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Ectoparasiticides

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Gopi sankar
Gopi sankar

Ectoparasiticides are drugs used to kill parasites that live on the body surface, such as lice and mites. The document discusses several drugs used for this purpose, including permethrin, lindane, benzyl benzoate, crotamiton, and ivermectin. Permethrin is the most convenient drug for scabies and lice, providing a nearly 100% cure rate with a single application and no development of resistance. Lindane affects the nervous system and provides a lower efficacy than permethrin, with both lice and mites developing resistance, while benzyl benzoate is convenient for scabies treatment. Ivermectin is the only or

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Ectoparasiticides Used to kill parasites that live on the body surface
1. Lice – Pediculus wingless insects 2. Mites – Sarcoptes /Acrus scabiei
Drugs Permethrin  Lindane (BHC)  Benzyl Benzoate  Crotamiton  Sulfur  Dicophane (DDT)  Ivermectin
Permethrin  Most convenient drug for scabies and lice  Delayed depolarization  neurological paralysis in insects  Minimal systemic absorption  Nearly 100% cure rate in scabies and pediculosis  Single application is needed in most cases  No development of resistance
Lindane  Affects the nervous system  For head lice and scabies  Single treatment needed  Efficacy is lower than Permethrin  Both Lice and mites can develop resistance to Lindane  Lindane + Benzylbenzoate  avoids resistance ,improves the cure rate to 100%  Systemic toxicity
Benzyl Benzoate  Aromatic  Scabies  Convenient  CI in children  2nd choice for scabies  Not used for pediculosis
Crotamiton  Effective scabicide , pediculocide , anti pruritic  Preferred in children
Ivermectin  Antihelminthic drug  Scabies and pediculosis  Only orally, administered drug for ectoparasites  0.2 mg / kg - single dose  AIDS patient with scabies also respond  CI – children , 5 yrs  CI in pregnancy and lactation  First line for scabies and pediculosis

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Ectoparasiticides

  • 1. Ectoparasiticides Used to kill parasites that live on the body surface
  • 2. 1. Lice – Pediculus wingless insects 2. Mites – Sarcoptes /Acrus scabiei
  • 3. Drugs Permethrin  Lindane (BHC)  Benzyl Benzoate  Crotamiton  Sulfur  Dicophane (DDT)  Ivermectin
  • 4. Permethrin  Most convenient drug for scabies and lice  Delayed depolarization  neurological paralysis in insects  Minimal systemic absorption  Nearly 100% cure rate in scabies and pediculosis  Single application is needed in most cases  No development of resistance
  • 5. Lindane  Affects the nervous system  For head lice and scabies  Single treatment needed  Efficacy is lower than Permethrin  Both Lice and mites can develop resistance to Lindane  Lindane + Benzylbenzoate  avoids resistance ,improves the cure rate to 100%  Systemic toxicity
  • 6. Benzyl Benzoate  Aromatic  Scabies  Convenient  CI in children  2nd choice for scabies  Not used for pediculosis
  • 7. Crotamiton  Effective scabicide , pediculocide , anti pruritic  Preferred in children
  • 8. Ivermectin  Antihelminthic drug  Scabies and pediculosis  Only orally, administered drug for ectoparasites  0.2 mg / kg - single dose  AIDS patient with scabies also respond  CI – children , 5 yrs  CI in pregnancy and lactation  First line for scabies and pediculosis