{"id":"https://openalex.org/W4406167405","doi":"https://doi.org/10.1016/j.compbiomed.2024.109642","title":"Brain tumour histopathology through the lens of deep learning: A systematic review","display_name":"Brain tumour histopathology through the lens of deep learning: A systematic review","publication_year":2025,"publication_date":"2025-01-08","ids":{"openalex":"https://openalex.org/W4406167405","doi":"https://doi.org/10.1016/j.compbiomed.2024.109642","pmid":"https://pubmed.ncbi.nlm.nih.gov/39787663"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2024.109642","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109642","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiomed.2024.109642","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044140645","display_name":"Chun Kiet Vong","orcid":null},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I39854758","display_name":"Auckland University of Technology","ror":"https://ror.org/01zvqw119","country_code":"NZ","type":"education","lineage":["https://openalex.org/I39854758"]},{"id":"https://openalex.org/I4210151947","display_name":"Brain Research New Zealand","ror":"https://ror.org/04m9wnx11","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I4210151947"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Chun Kiet Vong","raw_affiliation_strings":["Auckland Bioengineering Institute, The University of Auckland, New Zealand; Centre for Brain Research, The University of Auckland, New Zealand"],"raw_orcid":"https://orcid.org/0000-0001-9243-3038","affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand; Centre for Brain Research, The University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210151947","https://openalex.org/I39854758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021051118","display_name":"Alan Wang","orcid":"https://orcid.org/0000-0003-1610-2397"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I39854758","display_name":"Auckland University of Technology","ror":"https://ror.org/01zvqw119","country_code":"NZ","type":"education","lineage":["https://openalex.org/I39854758"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Alan Wang","raw_affiliation_strings":["Auckland Bioengineering Institute, The University of Auckland, New Zealand; Centre for Brain Research, The University of Auckland, New Zealand; Faculty of Medical and Health Sciences, The University of Auckland, New Zealand"],"raw_orcid":"https://orcid.org/0000-0003-1610-2397","affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand; Centre for Brain Research, The University of Auckland, New Zealand; Faculty of Medical and Health Sciences, The University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I39854758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043163123","display_name":"Mike Dragunow","orcid":null},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210151947","display_name":"Brain Research New Zealand","ror":"https://ror.org/04m9wnx11","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I4210151947"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Mike Dragunow","raw_affiliation_strings":["Centre for Brain Research, The University of Auckland, New Zealand; Department of Pharmacology, The Faculty of Medical and Health Sciences, The University of Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, The University of Auckland, New Zealand; Department of Pharmacology, The Faculty of Medical and Health Sciences, The University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210151947"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437010","display_name":"Thomas Park","orcid":"https://orcid.org/0000-0002-7995-8865"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I4210151947","display_name":"Brain Research New Zealand","ror":"https://ror.org/04m9wnx11","country_code":"NZ","type":"facility","lineage":["https://openalex.org/I4210151947"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Thomas I-H. Park","raw_affiliation_strings":["Centre for Brain Research, The University of Auckland, New Zealand; Department of Pharmacology, The Faculty of Medical and Health Sciences, The University of Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Brain Research, The University of Auckland, New Zealand; Department of Pharmacology, The Faculty of Medical and Health Sciences, The University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I4210151947"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000359126","display_name":"Vickie Shim","orcid":"https://orcid.org/0000-0002-1680-4287"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]},{"id":"https://openalex.org/I39854758","display_name":"Auckland University of Technology","ror":"https://ror.org/01zvqw119","country_code":"NZ","type":"education","lineage":["https://openalex.org/I39854758"]}],"countries":["NZ"],"is_corresponding":true,"raw_author_name":"Vickie Shim","raw_affiliation_strings":["Auckland Bioengineering Institute, The University of Auckland, New Zealand. Electronic address: v.shim@auckland.ac.nz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand. Electronic address: v.shim@auckland.ac.nz","institution_ids":["https://openalex.org/I154130895","https://openalex.org/I39854758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000359126"],"corresponding_institution_ids":["https://openalex.org/I154130895","https://openalex.org/I39854758"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":{"value":2610,"currency":"USD","value_usd":2610},"fwci":2.7643,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87414686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"186","issue":null,"first_page":"109642","last_page":"109642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.26759999990463257,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.09269999712705612,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histopathology","display_name":"Histopathology","score":0.8483584523200989},{"id":"https://openalex.org/keywords/lens","display_name":"Lens (geology)","score":0.5401031970977783},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4207971692085266},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.406511515378952},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.392853319644928},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.37109076976776123},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3664035201072693},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15143850445747375}],"concepts":[{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.8483584523200989},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5401031970977783},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4207971692085266},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.406511515378952},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.392853319644928},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.37109076976776123},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3664035201072693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15143850445747375},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiomed.2024.109642","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109642","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:39787663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39787663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.compbiomed.2024.109642","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2024.109642","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320801","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W1835905048","https://openalex.org/W1900291629","https://openalex.org/W1966803171","https://openalex.org/W1979172787","https://openalex.org/W1987681742","https://openalex.org/W2008263861","https://openalex.org/W2031604000","https://openalex.org/W2045280848","https://openalex.org/W2075583742","https://openalex.org/W2091712338","https://openalex.org/W2113942802","https://openalex.org/W2121396361","https://openalex.org/W2130511906","https://openalex.org/W2161289668","https://openalex.org/W2164675211","https://openalex.org/W2165553904","https://openalex.org/W2200290088","https://openalex.org/W2280351290","https://openalex.org/W2295309472","https://openalex.org/W2336951703","https://openalex.org/W2366536035","https://openalex.org/W2470130773","https://openalex.org/W2520107416","https://openalex.org/W2550409828","https://openalex.org/W2587828787","https://openalex.org/W2604338145","https://openalex.org/W2618999197","https://openalex.org/W2753870844","https://openalex.org/W2797624406","https://openalex.org/W2798643036","https://openalex.org/W2803405718","https://openalex.org/W2804047087","https://openalex.org/W2811121616","https://openalex.org/W2890911268","https://openalex.org/W2947160815","https://openalex.org/W2950387367","https://openalex.org/W2952317280","https://openalex.org/W2995682532","https://openalex.org/W2998401461","https://openalex.org/W2999083487","https://openalex.org/W3008837427","https://openalex.org/W3010168554","https://openalex.org/W3018227011","https://openalex.org/W3033946900","https://openalex.org/W3043484350","https://openalex.org/W3081495241","https://openalex.org/W3091990926","https://openalex.org/W3092790135","https://openalex.org/W3113444169","https://openalex.org/W3119640668","https://openalex.org/W3126609356","https://openalex.org/W3132927229","https://openalex.org/W3136979370","https://openalex.org/W3144323339","https://openalex.org/W3154431974","https://openalex.org/W3157774828","https://openalex.org/W3165840317","https://openalex.org/W3169293208","https://openalex.org/W3177525997","https://openalex.org/W3182041383","https://openalex.org/W3182740182","https://openalex.org/W3186288132","https://openalex.org/W3193532867","https://openalex.org/W3197282828","https://openalex.org/W4213418123","https://openalex.org/W4225982186","https://openalex.org/W4248502591","https://openalex.org/W4280536756","https://openalex.org/W4282579661","https://openalex.org/W4283076086","https://openalex.org/W4285733581","https://openalex.org/W4287844213","https://openalex.org/W4291021272","https://openalex.org/W4292136387","https://openalex.org/W4292212642","https://openalex.org/W4293193031","https://openalex.org/W4293330295","https://openalex.org/W4294215472","https://openalex.org/W4310863344","https://openalex.org/W4390582732","https://openalex.org/W4390741901","https://openalex.org/W6679331151","https://openalex.org/W6687627716","https://openalex.org/W6697140671","https://openalex.org/W6697722981","https://openalex.org/W6720260345","https://openalex.org/W6791758887","https://openalex.org/W6841932043","https://openalex.org/W6842722106","https://openalex.org/W6847912000"],"related_works":["https://openalex.org/W3039419443","https://openalex.org/W4386772532","https://openalex.org/W4393212117","https://openalex.org/W2115661411","https://openalex.org/W2399391471","https://openalex.org/W2400254106","https://openalex.org/W2970729894","https://openalex.org/W4381996710","https://openalex.org/W4294739205","https://openalex.org/W4308553438"],"abstract_inverted_index":{"PROBLEM:":[0],"Machine":[1],"learning":[2,4],"(ML)/Deep":[3],"(DL)":[5],"techniques":[6,46],"have":[7,47,156],"been":[8,18,157],"evolving":[9],"to":[10,32,42,109,116,136,185,202,210,225,228,234],"solve":[11],"more":[12,159],"complex":[13,35],"diseases,":[14],"but":[15],"it":[16,106],"has":[17],"used":[19,85,166],"relatively":[20],"little":[21],"in":[22,57,111,121,130,167],"Glioblastoma":[23],"(GBM)":[24],"histopathological":[25,54,87,208],"studies,":[26],"which":[27],"could":[28],"benefit":[29],"greatly":[30],"due":[31],"the":[33,49,66,75,91,103,112,131,171,231,236,243],"disease's":[34],"pathogenesis.":[36],"AIM:":[37],"Conduct":[38],"a":[39,179,195],"systematic":[40],"review":[41],"investigate":[43],"how":[44],"ML/DL":[45,95,104,134,164,200,232],"influenced":[48],"progression":[50],"of":[51,77,82,90,94,119,182],"brain":[52,78],"tumour":[53],"research,":[55],"particularly":[56],"GBM.":[58],"METHODS:":[59],"54":[60],"eligible":[61,132],"studies":[62,129,155,183],"were":[63,114],"collected":[64],"from":[65],"PubMed":[67],"and":[68,71,96,99,102,174,188,207,239,241],"ScienceDirect":[69],"databases,":[70],"their":[72],"information":[73],"about":[74],"types":[76,81,93],"tumour/s":[79],"used,":[80],"-omics":[83,148],"data":[84,146,209],"with":[86,147],"data,":[88,92],"origins":[89],"its":[97],"training":[98,187],"evaluation":[100],"methodologies,":[101],"task":[105],"was":[107],"set":[108],"perform":[110],"study":[113],"extracted":[115],"inform":[117],"us":[118],"trends":[120],"GBM-related":[122,128,168],"ML/DL-based":[123],"research.":[124],"RESULTS:":[125],"Only":[126],"8":[127],"utilised":[133],"methodologies":[135,190,233],"gain":[137],"deeper":[138],"insights":[139,213],"into":[140,214],"GBM":[141,218],"pathogenesis":[142],"by":[143],"contextualising":[144],"histological":[145],"data.":[149],"However,":[150],"we":[151],"report":[152,230],"that":[153],"these":[154],"published":[158],"recently.":[160],"The":[161],"most":[162],"popular":[163],"models":[165,244],"research":[169,219],"are":[170,245],"SVM":[172],"classifier":[173],"ResNet-based":[175],"CNN":[176],"architecture.":[177],"Still,":[178],"considerable":[180],"number":[181],"failed":[184],"state":[186],"evaluative":[189],"clearly.":[191],"CONCLUSION:":[192],"There":[193],"is":[194],"growing":[196],"trend":[197],"towards":[198],"using":[199],"approaches":[201],"uncover":[203],"relationships":[204],"between":[205],"biological":[206],"bring":[211],"new":[212],"GBM,":[215],"thus":[216],"pushing":[217],"forward.":[220],"Much":[221],"work":[222],"still":[223],"needs":[224],"be":[226],"done":[227],"properly":[229],"showcase":[235],"models'":[237],"robustness":[238],"generalizability":[240],"ensure":[242],"reproducible.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}