{"id":"https://openalex.org/W4400932644","doi":"https://doi.org/10.1093/bib/bbae357","title":"Comparative analyses of gene networks mediating cancer metastatic potentials across lineage types","display_name":"Comparative analyses of gene networks mediating cancer metastatic potentials across lineage types","publication_year":2024,"publication_date":"2024-05-23","ids":{"openalex":"https://openalex.org/W4400932644","doi":"https://doi.org/10.1093/bib/bbae357","pmid":"https://pubmed.ncbi.nlm.nih.gov/39041189"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbae357","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae357","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae357/58609801/bbae357.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae357/58609801/bbae357.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100371324","display_name":"Sheng Wang","orcid":"https://orcid.org/0000-0003-4210-1670"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I180190047","display_name":"McCormick Theological Seminary","ror":"https://ror.org/033d6zz21","country_code":"US","type":"education","lineage":["https://openalex.org/I180190047"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sheng Wang","raw_affiliation_strings":["Department of Biomedical Engineering , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","Northwestern University , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60628, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","institution_ids":["https://openalex.org/I180190047"]},{"raw_affiliation_string":"Northwestern University , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60628, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067535832","display_name":"Emily K. Stroup","orcid":"https://orcid.org/0000-0001-8053-0295"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K Stroup","raw_affiliation_strings":["Department of Pharmacology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082439001","display_name":"Ting-You Wang","orcid":"https://orcid.org/0000-0003-4354-3198"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting-You Wang","raw_affiliation_strings":["Department of Urology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Department of Urology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States"],"raw_orcid":"https://orcid.org/0000-0003-4354-3198","affiliations":[{"raw_affiliation_string":"Department of Urology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Urology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074555821","display_name":"Rendong Yang","orcid":"https://orcid.org/0000-0002-9512-2240"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rendong Yang","raw_affiliation_strings":["Department of Urology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Department of Urology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Urology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029218568","display_name":"Zhe Ji","orcid":"https://orcid.org/0000-0002-1809-8099"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I180190047","display_name":"McCormick Theological Seminary","ror":"https://ror.org/033d6zz21","country_code":"US","type":"education","lineage":["https://openalex.org/I180190047"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Ji","raw_affiliation_strings":["Department of Biomedical Engineering , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","Department of Pharmacology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","Northwestern University , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States","Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60628, United States"],"raw_orcid":"https://orcid.org/0000-0002-1809-8099","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","institution_ids":["https://openalex.org/I180190047"]},{"raw_affiliation_string":"Department of Pharmacology , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University , Feinberg School of Medicine, , 303 E Superior Street, Chicago, IL 60611 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University , McCormick School of Engineering, , 2145 Sheridan Road, Evanston, IL 60628 , United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, United States","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60628, United States","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100371324"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I180190047"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.4453,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.63278187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"25","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7183499932289124},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7046114802360535},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6305605173110962},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.627673327922821},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6020346283912659},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5674406290054321},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.539240300655365},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5231912732124329},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4612810015678406},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.45513617992401123},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4215434491634369},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34231171011924744},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26688092947006226},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.20575791597366333}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7183499932289124},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7046114802360535},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6305605173110962},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.627673327922821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6020346283912659},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5674406290054321},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.539240300655365},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5231912732124329},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4612810015678406},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.45513617992401123},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4215434491634369},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34231171011924744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26688092947006226},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.20575791597366333}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbae357","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae357","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae357/58609801/bbae357.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:39041189","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39041189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11262869","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11262869","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11262869/pdf/bbae357.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbae357","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1093/bib/bbae357","pdf_url":"https://academic.oup.com/bib/article-pdf/25/4/bbae357/58609801/bbae357.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4300000071525574},{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G4173605594","display_name":null,"funder_award_id":"R01CA259388","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G533771145","display_name":null,"funder_award_id":"R35GM138192","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8001254711","display_name":null,"funder_award_id":"R01HL161389","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8523891126","display_name":null,"funder_award_id":"R00CA207865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4400932644.pdf","grobid_xml":"https://content.openalex.org/works/W4400932644.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1480336915","https://openalex.org/W1841961408","https://openalex.org/W1966327575","https://openalex.org/W1991110341","https://openalex.org/W2036008499","https://openalex.org/W2043398720","https://openalex.org/W2044702943","https://openalex.org/W2092180337","https://openalex.org/W2096283457","https://openalex.org/W2103017472","https://openalex.org/W2108068107","https://openalex.org/W2117692326","https://openalex.org/W2125789330","https://openalex.org/W2146373235","https://openalex.org/W2152310279","https://openalex.org/W2162142896","https://openalex.org/W2167715370","https://openalex.org/W2170989872","https://openalex.org/W2171115585","https://openalex.org/W2546514099","https://openalex.org/W2560367415","https://openalex.org/W2577490495","https://openalex.org/W2787091682","https://openalex.org/W2795989238","https://openalex.org/W2802787991","https://openalex.org/W2803345042","https://openalex.org/W2898830231","https://openalex.org/W2924391634","https://openalex.org/W2944727022","https://openalex.org/W2946899637","https://openalex.org/W3012307045","https://openalex.org/W3094540299","https://openalex.org/W3097029961","https://openalex.org/W3112600195","https://openalex.org/W3113331104","https://openalex.org/W3118017075","https://openalex.org/W3118322235","https://openalex.org/W3125448607","https://openalex.org/W3173769416","https://openalex.org/W4211214747","https://openalex.org/W4220831425","https://openalex.org/W4308834893","https://openalex.org/W6789578188"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2982720988","https://openalex.org/W2506149209","https://openalex.org/W2352153050","https://openalex.org/W3150324899","https://openalex.org/W4392059188","https://openalex.org/W4388725868","https://openalex.org/W2104762330"],"abstract_inverted_index":{"Studies":[0],"have":[1],"identified":[2],"genes":[3],"and":[4,51,61,66,84,155,192],"molecular":[5],"pathways":[6,79],"regulating":[7],"cancer":[8,19,47,123,144,158,180],"metastasis.":[9],"However,":[10],"it":[11],"remains":[12],"largely":[13],"unknown":[14],"whether":[15],"metastatic":[16,53,94,128,186,204],"potentials":[17,54,95,129,187],"of":[18,44,89,98,114,136,164],"cells":[20,124],"from":[21,143],"different":[22,31,72,189],"lineage":[23,99,190],"types":[24],"are":[25,91,151,167],"driven":[26],"by":[27],"the":[28,87,112,115,121],"same":[29],"or":[30],"gene":[32,64,73,116,183],"networks.":[33],"Here,":[34],"we":[35,70,109,146],"aim":[36],"to":[37,157],"address":[38],"this":[39],"question":[40],"through":[41],"integrative":[42],"analyses":[43],"493":[45],"human":[46],"cells'":[48,181],"transcriptomic":[49,140],"profiles":[50],"their":[52,127],"in":[55,120,153],"vivo.":[56],"Using":[57],"an":[58,131],"unsupervised":[59],"approach":[60],"considering":[62],"both":[63],"coexpression":[65],"protein-protein":[67],"interaction":[68],"networks,":[69],"identify":[71],"networks":[74,150,166,184],"associated":[75],"with":[76,93,130,169],"various":[77],"biological":[78],"(i.e.":[80],"inflammation,":[81],"cell":[82],"cycle,":[83],"RNA":[85],"translation),":[86],"expression":[88,162],"which":[90],"correlated":[92,168],"across":[96,188],"subsets":[97],"types.":[100],"By":[101,138],"developing":[102],"a":[103],"regularized":[104],"random":[105],"forest":[106],"regression":[107],"model,":[108],"show":[110,147],"that":[111,148],"combination":[113],"module":[117],"features":[118],"expressed":[119],"native":[122],"can":[125,195],"predict":[126],"overall":[132],"Pearson":[133],"correlation":[134],"coefficient":[135],"0.90.":[137],"analyzing":[139],"profile":[141],"data":[142],"patients,":[145],"these":[149,165],"conserved":[152],"vivo":[154],"contribute":[156],"aggressiveness.":[159],"The":[160],"intrinsic":[161,182],"levels":[163],"drug":[170],"sensitivity.":[171],"Altogether,":[172],"our":[173,193],"study":[174],"provides":[175],"novel":[176],"comparative":[177],"insights":[178],"into":[179],"mediating":[185],"types,":[191],"results":[194],"potentially":[196],"be":[197],"useful":[198],"for":[199,203],"designing":[200],"personalized":[201],"treatments":[202],"cancers.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-03-10T14:07:55.174380","created_date":"2025-10-10T00:00:00"}