabling studies, regulatory documentation, and biomarker discovery. - Proficiency in partnership management, publication record in high-impact journals, and hands-on experience with neurological animal models. Additional Company Details: This position operates in an office setting and requires in-person presence, with limited remote work. The job may also require availability outside regular hours for priority business needs. It is a largely sedentary role with no direct reports.

As an experienced professional in the field of Biology, you will be responsible for a variety of in vitro ADME assays, with a deep understanding of mechanistic ADME. Your role will involve applying new science and technologies to enhance these assays, ensuring they meet client requirements. You should be able to perform assays independently and provide guidance to the team when needed. Troubleshooting technical aspects and understanding bioanalytical data will be key aspects of your responsibilities. Key Responsibilities: - Conduct a wide variety of in vitro ADME assays such as PPB, Microsomal stability, and hepatocyte stability - Analyze data and maintain detailed, accurate study documentation - Support novel modalities and manage in vitro ADME assays effectively - Interpret findings independently and present them at internal and external meetings - Collaborate with team members and communicate effectively Qualifications Required: - Extensive experience in in vitro ADME assays (7-9 years with Masters, 2-5 years with Ph.D.) - Strong understanding of mechanistic ADME and metabolism concepts - Excellent communication skills - Proactive, organized, and passionate about ADME/drug disposition Additionally, you should have a track record of successfully applying new science and technologies to improve in vitro ADME assays. Your ability to communicate clearly, work collaboratively, and adapt to novel modalities will be crucial for success in this role.,

As a Biology expert, you will be responsible for the following key responsibilities: - Expertise in handling HPLC and LCMS, including troubleshooting techniques. - Proficiency in different extraction procedures and independent handling of bioanalysis for various matrices in PK and ADME studies. - Good understanding of various column chemistry and its application in method development. - Ensuring data integrity and maintaining good documentation practices, including recording data in LNB and completing studies as required. - Operating and maintaining laboratory equipment. - Ensuring all instruments are maintained in a calibrated status. - Managing consumables and chemicals necessary for the smooth conduction of PK studies without delays. Your required experience and skills include: - Master's degree with 6-10 years of experience in Pharmaceutical/Biotechnology/CRO industry in Bioanalysis, focusing on NCE, peptides, nucleosides, etc. - Solid knowledge and broad experience in Bioanalysis of various DMPK samples. - Familiarity with troubleshooting problems during Bioanalysis. - Excellent interpersonal skills and ability to work effectively in a team. - Proficiency in computer skills and a good understanding of statistics. - Demonstrating a strong sense of responsibility and work ethics.,

As a candidate for this role, your main responsibility will be to follow up with Buyers and End Users to obtain import documents for all Medchem, DMPK, and Biology shipments. You will also be coordinating with Carriers/CHA on shipments documentation. Your tasks will include verifying shipment documents, approving checklists, and sharing shipment documents with Stores for the shipment handover process. Additionally, you will be required to follow up with carriers and Brokers to ensure timely clearance of shipments and obtain post-shipping documents. Your duties will also involve maintaining Management Information System (MIS) data related to both Export and Import shipments. You will be responsible for sending the daily import and export tracker to all stakeholders before the end of the day. Furthermore, you will be tasked with collecting Billing/Non-Billable data for all Export and Import shipments. In this role, it is crucial that you maintain Billing data accurately and submit Bills with all corresponding supporting documents. Qualifications Required: - Strong communication skills to effectively follow up with Buyers, End Users, carriers, and brokers - Attention to detail for verifying shipment documents and maintaining accurate data - Proficiency in MS Excel for maintaining MIS data and tracking shipments - Ability to work collaboratively with internal and external stakeholders to ensure smooth shipment processes Feel free to omit this section if there are no additional details about the company in the job description.,

You will be responsible for providing drug metabolism and pharmacokinetic support for discovery programs. Your duties will include monitoring Pharmacokinetics studies, supporting bioanalysis, and offering pre-clinical ADME lead optimization support to small molecule Drug Discovery programs. This support will range from Hit Identification to Clinical Candidate Selection in areas such as Inflammation, Neuroscience, Metabolic Disorders, and Anti-infective Research. As a DMPK subject matter lead, you will collaborate in multidisciplinary/cross-functional teams to understand Chemical Structure-ADME relationships and design strategies to enhance Drug like Properties of New Chemical Entities. Key Responsibilities: - Provide drug metabolism and pharmacokinetic support for discovery programs - Monitor Pharmacokinetics studies and support bioanalysis - Offer pre-clinical ADME lead optimization support to small molecule Drug Discovery programs - Collaborate in multidisciplinary/cross-functional teams to enhance Drug like Properties of New Chemical Entities Qualifications: - M. Pharm in Pharmacology or Pharmaceutical Analysis - M.Sc. in Biochemistry or Pharmaceutical Chemistry Please note that the company details were not provided in the job description.,

As a Principal Investigator at Syngene, you will be responsible for providing strategic and scientific leadership to integrated drug discovery projects for clients in the Medicinal Chemistry department. Your role will involve working closely with the Functional Head to prioritize projects, analyze SAR, design new compounds using Comp Chem tools, and ensure project deliverables are met. You will supervise medicinal chemistry projects, collaborate with cross-functional teams, and provide regular updates on project progress. Your core commitment to safety, integrity, compliance, quality, and service is paramount. **Key Responsibilities:** - Minimum of 6-10 years of experience in drug discovery from the pharmaceutical or biotech industry. - Excellent understanding of drug discovery concepts and experience in progressing projects from hit identification to lead optimization. - Prior experience working with cross-functional teams including assay biologists, structural biologists, DMPK scientists, computational chemists, and safety pharmacologists. - Familiarity with molecular modeling concepts and tools, data analysis, and informatics tools. - Knowledge of cGMP, regulatory requirements, synthesis planning, synthetic methods, and modern analytical tools. - Strong client communication and presentation skills. - Proven ability to lead and motivate teams. - Excellent written and verbal communication skills. - Team player with multi-disciplinary collaboration skills. - Strong planning, time management, and organizational capabilities. **Educational Qualification:** - Ph.D./PDF in Organic/Medicinal Chemistry or relevant field. **Technical/Functional Skills:** - High scientific capability. - Knowledge of route scouting, process safety, and hazard evaluation. - Proficiency in data analysis software. - Strong client communication skills. - Cross-departmental interaction experience. **Behavioral Skills:** - Interpersonal skills. - Team skills. - Time management skills. - System thinking and troubleshooting ability. - Leadership qualities. At Syngene, safety is a top priority, and you are expected to adhere to safety guidelines, procedures, and SOPs diligently. You will contribute to the development of safety practices and systems, promote an environment, health, and safety mindset, and ensure compliance with quality standards. Additionally, you will be responsible for completing mandatory trainings related to data integrity, health, and safety measures for yourself and your team.,

As a candidate for the position, your role will involve performing and analyzing in vitro and in vivo DMPK studies to support drug discovery and development projects. This includes planning, designing, and setting up DMPK experiments, handling instruments, maintaining the laboratory, preparing and reviewing protocols, writing reports, communicating with the project team, and presenting DMPK data in project meetings. Key Responsibilities: - Perform and analyze in vitro and in vivo DMPK studies - Plan, design, and set up DMPK experiments - Handle instruments and maintain the laboratory - Prepare and review protocols - Write reports, communicate with the project team, and present DMPK data in project meetings Required Qualifications: - Ability to set up and perform physiochemical assays such as solubility and logP - Experience in conducting in vitro DMPK assays (microsomal and hepatocyte stability, plasma stability, CYP inhibition, blood/plasma ratio) - Development and validation of bioanalytical methods across various biological matrices - Analysis of in-vivo pharmacokinetic samples - Knowledge of sample processing techniques (protein precipitation, liquid-liquid extraction, solid-phase extraction) - Proficiency in handling LC-MS/MS for quantitative analysis - Protocol preparation, report writing, and presentation of DMPK data in scientific team meetings Additional Details: - Experience in animal handling and conducting pharmacokinetic (PK) studies is beneficial - Working with cell lines such as Caco-2 - Ability to interpret pharmacokinetic data using Phoenix WinNonlin - Experience in a GLP or GLP-like environment Basic Skills Required: - Ability to work independently with enthusiasm and self-motivation - Strong decision-making and problem-solving skills - Effective collaboration and teamwork across multidisciplinary functions - Knowledge of drug discovery and development processes - Excellent oral, written, and interpersonal communication skills with proficiency in English - Proficiency in computer applications including word processing, spreadsheets, and presentation tools Qualifications: - M.Pharm or MS (Pharm) or PhD degree - Industry experience of 2 to 5 years - Candidate must be an Indian citizen - Salary will be commensurate with experience,

As an experienced candidate with a Master's degree and 8 to 12 years of relevant experience, you will be responsible for the following key tasks: - Well versed in handling LC-MS/MS instruments for ADME bioanalysis - Handling and troubleshooting LC-MS/MS related problems - Executing Bioanalytical assays for all ADME Assays including MDCK, Caco-2, PAMPA, CYP-Inhibition, and more - Maintaining the Bioanalytical project flow for In vitro studies - Handling and executing Kinetic solubility, Thermodynamic solubility & Chromatographic Log D studies - Analyzing MET-ID samples and preparing reports - Training team members in Bioanalysis If you are interested in this opportunity, please share your profiles to pranavgayal@aurigeneservices.com.,

As a Research Scientist - In Vitro ADME, your primary role is to generate high-quality and reproducible in-vitro ADME data to support medicinal chemistry and discovery biology teams in optimizing molecular properties. This involves robust ADME assay execution, scientific interpretation, innovation in assay methodologies, and effective cross-functional collaboration to accelerate hit-to-lead and lead optimization programs. Key Responsibilities: - Provide strategic ADME insights to Medicinal Chemistry and Biology for compound prioritization. - Influence project direction by interpreting trends in clearance, permeability, solubility, DDI risk, and transporter interactions. - Contribute to defining the ADME package for hit-to-lead, lead optimization, and early preclinical milestones. - Identify and introduce emerging ADME assay technologies, automation opportunities, and predictive tools (e.g., IVIVE, ADMET modelling). - Support long-term capability building of the DMPK platform. Operational Responsibilities: - Independently design, execute, and troubleshoot in-vitro ADME assays such as metabolic stability, plasma stability, protein binding, CYP inhibition/induction, phenotyping, PAMPA, Caco-2, MDCK, transporter assays, solubility, and DDI workflows. - Analyse and interpret LC-MS/MS data to calculate intrinsic clearance, permeability coefficients, efflux ratios, enzyme contributions, and stability parameters. - Maintain meticulous documentation through ELNs, assay worksheets, and technical reports. - Coordinate with cross-functional teams for sample management, study timelines, and data delivery. - Maintain lab infrastructure including LC-MS/MS, automation systems (TECAN), incubators, and cell culture platforms. - Support assay validation, SOP drafting, and continuous improvement initiatives. Financial Responsibilities: - Optimize usage of consumables, enzymes, reagents, plates, and solvents to minimize assay costs. - Ensure efficient LC-MS/MS run scheduling to maximize instrument throughput and reduce operational overheads. - Contribute to budgeting for ADME assays, method development projects, and instrument maintenance needs. - Avoid repeat experiments through strong assay robustness and error-free execution. People Responsibilities: - Mentor junior team members on ADME assay execution, data analysis, and instrument handling. - Foster a culture of scientific rigor, collaboration, and knowledge sharing across the discovery teams. - Provide training on new assays, safety practices, LC-MS/MS operations, and automation tools. - Demonstrate collaboration with Medicinal Chemistry, Biology, and PK/PD teams by ensuring timely delivery of ADME insights. Risk & Compliance Responsibilities: - Ensure adherence to internal SOPs, quality standards, and audit requirements. - Follow all safety guidelines related to chemical handling, biohazards, waste disposal, and lab operations. - Conduct periodic instrument checks, calibration, and preventive maintenance to avoid operational risks. - Maintain strict data integrity (ALCOA+), traceability, and documentation discipline. - Flag scientific, operational, or compliance risks (e.g., assay drift, QC failures) proactively.,