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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>We detect and interactively visualize occurrence, frequency, sequence, and clustering of extraintestinal manifestations (EIM) and associated immune disorders (AID) in 30,334 inflammatory bowel disease (IBD) patients (Crohn\u2019s disease (CD) <jats:italic>n<\/jats:italic>\u2009=\u200915924, ulcerative colitis (UC) <jats:italic>n<\/jats:italic>\u2009=\u200911718, IBD unclassified, IBD-U <jats:italic>n<\/jats:italic>\u2009=\u20092692, 52% female, median age 40 years (IQR: 25)) with artificial intelligence (AI). 57% (CD\u2009&gt;\u2009UC 60% vs. 54%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) had one or more EIM and\/or AID. Mental, musculoskeletal and genitourinary disorders were most frequently associated with IBD: 18% (CD vs. UC 19% vs. 16%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), 17% (CD vs. UC 20% vs. 15%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001) and 11% (CD vs. UC 13% vs. 9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), respectively. AI detected 4 vs. 5 vs. 5 distinct EIM\/AID communities with 420 vs. 396 vs. 467 nodes and 11,492 vs. 9116 vs. 16,807 edges (links) in CD vs. UC vs. IBD, respectively. Our newly developed interactive free web app shows previously unknown communities, relationships, and temporal patterns\u2014the diseasome and interactome.<\/jats:p>","DOI":"10.1038\/s41746-025-01504-6","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T18:26:06Z","timestamp":1744741566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn\u2019s disease and ulcerative colitis"],"prefix":"10.1038","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-507X","authenticated-orcid":false,"given":"Daniel C.","family":"Baumgart","sequence":"first","affiliation":[]},{"given":"C. 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