DNA-dependent protein kinase activity is not required for immunoglobulin class switching (Q36371923)

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English	DNA-dependent protein kinase activity is not required for immunoglobulin class switching	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

DNA-dependent protein kinase activity is not required for immunoglobulin class switching (English)

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

author name string

Gayle C Bosma

1

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Jiyoon Kim

2

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Teresa Urich

3

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Donna M Fath

4

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Maria G Cotticelli

5

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Norman R Ruetsch

6

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Marko Z Radic

7

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Melvin J Bosma

8

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

language of work or name

0 references

publication date

1 December 2002

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

196

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

11

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

1483-1495

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

Synapsis of DNA ends by DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Emerging links between hypermutation of antibody genes and DNA polymerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Mechanism and control of class-switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA double-strand breaks: signaling, repair and the cancer connection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA double strand break repair in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Regulation of anti-DNA B cells in recombination-activating gene-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Antibody class switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Gene conversion and homologous recombination in murine B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

B cell differentiation and isotype switching is related to division cycle number

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA sequences at immunoglobulin switch region recombination sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Characterization of broken DNA molecules associated with V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Light chain replacement: a new model for antibody gene rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Cell cycle regulation of immunoglobulin class switch recombination and germ-line transcription: potential role of Ets family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Somatic hypermutation: how many mechanisms diversify V region sequences?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Somatic generation of antibody diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Evidence of functional lymphocytes in some (leaky) scid mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Differential regulation of IgG1 and IgE synthesis by interleukin 4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

A DNA-activated protein kinase from HeLa cell nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Copy choice mechanism of immunoglobulin heavy-chain switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

The SCID mouse mutant: definition, characterization, and potential uses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Formation and resolution of double-strand break intermediates in V(D)J rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

30 September 2017

Ku80 is required for immunoglobulin isotype switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Nucleotide sequences of switch regions of immunoglobulin C epsilon and C gamma genes and their comparison

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Cell cycle kinetics model of LPS-stimulated spleen cells correlates switch region rearrangements with S phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

DNA sequence of the murine gamma 1 switch segment reveals novel structural elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Analysis of the defect in DNA end joining in the murine scid mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

28 June 2018

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

21 September 2018

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2194268

21 September 2018

Ig heavy chain class switching in Rag-deficient mice

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20001871

21 January 2018

Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20001871

21 January 2018

Origin of Antibody Variation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20001871

21 January 2018

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD43 (S7) expression identifies peripheral B cell subsets

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation to IgG secretion by lipopolysaccharide requires several proliferation cycles

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of DNA-Dependent Protein Kinase Holoenzyme Upon Induction of Lymphocyte Differentiation and V(D)J Recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of anti-single-stranded DNA B cells in a non-autoimmune background

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The murine IgG1/IgE class switch program

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-4 induction of IgE class switching by lipopolysaccharide-activated murine B cells occurs predominantly through sequential switching

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12461083

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20001871

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

13 August 2017

ResearchGate publication ID

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