{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:58:13Z","timestamp":1763726293228,"version":"3.37.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Statistics & Data Analysis"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.csda.2009.04.017","type":"journal-article","created":{"date-parts":[[2009,5,14]],"date-time":"2009-05-14T08:47:37Z","timestamp":1242290857000},"page":"3907-3915","source":"Crossref","is-referenced-by-count":5,"title":["Population pharmacokinetic\/pharmacodynamic mixture models via maximum a posteriori estimation"],"prefix":"10.1016","volume":"53","author":[{"given":"Xiaoning","family":"Wang","sequence":"first","affiliation":[]},{"given":"Alan","family":"Schumitzky","sequence":"additional","affiliation":[]},{"given":"David Z.","family":"D\u2019Argenio","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"year":"2001","series-title":"Bayesian Theory, Section 5.3.2","author":"Bernardo","key":"10.1016\/j.csda.2009.04.017_b1"},{"key":"10.1016\/j.csda.2009.04.017_b2","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.csda.2007.04.005","article-title":"Model-based clustering for longitudinal data","volume":"52","author":"Cruz-Mes\u00eda","year":"2008","journal-title":"Comput. Stat. Data Anal."},{"key":"10.1016\/j.csda.2009.04.017_b3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","article-title":"Maximum likelihood from incomplete data via the EM algorithm","volume":"39","author":"Dempster","year":"1977","journal-title":"J. Roy. Statist. Soc. B"},{"key":"10.1016\/j.csda.2009.04.017_b4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.286.5439.487","article-title":"Pharmacogenomics: Translating functional genomics into rational therapeutics","volume":"286","author":"Evans","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.csda.2009.04.017_b5","doi-asserted-by":"crossref","unstructured":"Fraley, C., Raftery, A.E., 2005. Bayesian regularization for Normal mixture estimation and model-based clustering. Technical Report No. 486, Department of Statistics, University of Washington. http:\/\/handle.dtic.mil\/100.2\/ADA454825","DOI":"10.21236\/ADA454825"},{"key":"10.1016\/j.csda.2009.04.017_b6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2307\/2289776","article-title":"Sampling-based approaches to calculating marginal densities","volume":"85","author":"Gelfand","year":"1990","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.csda.2009.04.017_b7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2307\/2530529","article-title":"Bayesian approach to the analysis of nonlinear models: Implementation and evaluation","volume":"37","author":"Katz","year":"1981","journal-title":"Biometrics"},{"key":"10.1016\/j.csda.2009.04.017_b8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10928-006-9038-9","article-title":"Mixture models and subpopulation classification: A pharmacokinetic simulation study and application to metoprolol CYP2D6 phenotype","volume":"34","author":"Kaila","year":"2007","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.csda.2009.04.017_b9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10928-006-9039-8","article-title":"Mixture modeling for the detection of subpopulations in a pharmacokinetic\/pharmacodynamic analysis","volume":"34","author":"Lemenuel-diot","year":"2006","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.csda.2009.04.017_b10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1020206907668","article-title":"Bayesian analysis of population PK\/PD models: General concepts and software","volume":"29","author":"Lunn","year":"2002","journal-title":"J. Pharmacokin. Pharmacodyn."},{"key":"10.1016\/j.csda.2009.04.017_b11","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/biomet\/84.2.429","article-title":"Optimal design in random effect regression models","volume":"84","author":"Mentr\u00e9","year":"1997","journal-title":"Biometrika"},{"key":"10.1016\/j.csda.2009.04.017_b12","unstructured":"Minka, T., 2000. Old and new matrix algebra useful for statistics. MIT Media Lab. http:\/\/research.microsoft.com\/minka\/papers\/matrix"},{"key":"10.1016\/j.csda.2009.04.017_b13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1109\/72.701177","article-title":"Averaging, maximum penalized likelihood and Bayesian estimation for improving Gaussian mixture probability density estimates","volume":"9","author":"Ormoneit","year":"1998","journal-title":"IEEE Trans. Neural Netw."},{"key":"10.1016\/j.csda.2009.04.017_b14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.0006-341X.2000.00464.x","article-title":"A mixture model for longitudinal data with application to assessment of noncompliance","volume":"56","author":"Pauler","year":"2000","journal-title":"Biometrics"},{"key":"10.1016\/j.csda.2009.04.017_b15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02504623","article-title":"Asymptotic normality of the maximum likelihood estimate in the independent but not identically distributed case","volume":"27","author":"Philppou","year":"1975","journal-title":"Ann. Inst. Stat. Math."},{"key":"10.1016\/j.csda.2009.04.017_b16","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2307\/2530972","article-title":"A Bayesian approach to non-linear random effects models","volume":"41","author":"Racine-Poon","year":"1985","journal-title":"Biometrics"},{"key":"10.1016\/j.csda.2009.04.017_b17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1025784113869","article-title":"Bayesian population pharmacokinetic and pharmacodynamic analyses using mixture models","volume":"2","author":"Rosner","year":"1997","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.csda.2009.04.017_b18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.7326\/0003-4819-82-5-619","article-title":"Improved computer assisted digoxin therapy: A method using feedback of measured serum digoxin concentrations","volume":"82","author":"Sheiner","year":"1975","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.csda.2009.04.017_b19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1287\/moor.1030.0073","article-title":"An analysis of the EM algorithm and entropy-like proximal point methods","volume":"29","author":"Tseng","year":"2005","journal-title":"Math. Oper. Res."},{"key":"10.1016\/j.csda.2009.04.017_b20","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2307\/2986121","article-title":"Bayesian analysis of linear and non-linear population models by using the Gibbs sampler","volume":"43","author":"Wakefield","year":"1994","journal-title":"Appl. Stat."},{"key":"10.1016\/j.csda.2009.04.017_b21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1025736230707","article-title":"Bayesian nonparametric population models: formulation and comparison with likelihood approaches","volume":"25","author":"Wakefield","year":"1997","journal-title":"J. Pharmacokinet. Biopharm."},{"key":"10.1016\/j.csda.2009.04.017_b22","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.csda.2007.03.008","article-title":"Nonlinear random effects mixture models: Maximum likelihood estimation via the EM algorithm","volume":"51","author":"Wang","year":"2007","journal-title":"Comput. Stat. Data Anal."},{"year":"1994","series-title":"Estimation, Inference and Specification Analysis","author":"White","key":"10.1016\/j.csda.2009.04.017_b23"},{"key":"10.1016\/j.csda.2009.04.017_b24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1214\/aos\/1176346060","article-title":"On the convergence properties of the EM algorithm","volume":"11","author":"Wu","year":"1983","journal-title":"Ann. Stat."}],"container-title":["Computational Statistics & Data Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167947309001649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167947309001649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T11:48:32Z","timestamp":1739101712000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167947309001649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0167947309001649"],"URL":"https:\/\/doi.org\/10.1016\/j.csda.2009.04.017","relation":{},"ISSN":["0167-9473"],"issn-type":[{"type":"print","value":"0167-9473"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}