{"id":"https://openalex.org/W6929448403","doi":"https://doi.org/10.48550/arxiv.2407.18492","title":"Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas","display_name":"Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas","publication_year":2024,"publication_date":"2024-07-26","ids":{"openalex":"https://openalex.org/W6929448403","doi":"https://doi.org/10.48550/arxiv.2407.18492"},"language":"en","primary_location":{"id":"doi:10.48550/arxiv.2407.18492","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2407.18492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"type":"preprint","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.48550/arxiv.2407.18492","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Feng, Yu","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Feng, Yu","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zeng, Weiming","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zeng, Weiming","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xie, Yifan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xie, Yifan","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Chen, Hongyu","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Hongyu","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wang, Lei","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Lei","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wang, Yingying","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Yingying","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yan, Hongjie","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan, Hongjie","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhang, Kaile","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Kaile","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tao, Ran","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tao, Ran","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Siok, Wai Ting","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Siok, Wai Ting","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Wang, Nizhuan","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wang, Nizhuan","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7694000005722046,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7694000005722046,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.661300003528595},{"id":"https://openalex.org/keywords/negative-emotion","display_name":"Negative emotion","score":0.46000000834465027},{"id":"https://openalex.org/keywords/parahippocampal-gyrus","display_name":"Parahippocampal gyrus","score":0.40869998931884766},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.4007999897003174},{"id":"https://openalex.org/keywords/neural-correlates-of-consciousness","display_name":"Neural correlates of consciousness","score":0.36469998955726624},{"id":"https://openalex.org/keywords/functional-neuroimaging","display_name":"Functional neuroimaging","score":0.3646000027656555},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.3578000068664551},{"id":"https://openalex.org/keywords/affective-neuroscience","display_name":"Affective neuroscience","score":0.3447999954223633}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.661300003528595},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6085000038146973},{"id":"https://openalex.org/C3020014160","wikidata":"https://www.wikidata.org/wiki/Q6987190","display_name":"Negative emotion","level":2,"score":0.46000000834465027},{"id":"https://openalex.org/C2778048536","wikidata":"https://www.wikidata.org/wiki/Q1545429","display_name":"Parahippocampal gyrus","level":4,"score":0.40869998931884766},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.4007999897003174},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.397599995136261},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.3646000027656555},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C14855644","wikidata":"https://www.wikidata.org/wiki/Q3625500","display_name":"Affective neuroscience","level":3,"score":0.3447999954223633},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.3285999894142151},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C2911163904","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional Brain Imaging","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C2777438025","wikidata":"https://www.wikidata.org/wiki/Q1339090","display_name":"Emotion recognition","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2986949344","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Neural system","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48550/arxiv.2407.18492","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2407.18492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.48550/arxiv.2407.18492","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2407.18492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"score":0.42562201619148254,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Although":[1],"it":[2,44],"has":[3],"been":[4],"noticed":[5],"that":[6,115],"depressed":[7,120,144,199],"patients":[8,98,121,145],"show":[9],"differences":[10,142,174],"in":[11,74,78,96,149,207,224,240],"processing":[12],"emotions,":[13],"the":[14,48,79,116,134,154,158,169,179,192,201,213],"precise":[15],"neural":[16,49],"modulation":[17,218,239],"mechanisms":[18],"of":[19,51,81,119,198,237],"positive":[20,70,82],"and":[21,39,71,86,102,125,146,163,185,196,219,227,246],"negative":[22,72,87],"emotions":[23,73],"remain":[24],"elusive.":[25],"FMRI":[26],"is":[27],"a":[28,129],"cutting-edge":[29],"medical":[30],"imaging":[31],"technology":[32],"renowned":[33],"for":[34,47,244],"its":[35],"high":[36],"spatial":[37],"resolution":[38],"dynamic":[40],"temporal":[41],"information,":[42],"making":[43],"particularly":[45],"suitable":[46],"dynamics":[50],"depression":[52,97,230],"research.":[53],"Methods:":[54],"To":[55],"address":[56],"this":[57],"gap,":[58],"our":[59,235],"study":[60],"firstly":[61],"leveraged":[62],"fMRI":[63],"to":[64,133,191],"delineate":[65],"activated":[66],"regions":[67],"associated":[68],"with":[69,242],"healthy":[75,147],"individuals,":[76],"resulting":[77],"creation":[80],"emotion":[83,88,217,238],"atlas":[84,89],"(PEA)":[85],"(NEA).":[90],"Subsequently,":[91],"we":[92],"examined":[93],"neuroimaging":[94],"changes":[95],"using":[99],"these":[100],"atlases":[101],"evaluated":[103],"their":[104],"diagnostic":[105],"performance":[106],"based":[107,122],"on":[108,123,157],"machine":[109],"learning.":[110],"Results:":[111],"Our":[112],"findings":[113,211],"demonstrate":[114],"classification":[117],"accuracy":[118],"PEA":[124,170,226],"NEA":[126,228],"exceeded":[127],"0.70,":[128],"notable":[130],"improvement":[131],"compared":[132],"whole-brain":[135],"atlases.":[136],"Furthermore,":[137],"ALFF":[138],"analysis":[139],"unveiled":[140],"significant":[141,222],"between":[143,216],"controls":[148],"eight":[150],"functional":[151],"clusters":[152],"during":[153],"NEA,":[155],"focusing":[156],"left":[159],"cuneus,":[160],"cingulate":[161],"gyrus,":[162,182,184],"superior":[164],"parietal":[165,187],"lobule.":[166,188],"In":[167],"contrast,":[168],"revealed":[171],"more":[172],"pronounced":[173],"across":[175],"fifteen":[176],"clusters,":[177],"involving":[178],"right":[180],"fusiform":[181],"parahippocampal":[183],"inferior":[186],"Limitations:":[189],"Due":[190],"limited":[193],"sample":[194],"size":[195],"subtypes":[197],"patients,":[200],"efficacy":[202],"may":[203],"need":[204],"further":[205],"validation":[206],"future.":[208],"Conclusions:":[209],"These":[210],"emphasize":[212],"complex":[214],"interplay":[215],"depression,":[220,241],"showcasing":[221],"alterations":[223],"both":[225],"among":[229],"patients.":[231],"This":[232],"research":[233],"enhances":[234],"understanding":[236],"implications":[243],"diagnosis":[245],"treatment":[247],"evaluation.":[248]},"counts_by_year":[],"updated_date":"2025-11-06T06:51:31.235846","created_date":"2025-10-10T00:00:00"}