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Med."],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Infectious disease specialists (IDS) improve outcomes of patients with Staphylococcus bacteremia, but immediate IDS access is not always guaranteed. We investigated whether a care-integrated computerized decision support system (CDSS) can safely enhance the standard of care (SOC) for these patients. We conducted a multicenter, noninferiority, interventional stepped-wedge cluster randomized controlled trial relying on the data integration centers at five university hospitals. By this means, electronic medical records can be used for part of the trial documentation. We analyzed 5056 patients from 134 wards (<jats:italic>Staphylococcus<\/jats:italic>\n            <jats:italic>aureus<\/jats:italic> (SAB): <jats:italic>n<\/jats:italic>\u2009=\u2009812, coagulase-negative staphylococci (CoNS): <jats:italic>n<\/jats:italic>\u2009=\u20094244) and found that the CDSS was noninferior to the SOC for hospital mortality in all patients. Noninferiority regarding the 90-day mortality\/relapse in SAB patients was not observed and there was no evidence for differences in vancomycin usage among CoNS patients. Despite low reported usage, physicians rated the CDSS\u2019s usability favorably. <jats:bold>Trial registration<\/jats:bold>: drks.de; Identifier: DRKS00014320; Registration Date: 2019-05-06.<\/jats:p>","DOI":"10.1038\/s41746-025-01569-3","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T09:16:43Z","timestamp":1743153403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Leveraging electronic medical records to evaluate a computerized decision support system for staphylococcus 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K\u00f6hler Chemie, MSD, Novartis, Roche, Pfizer, Sanofi, Takeda, TEVA, Tillotts Pharma and UCB. OW is supported by an unrestricted grant from the Rudolf-Ackermann-Stiftung (Stiftung f\u00fcr Klinische Infektiologie). MPl has received speaker fees and honoraria from MSD, Pfizer, GSK, Gilad, Thermo Fisher, Infectopharm, Roche and BioNtech and has received a Pfizer grant for a study on CAP. SH has received speaker fees from Pfizer, MSD, Infectopharm, Philips, Advanz, Beckman Coulter, Shionogi, and Tillots. G.M. has received speaker fees and honoraria from M\u00e4rz AG, BBraun Melsungen and 4TEEN4. The remaining authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"180"}}