Since the discovery of penicillin, antibiotics have been a reliable way to treat bacterial infections and can be life-saving in certain situations. It’s important to know that antibiotics only treat bacterial infections and do not treat viral infections, such as the common cold, the flu, COVID-19, and herpes simplex virus (cold sores). Although you can get some topical antibiotics over the counter to prevent skin infections, you need a prescription for oral antibiotics. The most prescribed antibiotics are azithromycin and amoxicillin, which may be prescribed for a range of common bacterial infections, such as pneumonia, urinary tract infections (UTIs), and strep throat. Although antibiotics are priced lower than many other types of drugs, they can put a dent in your wallet. Thankfully, a SingleCare prescription discount card can help make these vital medications more affordable, saving people up to 80% on some antibiotics—even antibiotics for pets.
| Drug name | Our lowest price ( with free signup ) Our lowest price ( with signup ) | Coupons |
|---|---|---|
| Amoxicillin | loading... | See all discounts |
| Azithromycin | loading... | See all discounts |
| Cefdinir | loading... | See all discounts |
| Cephalexin | loading... | See all discounts |
| Ciprofloxacin HCl | loading... | See all discounts |
| Ciprofloxacin Dexamethasone | loading... | See all discounts |
| Doxycycline Hyclate | loading... | See all discounts |
| Doxycycline Monohydrate | loading... | See all discounts |
| Erythromycin | loading... | See all discounts |
| Metronidazole | loading... | See all discounts |
Most health insurance plans, including Medicare and Medicaid, cover antibiotics, although they’re more likely to cover generic antibiotics than brand-name antibiotics. You may have to pay a copay or coinsurance for your prescription, depending on the details of your drug plan. Free SingleCare coupons can help people save on antibiotics if they don’t have health insurance or if their antibiotics are too expensive with insurance. You can use SingleCare if you have health insurance, but you can’t use it with your insurance.
Using a SingleCare coupon is easy.
Search for your prescription on our website or app, or use the links to popular antibiotics coupons above.
Enter the correct form, dosage, and quantity for your prescription to ensure that you receive the most accurate price at the pharmacy.
Show your pharmacy your SingleCare card or coupon when filling your prescription.
You can save even more money on your prescription by signing up for free. SingleCare is free to use and available to everyone. Registered members can save even more, and it's fast and free to join!
You need a prescription from a healthcare provider for most antibiotics in the U.S., especially for oral antibiotics. If you don’t want to make a trip to their office, you may be able to make a telehealth appointment, as many telehealth providers are able to prescribe antibiotics virtually when deemed necessary. Just be aware that they’ll ask you several questions to determine whether you have a bacterial or viral infection. If they believe you have a viral infection, they won’t prescribe antibiotics. Some topical antibiotics are available over the counter (OTC) without a prescription.
There are a variety of topical OTC antibiotics you can get without a prescription, including Bacitracin, Neomycin, and brand-name Neosporin, or generic triple antibiotic ointment. Your pharmacist or healthcare provider can help recommend an OTC topical antibiotic.
If you have insurance that covers the cost of prescription drugs, you’ll pay your plan’s copay or coinsurance for UTI antibiotics. Without insurance, the cost of UTI antibiotics varies by type and whether you’re using brand-name or generic. Generic antibiotics are typically more affordable than brand-name versions. For example, brand-name Macrodantin costs an average of $115 for 14, 100 mg capsules, while generic nitrofurantoin macrocystals cost about $57. You could pay about $15 for this generic medication with a SingleCare coupon, depending on your choice of pharmacy.
Taking antibiotics when you don’t need them can speed up the process of antibiotic resistance, which is when bacteria become resistant to antibiotics. As a result, infections become harder to treat, which is why healthcare providers are very careful not to prescribe them unless they believe you truly need them. You may also experience side effects from the antibiotic, which may include gastrointestinal side effects, rash, headaches, or yeast infections.
The cost of antibiotics without insurance depends on various factors, such as the type of antibiotic, the dosage prescribed, and the pharmacy. Generally, brand-name antibiotics cost more than generic antibiotics. For example, a brand-name Zithromax Z-Pak costs about $49 for 6 tablets, while generic azithromycin costs about $4 with a SingleCare coupon.
If you miss a dose of antibiotics, take it as soon as you remember, unless you are more than halfway toward your next dose. For example, if you’re supposed to take your antibiotic every 12 hours, wait until the timing of your next dose if more than six hours have passed since your last dose. This will extend the course of treatment by one dose. If you miss more than one dose, there’s a chance that your antibiotics won’t work as quickly or effectively. Call your healthcare provider if you have questions about missed doses of antibiotics.
No single antibiotic is considered the strongest or most effective. This is because an antibiotic’s effectiveness depends on the type of bacteria causing the infection, how resistant the bacteria are, how serious the infection is, and other various factors. For example, clindamycin is more likely to cause life-threatening colitis than other antibiotics, so it is only prescribed to treat serious infections that can’t be treated by other antibiotics.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
...Antibiotics 101: What are they and why do we need them? SingleCare (2019)
What is amoxicillin: Uses, warnings & interactions, SingleCare (2025)
What is azithromycin: Uses, warnings & interactions, SingleCare (2025)
Outpatient antibiotic prescriptions — United States, 2022, Centers for Disease Control and Prevention (2023)
Viral infection, Cleveland Clinic (2022)
Antibiotic resistance, National Foundation for Infectious Diseases (2024)
What happens if you don’t finish antibiotics?, SingleCare (2024)
Clindamycin, MedlinePlus (2024)
Management of uncomplicated urinary tract infections, Western Journal of Medicine (2002)
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved