{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T04:19:08Z","timestamp":1726460348920},"reference-count":40,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Intelligence in Medicine"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.artmed.2005.01.009","type":"journal-article","created":{"date-parts":[[2005,8,10]],"date-time":"2005-08-10T10:08:39Z","timestamp":1123668519000},"page":"61-73","source":"Crossref","is-referenced-by-count":10,"title":["Efficient RNAi-based gene family knockdown via set cover optimization"],"prefix":"10.1016","volume":"35","author":[{"given":"Wenzhong","family":"Zhao","sequence":"first","affiliation":[]},{"given":"M. Leigh","family":"Fanning","sequence":"additional","affiliation":[]},{"given":"Terran","family":"Lane","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.artmed.2005.01.009_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1439-7633(20010401)2:4<239::AID-CBIC239>3.0.CO;2-R","article-title":"RNA interference and small interfering RNAs","volume":"2","author":"Tuschl","year":"2001","journal-title":"Chembiochem"},{"key":"10.1016\/j.artmed.2005.01.009_bib2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/418244a","article-title":"RNA interference","volume":"418","author":"Hannon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.artmed.2005.01.009_bib3","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1126\/science.1069132","article-title":"RNA-dependent RNA polymerases, viruses, and RNA silencing","volume":"296","author":"Ahlquist","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.artmed.2005.01.009_bib4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1126\/science.1072148","article-title":"RNA silencing: the genome\u2019s immune system.","author":"Plasterk","year":"2002","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.artmed.2005.01.009_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/MMBR.67.4.657-685.2003","article-title":"RNA interference: biology, mechanism, and applications","volume":"67","author":"Agrawal","year":"2003","journal-title":"Microbiol Mol Biol Reviews"},{"key":"10.1016\/j.artmed.2005.01.009_bib6","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature00896","article-title":"Modulation of HIV-1 replication by RNA interference","volume":"418","author":"Jacque","year":"2002","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.artmed.2005.01.009_bib7","doi-asserted-by":"crossref","first-page":"12963","DOI":"10.1128\/JVI.76.24.12963-12973.2002","article-title":"RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication","volume":"76","author":"Surabhi","year":"2002","journal-title":"J Virol"},{"key":"10.1016\/j.artmed.2005.01.009_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","article-title":"Therapeutic silencing of an endogenous gene by systemic administration of modified sirnas","volume":"432","author":"Soutscheck","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.artmed.2005.01.009_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nm1076","article-title":"RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia","volume":"10","author":"Xia","year":"2004","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.artmed.2005.01.009_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1535-6108(02)00129-0","article-title":"Blocking oncogenes in malignant cells by RNA interference \u2014 new hope for a highly specific cancer treatment?","volume":"2","author":"Borkhardt","year":"2002","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.artmed.2005.01.009_bib11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/07853890410018817","article-title":"Development of gene-specific double-stranded RNA drugs","volume":"36","author":"Barik","year":"2004","journal-title":"Ann Med"},{"issue":"11","key":"10.1016\/j.artmed.2005.01.009_bib12","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1073\/pnas.1037853100","article-title":"Genomewide view of gene silencing by small interfering RNAs","volume":"100","author":"Chi","year":"2003","journal-title":"PNAS"},{"key":"10.1016\/j.artmed.2005.01.009_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.artmed.2005.01.009_bib14","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/nar\/gkh238","article-title":"A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens","volume":"32","author":"Hsieh","year":"2004","journal-title":"Nucleic Acid Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib15","first-page":"32","article-title":"siRNA: enhanced functionality through relational design and chemical modification","author":"Karpilow","year":"2004","journal-title":"PharmaGenomics"},{"key":"10.1016\/j.artmed.2005.01.009_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1287\/moor.4.3.233","article-title":"A greedy heuristic for the set covering problem","volume":"4","author":"Chvatal","year":"1979","journal-title":"Math Oper Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1126\/science.1088069","article-title":"Diversification of Ig superfamily genes in an invertebrate","volume":"305","author":"Zhang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.artmed.2005.01.009_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.gene.2004.07.003","article-title":"Representation of an immune responsive gene family encoding fibrinogen-related proteins in the freshwater mollusc Biomphalaria glabrata, an intermediate host for Schistosoma mansoni","volume":"341","author":"Zhang","year":"2004","journal-title":"Gene"},{"key":"10.1016\/j.artmed.2005.01.009_bib19","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/(SICI)1521-1878(199912)22:1<1011::AID-BIES5>3.0.CO;2-V","article-title":"Chemosensory signaling in C. elegans","volume":"21","author":"Troemel","year":"1999","journal-title":"BioEssays"},{"key":"10.1016\/j.artmed.2005.01.009_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1101\/gad.862301","article-title":"RNA interfernce is mediated by 21- and 22-nucleotide RNAs","volume":"15","author":"Elbashir","year":"2001","journal-title":"Gene Dev"},{"issue":"3","key":"10.1016\/j.artmed.2005.01.009_bib21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt936","article-title":"Rational siRNA design for RNA interference","volume":"22","author":"Reynolds","year":"2004","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.artmed.2005.01.009_bib22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2004.06.116","article-title":"A comparison of siRNA efficacy predictors","volume":"321","author":"Satrom","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.artmed.2005.01.009_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1046-2023(02)00023-3","article-title":"Analysis of gene function in somatic mammalian cells using small interfering RNAs","volume":"26","author":"Elbashir","year":"2002","journal-title":"Methods"},{"key":"10.1016\/j.artmed.2005.01.009_bib24","doi-asserted-by":"crossref","first-page":"W135","DOI":"10.1093\/nar\/gkh449","article-title":"Sfold web server for statistical folding and rational design of nucleic acids.","volume":"32","author":"Ding","year":"2004","journal-title":"Nucleic Acid Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib25","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkh366","article-title":"siRNA selection server: an automated sirna oligonucleotide prediction server","volume":"32","author":"Yuan","year":"2004","journal-title":"Nucleic Acid Res"},{"year":"1979","series-title":"Computers and intractability: a guide to the theory of NP-completeness","author":"Garey","key":"10.1016\/j.artmed.2005.01.009_bib26"},{"key":"10.1016\/j.artmed.2005.01.009_bib27","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbrc.2004.04.027","article-title":"The gene-silensing efficacy of siRNA is strongly dependent on the local structure of mRNA at the targeted region","volume":"318","author":"Luo","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.artmed.2005.01.009_bib28","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/nar\/gkh314","article-title":"T Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silensing efficacy using Eulerian graph representation of siRNA","volume":"32","author":"Pancoska","year":"2004","journal-title":"Nucleic Acid Res"},{"year":"1994","series-title":"Synthesis and optimization of digital circuits","author":"De Micheli","key":"10.1016\/j.artmed.2005.01.009_bib29"},{"key":"10.1016\/j.artmed.2005.01.009_bib30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1287\/opre.44.6.875","article-title":"A dynamic subgradient-based branch-and-bound procedure for set covering","volume":"44","author":"Balas","year":"1996","journal-title":"Oper Res"},{"issue":"2","key":"10.1016\/j.artmed.2005.01.009_bib31","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0167-6377(89)90002-3","article-title":"A probabilistic heuristic for a computationally difficult set covering problem","volume":"8","author":"Feo","year":"1989","journal-title":"Oper Res Lett"},{"key":"10.1016\/j.artmed.2005.01.009_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0377-2217(87)90141-X","article-title":"An algorithm for set covering problems","volume":"31","author":"Beasley","year":"1987","journal-title":"Eur J Oper Res"},{"issue":"2","key":"10.1016\/j.artmed.2005.01.009_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1287\/inte.15.2.10","article-title":"An application oriented guide to lagrangian relaxation","volume":"15","author":"Fisher","year":"1985","journal-title":"Interfaces"},{"key":"10.1016\/j.artmed.2005.01.009_bib34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01581106","article-title":"A lagrangian-based heuristic for large-scale set covering problems","volume":"81","author":"Ceria","year":"1998","journal-title":"Math Program"},{"key":"10.1016\/j.artmed.2005.01.009_bib35","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1287\/opre.47.5.730","article-title":"A heuristic method for the set covering problem","volume":"47","author":"Caprara","year":"1999","journal-title":"Oper Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/0377-2217(95)00159-X","article-title":"A genetic algorithm for the set covering problem","volume":"94","author":"Beasley","year":"1996","journal-title":"Eur J Oper Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib37","series-title":"Proceedings of the Operational Research","first-page":"175","article-title":"A genetic algorithm with a non-binary representation for the set covering problem","author":"Eremeev","year":"1998"},{"key":"10.1016\/j.artmed.2005.01.009_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1023\/A:1019225027893","article-title":"Algorithm for the set covering problem","volume":"98","author":"Caprara","year":"2000","journal-title":"Ann Oper Res"},{"key":"10.1016\/j.artmed.2005.01.009_bib39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF01096763","article-title":"Greedy randomized adaptive search procedures","volume":"6","author":"Feo","year":"1995","journal-title":"J Glob Optim"},{"key":"10.1016\/j.artmed.2005.01.009_bib40","unstructured":"The Sanger Institute. From Wormbase\u2014the C. elegans genome database, http:\/\/www.wormbase.org\/, 2004."}],"container-title":["Artificial Intelligence in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093336570500059X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S093336570500059X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T15:57:22Z","timestamp":1548259042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S093336570500059X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":40,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S093336570500059X"],"URL":"https:\/\/doi.org\/10.1016\/j.artmed.2005.01.009","relation":{},"ISSN":["0933-3657"],"issn-type":[{"type":"print","value":"0933-3657"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}